Inhibition of adipogenesis by Tempol in 3T3-L1 cells

Free Radical Biology and Medicine

Volumn 49, Issue 4, 2010, Pages 667-673

  Samuni, Yuval ^a   Cook, John A ^a   Choudhuri, Rajani ^a   DeGraff, William ^a   Sowers, Anastasia L ^a   Krishna, Murali C ^a   Mitchell, James B ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Adipogenesis; Free radicals; Nitroxide; Obesity; Oxidative stress; Tempol

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; SOMATOMEDIN C; TEMPOL;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; DOWN REGULATION; FEMALE; INHIBITION KINETICS; LIPID STORAGE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; UPREGULATION; WEIGHT REDUCTION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; ANTIOXIDANTS; CELL DIFFERENTIATION; CELLS, CULTURED; CYCLIC N-OXIDES; FEMALE; MICE; MICE, INBRED C3H; MICROSCOPY, FLUORESCENCE; SPIN LABELS; WEIGHT GAIN;

MUS;

EID: 77954536748     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.05.028     Document Type: Article

References (47)

1. Yanovski S.Z., Yanovski J.A. Obesity. N. Engl. J. Med. 2002, 346:591-602.
2. Holliday R. Food, reproduction and longevity: is the extended lifespan of calorie-restricted animals an evolutionary adaptation?. BioEssays 1989, 10:125-127.
3. Wheatley K.E., Williams E.A., Smith N.C., Dillard A., Park E.Y., Nunez N.P., Hursting S.D., Lane M.A. Low-carbohydrate diet versus caloric restriction: effects on weight loss, hormones, and colon tumor growth in obese mice. Nutr. Cancer 2008, 60:61-68.
4. Gesta S., Tseng Y.H., Kahn C.R. Developmental origin of fat: tracking obesity to its source. Cell 2007, 131:242-256.
5. Hirsch J., Batchelor B. Adipose tissue cellularity in human obesity. Clin. Endocrinol. Metab. 1976, 5:299-311.
6. Spalding K.L., Arner E., Westermark P.O., Bernard S., Buchholz B.A., Bergmann O., Blomqvist L., Hoffstedt J., Naslund E., Britton T., Concha H., Hassan M., Ryden M., Frisen J., Arner P. Dynamics of fat cell turnover in humans. Nature 2008, 453:783-787.
7. MacDougald O.A., Lane M.D. Transcriptional regulation of gene expression during adipocyte differentiation. Annu. Rev. Biochem. 1995, 64:345-373.
8. Farmer S.R. Transcriptional control of adipocyte formation. Cell Metab. 2006, 4:263-273.
9. Rosen E.D., MacDougald O.A. Adipocyte differentiation from the inside out. Nat. Rev. Mol. Cell Biol. 2006, 7:885-896.
10. Cowherd R.M., Lyle R.E., McGehee R.E.J. Molecular regulation of adipocyte differentiation. Semin. Cell Dev. Biol. 1999, 10:3-10.
11. Barak Y., Nelson M.C., Ong E.S., Jones Y.Z., Ruiz-Lozano P., Chien K.R., Koder A., Evans R.M. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol. Cell 1999, 4:585-595.
12. Rosen E.D., Sarraf P., Troy A.E., Bradwin G., Moore K., Milstone D.S., Spiegelman B.M., Mortensen R.M. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell 1999, 4:611-617.
13. Nakano R., Kurosaki E., Yoshida S., Yokono M., Shimaya A., Maruyama T., Shibasaki M. Antagonism of peroxisome proliferator-activated receptor gamma prevents high-fat diet-induced obesity in vivo. Biochem. Pharmacol. 2006, 72:42-52.
14. Gerhold D.L., Liu F., Jiang G., Li Z., Xu J., Lu M., Sachs J.R., Bagchi A., Fridman A., Holder D.J., Doebber T.W., Berger J., Elbrecht A., Moller D.E., Zhang B.B. Gene expression profile of adipocyte differentiation and its regulation by peroxisome proliferator-activated receptor-gamma agonists. Endocrinology 2002, 143:2106-2118.
15. Greenberg A.S., Egan J.J., Wek S.A., Garty N.B., Blanchette-Mackie E.J., Londos C. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J. Biol. Chem. 1991, 266:11341-11346.
16. Furukawa S., Fujita T., Shimabukuro M., Iwaki M., Yamada Y., Nakajima Y., Nakayama O., Makishima M., Matsuda M., Shimomura I. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 2004, 114:1752-1761.
17. Kim J.R., Ryu H.H., Chung H.J., Lee J.H., Kim S.W., Kwun W.H., Baek S.H., Kim J.H. Association of anti-obesity activity of N-acetylcysteine with metallothionein-II down-regulation. Exp. Mol. Med. 2006, 38:162-172.
18. Kamigaki M., Sakaue S., Tsujino I., Ohira H., Ikeda D., Itoh N., Ishimaru S., Ohtsuka Y., Nishimura M. Oxidative stress provokes atherogenic changes in adipokine gene expression in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 2006, 339:624-632.
19. Yun Z., Maecker H.L., Johnson R.S., Giaccia A.J. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev. Cell 2002, 2:331-341.
20. Regazzetti C., Peraldi P., Gremeaux T., Najem-Lendom R., Ben-Sahra I., Cormont M., Bost F., Le Marchand-Brustel Y., Tanti J.F., Giorgetti-Peraldi S. Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes 2009, 58:95-103.
