Interpreting CFSE obtained division histories of B cells in vitro with Smith-Martin and cyton type models

Bulletin of Mathematical Biology

Volumn 71, Issue 7, 2009, Pages 1649-1670

  Lee, Ha Youn ^a   Hawkins, Edwin ^b   Zand, Martin S ^c   Mosmann, Tim ^c   Wu, Hulin ^a   Hodgkin, Philip D ^b   Perelson, Alan S ^d  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

B cell; CFSE; Cyton model; IL 4; Smith Martin cell cycle model; Thymidine labeling

Indexed keywords

5 (6) CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; 5-(6)-CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; DEMECOLCINE; FLUORESCEIN DERIVATIVE; FLUORESCENT DYE; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; SUCCINIMIDE DERIVATIVE; THYMIDINE;

ALGORITHM; ANIMAL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BIOLOGICAL MODEL; CELL COUNT; CELL CULTURE; CELL DIVISION; CELL PROLIFERATION; COMPUTER SIMULATION; CYTOLOGY; DRUG EFFECT; METABOLISM; MOUSE; PHYSIOLOGY; PROBABILITY; STAINING; STATISTICS;

ALGORITHMS; ANIMALS; APOPTOSIS; B-LYMPHOCYTES; CELL COUNT; CELL DIVISION; CELL PROLIFERATION; CELLS, CULTURED; COMPUTER SIMULATION; DEMECOLCINE; FLUORESCEINS; FLUORESCENT DYES; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; MICE; MODELS, BIOLOGICAL; PROBABILITY; STAINING AND LABELING; STOCHASTIC PROCESSES; SUCCINIMIDES; THYMIDINE;

EID: 74049093675     PISSN: 00928240     EISSN: 15229602     Source Type: Journal    
DOI: 10.1007/s11538-009-9418-6     Document Type: Article

References (37)

