Blind T-cell homeostasis and the CD4/CD8 ratio in the thymus and peripheral blood

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 14, Issue 5, 1997, Pages 387-398

  Mehr, Ramit ^a   Perelson, Alan S ^b  

^a PRINCETON UNIVERSITY   (United States)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

Blind T cell homeostasis; Mathematical model; Thymus

Indexed keywords

ANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN;

ARTICLE; BLOOD; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; FEEDBACK SYSTEM; HOMEOSTASIS; LYMPHOCYTE DIFFERENTIATION; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; THYMUS;

EID: 0030924884     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199704150-00001     Document Type: Article

References (59)

1. Fauci AS. Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science 1993;262:1011-8.
2. Schnittman SM, Fauci AS. Human immunodeficiency virus and acquired immunodeficiency syndrome: an update. Adv Intern Med 1994;39:305-55.
3. + (T4) lymphocyte depletion. Proc Natl Acad Sci USA 1990;87:7727-31.
4. Dupuy JM, Gilmore N, Goldman H, et al. Thymic epithelial cell transplantation in patients with acquired immunodeficiency syndrome, evidence for infection by HIV-I of newly differentiated T cells at the site of transplantation. Thymus 1991;17:205-18.
5. Hays EF, Uittenbogaart CH, Brewer JC, Vollger LW, Zack JA. In vitro studies of HIV-1 expression in thymocytes from infants and children. AIDS 1992;6:265-72.
6. Bonyhadi ML, Rabin L, Salimi S, et al. HIV induces thymus depletion in vivo. Nature 1993;363:728-32.
7. Su L, Kaneshima H, Bonyhadi ML, et al. HIV-1-induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo. Immunity 1995;2:25-36.
8. Numazaki K, Bai XQ, Goldman H, Wong I, Spira B, Wainberg MA. Infection of cultured human thymic epithelial cells by human immunodeficiency virus. Clin Immunol Immunopathol 1989;51:185-95.
9. Numazaki K, Goldman H, Bai XQ, Wong I, Wainberg MA. Effects of infection by HIV-1, cytomegalovirus, and human measles virus on cultured human thymic epithelial cells. Microbiol Immunol 1989;33:733-45.
10. Stanley SK, McCune JM, Kaneshima H, et al. Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse. J Exp Med 1993;178:1151-63.
11. De Rossi A, Calabro ML, Panozzo M, et al. In vitro studies of HIV-1 infection in thymic lymphocytes: a putative role of the thymus in AIDS pathogenesis. AIDS Res Hum Retroviruses 1990;6:287-98.
12. Harris PJ, Candeloro PD, Bunn J. HIV infection of the adult thymus: an even more conventional theory explaining CD4 cell decrease and CD8 cell increase in AIDS. Med Hypotheses 1991;36:379-80.
13. Adleman LM, Wofsy D. T-cell homeostasis: implications in HIV infection. J Acquir immune Defic Syndr 1993;6:144-52.
14. Stanley S, Fauci AS. T cell homeostasis in HIV infection: part of the solution or part of the problem? J Acquir Immune Defic Syndr 1993;6:142-3.
15. + lymphocytes. J Acquir Immune Defic Syndr 1993;6:153-61.
16. Adleman LM, Wofsy D. Blind T-cell homeostasis in CD4-deficient mice. J Acquir Immune Defic Syndr Hum Retroviruses 1996;11:334-40.
17. + cells but markedly decreased helper cell activity in mice lacking CD4. Nature 1991;353:180-4.
18. Fung-Leung WP, Schilham MW, Rahemtulla A, et al. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 1991;65:443-9.
19. Margolick JB, Muñoz A, Donnenberg AD, et al for the Multicenter AIDS Cohort Study. Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. Nat Med 1995;1:674-80.
20. Rabin RL, Roederer M, Maldonado Y, Petru A, Herzenberg LA, Herzenberg LA. Altered representation of naive and memory CD8 T cell subsets in HIV-infected children. J Clin Invest 1995;95:2054-60.
21. Roederer M, Dubs GJ, Anderson MT, Raju PA, Herzenberg LA, Herzenberg LA. CD8 naive T cell counts decrease progressively in HIV-infected adults. J Clin Invest 1995;95:2061-6.
22. Roederer M. T-cell dynamics of immunodeficiency [comment]. Nat Med 1995;1:621-622.
23. + T cells and thymocytes: agerelated differential effects. Mech Ageing Dev 1994;73:169-78.
24. Eren R, Abel L, Globerson A. Syngeneic preference manifested by thymic stroma during development of thymocytes from bone marrow cells. Enr J Immunol 1989;19:2087-92.
25. Sharp A, Kukulansky T, Globerson A. Interactions of bone marrow cells from young and old mice with syngeneic and allogeneic thymic tissue. Cell Immunol 1991;138:280-8.
26. Sharp A, Fridkis-Hareli M, Eren R, Kukulansky T, Abel L, Globerson A. MHC-linked colonization of the thymus and thymocyte development: effects of mature T lymphocytes. Int Arch Allergy Immunol 1995;106:13-9.
27. Fridkis-Hareli M, Eren R, Sharp A, Abel L, Kukulansky T, Globerson A. MHC recognition in colonization of the thymus by bone marrow cells. Cell Immunol 1993;149:91-8.
