A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders

Archives of General Psychiatry

Volumn 55, Issue 7, 1998, Pages 633-641

  McDougle, Christopher J ^a,f   Holmes, Janice P ^b   Carlson, C ^b   Pelton, Gregory H ^d   Cohen, Donald J ^b,c   Price, Lawrence H ^e  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^e BROWN UNIVERSITY   (United States)

^f RILEY HOSPITAL FOR CHILDREN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR BLOCKING AGENT; PLACEBO; RISPERIDONE; SEROTONIN 2A ANTAGONIST;

ADULT; AGGRESSION; ANXIETY; ARTICLE; AUTISM; BEHAVIOR DISORDER; CLINICAL ARTICLE; CLINICAL TRIAL; COMPULSION; CONTROLLED STUDY; DEPRESSION; DEVELOPMENTAL DISORDER; DOUBLE BLIND PROCEDURE; DRUG RESPONSE; FEMALE; HUMAN; IRRITABILITY; LANGUAGE; MALE; NERVOUSNESS; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; SOCIAL BEHAVIOR; SOMNOLENCE;

ADOLESCENT; ADULT; AGE FACTORS; AGGRESSION; ANTIPSYCHOTIC AGENTS; AUTISTIC DISORDER; CHILD DEVELOPMENT DISORDERS, PERVASIVE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PLACEBOS; PSYCHIATRIC STATUS RATING SCALES; RISPERIDONE; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; WEIGHT GAIN;

EID: 0031855086     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.55.7.633     Document Type: Article

References (38)

