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Volumn 64, Issue 6, 2012, Pages 1291-1304

Drug therapy in autism: A present and future perspective

Author keywords

ASD; Autism; Behavior; Clinical studies; Drugs

Indexed keywords

AMANTADINE; ARIPIPRAZOLE; ASCORBIC ACID; ATYPICAL ANTIPSYCHOTIC AGENT; CHOLINESTERASE INHIBITOR; CLOMIPRAMINE; CLONIDINE; CLOZAPINE; CYANOCOBALAMIN; DESIPRAMINE; DOCOSAHEXAENOIC ACID; FLUOXETINE; FLUVOXAMINE; GLUTAMATE RECEPTOR ANTAGONIST; GUANFACINE; IMIPRAMINE; LAMOTRIGINE; MELATONIN; METHYLPHENIDATE; NALTREXONE; NORTRIPTYLINE; OMEGA 3 FATTY ACID; PLACEBO; PROBIOTIC AGENT; RISPERIDONE; RIVASTIGMINE; UNINDEXED DRUG; VALPROATE SEMISODIUM; VENLAFAXINE; ZIPRASIDONE;

EID: 84873712460     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(12)70927-1     Document Type: Review
Times cited : (55)

References (133)
  • 1
    • 42349095075 scopus 로고    scopus 로고
    • Advances in autism genetics: On the threshold of a new neurobiology
    • DOI 10.1038/nrg2346, PII NRG2346
    • Abrahams BS, Geschwind DH: Advances in autism genetics: on the threshold of a new neurobiology. Nat RevGenet, 2008, 9, 341-355. (Pubitemid 351556064)
    • (2008) Nature Reviews Genetics , vol.9 , Issue.5 , pp. 341-355
    • Abrahams, B.S.1    Geschwind, D.H.2
  • 2
    • 77957228730 scopus 로고    scopus 로고
    • The severity of autism is associated with toxic metal body burden and red blood cellglutathione levels
    • Adams JB, Baral M, Geis E, Mitchell J, Ingram J,Hensley A, Zappia I et al.: The severity of autism is associated with toxic metal body burden and red blood cellglutathione levels. J Toxicol, 2009, 2009, 532-640.
    • (2009) J Toxicol , vol.2009 , pp. 532-640
    • Adams, J.B.1    Baral, M.2    Geis, E.3    Mitchell, J.4    Ingram, J.5    Hensley, A.6    Zappia, I.7
  • 3
    • 6344263841 scopus 로고    scopus 로고
    • Management of hyperactivity and otheracting-out problems in patients with autism spectrumdisorder
    • Aman MG: Management of hyperactivity and otheracting-out problems in patients with autism spectrumdisorder. Semin Pediatr Neurol, 2004, 11, 225-228.
    • (2004) Semin Pediatr Neurol , vol.11 , pp. 225-228
    • Aman, M.G.1
  • 6
    • 33746929827 scopus 로고    scopus 로고
    • Divalproex versus placebo for the prevention of irritability associated with fluoxetine treatment in autism spectrum disorder [11]
    • DOI 10.1097/01.jcp.0000227703.72117.bc, PII 0000471420060800000026
    • Anagnostou E, Esposito K, Soorya L, Chaplin W,Wasserman S, Hollander E: Divalproex versus placebofor the prevention of irritability associated with fluoxetine treatment in autism spectrum disorder. J Clin Psychopharmacol, 2006, 26, 444-446. (Pubitemid 44187659)
    • (2006) Journal of Clinical Psychopharmacology , vol.26 , Issue.4 , pp. 444-446
    • Anagnostou, E.1    Esposito, K.2    Soorya, L.3    Chaplin, W.4    Wasserman, S.5    Hollander, E.6
  • 7
    • 38449097271 scopus 로고    scopus 로고
    • McKinnonR: Children and autism - Part 2 - Management with complementary medicines and dietary interventions
    • Angley M, Semple S, Hewton C, Paterson F, McKinnonR: Children and autism - Part 2 - Management with complementary medicines and dietary interventions.Aust Fam Physician, 2007, 36, 827-830.
    • (2007) Aust Fam Physician , vol.36 , pp. 827-830
    • Angley, M.1    Semple, S.2    Hewton, C.3    Paterson, F.4
  • 9
    • 70349608578 scopus 로고    scopus 로고
    • Omega-3 fatty acidsfor autistic spectrum disorder: A systematic review
    • Bent S, Bertoglio K, Hendren RL: Omega-3 fatty acidsfor autistic spectrum disorder: a systematic review.J Autism Dev Disord, 2009, 39, 1145-1154.
    • (2009) J Autism Dev Disord , vol.39 , pp. 1145-1154
    • Bent, S.1    Bertoglio, K.2    Hendren, R.L.3
  • 10
    • 78549253107 scopus 로고    scopus 로고
    • Associating neural alterations and genotype in autismand fragile X syndrome: Incorporating perceptual phenotypes in causal modeling
    • Bertone A, Hanck J, Kogan C, Chaudhuri A, Cornish K:Associating neural alterations and genotype in autismand fragile X syndrome: incorporating perceptual phenotypes in causal modeling. J Autism Dev Disord, 2010,40, 1541-1548.