28. Hirokawa K, Utsuyama M, Sado T. Immunohistological analysis of immigration of thymocyte-precursors into the thymus: evidence for immigration of peripheral T cells into the thymic medulla. Cell Immunol 1989;119:160-70.
29. Agus DB, Surh CD, Sprent J. Reentry of T cells to the adult thymus is restricted to activated T cells. J Exp Med 1991; 173:1039-46.
30. Surh CD, Sprent J, Webb SR. Exclusion of circulating T cells from the thymus does not apply in the neonatal period. J Exp Med 1993;177:379-85.
31. Gossmann J, Lohler J, Lehmann-Grube F. Entry of antivirally active T lymphocytes into the thymus of virus-infected mice. J Immunol 1991;146:293-7.
32. Fink PJ, Bevan MJ, Weissman IL. Thymic cytotoxic T lymphocytes are primed in vivo to minor histocompatibility antigens. J Exp Med 1984;159:436-51.
33. Mehr R, Perelson A, Globerson A. Feedback regulation of T cell development in the thymus. J Theor Biol 1996;181:157-67.
34. Mehr R, Perelson A, Globerson A. Feedback regulation of T cell development: manifestations in aging. Mech Ageing Dev 1996;91:195-210.
35. Mehr R, Globerson A, Perelson A. Modeling positive and negative selection and differentiation processes in the thymus. J Theor Biol 1995;175:103-26.
36. Mehr R, Globerson A, Perelson A. Models for selection processes in the thymus. J Appl Sci Comp 1996;3:1-24.
37. Mehr R, Abel L, Ubezio P, Globerson A, Agur Z. A mathematical model of the effect of aging on bone marrow cells colonizing the thymus. Mech Ageing Dev 1993;67:159-72.
38. Mehr R, Ubezio P, Kukulansky T, Globerson A. Differential effects of aging on various cell-cycle parameters in the T cell compartment. Aging Immunol Infect Dis 1996;6:133-140.
39. Mehr R, Segel L, Sharp A, Globerson A. Colonization of the thymus by T cell progenitors: models for cell-cell interactions. J Theor Biol 1994;170:247-57.
40. Mehr R, Fridkis-Hareli M, Abel L, Segel L, Globerson A. Lymphocyte development in irradiated thymuses: dynamics of colonization by progenitor cells and regeneration of resident cells. J Theor Biol 1995;177:181-92.
41. Shortman K, Egerton M, Spangrude G, Scollay R. The generation and fate of thymocytes. Semin Immunol 1990;2:3-12.
42. Good RA, Gabrielsen AB. The Thymus in Immunobiology: Structure, Function, and Role in Disease. New York: Hoeber Medical Division, Harper & Row, 1964.
43. Abbas AK, Lichtman AH, Pober JS. Cellular and Molecular Immunology. Philadelphia: WB Saunders, 1994.
44. + T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med 1995;332:143-9.
45. De Bruin HG, Astaldi A, Leupers T, et al. T lymphocyte characteristics in bone marrow transplant patients. II. Analysis with monoclonal antibodies. J Immunol 1981;127:244.
46. Atkinson K, Hansen JA, Storb R, Goehle S, Goldstein G, Thomas ED. T-cell subpopulations identified by monoclonial antibodies after human marrow transplantation. I. Helper-inducer and cytotoxic-suppressor subsets. Blood 1982;59:1292.
47. Atkinson K. T cell subpopulations defined by monoclonal antibodies after HLA-identical sibling marrow transplantation. II. Activated and functional subsets of the helper-inducer and the cytotoxic-suppressor subpopulations defined by two colour fluorescence flow cytometry. Bone Marrow Transplant 1986;1:121-32.
48. Amadori A, Zamarchi R, Chieco-Bianchi L. CD4:CD8 ratio and HIV infection: the "tap-and-drain" hypothesis. Immunol Today 1996;17:414-7.
49. Ho DD, Neumann ALJ, Perelson A, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995;373:123-6.
50. Perelson A. Modeling the interaction of the immune system with HIV. In: Castillo-Chavez C, ed. Mathematical and Statistical Approaches to AIDS Epidemiology, vol 83 of Lecture Notes in Biomathematics. New York: Springer-Verlag, 1989:350-370.
51. + T cells. Math Biosci 1993;114:81-125.
52. Egerton M, Shortman K, Scollay R. The kinetics of immature murine thymocyte development in vivo. Int Immunol 1990; 2:501-7.
53. Boersma W, Kokenberg E, Van der Westen G, Haaijman J. Post-irradiation thymocyte regeneration after bone marrow transplantation. III. Intrathymic differentiation and development of thymocyte subpopulations. Eur J Immunol 1982;12:615-9.
54. Lesley J, Trotter J, Schulte R, Hyman R. Phenotypic analysis of the early events during repopulation of the thymus by the bone marrow prothymocyte. Cell Immunol 1990;128:63-78.
55. Spangrude G, Scollay R. Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes: kinetics and phenotype of progeny. J Immunol 1990;145:3661-8.
56. + acquisition parallels down-regulation of the interleukin 2 receptor α chain. Eur J Immunol 1990;20:2813-5.
57. + acquisition in vivo and in vitro. J Exp Med 1990,172:1538-88.
58. Baron C, Penit C. Study of the thymocyte cell cycle by bivariate analysis of incorporated bromodeoxyuridine and DNA content. Eur J Immunol 1990;20:1231-6.
59. Egerton M, Scollay R, Shortman K. Kinetics of mature T-cell development in the thymus. Proc Natl Acad Sci USA 1990;87:2579-82.