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Volumn 4, Issue 2, 2008, Pages 208-217

Evidence of mitochondrial dysfunction in autism and implications for treatment

Author keywords

Ammonia; Antioxidants; Co Enzyme Q10; Hyperbaric oxygen therapy; Inflammation; Lactate; Mitochondria; Oxidative stress

Indexed keywords

AMMONIA; DISEASES; METABOLISM; MITOCHONDRIA; OXIDATIVE STRESS; PATHOLOGY;

EID: 42449106018     PISSN: 15533468     EISSN: None     Source Type: Journal    
DOI: 10.3844/ajbbsp.2008.208.217     Document Type: Review
Times cited : (54)

References (115)
  • 1
    • 0004235298 scopus 로고
    • American Psychiatric Association, 4th ed. Washington, DC: American Psychiatric Press
    • American Psychiatric Association, 1994. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Press.
    • (1994) Diagnostic and Statistical Manual of Mental Disorders
  • 2
    • 33747200899 scopus 로고    scopus 로고
    • Autism: A brain disorder, or a disorder that affects the brain? Clin
    • Herbert, M.R, 2005. Autism: a brain disorder, or a disorder that affects the brain? Clin. Neuropsych., 2:354-379.
    • (2005) Neuropsych , vol.2 , pp. 354-379
    • Herbert, M.R.1
  • 3
    • 0034757723 scopus 로고    scopus 로고
    • Prevalence of autism in a United States population: The Brick Township, New Jersey, investigation
    • Bertrand, J., A. Mars, C. Boyle, F. Bove, M. Yeargin-Allsopp, P. Decoufle, 2001. Prevalence of autism in a United States population: the Brick Township, New Jersey, investigation. Pediatrics, 108:1155-1161.
    • (2001) Pediatrics , vol.108 , pp. 1155-1161
    • Bertrand, J.1    Mars, A.2    Boyle, C.3    Bove, F.4    Yeargin-Allsopp, M.5    Decoufle, P.6
  • 4
    • 0035958295 scopus 로고    scopus 로고
    • Pervasive developmental disorders in preschool children
    • Chakrabarti, S., E. Fombonne, 2001. Pervasive developmental disorders in preschool children. JAMA, 285:3093-3099.
    • (2001) JAMA , vol.285 , pp. 3093-3099
    • Chakrabarti, S.1    Fombonne, E.2
  • 6
    • 33846951841 scopus 로고    scopus 로고
    • Prevalence of Autism Spectrum Disorders - Autism and Developmental Disabilities Monitoring Network, Six Sites, United States, 2000
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention, 2007. Prevalence of Autism Spectrum Disorders - Autism and Developmental Disabilities Monitoring Network, Six Sites, United States, 2000. M.M.W.R., 56:1-40.
    • (2007) M.M.W.R , vol.56 , pp. 1-40
  • 7
    • 0029872978 scopus 로고    scopus 로고
    • Bailey, A., W. Phillips, M. Rutter, 1996. Autism: towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives. J. Child. Psychol. Psychiatry, 37:89-126.
    • Bailey, A., W. Phillips, M. Rutter, 1996. Autism: towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives. J. Child. Psychol. Psychiatry, 37:89-126.
  • 8
    • 0029748322 scopus 로고    scopus 로고
    • Neurological presentations of mitochondrial diseases
    • Zeviani, M., B. Bertagnolio, G. Uziel, 1996. Neurological presentations of mitochondrial diseases. J. Inherit. Metab. Dis., 19:504-520.
    • (1996) J. Inherit. Metab. Dis , vol.19 , pp. 504-520
    • Zeviani, M.1    Bertagnolio, B.2    Uziel, G.3
  • 9
    • 0036592842 scopus 로고    scopus 로고
    • Filiano, J.J., M.J. Goldenthal, C.H. Rhodes, J. Marin-Garcia, 2002. Mitochondrial dysfunction in patients with hypotonia, epilepsy, autism, and developmental delay: HEADD syndrome. J. Child Neurol., 17:435-439.
    • Filiano, J.J., M.J. Goldenthal, C.H. Rhodes, J. Marin-Garcia, 2002. Mitochondrial dysfunction in patients with hypotonia, epilepsy, autism, and developmental delay: HEADD syndrome. J. Child Neurol., 17:435-439.
  • 12
    • 27744541681 scopus 로고    scopus 로고
    • Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31
    • Segurado, R., J. Conroy, E. Meally, M. Fitzgerald, M. Gill, L. Gallagher, 2005. Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31. Am. J. Psychiatry, 162:2182-2184.