    • (2010) J Autism Dev Disord , vol.40 , pp. 1541-1548
    • Bertone, A.1    Hanck, J.2    Kogan, C.3    Chaudhuri, A.4    Cornish, K.5
  • 11
    • 0034757723 scopus 로고    scopus 로고
    • Prevalence of autism in a United States population: The Brick Township, New Jersey, investigation
    • DOI 10.1542/peds.108.5.1155
    • Bertrand J, Mars A, Boyle C, Bove F, Yeargin-AllsoppM, Decoufle P: Prevalence of autism in a United Statespopulation: the Brick Township, New Jersey, investigation. Pediatrics, 2001, 108, 1155-1161. (Pubitemid 33021192)
    • (2001) Pediatrics , vol.108 , Issue.5 , pp. 1155-1161
    • Bertrand, J.1    Mars, A.2    Boyle, C.3    Bove, F.4    Yeargin-Allsopp, M.5    Decoufle, P.6
  • 12
    • 0024709899 scopus 로고
    • Autism, Asperger's syndrome and semantic-pragmatic disorder: Where are the boundaries?
    • Bishop DVM
    • Bishop DVM: Autism, Asperger's syndrome and semantic-pragmatic disorder: where are the boundaries?Br J Disord Commun, 1989, 24, 107-121.
    • (1989) Br J Disord Commun , vol.24 , pp. 107-121
  • 13
    • 34548329642 scopus 로고    scopus 로고
    • Pharmacokinetics of a guanfacine extended-release formulation in children and adolescents with attention-deficit-hyperactivity disorder
    • DOI 10.1592/phco.27.9.1253
    • Boellner SW, Pennick M, Fiske K, Lyne A, Shojaei A:Pharmacokinetics of a guanfacine extended-release formulation in children and adolescents with attention-deficit-hyperactivity disorder. Pharmacotherapy, 2007,27, 1253-1262. (Pubitemid 47339123)
    • (2007) Pharmacotherapy , vol.27 , Issue.9 I , pp. 1253-1262
    • Boellner, S.W.1    Pennick, M.2    Fiske, K.3    Lyne, A.4    Shojaei, A.5
  • 14
    • 0037373449 scopus 로고    scopus 로고
    • Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males
    • DOI 10.1016/S0891-5849(02)01356-4
    • Borras C, Sastre J, Garcia-Sala D, Lloret A, Pallardo FV,Vina J: Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damagethan males. Free Radic Biol Med, 2003, 34, 546-552. (Pubitemid 36254828)
    • (2003) Free Radical Biology and Medicine , vol.34 , Issue.5 , pp. 546-552
    • Borras, C.1    Sastre, J.2    Garcia-Sala, D.3    Lloret, A.4    Pallardo, F.V.5    Vina, J.6
  • 15
    • 0028802504 scopus 로고
    • Low-dosenaltrexone effects on plasma chemistries and clinicalsymptoms in autism: A double-blind, placebo-controlledstudy
    • Bouvard MP, Leboyer M, Launay JM, Recasens C, Plumet MH, Waller-Perotte D, Tabuteau F et al.: Low-dosenaltrexone effects on plasma chemistries and clinicalsymptoms in autism: a double-blind, placebo-controlledstudy. Psychiatry Res, 1995, 58, 191-201.
    • (1995) Psychiatry Res , vol.58 , pp. 191-201
    • Bouvard, M.P.1    Leboyer, M.2    Launay, J.M.3    Recasens, C.4    Plumet, M.H.5    Waller-Perotte, D.6    Tabuteau, F.7
  • 16
    • 77952501114 scopus 로고    scopus 로고
    • Biomarker-guided interventions of clinically relevantconditions associated with autism spectrum disordersand attention deficit hyperactivity disorder
    • Bradstreet JJ, Smith S, Baral M, Rossignol DA:Biomarker-guided interventions of clinically relevantconditions associated with autism spectrum disordersand attention deficit hyperactivity disorder. Altern MedRev, 2010, 15, 15-32.
    • (2010) Altern MedRev , vol.15 , pp. 15-32
    • Bradstreet, J.J.1    Smith, S.2    Baral, M.3    Rossignol, D.A.4
  • 19
    • 33344472157 scopus 로고    scopus 로고
    • Low-dose venlafaxine in three adolescents and young adults with autistic disorder improves self-injurious behavior and attention deficit/hyperactivity disorders (ADHD)-like symptoms
    • DOI 10.1016/j.pnpbp.2005.10.002, PII S027858460500309X
    • Carminati GG, Deriaz N, Bertschy G: Low-dose venlafaxine in three adolescents and young adults with autisticdisorder improves self-injurious behaviour and attentiondeficit/hyperactivity disorders (ADHD)-like symptoms.Prog Neuropsychopharmacol Biol Psychiatry, 2006, 30,312-315. (Pubitemid 43288074)
    • (2006) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.30 , Issue.2 , pp. 312-315
    • Carminati, G.G.1    Deriaz, N.2    Bertschy, G.3
  • 20
    • 33646241761 scopus 로고    scopus 로고
    • Mental health in the United States: Parental report ofdiagnosed autism in children aged 4-17 years - United States, 2003-2004
    • Centers for Disease Control and Prevention (CDC)
    • Centers for Disease Control and Prevention (CDC):Mental health in the United States: parental report ofdiagnosed autism in children aged 4-17 years - United States, 2003-2004. MMWR Morb Mortal Wkly Rep, 2006, 55, 481-486.
