메뉴 건너뛰기




Volumn 13, Issue 10, 2012, Pages 5143-5148

Use of oral antidiabetic drugs (metformin and pioglitazone) in diabetic patients with breast cancer: How does it effect on serum hif-1 alpha and 8ohdg levels?

Author keywords

8 OhdG; Breast cancer; Diabetes; HIF 1 levels

Indexed keywords


EID: 84874001818     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.10.5143     Document Type: Article
Times cited : (26)

References (61)
  • 1
    • 0842306338 scopus 로고    scopus 로고
    • Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus
    • Abbasi F, Chu JW, McLaughlin T, et al (2004). Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus. Metabolism, 53, 159-64.
    • (2004) Metabolism , vol.53 , pp. 159-164
    • Abbasi, F.1    Chu, J.W.2    McLaughlin, T.3
  • 2
    • 84874017086 scopus 로고    scopus 로고
    • Executive Summary: Standarts of Medical Care in Diabetes
    • ADA Guidelines ,PAGE?
    • ADA Guidelines (2012). Executive Summary: Standarts of Medical Care in Diabetes. Diabetes Care v, 35, PAGE?.
    • (2012) Diabetes Care v , vol.35
  • 3
    • 77955065596 scopus 로고    scopus 로고
    • 8-Hydroxy-2-deoxy-guanosine identifies oxidative DNA damage in a rural prediabetes cohort
    • Al-Aubaidy HA, Jelinek HF (2010). 8-Hydroxy-2-deoxy-guanosine identifies oxidative DNA damage in a rural prediabetes cohort. Redox Rep, 15, 155-60.
    • (2010) Redox Rep , vol.15 , pp. 155-160
    • Al-Aubaidy, H.A.1    Jelinek, H.F.2
  • 4
    • 0032574314 scopus 로고    scopus 로고
    • An examination of DNA strand breakage in the comet assay and antioxidant capacity in diabetic patients
    • Anderson D, Yu TW, Wright J, et al (1998). An examination of DNA strand breakage in the comet assay and antioxidant capacity in diabetic patients. Mutat Res, 398, 151-6.
    • (1998) Mutat Res , vol.398 , pp. 151-156
    • Anderson, D.1    Yu, T.W.2    Wright, J.3
  • 5
    • 76449111364 scopus 로고    scopus 로고
    • DNA damage and plasma antioxidant indices in Bangladeshi type 2 diabetic patients
    • Arif M, Islam MR, Hassan F, et al (2010). DNA damage and plasma antioxidant indices in Bangladeshi type 2 diabetic patients. Diabetes Metab, 36, 51-7.
    • (2010) Diabetes Metab , vol.36 , pp. 51-57
    • Arif, M.1    Islam, M.R.2    Hassan, F.3
  • 6
    • 79956226830 scopus 로고    scopus 로고
    • Cohort study of pioglitazone and cancer incidence in patients with diabetes
    • Assiamira Ferrara, James DL, Charles PQ, et al (2011). Cohort study of pioglitazone and cancer incidence in patients with diabetes. Diabetes Care, 34, 923-9.
    • (2011) Diabetes Care , vol.34 , pp. 923-929
    • Ferrara, A.1    James, D.L.2    Charles, P.Q.3
  • 7
    • 0030605388 scopus 로고    scopus 로고
    • Metformin N Engl
    • Bailey CJ, Turner RC (1996). Metformin N Engl J Med, 334, 574-9.
    • (1996) J Med , vol.334 , pp. 574-579
    • Bailey, C.J.1    Turner, R.C.2
  • 8
    • 0036595970 scopus 로고    scopus 로고
    • Oxidative and nitrosative stress induces peroxiredoxins in pancreatic beta cells
    • Bast A, Wolf G, Oberbäumer I, et al (2002) Oxidative and nitrosative stress induces peroxiredoxins in pancreatic beta cells. Diabetologia, 45, 867-76.
