An examination of DNA strand breakage in the comet assay and antioxidant capacity in diabetic patients

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 398, Issue 1-2, 1998, Pages 151-161

  Anderson, D ^a   Yu, T W ^a   Wright, J ^b   Ioannides, C ^b  

^a BIBRA INTERNATIONAL   (United Kingdom)

^b UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Antioxidant capacity; Comet assay; Creatinine level; Diabetic patient; HbA(1C); Oxygen radical

Indexed keywords

ANTIOXIDANT; CREATININE; HEMOGLOBIN A1C; OXYGEN RADICAL;

ARTICLE; ASSAY; BLOOD SAMPLING; CONTROLLED STUDY; DNA DAMAGE; DNA DETERMINATION; DNA STRAND BREAKAGE; DRINKING; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LIFESTYLE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; QUESTIONNAIRE; VITAMIN INTAKE;

ADULT; AGED; ANTIOXIDANTS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DNA DAMAGE; ELECTROPHORESIS; FEMALE; HUMANS; MALE; MIDDLE AGED;

EID: 0032574314     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00271-6     Document Type: Article

References (30)

1. Greismacher A., Kindhauser M., Andert S.E., Andert M.D., Schreiner W., Toma C., Knoebl P., Peitschmann Prager R., Schnack C., Schernthaner G., Mathias M., Mueller M.D. Enhanced serum levels of thiobarbituric-acid-reactive substances in diabetes mellitus. Am. J. Med. 98:1995;469-474.
2. Baynes J.W. Role of oxidative stress in development of complications of diabetes. Diabetes. 40:1991;405-412.
3. J.W. Baynes, Reactive oxygen in the aetiology and complications of diabetes, in: C. Ioannides, P.R. Flatt (Eds.), Drugs, Diet and Disease, Vol. 2, Mechanistic Approaches to Diabetes, Ellis Horwood, Hemel Hempstead, UK, 1995.
4. Anderson D., Yu T-W., Phillips B.J., Schmezer P. The effect of various antioxidant and other modifying agents on oxygen-radical generated DNA damage in human lymphocytes in the Comet assay. Mutat. Res. 307:1994;261-271.
5. Miller N.J., Rice-Evans C., Davies M.J., Gopinathan V., Milner A. A novel method for measuring antioxidant capacity and application to monitoring the antioxidant status in premature neonates. Clin. Sci. 84:1993;407-412.
6. Anderson D., Jenkinson P.C., Dewdney R.S., Francis A.J., Godbert P., Butterworth K.R. Mitogen-induced blastogenesis and proliferative rate index in peripheral lymphocytes from 106 control individuals of the UK population. Mutat. Res. 204:1988;407-421.
7. Pool-Zobel B.L., Klein R.G., Wegibel U.M., Kuchenmeister F., Weber S., Schmezer P. Systemic genotoxic effect of tobacco-related nitrosamines following oral and inhalation administration to Sprague-Dawley rats. Clin. Invest. 70:1972;299-306.
8. Pool-Zobel B.L., Guigas C., Klein R., Neudecker C.H., Renner H.W., Schmezer P. Assessment of genotoxic effects by lindane. Food Chem. Toxicol. 31:1993;271-283.
9. James G.J., Enger S.M., Makinodan T. DNA strand breaks and DNA repair response in lymphocytes after chronic in vivo exposure to very low doses of ionising radiation in mice. Mutat. Res. 249:1991;255-263.
10. Collins A.R., Duthie S.J., Dobson V.L. Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis. 14:1993;1733-1735.
11. D. Anderson, T.-W. Yu, B.J. Phillips, P. Schmezer, A.J. Edwards, K.R. Butterworth, R. Ayesh, The use of the Comet assay as a biomarker to measure the genetic effects of food chemicals and protective effects of antioxidants administered in vitro and in vivo, in: H.M. Crews, A.B. Hanley (Eds.), Biomarkers in Food Chemical Risk Assessment, The Royal Soc. of Chem., 1995, pp. 48-55.
12. Anderson D., Phillips B.J., Yu T-W., Edwards A.J., Ayesh R., Butterworth K.R. The effect of Vitamin C supplementation on biomarkers of oxygen radical generated damage in human volunteers with low or high cholesterol levels. Environ. Mol. Mutagen. 20:1997;161-174.