    • (2006) MMWR Morb Mortal Wkly Rep , vol.55 , pp. 481-486
  • 21
    • 78149431869 scopus 로고    scopus 로고
    • Dysfunction in GABA signallingmediates autism-like stereotypies and Rett syndromephenotypes
    • Chao HT, Chen H, Samaco RC, Xue M, Chahrour M,Yoo J, Neul JL et al.: Dysfunction in GABA signallingmediates autism-like stereotypies and Rett syndromephenotypes. Nature, 2010, 468, 263-269.
    • (2010) Nature , vol.468 , pp. 263-269
    • Chao, H.T.1    Chen, H.2    Samaco, R.C.3    Xue, M.4    Chahrour, M.5    Yoo, J.6    Neul, J.L.7
  • 22
    • 0036517812 scopus 로고    scopus 로고
    • Practitioner review: Diagnosis of autism spectrum disorder in 2- And 3-year-old children
    • DOI 10.1111/1469-7610.00022
    • Charman T, Baird G: Practitioner review: Diagnosis ofautism spectrum disorder in 2- and 3- year-old children.J Child Psychol Psychiatry, 2002, 43, 289-305. (Pubitemid 36939219)
    • (2002) Journal of Child Psychology and Psychiatry and Allied Disciplines , vol.43 , Issue.3 , pp. 289-305
    • Charman, T.1    Baird, G.2
  • 24
    • 33745699617 scopus 로고    scopus 로고
    • Oxidative stress in autism
    • Chauhan A, Chauhan V: Oxidative stress in autism.Pathophysiology, 2006, 13, 171-181.
    • (2006) Pathophysiology , vol.13 , pp. 171-181
    • Chauhan, A.1    Chauhan, V.2
  • 25
    • 4444347472 scopus 로고    scopus 로고
    • Oxidative stress in autism: Increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin - The antioxidant proteins
    • DOI 10.1016/j.lfs.2004.04.038, PII S0024320504006605
    • Chauhan A, Chauhan V, Brown WT, Cohen I: Oxidativestress in autism: increased lipid peroxidation and reducedserum levels of ceruloplasmin and transferrin - the antioxidant proteins. Life Sci, 2004, 75, 2539-2549. (Pubitemid 39195260)
    • (2004) Life Sciences , vol.75 , Issue.21 , pp. 2539-2549
    • Chauhan, A.1    Chauhan, V.2    Brown, W.T.3    Cohen, I.4
  • 27
    • 2342436849 scopus 로고    scopus 로고
    • Treating autistic spectrum disorders in children: Utility of the cholinesterase inhibitor rivastigmine tartrate
    • Chez MG, Aimonovitch M, Buchanan T, Mrazek S,Tremb RJ: Treating autistic spectrum disorders in children: utility of the cholinesterase inhibitor rivastigminetartate. J Child Neurol, 2004, 19, 165-169. (Pubitemid 38559707)
    • (2004) Journal of Child Neurology , vol.19 , Issue.3 , pp. 165-169
    • Chez, M.G.1    Aimonovitch, M.2    Buchanan, T.3    Mrazek, S.4    Tremb, R.J.5
  • 28
    • 34250731835 scopus 로고    scopus 로고
    • Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: An observation of initial clinical response and maintenance tolerability
    • DOI 10.1177/0883073807302611
    • Chez MG, Burton Q, Dowling T, Chang M, Khanna P,Kramer C: Memantine as adjunctive therapy in childrendiagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability. J Child Neurol, 2007, 22, 574-579. (Pubitemid 46951501)
    • (2007) Journal of Child Neurology , vol.22 , Issue.5 , pp. 574-579
    • Chez, M.G.1    Burton, Q.2    Dowling, T.3    Chang, M.4    Khanna, P.5    Kramer, C.6
  • 29
    • 84855528326 scopus 로고    scopus 로고
    • Glutamate mediatedsignaling in the pathophysiology of autism spectrumdisorders
    • Choudhury PR, Lahiri S, Rajamma U: Glutamate mediatedsignaling in the pathophysiology of autism spectrumdisorders. Pharmacol Biochem Behav, 2012, 100, 841-849.
    • (2012) Pharmacol Biochem Behav , vol.100 , pp. 841-849
    • Choudhury, P.R.1    Lahiri, S.2    Rajamma, U.3
  • 32
    • 0035986909 scopus 로고    scopus 로고
    • Structural and functionalmagnetic resonance imaging of autism
    • Cody H, Pelphrey K, Piven J: Structural and functionalmagnetic resonance imaging of autism. Int J Dev Neurosci, 2002, 20, 421-438.
    • (2002) Int J Dev Neurosci , vol.20 , pp. 421-438
    • Cody, H.1    Pelphrey, K.2    Piven, J.3
  • 34
    • 0003651576 scopus 로고    scopus 로고
    • Committee on Educational Interventions for Childrenwith Autism, National Research Council National Academy Press, Washington,DC
    • Committee on Educational Interventions for Childrenwith Autism, National Research Council: Educating children with autism, National Academy Press, Washington,DC, 2001.