    • (2005) Am. J. Psychiatry , vol.162 , pp. 2182-2184
    • Segurado, R.1    Conroy, J.2    Meally, E.3    Fitzgerald, M.4    Gill, M.5    Gallagher, L.6
  • 15
    • 42449117749 scopus 로고    scopus 로고
    • Prevalence of common mitochondrial point mutations in autism
    • Serajee, F.J., H. Zhang, A.H.M.M Huq, 2006. Prevalence of common mitochondrial point mutations in autism. Neuropediatrics, 37(Suppl 1):S127.
    • (2006) Neuropediatrics , vol.37 , Issue.SUPPL. 1
    • Serajee, F.J.1    Zhang, H.2    Huq, A.H.M.M.3
  • 17
    • 0027992315 scopus 로고
    • Serum serotonin, lactate and pyruvate levels in infantile autistic children
    • Laszlo, A., E. Horvath, E. Eck, M. Fekete, 1994. Serum serotonin, lactate and pyruvate levels in infantile autistic children. Clin. Chim. Acta., 229:205-207.
    • (1994) Clin. Chim. Acta , vol.229 , pp. 205-207
    • Laszlo, A.1    Horvath, E.2    Eck, E.3    Fekete, M.4
  • 18
    • 33646830596 scopus 로고    scopus 로고
    • Developmental regression and mitochondrial dysfunction in a child with autism
    • Poling, J.S., R.E. Frye, J. Shoffner, A.W. Zimmerman, 2006. Developmental regression and mitochondrial dysfunction in a child with autism. J. Child Neurol., 21:170-172.
    • (2006) J. Child Neurol , vol.21 , pp. 170-172
    • Poling, J.S.1    Frye, R.E.2    Shoffner, J.3    Zimmerman, A.W.4
  • 21
    • 0031748285 scopus 로고    scopus 로고
    • Autism: A mitochondrial disorder?
    • Lombard, J., 1998 Autism: a mitochondrial disorder? Med. Hypotheses, 50:497-500.
    • (1998) Med. Hypotheses , vol.50 , pp. 497-500
    • Lombard, J.1
  • 23
    • 33746039656 scopus 로고    scopus 로고
    • Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: On defects in the cytochrome c oxidase complex and aldehyde detoxification
    • Ohta, S., I. Ohsawa, 2006. Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification. J. Alzheimers Dis., 9:155-166.
    • (2006) J. Alzheimers Dis , vol.9 , pp. 155-166
    • Ohta, S.1    Ohsawa, I.2
  • 24
    • 33646152108 scopus 로고    scopus 로고
    • Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: Implications for free radical generation and oxidative damage in disease progression
    • Manczak, M., T.S. Anekonda, E. Henson, B.S. Park, J. Quinn, P.H. Reddy, 2006. Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum. Mol. Genet., 15:1437-1449.
    • (2006) Hum. Mol. Genet , vol.15 , pp. 1437-1449
    • Manczak, M.1    Anekonda, T.S.2    Henson, E.3    Park, B.S.4    Quinn, J.5    Reddy, P.H.6
  • 25
    • 33845353404 scopus 로고    scopus 로고
    • Mitochondriopathy in Parkinson disease and amyotrophic lateral sclerosis
    • Martin, L.J., 2006. Mitochondriopathy in Parkinson disease and amyotrophic lateral sclerosis. J Neuropathol. Exp. Neurol., 65:1103-1110.
    • (2006) J Neuropathol. Exp. Neurol , vol.65 , pp. 1103-1110
    • Martin, L.J.1
  • 26
    • 34247158550 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases
    • Trushina, E., C.T. McMurray, 2007. Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases. Neuroscience, 145:1233-1248.
    • (2007) Neuroscience , vol.145 , pp. 1233-1248
    • Trushina, E.1    McMurray, C.T.2
  • 27
    • 0037101606 scopus 로고    scopus 로고
    • Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses
    • Billups, B., I.D. Forsythe, 2002. Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses. J. Neurosci., 22:5840-5847.
    • (2002) J. Neurosci , vol.22 , pp. 5840-5847
    • Billups, B.1    Forsythe, I.D.2
  • 28
    • 0027337120 scopus 로고
    • A preliminary 31P MRS study of autism: Evidence for undersynthesis and increased degradation of brain membranes
    • Minshew, N.J., G. Goldstein, S.M. Dombrowski, K. Panchalingam, J.W. Pettegrew, 1993. A preliminary 31P MRS study of autism: evidence for undersynthesis and increased degradation of brain membranes. Biol. Psychiatry, 33:762-773.
    • (1993) Biol. Psychiatry , vol.33 , pp. 762-773
    • Minshew, N.J.1    Goldstein, G.2    Dombrowski, S.M.3    Panchalingam, K.4    Pettegrew, J.W.5
  • 30
    • 0037104723 scopus 로고    scopus 로고
    • An in vitro model of Parkinson's disease: Linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
    • Sherer, T.B., R. Betarbet, A.K. Stout, S. Lund, M. Baptista, A.V. Panov, M.R. Cookson, J.T. Greenamyre, 2002. An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J. Neurosci., 22:7006-7015.