    • (2002) Diabetologia , vol.45 , pp. 867-876
    • Bast, A.1    Wolf, G.2    Oberbäumer, I.3
  • 9
    • 79960904880 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetes
    • Bento CF, Pereira P (2011). Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetes. Diabetologia, 54, 1946-56.
    • (2011) Diabetologia , vol.54 , pp. 1946-1956
    • Bento, C.F.1    Pereira, P.2
  • 10
    • 0141884341 scopus 로고    scopus 로고
    • Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type 2 diabetes mellitus with nephropathy
    • Bhatia S, Shukla R, Venkata Madhu, et al (2003). Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type 2 diabetes mellitus with nephropathy. Clin Biochem, 36, 557-62.
    • (2003) Clin Biochem , vol.36 , pp. 557-562
    • Bhatia, S.1    Shukla, R.2    Madhu, V.3
  • 11
    • 0033937272 scopus 로고    scopus 로고
    • Consequences of the diabetic status on the oxidant/antioxidant balance
    • Bonnefont-Rousselot D, Bastard JP, Jaudon MC, et al (2000). Consequences of the diabetic status on the oxidant/antioxidant balance. Diabetes Metab, 26, 163-76.
    • (2000) Diabetes Metab , vol.26 , pp. 163-176
    • Bonnefont-Rousselot, D.1    Bastard, J.P.2    Jaudon, M.C.3
  • 12
    • 0035925072 scopus 로고    scopus 로고
    • Levels of hypoxia-inducible factor 1 alpha during breast carcinogenesis
    • Bos R, Zhong H, Hanrahan CF, et al (2002). Levels of hypoxia-inducible factor 1 alpha during breast carcinogenesis. J Natl Cancer Res, 93, 309-14.
    • (2002) J Natl Cancer Res , vol.93 , pp. 309-314
    • Bos, R.1    Zhong, H.2    Hanrahan, C.F.3
  • 13
    • 80053408653 scopus 로고    scopus 로고
    • Disruption of Hypoxia-inducible factor 1 in adipocytes improves insülin sensitivity and decreases adiposity in high-fat diet-fed mice
    • Changtao J, Aijuan Q, Tsutomu M, et al (2011). Disruption of Hypoxia-inducible factor 1 in adipocytes improves insülin sensitivity and decreases adiposity in high-fat diet-fed mice. Diabetes, 60, 2484-95.
    • (2011) Diabetes , vol.60 , pp. 2484-2495
    • Changtao, J.1    Aijuan, Q.2    Tsutomu, M.3
  • 14
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    • Currie CJ, Poole CD, Gale EAM (2009). The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. JOURNAL?, 52, 1766-77.
    • (2009) JOURNAL? , vol.52 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.M.3
  • 15
    • 0031984686 scopus 로고    scopus 로고
    • Insulin and related factors in premenopausal breast cancer risk
    • Del Giudice ME, Fantus IG, Ezzat S, et al (1998). Insulin and related factors in premenopausal breast cancer risk. Breast Cancer Res Treat, 47, 111-20.
    • (1998) Breast Cancer Res Treat , vol.47 , pp. 111-120
    • Del Giudice, M.E.1    Fantus, I.G.2    Ezzat, S.3
  • 16
    • 26244453309 scopus 로고    scopus 로고
    • PROactive investigators. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
    • Dormandy JA, Charbonnel B, Eckland DJ, et al (2005). PROactive investigators. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet, 366, 1279-89.
    • (2005) Lancet , vol.366 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.3
  • 17
    • 0032555196 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
    • Elstner E, Müller C, Koshizuka K, et al (1998). Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA, 95, 8806-11.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8806-8811
    • Elstner, E.1    Müller, C.2    Koshizuka, K.3
  • 18
    • 84874006132 scopus 로고    scopus 로고
    • European Medicines Agency, Committee for medicinal products for human use.Pioglitazon Accord, Summary of opinion (initial authorisation), website e-mail: info@ema.europa. eu 21 July
    • European Medicines Agency, Committee for medicinal products for human use. (21 July 2011). Pioglitazon Accord, Summary of opinion (initial authorisation), website: www.ema.europa.eu ; e-mail: info@ema.europa.eu
    • (2011)
  • 19
    • 20444461067 scopus 로고    scopus 로고
    • Metformin and reduced risk of cancer in diabetic patients
    • Evans JM, Donnelly LA, Emslie-Smith AM, et al (2005) Metformin and reduced risk of cancer in diabetic patients. BMJ, 330, 1304-5.