    • (2001) Educating Children with Autism
  • 36
    • 0036772795 scopus 로고    scopus 로고
    • Fluoxetine response in children with autistic spectrum disorders: Correlation with familial major affective disorder and intellectual achievement
    • DOI 10.1017/S0012162201002717
    • DeLong GR, Ritch CR, Burch S: Fluoxetine response inchildren with autistic spectrum disorders: correlationwith familial major affective disorder and intellectualachievement. Dev Med Child Neurol, 2002, 44, 652-659. (Pubitemid 35230025)
    • (2002) Developmental Medicine and Child Neurology , vol.44 , Issue.10 , pp. 652-659
    • DeLong, G.R.1    Ritch, C.R.2    Burch, S.3
  • 37
    • 58249135425 scopus 로고    scopus 로고
    • Expression ofthe GABAergic system in animal models for fragile Xsyndrome and fragile X associated tremor/ataxia syndrome (FXTAS)
    • D'Hulst C, Heulens I, Brouwer JR, Willemsen R, De Geest N, Reeve SP, De Deyn PP: Expression ofthe GABAergic system in animal models for fragile Xsyndrome and fragile X associated tremor/ataxia syndrome (FXTAS). Brain Res, 2009, 1253, 176-183.
    • (2009) Brain Res , vol.1253 , pp. 176-183
    • D'Hulst, C.1    Heulens, I.2    Brouwer, J.R.3    Willemsen, R.4    De Geest, N.5    Reeve, S.P.6    De Deyn, P.P.7
  • 38
    • 3342976049 scopus 로고    scopus 로고
    • Methylphenidate for pervasive developmental disorders: Safety and efficacy of acute single dose test and ongoing therapy: An open-pilot study
    • DOI 10.1089/1044546041649011
    • Di Martino A, Melis G, Cianchetti C, Zuddas A:Methylphenidate for pervasive developmental disorders:safety and efficacy of acute single dose test and ongoingtherapy: an open-pilot study. J Child Adolesc Psychopharmacol, 2004, 14, 207-218 (Pubitemid 38988787)
    • (2004) Journal of Child and Adolescent Psychopharmacology , vol.14 , Issue.2 , pp. 207-218
    • Di, M.A.1    Melis, G.2    Cianchetti, C.3    Zuddas, A.4
  • 41
    • 79651475390 scopus 로고    scopus 로고
    • Rapamycin for treating tuberoussclerosis and autism spectrum disorders
    • Ehninger D, Silva AJ: Rapamycin for treating tuberoussclerosis and autism spectrum disorders. Trends MolMed, 2011, 17, 78-87.
    • (2011) Trends MolMed , vol.17 , pp. 78-87
    • Ehninger, D.1    Silva, A.J.2
  • 42
    • 33745115657 scopus 로고    scopus 로고
    • Efficacy and safety of naltrexone use in pediatric patients with autistic disorder
    • DOI 10.1345/aph.1G499
    • Elchaar GM, Maisch NM, Augusto LM, Wehring HJ:Efficacy and safety of naltrexone use in pediatric patientswith autistic disorder. Ann Pharmacother, 2006, 40,1086-1095. (Pubitemid 43886966)
    • (2006) Annals of Pharmacotherapy , vol.40 , Issue.6 , pp. 1086-1095
    • Elchaar, G.M.1    Maisch, N.M.2    Gianni, A.L.M.3    Wehring, H.J.4
  • 43
    • 0037837515 scopus 로고    scopus 로고
    • Autism and mental retardation: The genetic relationship and contribution
    • El-Hazmi MA: Autism and mental retardation: the genetic relationship and contribution. East Mediterr HealthJ, 2001, 7, 536-543. (Pubitemid 33758977)
    • (2001) Eastern Mediterranean Health Journal , vol.7 , Issue.3 , pp. 536-543
    • El-Hazmi, M.A.F.1
  • 46
    • 77955883112 scopus 로고    scopus 로고
    • MRNA and protein levels forGABAAa4, a5, b1 and GABABR1 receptors are alteredin brains from subjects with autism
    • Fatemi SH, Reutiman TJ, Folsom TD, Rooney RJ, PatelDH, Thuras PD: mRNA and protein levels forGABAAa4, a5, b1 and GABABR1 receptors are alteredin brains from subjects with autism. J Autism Dev Disord, 2010, 40, 743-750.
    • (2010) J Autism Dev Disord , vol.40 , pp. 743-750
    • Fatemi, S.H.1    Reutiman, T.J.2    Folsom, T.D.3    Rooney, R.J.4    Patel, D.H.5    Thuras, P.D.6
  • 48
    • 31144477401 scopus 로고    scopus 로고
    • Pharmacologic treatment of behavioralsymptoms in autism and pervasive developmental disorders
    • Findling RL: Pharmacologic treatment of behavioralsymptoms in autism and pervasive developmental disorders. J Clin Psychiatry, 2005, 66, 26-31.
    • (2005) J Clin Psychiatry , vol.66 , pp. 26-31
    • Findling, R.L.1
  • 49
    • 31144444162 scopus 로고    scopus 로고
    • Epidemiology of autistic disorder andother pervasive developmental disorders
    • Fombonne E: Epidemiology of autistic disorder andother pervasive developmental disorders. J Clin Psychiatry, 2005, 66, 3-8.