1. Asquith, B., Debacq, C., Florins, A., Gillet, N., Sanchez-Alcaraz, T., Mosley, A., Willems, L., 2006. Quantifying lymphocyte kinetics in vivo using carboxyfluorescein diacetate succinimidyl ester (CFSE). Proc. R. Soc. B 273, 1165-1171.
2. Bernard, S., Pujo-Menjouret, L., Mackey, M. C., 2003. Analysis of cell kinetics using a cell division marker: mathematical modeling of experimental data. Biophys. J. 84, 3414-3424.
3. Bird, J. J., Brown, D. R., Mullen, A. C., 1998. Helper T cell differentiation is controlled by the cell cycle. Immunity 9, 229-237.
4. Brooks, R. F., Bennett, D. C., Smith, J. A., 1980. Mammalian cell cycles need two random transitions. Cell 19, 493-504.
5. Cory, S., Huang, D. C., Adams, J. M., 2003. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22, 8590-8607.
6. De Boer, R. J., Perelson, A. S., 2005. Estimating division and death rates from CFSE data. J. Comput. Appl. Math. 184, 140-164.
7. De Boer, R. J., Ganusov, V. V., Milutinovic, D., Hodgkin, P. D., Perelson, A. S., 2006. Estimating lymphocyte division and death rates from CFSE data. Bull. Math. Biol. 68, 1011-1031.
8. Deenick, E. K., Hasbold, J., Hodgkin, P. D., 1999a. Switching to IgG3, IgG2b, and IgA is division linked and independent, revealing a stochastic framework for describing differentiation. J. Immunol. 163, 4707-4714.
9. Deenick, E. K., Hasbold, J., Hodgkin, P. D., 1999b. Switching to IgG3, IgG2b, and IgA is division linked and independent, revealing a stochastic framework for describing differentiation. J. Immunol. 163, 4707-4714.
10. Deenick, E. K., Gett, A. V., Hodgkin, P. D., 2003. Stochastic model of T cell proliferation: a calculus revealing IL-2 regulation of precursor frequencies, cell cycle time, and survival. J. Immunol. 170, 4963-4972.
11. Dufort, F. J., Beiman, B. F., Gumina, M. R., Blair, D., Wagner, D. J., Roberts, M. F., Abu-Amer, Y., Chiles, T. C., 2007. IL-4-mediated protection of primary B lymphocytes from apoptosis via Stat6-dependent regulation of glycolytic metabolism. J. Immunol. 179, 4953-4957.
12. Efron, B., Tibshirani, R., 1986. Bootstrap methods for standard errors, confidence intervals, and other measures of statistical accuracy. Stat. Sci. 1, 54-77.
13. Fazekas de St Groth, B., Smith, A. L., Koh, W.-P., Girgis, L., Cook, M. C., Bertolino, P., 1999. Carboxyfluorescein diacetate succinimidyl ester and the virgin lymphocyte: A marriage made in heaven. Immnol. Cell Biol. 77, 530-538.
14. Ganusov, V. V., Pilyugin, S. S., De Boer, R. J., Murali-Krishna, K., Ahmed, R., Antia, R., 2005. Quantifying cell turnover using CFSE data. J. Immunol. Methods 298, 183-200.
15. Ganusov, V. V., Milutinovic, D., De Boer, R. J., 2007. IL-2 regulates expansion of CD4+ T cell populations by affecting cell death: insights from modeling CFSE data. J. Immunol. 179, 950-957.
16. Gascan, H., Gauchat, J. F., Roncarolo, M. G., Yssel, H., Spits, H., de Vries, J. E., 1991. Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones. J. Exp. Med. 173, 747-750.
17. Gett, A. V., Hodgkin, P. D., 1998. Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation. Proc. Natl. Acad. Sci. USA 95, 9488-9493.
18. Gett, A. V., Hodgkin, P. D., 2000. A cellular calculus for signal integration by T cells. Nat. Immunol. 1, 239-244.
19. Guo, B., Blair, D., Chiles, T. C., Lowell, C. A., Rothstein, T. L., 2007. B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn. J. Immunol. 178, 4726-4730.
20. Hasbold, J. A., Lyons, A. B., Kehry, M. R., Hodgkin, P. D., 1998. Cell division number regulates IgG1 and IgE switching of B cells following stimulation by CD40 ligand and IL-4. Eur. J. Immunol. 28, 1040-1051.
21. Hawkins, E. D., Turner, M. L., Dowling, M. R., van Gend, C., Hodgkin, P. D., 2007. A model of immune regulation as a consequence of randomized lymphocyte division and death times. Proc. Natl. Acad. Sci. USA 104, 5032-5037.
22. Hodgkin, P. D., Go, N. F., Cupp, J. E., Howard, M., 1991. Interleukin-4 enhances anti-IgM stimulation of B cells by improving cell viability and by increasing the sensitivity of B cells by improving cell viability and by increasing the sensitivity of B cells to the anti-IgM signal. Cell. Immunol. 134, 14-30.
23. Hodgkin, P. D., Lee, J. H., Lyons, A. B., 1996. B cell differentiation and isotype switching is related to division cycle number. J. Exp. Med. 184, 277-281.
24. Illera, V. A., Perandones, C. E., Stunz, L. L., Mower, D. A. Jr., Ashman, R. F., 1993. Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL-4. J. Immunol. 151, 2965-2973.
25. Lee, H. Y., Perelson, A. S., 2008. Modeling T cell proliferation and death in vitro based on labeling data: generalizations of the Smith-Martin cell cycle model. Bull. Math. Biol. 70, 21-44.
26. Leon, K., Faro, J., Carneiro, J., 2004. A general mathematical framework to model generation structure in a population of asynchronously dividing cells. J. Theor. Biol. 229, 455-476.
27. Lyons, A. B., 2000. Analyzing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J. Immunol. Methods 243, 147-154.
28. Lyons, A. B., Parish, C. R., 1994. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 171, 131-137.
29. Nordon, R. E., Nakamura, M., Ramirez, C., Odell, R., 1999. Analysis of growth kinetics by division tracking. Immunol. Cell. Biol. 77, 523-529.
30. Nurse, P., 2000. A long twentieth century of the cell cycle and beyond. Cell 100, 71-78.
31. 2. Proc. Natl. Acad. Sci. 85, 6880-6884.
32. Pilyugin, S. S., Ganusov, V. V., Murali-Krishna, K., Ahmed, R., Antia, R., 2003. The rescaling method for quantifying the turnover of cell population. J. Theor. Biol. 225, 275-283.
33. Revy, P., Sospedra, M., Barbour, B., Trautmann, A., 2001. Functional antigen-independent synapses formed between T cells and dendritic cells. Nat. Immunol. 2, 925-931.
34. Smith, J. A., Martin, L., 1973. Do cells cycle? Proc. Natl. Acad. Sci. USA 70, 1263-1267.
35. Tangye, S. G., Avery, D. T., Deenick, E. K., Hodgkin, P. D., 2003. Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune response. J. Immunol. 170, 686-694.
36. Wagner, E. F., Hleb, M., Hanna, N., Sharma, S., 1998. A pivotal role of cyclin D3 and cyclin-dependent kinase inhibitor p27 in the regulation of IL-2-, IL-4-, or IL-10-mediated human B cell proliferation. J. Immunol. 161, 1123-1131.
37. Wagner, E. F., Hanna, N., Fast, L. D., Kouttab, N., Shank, P. R., Vazquez, A., Sharma, S., 2000. Novel diversity in IL-4 mediated responses in resting human naive B cells versus germinal center/memory B cells. J. Immunol. 165, 5573-5579.