1. McDougle CJ. Psychopharmacology. In: Cohen DJ, Volkmar FV, eds. Handbook of Autism and Pervasive Developmental Disorders. 2nd ed. New York, NY: John Wiley & Sons Inc; 1997:707-729.
2. Gillberg C, Svennerholm L, Hamilton-Hellberg C. Childhood psychosis and monoamine metabolites in spinal fluid. J Autism Dev Discord. 1983;13:383-396.
3. McDougle CJ, Naylor ST, Cohen DJ, Aghajanian SK, Heninger GR, Price LH. Effects of tryptophan depletion in drug-free adults with autistic disorder. Arch Gen Psychiatry. 1996;53:993-1000.
4. Cook EH, Leventhal BL. The serotonin system in autism. Curr Opin Pediatr. 1996;8:348-354.
5. Anderson LT, Campbell M, Grega DM, Perry R, Small AM, Green WH, Haloperidol in the treatment of infantile autism: effects on learning and behavioral symptoms. Am J Psychiatry. 1984;141:1195-1202.
6. Campbell M, Armenteros JL, Malone RP, Adams PB, Eisenberg ZW, Overall JE. Neuroleptic-related dyskinesias in autistic children: a prospective, longitudinal study. J Am Acad Child Adolesc Psychiatry. 1997;36:835-843.
7. Gordon CT, Rapoport JL, Hamburger SD, State RC, Mannheim GB, Differential response of seven subjects with autistic disorder to ciomipramine and desipramine, Am J Psychiatry. 1992;149:363-366.
8. Gordon CT, State RC, Nelson JE, Hamburger SD, Rapoport JL. A double-blind comparison of ciomipramine, desipramine, and placebo in the treatment of autistic disorder. Arch Gen Psychiatry. 1993;50:441-447.
9. McDougle CJ, Naylor ST, Cohen DJ, Volkmar FV, Heninger GR, Price LH. A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Arch Gen Psychiatry, 1996;53:1001-1008.
10. Leysen JE, Janssen PMF, Megens AAHP, Schotte A, Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994;55(suppl 5): 5-12.
11. Chouinard G, Jones B, Remington G, Bloom D, Addington D, MacEwan GW, Labelle A, Beauclair L, Arnott W. A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients. J Clin Psychopharmacol. 1993;13:25-40.
12. Marder SR, Meibach RC. Risperidone in the treatment of schizophrenia. Am J Psychiatry. 1994;151:825-835.
13. Simeon JG, Carrey NJ, Wiggins DM, Milin RP, Hosendocus SN. Risperidone effects in treatment-resistant adolescents: preliminary case reports. J Child Adoiesc Psychopharmacol. 1995;5:69-79.
14. Demb H Risperidone: maybe this shouldn't be the last resort. In: Antanitus D, ed. Success Stories in Developmental Disabilities. Vol 4. Waltham, Mass: Liberty Healthcare Corp; 1995:11-14.
15. Demb HB. Risperidone in young children with pervasive developmental disorders and other developmental disabilities. J Child Adolesc Psychopharmacol. 1996;6:79-80.
16. Fisman S, Steele M. Use of risperidone in pervasive developmental disorders: a case series. J Child Adolesc Psychopharmacol. 1996;6:177-190.
17. Fisman S, Steele M, Short J, Byrne T, Lavallee C. Case study: anorexia nervosa and autistic disorder in an adolescent girl. J Am Acad Child Adolesc Psychiatry. 1996;35:937-940.
18. Hardan A, Johnson K, Johnson C, Hrecznyj B. Case study: risperidone treatment of children and adolescents with developmental disorders. J Am Acad Child Adolesc Psychiatry. 1996;35:1551-1556.
19. Perry RI, Pataki CS, Munoz-Silva DM, Armenteros J, Silva RR. Risperidone in children and adolescents with pervasive developmental disorder: pilot trial and follow-up. J Child Adolesc Psychopharmacol. 1997;7:167-179.
20. Frischauf E. Drug therapy in autism. J Am Acad Child Adolesc Psychiatry. 1997;36:577.
21. McDougle CJ, Holmes JP, Bronson MR, Anderson GM, Volkmar FR, Price LH, Cohen DJ. Risperidone treatment of children and adolescents with pervasive developmental disorders: a prospective open-label study. J Am Acad Child Adolesc Psychiatry. 1997;36:685-693.
22. Rubin M. Use of atypical antipsychotics in children with mental retardation, autism, and other developmental disabilities. Psychiatr Ann. 1997;27:219-221.
23. Purdon SE, Lit W, Labelle A, Jones BD. Risperidone in the treatment of pervasive developmental disorder. Can J Psychiatry. 1994;39:400-405.
24. McDougle CJ, Brodkin ES, Yeung PP, Naylor ST, Cohen DJ, Price LH. Risperidone in adults with autism or pervasive developmental disorder. J Child Adolesc Psychopharmacol. 1995;5:273-282.
25. Lott RS, Kerrick JM, Cohen SA. Clinical and economic aspects of risperidone treatment in adults with mental retardation and behavioral disturbance. Psychopharmacol Bull. 1996;32:721-729.
26. Horrigan JP, Barnhill LJ. Risperidone and explosive aggressive autism. J Autism Dev Disord. 1997;27:313-323.
27. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: American Psychiatric Association; 1994.
28. Le Couteur A, Rutter M, Lord C, Rios P, Robertson S, Holdgrafer M, McLennan J. Autism Diagnostic Interview: a standardized investigator-based instrument. J Autism Dev Disord. 1989;19:363-387.
29. Lord C, Rutter M, Goode S, Heemsbergen J, Jordan H, Mawhood L, Schopler E. Autism Diagnostic Observation Schedule: a standardized observation of communicative and social behavior. J Autism Dev Disord. 1989;19:185-212.
30. Guy W. ECDEU Assessment Manual for Psychopharmacology. Washington, DC: National Institute of Mental Health. US Dept of Health, Education, and Welfare; 1976. Publication 76-338.
31. Wechsler D. Manual for the Wechsler Adult Intelligence Scale-Revised. San Antonio, Tex: Psychological Corp; 1981.
32. Leiter RG. Leiter International Performance Scale. Chicago, III: Stoelting Co; 1948.
33. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann R, Hill C, Heninger GR, Charney DS. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS), I: development, use, and reliability. Arch Gen Psychiatry. 1989;46: 1006-1011.
34. Goodman WK, Price LH, Rasmussen SA, Mazure C, Delgado P, Heninger GR, Charney DS. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS), II: validity. Arch Gen Psychiatry. 1989;46:1012-1016.
35. McDougle CJ, Kresch LE, Goodman WK, Naylor ST, Volkmar FR, Cohen DJ, Price LH. A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder. Am J Psychiatry. 1995;152:772-777.
36. Freeman BJ, Ritvo ER, Yokota A, Ritvo A. A scale for rating symptoms of patients with the syndrome of autism in real life settings. J Am Acad Child Adolesc Psychiatry. 1986;25:130-136.
37. McDougle CJ, Naylor ST, Goodman WK, Volkmar FR, Cohen DJ, Price LH. Acute tryptophan depletion in autistic disorder: a controlled case study. Biol Psychiatry. 1993;33:547-550.
38. Feeney DJ, Klykylo W. Risperidone and tardive dyskinesia. J Am Acad Child Adolesc Psychiatry. 1996;35:1421-1422.