    • (2005) J Clin Psychiatry , vol.66 , pp. 3-8
    • Fombonne, E.1
  • 51
    • 0036370044 scopus 로고    scopus 로고
    • Diet in autism and associated disorders
    • Garvey J: Diet in autism and associated disorders. J FamHealth Care, 2002, 12, 34-38.
    • (2002) J FamHealth Care , vol.12 , pp. 34-38
    • Garvey, J.1
  • 52
    • 0034789235 scopus 로고    scopus 로고
    • Long-term treatment with clozapine in an adult with autistic disorder
    • Gobbi G, Pulvirenti L: Long-term treatment with clozapine in an adult with autistic disorder. J Psychiatry Neurosci, 2001, 26, 340-341
    • (2001) J Psychiatry Neurosci , vol.26 , pp. 340-341
    • Gobbi, G.1    Pulvirenti, L.2
  • 55
    • 0033798312 scopus 로고    scopus 로고
    • Efficacy ofmethylphenidate among children with autism and symptoms of attention-deficit hyperactivity disorder
    • Handen BL, Johnson CR, Lubetsky M: Efficacy ofmethylphenidate among children with autism and symptoms of attention-deficit hyperactivity disorder. J AutismDev Disord, 2000, 30, 245-255
    • (2000) J AutismDev Disord , vol.30 , pp. 245-255
    • Handen, B.L.1    Johnson, C.R.2    Lubetsky, M.3
  • 57
    • 0036749941 scopus 로고    scopus 로고
    • A retrospective open trial of adjunctive donepezil in children and adolescents with autistic disorder
    • Hardan AY, Handen BL: A retrospective open trial of adjunctive donepezil in children and adolescents with autistic disorder. J Child Adolesc Psychopharmacol, 2002, 12,237-241. (Pubitemid 35191350)
    • (2002) Journal of Child and Adolescent Psychopharmacology , vol.12 , Issue.3 , pp. 237-241
    • Hardan, A.Y.1    Handen, B.L.2
  • 59
    • 33747200899 scopus 로고    scopus 로고
    • Autism: A brain disorder or a disorder that affectsthe brain?
    • Herbert MR: Autism: a brain disorder or a disorder that affectsthe brain? Clin Neuropsychiatry, 2005, 2, 354-379.
    • (2005) Clin Neuropsychiatry , vol.2 , pp. 354-379
    • Herbert, M.R.1
  • 60
    • 76749085678 scopus 로고    scopus 로고
    • Divalproex sodiumvs placebo for the treatment of irritability in children andadolescents with autism spectrum disorders
    • Hollander E, Chaplin W, Soorya L, Wasserman S,Novotny S, Rusoff J, Feirsen N et al.: Divalproex sodiumvs placebo for the treatment of irritability in children andadolescents with autism spectrum disorders. Neuropsychopharmacology, 2010, 35, 990-998.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 990-998
    • Hollander, E.1    Chaplin, W.2    Soorya, L.3    Wasserman, S.4    Novotny, S.5    Rusoff, J.6    Feirsen, N.7
  • 61
    • 13944264748 scopus 로고    scopus 로고
    • A placebo controlled crossover trial of liquid fluoxetine on repetitive behaviors in childhood and adolescent autism
    • DOI 10.1038/sj.npp.1300627
    • Hollander E, Phillips A, Chaplin W, Zagursky K,Novotny S, Wasserman S, Iyengar R: A placebo controlled crossover trial of liquid fluoxetine on repetitivebehaviors in childhood and adolescent autism. Neuropsychopharmacology, 2005, 30, 582-589. (Pubitemid 40271160)
    • (2005) Neuropsychopharmacology , vol.30 , Issue.3 , pp. 582-589
    • Hollander, E.1    Phillips, A.2    Chaplin, W.3    Zagursky, K.4    Novotny, S.5    Wasserman, S.6    Iyengar, R.7
  • 62
    • 0042329245 scopus 로고    scopus 로고
    • Targeted treatments for symptom domains in child and adolescent autism
    • DOI 10.1016/S0140-6736(03)14236-5
    • Hollander E, Phillips AT, Yeh CC: Targeted treatmentsfor symptom domains in child and adolescent autism.Lancet, 2003, 362, 732-734. (Pubitemid 37101074)
    • (2003) Lancet , vol.362 , Issue.9385 , pp. 732-734
    • Hollander, E.1    Phillips, A.T.2    Yeh, C.-C.3
  • 69
    • 17144419260 scopus 로고    scopus 로고
    • Dysregulated innate immune responses in young children with autism spectrum disorders: Their relationship to gastrointestinal symptoms and dietary intervention
    • DOI 10.1159/000084164
    • Jyonouchi H, Geng L, Ruby A, Zimmerman-Bier B:Dysregulated innate immune responses in young children with autism spectrum disorders: their relationshipto gastrointestinal symptoms and dietary intervention.Neuropsychobiology, 2005, 51, 77-85. (Pubitemid 40522799)
    • (2005) Neuropsychobiology , vol.51 , Issue.2 , pp. 77-85
    • Jyonouchi, H.1    Geng, L.2    Ruby, A.3    Zimmerman-Bier, B.4
  • 70
    • 33744753691 scopus 로고    scopus 로고
    • Autism: A review for family physicians
    • Karande S: Autism: A review for family physicians.Indian J Med Sci, 2006, 60, 205-215.