    • (2005) BMJ , vol.330 , pp. 1304-1305
    • Evans, J.M.1    Donnelly, L.A.2    Emslie-Smith, A.M.3
  • 20
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z, Zhang H, Levine AJ, et al (2005). The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci USA, 102, 8204-9.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3
  • 21
    • 84874008273 scopus 로고    scopus 로고
    • Food and Drug Administration FDA drug safety communication: ongoing safety review of actos (pioglitazone) and potential increased risk of bladder cancer after two years expose (Internet),
    • Food and Drug Administration (2010). FDA drug safety communication: ongoing safety review of actos (pioglitazone) and potential increased risk of bladder cancer after two years expose (Internet),
    • (2010)
  • 22
    • 33646036739 scopus 로고    scopus 로고
    • Reactive species and early manifestation of insulin resistance in type 2 diabetes
    • Fridlyand LE, Philipson LH (2006), Reactive species and early manifestation of insulin resistance in type 2 diabetes. Diabetes Obes Metab, 8, 136-145
    • (2006) Diabetes Obes Metab , vol.8 , pp. 136-145
    • Fridlyand, L.E.1    Philipson, L.H.2
  • 23
    • 0034862629 scopus 로고    scopus 로고
    • Postload plasma glucose concentration and 27-year prostate cancer mortality (United States)
    • Gapstur SM, Gann PH, Colangelo LA, et al (2001) Postload plasma glucose concentration and 27-year prostate cancer mortality (United States). Cancer Causes Control, 12, 763-72.
    • (2001) Cancer Causes Control , vol.12 , pp. 763-772
    • Gapstur, S.M.1    Gann, P.H.2    Colangelo, L.A.3
  • 24
  • 25
    • 34248192254 scopus 로고    scopus 로고
    • Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes
    • Govindarajan R, Ratnasinghe L, Simmons DL (2007). Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes. J Clin Oncol, 25, 1476-81.
    • (2007) J Clin Oncol , vol.25 , pp. 1476-1481
    • Govindarajan, R.1    Ratnasinghe, L.2    Simmons, D.L.3
  • 26
    • 23744439083 scopus 로고    scopus 로고
    • Loss of ARNT/HIF1β mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes
    • Gunton JE, Kulkarni RN, Yim S, et al (2005). Loss of ARNT/HIF1β mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell, 122, 337-49.
    • (2005) Cell , vol.122 , pp. 337-349
    • Gunton, J.E.1    Kulkarni, R.N.2    Yim, S.3
  • 27
    • 0034733798 scopus 로고    scopus 로고
    • Levels of peripheral blood cell DNA damage in insülin dependent diabetes mellitus human subjects
    • Hannon-Fletcher MP, O'Kane MJ, Moles KW, et al (2000). Levels of peripheral blood cell DNA damage in insülin dependent diabetes mellitus human subjects. Mutat Res, 460, 53-60.
    • (2000) Mutat Res , vol.460 , pp. 53-60
    • Hannon-Fletcher, M.P.1    O'Kane, M.J.2    Moles, K.W.3
  • 28
    • 0035542970 scopus 로고    scopus 로고
    • AMP-activated protein kinase: the energy charge hypothesis revisited
    • Hardie DG, Hamley SA (2001). AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays, 23, 1112-9.
    • (2001) Bioessays , vol.23 , pp. 1112-1119
    • Hardie, D.G.1    Hamley, S.A.2
  • 29
    • 0036324142 scopus 로고    scopus 로고
    • The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
    • Hawley SA, Gadalla AE, Olsen GS, et al (2002). The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes, 51, 2420-5.