13. B.N. Ames, Measuring oxidative damage in humans: relation to cancer and ageing, in: H. Barstsch, K. Hemminki, I.K. O'Neill (Eds.), Methods for Detecting DNA Damaging Agents in Humans. Applications in Cancer Epidemiology and Prevention, IARC Sci. Publ. No. 89, International Agency for Research on Cancer, Lyon, France, 1988a, pp. 407-416.
14. B.N. Ames, The measurement of oxidative damage in humans: relation to cancer and ageing, in: T. Yoshikawa (Ed.), Medical, Biochemical and Chemical Aspects of Free Radicals, Elsevier, Amsterdam, 1989.
15. Ames B.N. Endogenous DNA damage as related to cancer and ageing. Mutat. Res. 214:1989;41-46.
16. B.N. Ames, P. Motchnik, C. Fraga, H. Helbock, Antioxidant prevention of birth defects and childhood cancer, Abstract from Conference on Male-Mediated Developmental Toxicology, September 16-19, Pittsburgh, PA, 1992.
17. Betti C., Davini T., Giannessi L., Loprieno N., Barale R. Microgelelectrophoresis assay (Comet test) and SCE analysis in human lymphocytes from 100 normal individuals. Mutat. Res. 302:1994;323-333.
18. Rojas E., Valverde M., Sordo M., Ostrosky-Wegman P. DNA damage in exfoliated buccal cells of smokers assessed by the single cell gel electrophoresis assay. Mutat. Res. 370:1996;115-120.
19. Smith J.L., Hodges R.E. Serum levels of vitamin C in relation to dietary and supplemental intake of vitamin C in smokers and non-smokers. Ann. N.Y. Acad. Sci. 498:1987;144-152.
20. Everhart J., Wright D. Diabetes mellitus a risk factor for pancreatic cancer. JAMA. 273:1995;1605-1609.
21. Steenland K., Nowlin S., Palu S. Cancer incidence in the National Health and Nutrition Survey: I. Follow-up data: diabetes, cholesterol, pulse and physical activity. Cancer Epidemiol. Biomarkers Prev. 4:1995;807-811.
22. Collins A., Dusinská M., Franklin M., Somorovská M., Petrovská H., Duthie S., Fillion L., Panayiotidis M., Rašlová K., Vaughan N. Comet assay in human biomonitoring studies: reliability, validation and applications. Environ. Mol. Mutagen. 30:1997;139-146.
23. Anderson D., Hughes J.A., Cebulska-Wasilewska A., Wierzewska A., Kasper E. Biological monitoring of workers exposed to emissions from petroleum plants. Environ. Health Perspect. 104:1996;609-613.
24. Tompa A., Major J., Jakob M.G. Monitoring of benzene-exposed workers for genotoxic effects of benzene. Mutat. Res. 304:1994;159-165.
25. Peter A.L., Davidson M.B., Schriger D.L., Hasselblad V. A clinical approach for the diagnosis of Diabetes mellitus. JAMA. 276:1996;1246-1252.
26. Jain S.K., Palmer M. The effect of oxygen radicals, metabolites and vitamin E on glycosylation of proteins. Free Radic. Biol. Med. 22:1997;593-596.
27. Sechi L.A., Ceriello A., Griffin C.A., Catera C., Amsted P., Schambelan M., Bartoli E. Renal antioxidant enzyme mRNA levels are increased in rats with experimental Diabetes mellitus. Diabetologia. 40:1997;23-29.
28. Vandam P.S., Bravenboer B., Vanasbeck B.S., Vanoirschot J.F.L.M., Marx J.J.M., Gispen W.H. Effects of insulin treatment on endoneurial and systemic oxidative stress in relation to nerve conduction in streptozotocin-diabetic rats. Eur. J. Clin. Invest. 26:1997;1143-1149.
29. Matsuoka T., Kajimoto Y., Watada H., Kaneto H., Kishimoto M., Umayahara Y., Fujitani V., Kamada T., Kawamori R., Yamasaki Y. Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. J. Clin. Invest. 99:1997;144-150.
30. Orny D., Kimyagarov D., Yaffee P., Abir R., Raz I., Kohen R. Role of reactive oxygen species in diabetes-induced embryotoxicity studies or pre-implantation mouse embryos cultured in serum from Diabetic pregnant women. Isr. J. Med. Sci. 32:1997;1066-1073.