    • (2006) Indian J Med Sci , vol.60 , pp. 205-215
    • Karande, S.1
  • 71
    • 1242330971 scopus 로고    scopus 로고
    • Austistic spectrum disorder: A child population profile
    • DOI 10.1177/1362361304040637
    • Keen D, Ward S: Autistic spectrum disorder: A childpopulation profile. Autism, 2004, 8, 39-48. (Pubitemid 38239621)
    • (2004) Autism , vol.8 , Issue.1 , pp. 39-48
    • Keen, D.1    Ward, S.2
  • 76
    • 0013935852 scopus 로고
    • Clinical study of the response to nortriptyline onautistic children
    • Kurtis LB: Clinical study of the response to nortriptyline onautistic children. Int J Neuropsychiatry, 1966, 2, 298-301.
    • (1966) Int J Neuropsychiatry , vol.2 , pp. 298-301
    • Kurtis, L.B.1
  • 77
    • 50449102803 scopus 로고    scopus 로고
    • Complementary and alternativemedicine treatments for children with autism spectrumdisorders
    • Levy SE, Hyman SL: Complementary and alternativemedicine treatments for children with autism spectrumdisorders. Child Adolesc Psychiatr Clin N Am, 2008, 17,803-820.
    • (2008) Child Adolesc Psychiatr Clin N Am , vol.17 , pp. 803-820
    • Levy, S.E.1    Hyman, S.L.2
  • 78
    • 0037298453 scopus 로고    scopus 로고
    • Low-dose fluvoxamine treatment of children and adolescents with pervasive developmental disorders: A prospective, open-label study
    • DOI 10.1023/A:1022234605695
    • Martin A, Koenig K, Anderson GM, Scahill L: Lowdose fluvoxamine treatment in children and adolescentswith pervasive developmental disorders: a prospective,open-label study. J Autism Dev Disord, 2003, 33, 77-85. (Pubitemid 36323142)
    • (2003) Journal of Autism and Developmental Disorders , vol.33 , Issue.1 , pp. 77-85
    • Martin, A.1    Koenig, K.2    Anderson, G.M.3    Scahill, L.4
  • 79
    • 79959553854 scopus 로고    scopus 로고
    • Issuesin the management of challenging behaviours of adultswith autism spectrum disorder
    • Matson JL, Sipes M, Fodstad JC, Fitzgerald ME: Issuesin the management of challenging behaviours of adultswith autism spectrum disorder. CNS Drugs, 2011, 25,597-606.
    • (2011) CNS Drugs , vol.25 , pp. 597-606
    • Matson, J.L.1    Sipes, M.2    Fodstad, J.C.3    Fitzgerald, M.E.4
  • 83
    • 0031855086 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders
    • DOI 10.1001/archpsyc.55.7.633
    • McDougle CJ, Holmes JP, Carlson DC, Pelton GH,Cohen DJ, Price LH: A double-blind, placebo controlledstudy of risperidone in adults with autistic disorder andother pervasive developmental disorders. Arch Gen Psychiatry, 1998, 55, 633-641. (Pubitemid 28340352)
    • (1998) Archives of General Psychiatry , vol.55 , Issue.7 , pp. 633-641
    • McDougle, C.J.1    Holmes, J.P.2    Carlson, C.3    Pelton, G.H.4    Cohen, D.J.5    Price, L.H.6
  • 86
    • 0027478910 scopus 로고
    • Long-term outcome for children with autism who received early intensive behavioral treatment
    • McEachin JJ, Smith T, Lovaas OI: Long-term outcomefor children with autism who received early intensive behavioraltreatment. Am J Ment Retard, 1993, 97, 359-372. (Pubitemid 23104584)
    • (1993) American Journal on Mental Retardation , vol.97 , Issue.4 , pp. 359-372
    • McEachin, J.J.1    Smith, T.2    Lovaas, O.I.3
  • 87
    • 49549112474 scopus 로고    scopus 로고
    • Role ofpolyunsaturated fatty acids in the management of Egyptian children with autism
    • Meguid NA, Atta HM, Gouda AS, Khalil RO: Role ofpolyunsaturated fatty acids in the management of Egyptian children with autism. Clin Biochem, 2008, 41,1044-1048.
    • (2008) Clin Biochem , vol.41 , pp. 1044-1048
    • Meguid, N.A.1    Atta, H.M.2    Gouda, A.S.3    Khalil, R.O.4
  • 88
    • 45949091139 scopus 로고    scopus 로고
    • Use of clonidine in children with autism spectrum disorders
    • Ming X, Gordon E, Kang N, Wagner GC: Use of clonidine in children with autism spectrum disorders. BrainDev, 2008, 30, 454-460.
    • (2008) BrainDev , vol.30 , pp. 454-460
    • Ming, X.1    Gordon, E.2    Kang, N.3    Wagner, G.C.4
  • 89
    • 4143067899 scopus 로고    scopus 로고
    • Treating functional impairment of autism with selective serotonin-reuptake inhibitors
    • DOI 10.1345/aph.1D543
    • Moore ML, Eichner SF, Jones JR: Treating functionalimpairment of autism with selective serotonin reuptakeinhibitors. Ann Pharmacother, 2004, 38, 1515-1519. (Pubitemid 39100208)
    • (2004) Annals of Pharmacotherapy , vol.38 , Issue.9 , pp. 1515-1519
    • Moore, M.L.1    Eichner, S.F.2    Jones, J.R.3
  • 93
    • 0030534162 scopus 로고    scopus 로고
    • Controversial therapies for young childrenwith developmental disabilities
    • Nickel RE. Controversial therapies for young childrenwith developmental disabilities. Infants Young Child,1996, 8, 29-40.