    • (2002) J. Neurosci , vol.22 , pp. 7006-7015
    • Sherer, T.B.1    Betarbet, R.2    Stout, A.K.3    Lund, S.4    Baptista, M.5    Panov, A.V.6    Cookson, M.R.7    Greenamyre, J.T.8
  • 31
    • 0036153397 scopus 로고    scopus 로고
    • Influence of clinical factors, diet, and drugs on the human upper gastrointestinal glutathione system
    • Hoensch, H., I. Morgenstern, G. Petereit, M. Siepmann, W.H. Peters, H.M Roelofs, W. Kirch, 2002. Influence of clinical factors, diet, and drugs on the human upper gastrointestinal glutathione system. Gut, 50:235-240.
    • (2002) Gut , vol.50 , pp. 235-240
    • Hoensch, H.1    Morgenstern, I.2    Petereit, G.3    Siepmann, M.4    Peters, W.H.5    Roelofs, H.M.6    Kirch, W.7
  • 34
    • 33750313546 scopus 로고    scopus 로고
    • Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease
    • Valicenti-McDermott, M., K. McVicar, I. Rapin, B.K. Wershil, H. Cohen, S. Shinnar, 2006. Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease. J. Dev. Behav. Pediatr., 27(2 Suppl):S128-S136.
    • (2006) J. Dev. Behav. Pediatr , vol.27 , Issue.2 SUPPL.
    • Valicenti-McDermott, M.1    McVicar, K.2    Rapin, I.3    Wershil, B.K.4    Cohen, H.5    Shinnar, S.6
  • 35
    • 0030782409 scopus 로고    scopus 로고
    • Mitochondrial medicine
    • Chinnery, P.F., D.M. Turnbull, 1997. Mitochondrial medicine. Q.J.M., 90:657-667.
    • (1997) Q.J.M , vol.90 , pp. 657-667
    • Chinnery, P.F.1    Turnbull, D.M.2
  • 36
    • 33845964992 scopus 로고    scopus 로고
    • Management of epilepsy in children with autism
    • Peake, D., L.M. Notghi, S. Philip, 2006. Management of epilepsy in children with autism. Current Paediatrics, 16:489-494.
    • (2006) Current Paediatrics , vol.16 , pp. 489-494
    • Peake, D.1    Notghi, L.M.2    Philip, S.3
  • 37
    • 0031563047 scopus 로고    scopus 로고
    • Autism
    • Rapin, I., 1997. Autism. N. Engl. J. Med., 337:97-104.
    • (1997) N. Engl. J. Med , vol.337 , pp. 97-104
    • Rapin, I.1
  • 39
    • 0033955887 scopus 로고    scopus 로고
    • Secondary carnitine deficiency and impaired docosahexaenoic (22:6n-3) acid synthesis: A common denominator in the pathophysiology of diseases of oxidative phosphorylation and beta-oxidation
    • Infante, J.P., V.A. Huszagh, 2000. Secondary carnitine deficiency and impaired docosahexaenoic (22:6n-3) acid synthesis: a common denominator in the pathophysiology of diseases of oxidative phosphorylation and beta-oxidation. FEBS Lett., 468:1-5.
    • (2000) FEBS Lett , vol.468 , pp. 1-5
    • Infante, J.P.1    Huszagh, V.A.2
  • 40
    • 2542461342 scopus 로고    scopus 로고
    • Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial beta-oxidation by long chain acyl-CoA dehydrogenase
    • Clark-Taylor, T., B.E. Clark-Taylor, 2004. Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial beta-oxidation by long chain acyl-CoA dehydrogenase. Med. Hypotheses, 62:970-975.
    • (2004) Med. Hypotheses , vol.62 , pp. 970-975
    • Clark-Taylor, T.1    Clark-Taylor, B.E.2
  • 42
    • 33644845279 scopus 로고    scopus 로고
    • Amyloid precursor protein-mediated free radicals and oxidative damage: Implications for the development and progress of Alzheimer's disease
    • Reddy, P.H., 2006. Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progress of Alzheimer's disease. J. Neurochem., 96:1-13.
    • (2006) J. Neurochem , vol.96 , pp. 1-13
    • Reddy, P.H.1
  • 43
    • 33744465025 scopus 로고    scopus 로고
    • Mitochondrial damage checkpoint, aging, and cancer
    • Singh, K.K., 2006. Mitochondrial damage checkpoint, aging, and cancer. Ann. N.Y. Acad. Sci. 1067:182-190.
    • (2006) Ann. N.Y. Acad. Sci , vol.1067 , pp. 182-190
    • Singh, K.K.1
  • 45
    • 15244348759 scopus 로고    scopus 로고
    • Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
    • James, S.J., P. Cutler, S. Melnyk, S. Jernigan, L. Janak, D.W. Gaylor, J.A. Neubrander, 2004. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am. J. Clin. Nutr., 80:1611-1617.