    • (2002) Diabetes , vol.51 , pp. 2420-2425
    • Hawley, S.A.1    Gadalla, A.E.2    Olsen, G.S.3
  • 30
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N (2004). Upstream and downstream of mTOR. Genes Dev, 18, 1926-45.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 31
    • 79956217900 scopus 로고    scopus 로고
    • Risk of bladder cancer among diabetiv patients treated with pioglitazone
    • James D Lewis, Assiamira Ferrara, Tiffany Peng, et al (2011). Risk of bladder cancer among diabetiv patients treated with pioglitazone. Diabetes Care, 34, 916-22.
    • (2011) Diabetes Care , vol.34 , pp. 916-922
    • Lewis, J.D.1    Ferrara, A.2    Peng, T.3
  • 32
    • 0037323971 scopus 로고    scopus 로고
    • AMP-activated protein kinase, super metabolic regulator
    • 31:162-8. ndocrine-Related Cancer
    • Kemp BE, Stapleton D, Campbell DJ (2003). AMP-activated protein kinase, super metabolic regulator. Biochem Soc Trans, 31:162-8. ndocrine-Related Cancer, 13, 739-49.
    • (2003) Biochem Soc Trans , vol.13 , pp. 739-749
    • Kemp, B.E.1    Stapleton, D.2    Campbell, D.J.3
  • 33
    • 33751074452 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 in human breast and prostate cancer
    • Kimbro K S, Simons JW (2006). Hypoxia-inducible factor-1 in human breast and prostate cancer. Endocrine-Related Cancer, 13, 739-49.
    • (2006) Endocrine-Related Cancer , vol.13 , pp. 739-749
    • Kimbro, K.S.1    Simons, J.W.2
  • 34
    • 34249747832 scopus 로고    scopus 로고
    • Cancer risks in thiazolidinedione users compared to other anti-diabetic agents
    • Koro C, Barrett S, Qizilbash N (2007). Cancer risks in thiazolidinedione users compared to other anti-diabetic agents. Pharmaco-epidemiol Drug Saf, 16, 485492.
    • (2007) Pharmaco-epidemiol Drug Saf , vol.16 , pp. 485492
    • Koro, C.1    Barrett, S.2    Qizilbash, N.3
  • 35
    • 0032145363 scopus 로고    scopus 로고
    • Ligand for peroxisome proliferator-activated receptor gamma (Troglitazone) has potent antitumor effect against human prostat cancer both in vitro and in vivo
    • Kubota T, Koshizuka K, Williamson EA, et al (1998) Ligand for peroxisome proliferator-activated receptor gamma (Troglitazone) has potent antitumor effect against human prostat cancer both in vitro and in vivo. Cancer Res, 58, 3344-52.
    • (1998) Cancer Res , vol.58 , pp. 3344-3352
    • Kubota, T.1    Koshizuka, K.2    Williamson, E.A.3
  • 36
    • 3042616145 scopus 로고    scopus 로고
    • Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4
    • Liang Z, Wu T, Lou H, et al (2004). Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4. Cancer Res, 64, 4302-8.
    • (2004) Cancer Res , vol.64 , pp. 4302-4308
    • Liang, Z.1    Wu, T.2    Lou, H.3
  • 37
    • 11244341098 scopus 로고    scopus 로고
    • Ras-dependent induction of HIF-1 alpha785 via the Raf/MEK/ERK pathway: a novel mechanism of Ras-mediated tumor promotion
    • Lim JH, Lee ES, You HJ, et al (2004). Ras-dependent induction of HIF-1 alpha785 via the Raf/MEK/ERK pathway: a novel mechanism of Ras-mediated tumor promotion. Oncogene, 23, 9427-31.