21. Mitchell J.B., Xavier S., DeLuca A.M., Sowers A.L., Cook J.A., Krishna M.C., Hahn S.M., Russo A. A low molecular weight antioxidant decreases weight and lowers tumor incidence. Free Radic. Biol. Med. 2003, 34:93-102.
22. Green H., Kehinde O. Sublines of mouse 3T3 cells that accumulate lipid. Cell 1974, 1:113-116.
23. Daughaday W.H., Mariz I.K., Blethen S.L. Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol-extracted serum. J. Clin. Endocrinol. Metab. 1980, 51:781-788.
24. Lin Q., Lee Y.J., Yun Z. Differentiation arrest by hypoxia. J. Biol. Chem. 2006, 281:30678-30683.
25. Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J. Nutr. 2001, 131:3109S-3120S.
26. Kaewpila S., Venkataraman S., Buettner G.R., Oberley L.W. Manganese superoxide dismutase modulates hypoxia-inducible factor-1 alpha induction via superoxide. Cancer Res. 2008, 68:2781-2788.
27. Kim K.H., Song M.J., Chung J., Park H., Kim J.B. Hypoxia inhibits adipocyte differentiation in a HDAC-independent manner. Biochem. Biophys. Res. Commun. 2005, 333:1178-1184.
28. Giri S., Rattan R., Haq E., Khan M., Yasmin R., Won J.S., Key L., Singh A.K., Singh I. AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model. Nutr. Metab. (London) 2006, 3:31.
29. Lee Y.K., Lee W.S., Hwang J.T., Kwon D.Y., Surh Y.J., Park O.J. Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells. J. Agric. Food Chem. 2009, 57:305-310.
30. Yeh W.C., Bierer B.E., McKnight S.L. Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. Proc. Natl Acad. Sci. USA 1995, 92:11086-11090.
31. Qiu Z., Wei Y., Chen N., Jiang M., Wu J., Liao K. DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocyte differentiation into adipocytes. J. Biol. Chem. 2001, 276:11988-11995.
32. Martini C.N., Plaza M.V. Vila Mdel, C. PKA-dependent and independent cAMP signaling in 3T3-L1 fibroblasts differentiation. Mol. Cell. Endocrinol. 2009, 298:42-47.
33. Morrison R.F., Farmer S.R. Role of PPARgamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis. J. Biol. Chem. 1999, 274:17088-17097.
34. Inoue N., Yahagi N., Yamamoto T., Ishikawa M., Watanabe K., Matsuzaka T., Nakagawa Y., Takeuchi Y., Kobayashi K., Takahashi A., Suzuki H., Hasty A.H., Toyoshima H., Yamada N., Shimano H. Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance. J. Biol. Chem. 2008, 283:21220-21229.
35. Samuni A., Krishna C.M., Riesz P., Finkelstein E., Russo A. A novel metal-free low molecular weight superoxide dismutase mimic. J. Biol. Chem. 1988, 263:17921-17924.
36. Mitchell J.B., Samuni A., Krishna M.C., DeGraff W.G., Ahn M.S., Samuni U., Russo A. Biologically active metal-independent superoxide dismutase mimics. Biochemistry 1990, 29:2802-2807.
37. Hayes G.R., Lockwood D.H. Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide. Proc. Natl Acad. Sci. USA 1987, 84:8115-8119.
38. Rudich A., Kozlovsky N., Potashnik R., Bashan N. Oxidant stress reduces insulin responsiveness in 3T3-L1 adipocytes. Am. J. Physiol. 1997, 272:E935-E940.
39. Rudich A., Tirosh A., Potashnik R., Hemi R., Kanety H., Bashan N. Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. Diabetes 1998, 47:1562-1569.
40. Floyd Z.E., Kilroy G., Wu X., Gimble J.M. Effects of prolyl hydroxylase inhibitors on adipogenesis and hypoxia inducible factor 1 alpha levels under normoxic conditions. J. Cell. Biochem. 2007, 101:1545-1557.
41. Krishna M.C., Russo A., Mitchell J.B., Goldstein S., Dafni H., Samuni A. Do nitroxides antioxidants act as scavengers of superoxide or as SOD mimics?. J. Biol. Chem. 1996, 271:26026-26031.
42. Sara V.R., Hall K. Insulin-like growth factors and their binding proteins. Physiol. Rev. 1990, 70:591-614.
43. Wabitsch M., Blum W.F., Muche R., Heinze E., Haug C., Mayer H., Teller W. Insulin-like growth factors and their binding proteins before and after weight loss and their associations with hormonal and metabolic parameters in obese adolescent girls. Int. J. Obes. Relat. Metab. Disord. 1996, 20:1073-1080.
44. Takenaka A., Oki N., Takahashi S.I., Noguchi T. Dietary restriction of single essential amino acids reduces plasma insulin-like growth factor-I (IGF-I) but does not affect plasma IGF-binding protein-1 in rats. J. Nutr. 2000, 130:2910-2914.
45. Williams E.A., Perkins S.N., Smith N.C., Hursting S.D., Lane M.A. Carbohydrate versus energy restriction: effects on weight loss, body composition and metabolism. Ann. Nutr. Metab. 2007, 51:232-243.
46. Chan S.S., Schedlich L.J., Twigg S.M., Baxter R.C. Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3. Am. J. Physiol. Endocrinol. Metab. 2009, 296:E654-E663.
47. Jin S., Zhai B., Qiu Z., Wu J., Lane M.D., Liao K. c-Crk, a substrate of the insulin-like growth factor-1 receptor tyrosine kinase, functions as an early signal mediator in the adipocyte differentiation process. J. Biol. Chem. 2000, 275:34344-34352.