    • (1996) Infants Young Child , vol.8 , pp. 29-40
    • Nickel, R.E.1
  • 95
    • 0037079408 scopus 로고    scopus 로고
    • Galantamine may beeffective in treating autistic disorder
    • Niederhofer H, Staffen W, Mair A: Galantamine may beeffective in treating autistic disorder. BMJ, 2002, 325,1422.
    • (2002) BMJ , vol.325 , pp. 1422
    • Niederhofer, H.1    Staffen, W.2    Mair, A.3
  • 98
    • 0036717789 scopus 로고    scopus 로고
    • Is there more to GABAthansynaptic inhibition?
    • Owens DF, Kriegstein AR: Is there more to GABAthansynaptic inhibition? Nat Rev Neurosci, 2002, 3, 715-727.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 715-727
    • Owens, D.F.1    Kriegstein, A.R.2
  • 101
    • 0033646987 scopus 로고    scopus 로고
    • Behaviorphenotype of FG syndrome: Cognition, personality andbehavior: eleven affected boys
    • Ozonoff S, Williams BJ, Rauch AM, Opitz JO: Behaviorphenotype of FG syndrome: cognition, personality andbehavior: eleven affected boys. Am J Med Genet, 2000,97, 112-118.
    • (2000) Am J Med Genet , vol.97 , pp. 112-118
    • Ozonoff, S.1    Williams, B.J.2    Rauch, A.M.3    Opitz, J.O.4
  • 102
    • 0026046279 scopus 로고
    • Brief report: A synopsis ofan open-trial of naltrexone treatment of autism with fourchildren
    • Panksepp J, Lensing P: Brief report: a synopsis ofan open-trial of naltrexone treatment of autism with fourchildren. J Autism Dev Disord, 1991, 21, 243-249.
    • (1991) J Autism Dev Disord , vol.21 , pp. 243-249
    • Panksepp, J.1    Lensing, P.2
  • 103
    • 30644461549 scopus 로고    scopus 로고
    • Immunity, neuroglia and neuroinflammation in autism
    • DOI 10.1080/02646830500381930, PII H5XQ5V0MVN1G6411
    • Pardo CA, Vargas DL, Zimmerman AW: Immunity, neuroglia and neuroinflammation in autism. Int Rev Psychiatry, 2005, 17, 485-495. (Pubitemid 43086675)
    • (2005) International Review of Psychiatry , vol.17 , Issue.6 , pp. 485-495
    • Pardo, C.A.1    Vargas, D.L.2    Zimmerman, A.W.3
  • 104
    • 0037505644 scopus 로고    scopus 로고
    • Analysis of glutathione: Implication in redox and detoxification
    • DOI 10.1016/S0009-8981(03)00200-6
    • Pastore A, Federici G, Bertini E, Piemonte F: Analysisof glutathione: implication in redox and detoxification.Clin Chim Acta, 2003, 333, 19-39. (Pubitemid 36694824)
    • (2003) Clinica Chimica Acta , vol.333 , Issue.1-2 , pp. 19-39
    • Pastore, A.1    Federici, G.2    Bertini, E.3    Piemonte, F.4
  • 110
    • 3342982925 scopus 로고    scopus 로고
    • Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: A retrospective analysis of 80 cases
    • DOI 10.1089/1044546041649084
    • Posey DJ, Puntney JI, Sasher TM, Kem DL, McDougleCJ: Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: a retrospective analysis of 80 cases. J Child Adolesc Psychopharmacol, 2004, 14, 233-241 (Pubitemid 38988789)
    • (2004) Journal of Child and Adolescent Psychopharmacology , vol.14 , Issue.2 , pp. 233-241
    • Posey, D.J.1    Puntney, J.I.2    Sasher, T.M.3    Kem, D.L.4    McDougle, C.J.5
  • 111
    • 0035856428 scopus 로고    scopus 로고
    • Postmortem brain abnormalities of the glutamate neurotransmitter system in autism
    • Purcell AE, Jeon OH, Zimmerman AW, Blue ME,Pevsner J: Postmortem brain abnormalities of the glutamate neurotransmitter system in autism. Neurology,2001, 57, 1618-1628. (Pubitemid 33055480)
    • (2001) Neurology , vol.57 , Issue.9 , pp. 1618-1628
    • Purcell, A.E.1    Jeon, O.H.2    Zimmerman, A.W.3    Blue, M.E.4    Pevsner, J.5
  • 113
    • 33947701000 scopus 로고    scopus 로고
    • Hyperbaric oxygen therapy might improve certain pathophysiological findings in autism
    • Rossignol DA: Hyperbaric oxygen therapy might improve certain pathophysiological findings in autism.Med Hypotheses, 2007, 68, 1208-1227.
    • (2007) Med Hypotheses , vol.68 , pp. 1208-1227
    • Rossignol, D.A.1
  • 115
    • 33744739160 scopus 로고    scopus 로고
    • Hyperbaric oxygen therapy may improve symptoms in autistic children
    • Rossignol DA, Rossignol LW: Hyperbaric oxygen therapy may improve symptoms in autistic children. Med Hypotheses, 2006, 67, 216-228.