    • (2004) Am. J. Clin. Nutr , vol.80 , pp. 1611-1617
    • James, S.J.1    Cutler, P.2    Melnyk, S.3    Jernigan, S.4    Janak, L.5    Gaylor, D.W.6    Neubrander, J.A.7
  • 48
    • 0033796250 scopus 로고    scopus 로고
    • Mitochondrial free radical generation, oxidative stress, and aging
    • Cadenas, E., K.J. Davies, 2000. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic. Biol. Med., 29:222-230.
    • (2000) Free Radic. Biol. Med , vol.29 , pp. 222-230
    • Cadenas, E.1    Davies, K.J.2
  • 49
    • 0033624419 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease
    • Albers, D.S., M.F. Beal, 2000. Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J. Neural. Transm. Suppl., 59:133-154.
    • (2000) J. Neural. Transm. Suppl , vol.59 , pp. 133-154
    • Albers, D.S.1    Beal, M.F.2
  • 50
    • 33745699617 scopus 로고    scopus 로고
    • Oxidative stress in autism
    • Chauhan, A., V. Chauhan, 2006. Oxidative stress in autism. Pathophysiology, 13:171-181.
    • (2006) Pathophysiology , vol.13 , pp. 171-181
    • Chauhan, A.1    Chauhan, V.2
  • 51
    • 0036960604 scopus 로고    scopus 로고
    • Glutathione in defense and signaling: Lessons from a small thiol
    • Dickinson, D.A., H.J. Forman, 2002. Glutathione in defense and signaling: lessons from a small thiol. Ann. N. Y. Acad. Sci., 973:488-504.
    • (2002) Ann. N. Y. Acad. Sci , vol.973 , pp. 488-504
    • Dickinson, D.A.1    Forman, H.J.2
  • 54
    • 33747202981 scopus 로고    scopus 로고
    • Altered vascular phenotype in autism: Correlation with oxidative stress
    • Yao, Y., W.J. Walsh, W.R. McGinnis, D. Pratico, 2006. Altered vascular phenotype in autism: correlation with oxidative stress. Arch. Neurol., 63:1161-1164.
    • (2006) Arch. Neurol , vol.63 , pp. 1161-1164
    • Yao, Y.1    Walsh, W.J.2    McGinnis, W.R.3    Pratico, D.4
  • 55
    • 4444347472 scopus 로고    scopus 로고
    • Oxidative stress in autism: Increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin - the antioxidant proteins
    • Chauhan, A., V. Chauhan, W.T. Brown, I. Cohen, 2004. Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin - the antioxidant proteins. Life Sci., 75:2539-2549.
    • (2004) Life Sci , vol.75 , pp. 2539-2549
    • Chauhan, A.1    Chauhan, V.2    Brown, W.T.3    Cohen, I.4
  • 56
    • 0037373449 scopus 로고    scopus 로고
    • Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males
    • Borras, C., J. Sastre, D. Garcia-Sala, A. Lloret, F.V. Pallardo, J. Vina, 2003. Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males. Free Radic. Biol. Med., 34:546-552.
    • (2003) Free Radic. Biol. Med , vol.34 , pp. 546-552
    • Borras, C.1    Sastre, J.2    Garcia-Sala, D.3    Lloret, A.4    Pallardo, F.V.5    Vina, J.6
  • 57
    • 0030605162 scopus 로고    scopus 로고
    • Enhanced oxidative stress in female rat brain after gonadectomy
    • Kume-Kick, J., D.C. Ferris, I. Russo-Menna, M.E. Rice, 1996. Enhanced oxidative stress in female rat brain after gonadectomy. Brain Res., 738:8-14.
    • (1996) Brain Res , vol.738 , pp. 8-14
    • Kume-Kick, J.1    Ferris, D.C.2    Russo-Menna, I.3    Rice, M.E.4
  • 58
    • 0026759757 scopus 로고
    • Age-related changes in antioxidant enzyme activities are region and organ, as well as sex, selective in the rat
    • Carrillo, M.C., S. Kanai, Y. Sato, K. Kitani, 1992. Age-related changes in antioxidant enzyme activities are region and organ, as well as sex, selective in the rat. Mech. Ageing Dev., 65:187-198.
    • (1992) Mech. Ageing Dev , vol.65 , pp. 187-198
    • Carrillo, M.C.1    Kanai, S.2    Sato, Y.3    Kitani, K.4
  • 59
    • 0037309633 scopus 로고    scopus 로고
    • Plasma selenium and plasma and erythrocyte glutathione peroxidase activity increase with estrogen during the menstrual cycle
    • Ha, E.Jj, A.M. Smith, 2003. Plasma selenium and plasma and erythrocyte glutathione peroxidase activity increase with estrogen during the menstrual cycle. J. Am. Coll. Nutr., 22:43-51.
