Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver

Archives of Toxicology

Volumn 86, Issue 9, 2012, Pages 1399-1411

  Doktorova, Tatyana Y ^a   Ellinger Ziegelbauer, Heidrun ^b   Vinken, Mathieu ^a   Vanhaecke, Tamara ^a   Van Delft, Joost ^c   Kleinjans, Jos ^c   Ahr, Hans Juergen ^b   Rogiers, Vera ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b BAYER PHARMA AG   (Germany)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Genotoxic carcinogens; Global gene expression profiling; In vitro in vivo relevance; Non genotoxic carcinogens

Indexed keywords

2 NITROFLUORENE; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; AFLATOXIN B1; CARCINOGEN; CHLORIDE; CLONIDINE; METHAPYRILENE; NIFEDIPINE; PIPERONYL BUTOXIDE; PIRINIXIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE EXPRESSION SYSTEM; GENE IDENTIFICATION; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER CELL CULTURE; MALE; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOXIN ANALYSIS; TRANSCRIPTOMICS; VALIDATION PROCESS;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CELL CYCLE; CELLS, CULTURED; DNA DAMAGE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTES; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MUTAGENS; NEOPLASM PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RNA, MESSENGER; TOXICOGENETICS;

RATTUS; RODENTIA;

EID: 84866094390     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0847-x     Document Type: Article

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