    • (2006) Med Hypotheses , vol.67 , pp. 216-228
    • Rossignol, D.A.1    Rossignol, L.W.2
  • 118
    • 75649120356 scopus 로고    scopus 로고
    • A review of dietary interventions in autism
    • Srinivasan P: A review of dietary interventions in autism.Ann Clin Psychiatry, 2009, 21, 237-247.
    • (2009) Ann Clin Psychiatry , vol.21 , pp. 237-247
    • Srinivasan, P.1
  • 123
    • 0028598399 scopus 로고
    • Intractable epilepsy in children:the efficacy of lamotrigine treatment, including non-seizure-related benefits
    • Uvebrant P, Bauziene R: Intractable epilepsy in children:the efficacy of lamotrigine treatment, including non-seizure-related benefits. Neuropediatrics, 1994, 25,284-289.
    • (1994) Neuropediatrics , vol.25 , pp. 284-289
    • Uvebrant, P.1    Bauziene, R.2
  • 125
    • 11144230769 scopus 로고    scopus 로고
    • Neuroglial activation and neuroinflammation in the brain of patients with autism
    • DOI 10.1002/ana.20315
    • Vargas DL, Nascimbene C, Krishnan C, ZimmermanAW, Pardo CA: Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol,2005, 57, 67-81. (Pubitemid 40053317)
    • (2005) Annals of Neurology , vol.57 , Issue.1 , pp. 67-81
    • Vargas, D.L.1    Nascimbene, C.2    Krishnan, C.3    Zimmerman, A.W.4    Pardo, C.A.5
  • 126
    • 0032735937 scopus 로고    scopus 로고
    • Practice parameters for the assessment and treatmentof children, adolescents, and adults with autism andother pervasive developmental disorders: AmericanAcademy of Child and Adolescent Psychiatry WorkingGroup on Quality Issues
    • Volkmar F, Cook EH, Pomeroy J, Realmuto G, TanguayP: Practice parameters for the assessment and treatmentof children, adolescents, and adults with autism andother pervasive developmental disorders: AmericanAcademy of Child and Adolescent Psychiatry WorkingGroup on Quality Issues. J Am Acad Child Adolesc Psychiatry, 1999, 38, 32S-54S.
    • (1999) J Am Acad Child Adolesc Psychiatry , vol.38
    • Volkmar, F.1    Cook, E.H.2    Pomeroy, J.3    Realmuto, G.4    Tanguay, P.5
  • 127
    • 13844311589 scopus 로고    scopus 로고
    • Behavioral and cellular consequences of increasing serotonergic activity during braindevelopment: A role in autism?
    • Whitaker-Azmitia PM: Behavioral and cellular consequences of increasing serotonergic activity during braindevelopment: A role in autism? Int J Dev Neurosci,2005, 23, 75-83.
    • (2005) Int J Dev Neurosci , vol.23 , pp. 75-83
    • Whitaker-Azmitia, P.M.1
  • 129
    • 0030010710 scopus 로고    scopus 로고
    • The effects of chronic naltrexone treatment in young autistic children: A double-blind placebo-controlled crossover study
    • DOI 10.1016/0006-3223(95)00297-9
    • Willemsen-Swinkels SH, Buitelaar JK, van Engeland H:The effects of chronic naltrexone treatment in youngautistic children: a double-blind placebo-controlledcrossover study. Biol Psychiatry, 1996, 39, 1023-1031. (Pubitemid 26191350)
    • (1996) Biological Psychiatry , vol.39 , Issue.12 , pp. 1023-1031
    • Willemsen-Swinkels, S.H.N.1    Buitelaar, J.K.2    Van Engeland, H.3
  • 131
    • 79955942263 scopus 로고    scopus 로고
    • Regional cerebral blood flow in children withautism spectrum disorders: A quantitative 99 mTc-ECDbrain SPECT study with statistical parametric mappingevaluation
    • Yang WH, Jing J, Xiu LJ, Cheng MH, Wang X, Bao P,Wang QX: Regional cerebral blood flow in children withautism spectrum disorders: a quantitative 99 mTc-ECDbrain SPECT study with statistical parametric mappingevaluation. Chin Med J (Engl), 2011, 124, 1362-1366.
    • (2011) Chin Med J (Engl) , vol.124 , pp. 1362-1366
    • Yang, W.H.1    Jing, J.2    Xiu, L.J.3    Cheng, M.H.4    Wang, X.5    Bao, P.6    Wang, Q.X.7
  • 132
    • 0036251443 scopus 로고    scopus 로고
    • Treatment with fluvoxamine against self-injury and aggressive behavior in autistic children
    • Yokoyama H, Hirose M, Haginoya K, Munakata M,Iinuma K: Treatment with fluvoxamine against selfinjury and aggressive behavior in autistic children(Japanese). No To Hattatsu, 2002, 34, 249-253. (Pubitemid 34496308)
    • (2002) No to Hattatsu , vol.34 , Issue.3 , pp. 249-253
    • Yokoyama, H.1    Hirose, M.2    Haginoya, K.3    Munakata, M.4    Iinuma, K.5


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