    • (2003) J. Am. Coll. Nutr , vol.22 , pp. 43-51
    • Ha, E.J.1    Smith, A.M.2
  • 60
    • 25144524774 scopus 로고    scopus 로고
    • Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels
    • Stirone, C., S.P. Duckles, D.N. Krause, V. Procaccio, 2005. Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels. Mol. Pharmacol., 68:959-965.
    • (2005) Mol. Pharmacol , vol.68 , pp. 959-965
    • Stirone, C.1    Duckles, S.P.2    Krause, D.N.3    Procaccio, V.4
  • 66
    • 17544371896 scopus 로고    scopus 로고
    • Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl
    • Görker, I., U. Tüzün, 2005. Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl. J. Psychiatry Neurosci., 30:133-135.
    • (2005) J. Psychiatry Neurosci , vol.30 , pp. 133-135
    • Görker, I.1    Tüzün, U.2
  • 67
    • 0027988722 scopus 로고
    • Brain ATP depletion induced by acute ammonia intoxication in rats is mediated by activation of the NMDA receptor and Na+,K(+)-ATPase
    • Kosenko, E., Y. Kaminsky, E. Grau, M.D. Minana, G. Marcaida, S. Grisolia, V. Felipo, 1994. Brain ATP depletion induced by acute ammonia intoxication in rats is mediated by activation of the NMDA receptor and Na+,K(+)-ATPase. J. Neurochem., 63:2172-2178.
    • (1994) J. Neurochem , vol.63 , pp. 2172-2178
    • Kosenko, E.1    Kaminsky, Y.2    Grau, E.3    Minana, M.D.4    Marcaida, G.5    Grisolia, S.6    Felipo, V.7
  • 70
    • 0017809273 scopus 로고
    • Behavioral consequences of congenital rubella
    • Chess, S., P. Fernandez S. Korn, 1978. Behavioral consequences of congenital rubella. J. Pediatr., 93:699-703.
    • (1978) J. Pediatr , vol.93 , pp. 699-703
    • Chess, S.1    Fernandez, P.2    Korn, S.3
  • 71
    • 0141762576 scopus 로고    scopus 로고
    • Possible association between congenital cytomegalovirus infection and autistic disorder
    • Yamashita, Y., C. Fujimoto, E. Nakajima, T. Isagai, T. Matsuishi, 2003. Possible association between congenital cytomegalovirus infection and autistic disorder. J. Autism Dev. Disord., 33:455-459.
    • (2003) J. Autism Dev. Disord , vol.33 , pp. 455-459
    • Yamashita, Y.1    Fujimoto, C.2    Nakajima, E.3    Isagai, T.4    Matsuishi, T.5
  • 72
    • 0037036965 scopus 로고    scopus 로고
    • Paraoxonase polymorphisms and organophosphates
    • Worth, J., 2002. Paraoxonase polymorphisms and organophosphates. Lancet, 360:802-803.
    • (2002) Lancet , vol.360 , pp. 802-803
    • Worth, J.1
  • 74
    • 33748150467 scopus 로고    scopus 로고
    • Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco bay area
    • Windham, G.C., L. Zhang, R. Gunier, L.A. Croen, J.K. Grether, 2006. Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco bay area. Environ. Health Perspect., 114:1438-1444.
    • (2006) Environ. Health Perspect , vol.114 , pp. 1438-1444
    • Windham, G.C.1    Zhang, L.2    Gunier, R.3    Croen, L.A.4    Grether, J.K.5
  • 75
    • 0034447543 scopus 로고    scopus 로고
    • The neurotoxic etiology of the autistic spectrum disorders: A replication study
    • Edelson, S.B., D. Cantor, 2000. The neurotoxic etiology of the autistic spectrum disorders: a replication study. Toxicol. Indust. Health, 16:239-247.
    • (2000) Toxicol. Indust. Health , vol.16 , pp. 239-247
    • Edelson, S.B.1    Cantor, D.2
  • 76
    • 33845424655 scopus 로고    scopus 로고
    • Developmental neurotoxicity of industrial chemicals
    • Grandjean, P., P.J. Landrigan, 2006. Developmental neurotoxicity of industrial chemicals. Lancet, 368:2167-2178.
    • (2006) Lancet , vol.368 , pp. 2167-2178
    • Grandjean, P.1    Landrigan, P.J.2
  • 78
    • 28844448883 scopus 로고    scopus 로고
    • Environmental mercury release, special education rates, and autism disorder: An ecological study of Texas
    • Palmer, R.F., S. Blanchard, Z. Stein, D. Mandell, C. Miller, 2006. Environmental mercury release, special education rates, and autism disorder: an ecological study of Texas. Health Place, 12:203-209.
