Development of an in vitro liver toxicity prediction model based on longer term primary rat hepatocyte culture

Toxicology Letters

Volumn 206, Issue 2, 2011, Pages 189-196

  Hrach, J ^a   Mueller, S O ^b   Hewitt, P ^b  

^a FORIM GmbH   (Germany)

^b Merck Serono GmbH   (Germany)

Author keywords

Hepatotoxicity; In vitro; Predictive model; Toxicogenomics

Indexed keywords

ANIMAL CELL; ANIMAL USE; ARTICLE; COMPUTER MODEL; GENE EXPRESSION; IN VITRO STUDY; LIVER CELL CULTURE; LIVER TOXICITY; MALE; NONHUMAN; PILOT STUDY; PREDICTION; PRIORITY JOURNAL; RAT; TOXICOLOGY;

ANIMAL USE ALTERNATIVES; ANIMALS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; COLLAGEN TYPE I; DRUG-INDUCED LIVER INJURY; DRUGS, INVESTIGATIONAL; FEASIBILITY STUDIES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEPATOCYTES; MALE; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSMOLAR CONCENTRATION; PILOT PROJECTS; RATS; RATS, WISTAR; TOXICITY TESTS; TOXICOGENETICS;

ANIMALIA; RATTUS;

EID: 80052087024     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.07.012     Document Type: Article

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