A physiologically based toxicokinetic modelling approach to predict relevant concentrations for in vitro testing

Archives of Toxicology

Volumn 85, Issue 6, 2011, Pages 555-563

  Mielke, Hans ^a   Anger, Lennart T ^b   Schug, Markus ^c   Hengstler, Jan G ^c   Stahlmann, Ralf ^b   Gundert Remy, Ursula ^a,b  

^a FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^b Institute of Psychosocial Research for Health Promotion and Intervention   (Germany)

^c LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

In vitro in vivo extrapolation; PBTK modelling; Relevant concentrations in vitro

Indexed keywords

ABSORPTION; ANIMAL CELL; ARTICLE; BLOOD LEVEL; CARCINOGEN TESTING; CELL CULTURE; COMPUTER PREDICTION; CONCENTRATION (PARAMETERS); GASTROINTESTINAL TRACT; HEPATIC VEIN; IN VITRO STUDY; LIVER CELL; MODEL; NONHUMAN; PHYSIOLOGICALLY BASED TOXICOKINETIC MODELING; PORTAL VEIN; PRIORITY JOURNAL; RAT; SIMULATION; SYSTEMIC CIRCULATION; TOXICOKINETICS;

ANIMAL TESTING ALTERNATIVES; ANIMALS; BIOLOGICAL MARKERS; BIOTRANSFORMATION; CARCINOGENS; CELLS, CULTURED; COMPUTER SIMULATION; HEPATOCYTES; HUMANS; MODELS, BIOLOGICAL; MUTAGENS; OSMOLAR CONCENTRATION; PHARMACOKINETICS; PHYSICOCHEMICAL PHENOMENA; RATS; TISSUE DISTRIBUTION; TOXICITY TESTS;

EID: 79959618990     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-010-0612-y     Document Type: Article

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