    • (2006) Health Place , vol.12 , pp. 203-209
    • Palmer, R.F.1    Blanchard, S.2    Stein, Z.3    Mandell, D.4    Miller, C.5
  • 79
    • 0030093442 scopus 로고    scopus 로고
    • Attention deficit hyperactivity disorder, infantile autism, and elevated blood-lead: A possible relationship
    • Eppright, T.D., J.A. Sanfacon, E.A. Horwitz, 1996. Attention deficit hyperactivity disorder, infantile autism, and elevated blood-lead: a possible relationship. Missouri Medicine, 93:136-138.
    • (1996) Missouri Medicine , vol.93 , pp. 136-138
    • Eppright, T.D.1    Sanfacon, J.A.2    Horwitz, E.A.3
  • 80
    • 17044371854 scopus 로고    scopus 로고
    • Autism and autistic symptoms associated with childhood lead poisoning
    • Lidsky, T.I., J.S. Schneider, 2005. Autism and autistic symptoms associated with childhood lead poisoning. J. Appl. Research, 5:80-87.
    • (2005) J. Appl. Research , vol.5 , pp. 80-87
    • Lidsky, T.I.1    Schneider, J.S.2
  • 81
    • 0020525357 scopus 로고
    • Antagonism by d-amphetamine of trimethyltin-induced hyperactivity evidence toward an animal model of hyperkinetic behavior
    • Swartzwelder, H.S., W. Holahan, R.D. Myers, 1983. Antagonism by d-amphetamine of trimethyltin-induced hyperactivity evidence toward an animal model of hyperkinetic behavior. Neuropharmacology, 22:1049-1054.
    • (1983) Neuropharmacology , vol.22 , pp. 1049-1054
    • Swartzwelder, H.S.1    Holahan, W.2    Myers, R.D.3
  • 82
    • 0029953552 scopus 로고    scopus 로고
    • Oxidative Stress in neurotoxic effects of methylmercury poisoning
    • Yee, S., B.H. Choi, 1996. Oxidative Stress in neurotoxic effects of methylmercury poisoning. NeuroToxicology, 17:17-26.
    • (1996) NeuroToxicology , vol.17 , pp. 17-26
    • Yee, S.1    Choi, B.H.2
  • 83
    • 0033562940 scopus 로고    scopus 로고
    • Induction of apoptosis in human T-cells by methyl mercury: Temporal relationship between mitochondrial dysfunction and loss of reductive reserve
    • Shenker, B.J., T.L. Guo, I. O, I.M. Shapiro, 1999. Induction of apoptosis in human T-cells by methyl mercury: temporal relationship between mitochondrial dysfunction and loss of reductive reserve. Toxicol. Appl. Pharmacol., 157:23-35.
    • (1999) Toxicol. Appl. Pharmacol , vol.157 , pp. 23-35
    • Shenker, B.J.1    Guo, T.L.2    Shapiro, I.O.I.M.3
  • 84
    • 0344845135 scopus 로고    scopus 로고
    • Metal-induced apoptosis: Mechanisms
    • Pulido, M.D., A.R. Parrish, 2003. Metal-induced apoptosis: mechanisms. Mut. Res., 533:227-241.
    • (2003) Mut. Res , vol.533 , pp. 227-241
    • Pulido, M.D.1    Parrish, A.R.2
  • 85
    • 0028872906 scopus 로고
    • Effects of pesticides on isolated rat hepatocytes, mitochondria, and microsomes II
    • Yamano, T., S. Morita, 1995. Effects of pesticides on isolated rat hepatocytes, mitochondria, and microsomes II. Arch. Environ. Contam. Toxicol., 28:1-7.
    • (1995) Arch. Environ. Contam. Toxicol , vol.28 , pp. 1-7
    • Yamano, T.1    Morita, S.2
  • 86
    • 0034284232 scopus 로고    scopus 로고
    • The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles
    • Hiura, T.S., N. Li, R. Kaplan, M. Horwitz, J.C. Seagrave, A.E. Nel, 2000. The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles. J. Immunol., 165:2703-2711.
    • (2000) J. Immunol , vol.165 , pp. 2703-2711
    • Hiura, T.S.1    Li, N.2    Kaplan, R.3    Horwitz, M.4    Seagrave, J.C.5    Nel, A.E.6
  • 87
    • 33845391588 scopus 로고    scopus 로고
    • Neurobiological effects of intraventricular propionic acid in rats: Possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders
    • MacFabe, D.F., D.P. Cain, K. Rodriguez-Capote, A.E. Franklin, J.E. Hoffman, F. Boon, A.R. Taylor, M. Kavaliers, K.P. Ossenkopp, 2007. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behav. Brain Res., 176:149-169.