    • (2004) Oncogene , vol.23 , pp. 9427-9431
    • Lim, J.H.1    Lee, E.S.2    You, H.J.3
  • 38
    • 0038703477 scopus 로고    scopus 로고
    • PPARgamma ligands and ATRA inhibit the invasion of human breast cancer cells in vitro
    • Liu H, Zang C, Fenner MH et al (2003). PPARgamma ligands and ATRA inhibit the invasion of human breast cancer cells in vitro. Breast Cancer Res Treat, 79, 63-77.
    • (2003) Breast Cancer Res Treat , vol.79 , pp. 63-77
    • Liu, H.1    Zang, C.2    Fenner, M.H.3
  • 39
    • 80052744190 scopus 로고    scopus 로고
    • Expression of Hypoxia-inducible factor 1-α and vascular endothelial growth factor-C in locally advanced breast cancer patients
    • Luiz Gustavo Oliveira Brito, Viviane Fernandes Schiavon, Jurandyr Moreira da Andrade, et al (2011). Expression of Hypoxia-inducible factor 1-α and vascular endothelial growth factor-C in locally advanced breast cancer patients. Clin Sci, 66, 1313-9.
    • (2011) Clin Sci , vol.66 , pp. 1313-1319
    • Brito, L.G.O.1    Schiavon, V.F.2    da Andrade, J.M.3
  • 40
    • 77954162846 scopus 로고    scopus 로고
    • Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
    • Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB, et al (2010). Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle, 9, 3256-76.
    • (2010) Cell Cycle , vol.9 , pp. 3256-3276
    • Martinez-Outschoorn, U.E.1    Balliet, R.M.2    Rivadeneira, D.B.3
  • 41
    • 0031993322 scopus 로고    scopus 로고
    • Terminal differentiation of human breast cancer through PPAR gamma
    • Mueller E, Sarraf P, Tontonoz P, et al (1998). Terminal differentiation of human breast cancer through PPAR gamma. Mol Cell, 1, 465-70.
    • (1998) Mol Cell , vol.1 , pp. 465-470
    • Mueller, E.1    Sarraf, P.2    Tontonoz, P.3
  • 42
    • 0030176396 scopus 로고    scopus 로고
    • Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis
    • Musarrat J, Arezina-Wilson J, Wani AA (1996). Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis. Eur J Cancer, 32A, 1209-14.
    • (1996) Eur J Cancer , vol.32 A , pp. 1209-1214
    • Musarrat, J.1    Arezina-Wilson, J.2    Wani, A.A.3
  • 43
    • 60449089649 scopus 로고    scopus 로고
    • American Diabetes Association; European Association for Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, et al (2009). American Diabetes Association; European Association for Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care, 32, 193-203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 45
    • 4644240373 scopus 로고    scopus 로고
    • Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    • Rathmann W, Giani G (2004). Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care, 27, 2568-9.
    • (2004) Diabetes Care , vol.27 , pp. 2568-2569
    • Rathmann, W.1    Giani, G.2
  • 46
    • 0034939115 scopus 로고    scopus 로고
    • The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society
    • Rösen P, Nawroth PP, King G, et al (2001). The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes Metab Res Rev, 17, 189-212.
    • (2001) Diabetes Metab Res Rev , vol.17 , pp. 189-212
    • Rösen, P.1    Nawroth, P.P.2    King, G.3
  • 47
    • 34547661569 scopus 로고    scopus 로고
    • Safety issues and prospects for future generations of PPAR modulators
    • Rubenstrunk A, Hanf R, Hum DW, et al (2007). Safety issues and prospects for future generations of PPAR modulators. Biochim Biophys Acta, 1771, 1065-81.
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 1065-1081
    • Rubenstrunk, A.1    Hanf, R.2    Hum, D.W.3
  • 48
    • 24044513942 scopus 로고    scopus 로고
    • A review on role of antioxidants in the management of diabetes and its complications
    • Rahimi R, Nikfar S, Larijani B, et al (2005). A review on role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother. 59, 365-73.