    • (2007) Behav. Brain Res , vol.176 , pp. 149-169
    • MacFabe, D.F.1    Cain, D.P.2    Rodriguez-Capote, K.3    Franklin, A.E.4    Hoffman, J.E.5    Boon, F.6    Taylor, A.R.7    Kavaliers, M.8    Ossenkopp, K.P.9
  • 88
    • 33750721307 scopus 로고    scopus 로고
    • Evidence of toxicity, oxidative stress, and neuronal insult in autism
    • Kern, J.K., A.M. Jones, 2006. Evidence of toxicity, oxidative stress, and neuronal insult in autism. J. Toxicol. Environ. Health. B Crit. Rev., 9:485-499.
    • (2006) J. Toxicol. Environ. Health. B Crit. Rev , vol.9 , pp. 485-499
    • Kern, J.K.1    Jones, A.M.2
  • 89
    • 0032482999 scopus 로고    scopus 로고
    • Hagen, T.M., R.T. Ingersoll, C.M. Wehr, J. Lykkesfeldt, V. Vinarsky, J.C. Bartholomew, M.H. Song, B.N Ames, 1998. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc. Natl. Acad. Sci. U.S.A., 95:9562-9566.
    • Hagen, T.M., R.T. Ingersoll, C.M. Wehr, J. Lykkesfeldt, V. Vinarsky, J.C. Bartholomew, M.H. Song, B.N Ames, 1998. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc. Natl. Acad. Sci. U.S.A., 95:9562-9566.
  • 90
    • 0032555066 scopus 로고    scopus 로고
    • Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
    • Matthews, R.T., L. Yang, S. Browne, M. Baik, M.F. Beal, 1998. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc. Natl. Acad. Sci. U.S.A., 95:8892-8897.
    • (1998) Proc. Natl. Acad. Sci. U.S.A , vol.95 , pp. 8892-8897
    • Matthews, R.T.1    Yang, L.2    Browne, S.3    Baik, M.4    Beal, M.F.5
  • 92
    • 0024561803 scopus 로고
    • Mitochondrial encephalomyopathy (MELAS): Pathological study and successful therapy with coenzyme Q10 and idebenone
    • Ihara, Y., R. Namba, S. Kuroda, T. Sato, T. Shirabe, 1989. Mitochondrial encephalomyopathy (MELAS): pathological study and successful therapy with coenzyme Q10 and idebenone. J. Neurol. Sci., 90:263-271.
    • (1989) J. Neurol. Sci , vol.90 , pp. 263-271
    • Ihara, Y.1    Namba, R.2    Kuroda, S.3    Sato, T.4    Shirabe, T.5
  • 93
    • 0030612535 scopus 로고    scopus 로고
    • Coenzyme Q10 treatment in mitochondrial encephalomyopathies. Short-term double-blind, crossover study
    • Chen, R.S., C.C. Huang, N.S. Chu, 1997. Coenzyme Q10 treatment in mitochondrial encephalomyopathies. Short-term double-blind, crossover study. Eur. Neurol., 37:212-218.
    • (1997) Eur. Neurol , vol.37 , pp. 212-218
    • Chen, R.S.1    Huang, C.C.2    Chu, N.S.3
  • 95
    • 0343247698 scopus 로고    scopus 로고
    • Antioxidants, mitochondrial hyperoxidation and electrical recovery after anoxia in hippocampal slices
    • Perez-Pinzon, M.A., P.L. Mumford, M. Rosenthal, T.J. Sick, 1997. Antioxidants, mitochondrial hyperoxidation and electrical recovery after anoxia in hippocampal slices. Brain Res., 754:163-170.
    • (1997) Brain Res , vol.754 , pp. 163-170
    • Perez-Pinzon, M.A.1    Mumford, P.L.2    Rosenthal, M.3    Sick, T.J.4
  • 99
    • 0036943961 scopus 로고    scopus 로고
    • Functional neuroimaging and childhood autism
    • Boddaert, N., M. Zilbovicius, 2002. Functional neuroimaging and childhood autism. Pediatr. Radiol., 32:1-7.
    • (2002) Pediatr. Radiol , vol.32 , pp. 1-7
    • Boddaert, N.1    Zilbovicius, M.2
  • 100
    • 33947701000 scopus 로고    scopus 로고
    • Hyperbaric oxygen therapy might improve certain pathophysiological findings in autism
    • Rossignol, D.A, 2007. Hyperbaric oxygen therapy might improve certain pathophysiological findings in autism. Med. Hypotheses, 68:1208-1227.
    • (2007) Med. Hypotheses , vol.68 , pp. 1208-1227
    • Rossignol, D.A.1
  • 101
    • 0035892301 scopus 로고    scopus 로고
    • Altered levels of Bcl2 and p53 proteins in parietal cortex reflect deranged apoptotic regulation in autism
    • Fatemi, S.H., A.R. Halt, 2001. Altered levels of Bcl2 and p53 proteins in parietal cortex reflect deranged apoptotic regulation in autism. Synapse, 42:281-284.