    • (2005) Biomed Pharmacother , vol.59 , pp. 365-373
    • Rahimi, R.1    Nikfar, S.2    Larijani, B.3
  • 49
    • 0037401046 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists
    • Rikio Y, Masahide M, Yoshihiro S, et al (2003). Expression of peroxisome proliferator activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists. Int J Cancer, 104, 597-602.
    • (2003) Int J Cancer , vol.104 , pp. 597-602
    • Rikio, Y.1    Masahide, M.2    Yoshihiro, S.3
  • 50
    • 33747819801 scopus 로고    scopus 로고
    • mTOR and cancer: insights into a complex relationship
    • Sabatini DM (2006). mTOR and cancer: insights into a complex relationship. Nat Rev Cancer, 6, 729-34
    • (2006) Nat Rev Cancer , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 51
    • 77954536748 scopus 로고    scopus 로고
    • Inhibition of adipogenesis by Tempol in 3T3-L1 cells
    • Samuni Y, Cook JA, Choudhuri R, et al (2010) Inhibition of adipogenesis by Tempol in 3T3-L1 cells. Free Radic Biol Med, 49, 667-73.
    • (2010) Free Radic Biol Med , vol.49 , pp. 667-673
    • Samuni, Y.1    Cook, J.A.2    Choudhuri, R.3
  • 52
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza GL (2010). Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene, 29, 625-34.
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 53
    • 75249084816 scopus 로고    scopus 로고
    • Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat
    • Suzuki S, Arnold LL, Pennigton KL, et al (2010). Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat. Toxicol Sci, 113, 349-57.
    • (2010) Toxicol Sci , vol.113 , pp. 349-357
    • Suzuki, S.1    Arnold, L.L.2    Pennigton, K.L.3
  • 54
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1 alpha and HIF-2 alpha in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC, et al (2000). The expression and distribution of the hypoxia-inducible factors HIF-1 alpha and HIF-2 alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol, 157, 411-21.
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3
  • 55
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study KPDS Group
    • UK Prospective Diabetes Study (UKPDS) Group (1998). Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet, 352, 854-65.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 57
    • 77956236828 scopus 로고    scopus 로고
    • Oxidative/nitrosative stresses trigger I diabetes: preventable in streptozotocin rats and detectable in human disease
    • Van Dyke K, Jabbour N, Hoeldtke R, et al (2010). Oxidative/nitrosative stresses trigger I diabetes: preventable in streptozotocin rats and detectable in human disease. Ann N Y Acad Sci, 1203, 138-45.
    • (2010) Ann N Y Acad Sci , vol.1203 , pp. 138-145
    • Van Dyke, K.1    Jabbour, N.2    Hoeldtke, R.3
  • 58
    • 0345735389 scopus 로고    scopus 로고
    • Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics
    • Wu LL, Chiou CC, Chang PY, et al (2004). Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin ChimActa, 339, 1-9.
    • (2004) Clin ChimActa , vol.339 , pp. 1-9
    • Wu, L.L.1    Chiou, C.C.2    Chang, P.Y.3
  • 59
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN (2006). TOR signaling in growth and metabolism. Cell, 124, 471-84.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 60
    • 75949130069 scopus 로고    scopus 로고
    • Relationships between glucose excursion and the activation of oxidative stress in patients with newly diagnosed type 2 diabetes or impaired glucose regulation
    • Zheng F, Lu W, Jia C, et al (2010). Relationships between glucose excursion and the activation of oxidative stress in patients with newly diagnosed type 2 diabetes or impaired glucose regulation. Endocrine, 37, 201-8.
    • (2010) Endocrine , vol.37 , pp. 201-208
    • Zheng, F.1    Lu, W.2    Jia, C.3
  • 61
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor1 alpha in common human cancers and their metastases
    • Zong H, De Marzo AM, Laughner E, et al (1999). Overexpression of hypoxia-inducible factor1 alpha in common human cancers and their metastases. Cancer Res, 59, 5830-5.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zong, H.1    De Marzo, A.M.2    Laughner, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.