    • (2001) Synapse , vol.42 , pp. 281-284
    • Fatemi, S.H.1    Halt, A.R.2
  • 102
    • 0347355175 scopus 로고    scopus 로고
    • Levels of Bcl-2 and P53 are altered in superior frontal and cerebellar cortices of autistic subjects
    • Araghi-Niknam, M., S.H Fatemi, 2003. Levels of Bcl-2 and P53 are altered in superior frontal and cerebellar cortices of autistic subjects. Cell Mol. Neurobiol., 23:945-952.
    • (2003) Cell Mol. Neurobiol , vol.23 , pp. 945-952
    • Araghi-Niknam, M.1    Fatemi, S.H.2
  • 103
    • 0028110809 scopus 로고
    • Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
    • Graeber, T.G., J.F. Peterson, M. Tsai, K. Monica, A,J, Fornace Jr, A.J Giaccia, 1994. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell Biol., 14:6264-6277.
    • (1994) Mol. Cell Biol , vol.14 , pp. 6264-6277
    • Graeber, T.G.1    Peterson, J.F.2    Tsai, M.3    Monica, K.4    Fornace Jr, A.J.5    Giaccia, A.J.6
  • 104
  • 105
    • 29544450082 scopus 로고    scopus 로고
    • Acute and severe hypobaric hypoxia increases oxidative stress and impairs mitochondrial function in mouse skeletal muscle
    • Magalhães, J., A. Ascensão, J.M. Soares, R. Ferreira, M.J. Neuparth, F. Marques, J.A. Duarte, 2005. Acute and severe hypobaric hypoxia increases oxidative stress and impairs mitochondrial function in mouse skeletal muscle. J. Appl. Physiol., 99:1247-1253.
    • (2005) J. Appl. Physiol , vol.99 , pp. 1247-1253
    • Magalhães, J.1    Ascensão, A.2    Soares, J.M.3    Ferreira, R.4    Neuparth, M.J.5    Marques, F.6    Duarte, J.A.7
  • 106
    • 34147150556 scopus 로고    scopus 로고
    • Oxygen treatment restores energy status following experimental neonatal hypoxia-ischemia
    • Calvert, J.W., J.H. Zhang, 2007. Oxygen treatment restores energy status following experimental neonatal hypoxia-ischemia. Pediatr. Crit. Care Med., 8:165-173.
    • (2007) Pediatr. Crit. Care Med , vol.8 , pp. 165-173
    • Calvert, J.W.1    Zhang, J.H.2
  • 108
    • 0038504927 scopus 로고    scopus 로고
    • Hyperbaric oxygen therapy protects against mitochondrial dysfunction and delays onset of motor neuron disease in Wobbler mice
    • Dave, K.R., R. Prado, R. Busto, A.P. Raval, W.G. Bradley, D. Torbati, M.A. Perez-Pinzon, 2003. Hyperbaric oxygen therapy protects against mitochondrial dysfunction and delays onset of motor neuron disease in Wobbler mice. Neuroscience, 120:113-120.
    • (2003) Neuroscience , vol.120 , pp. 113-120
    • Dave, K.R.1    Prado, R.2    Busto, R.3    Raval, A.P.4    Bradley, W.G.5    Torbati, D.6    Perez-Pinzon, M.A.7
  • 109
    • 4143088238 scopus 로고    scopus 로고
    • Effects of hyperbaric oxygen therapy on cerebral oxygenation and mitochondrial function following moderate lateral fluid-percussion injury in rats
    • Daugherty, W.P., J.E. Levasseur, D. Sun, G.L. Rockswold, M.R. Bullock, 2004. Effects of hyperbaric oxygen therapy on cerebral oxygenation and mitochondrial function following moderate lateral fluid-percussion injury in rats. J. Neurosurg., 101:499-504.
    • (2004) J. Neurosurg , vol.101 , pp. 499-504
    • Daugherty, W.P.1    Levasseur, J.E.2    Sun, D.3    Rockswold, G.L.4    Bullock, M.R.5
  • 110
    • 0015882341 scopus 로고
    • The mitochondrial generation of hydrogen peroxide: General properties and effect of hyperbaric oxygen
    • Boveris, A., B. Chance, 1973. The mitochondrial generation of hydrogen peroxide: general properties and effect of hyperbaric oxygen. Biochem. J., 134:707-716.
    • (1973) Biochem. J , vol.134 , pp. 707-716
    • Boveris, A.1    Chance, B.2
  • 111
    • 0015719467 scopus 로고
    • Mitochondrial respiration and oxidative phosphorylation during hypothermic hyperbaric hepatic preservation
    • Gosalvez, M., J. Castillo Olivares, E. De Miguel, M. Blanco, D. Figuera, 1973. Mitochondrial respiration and oxidative phosphorylation during hypothermic hyperbaric hepatic preservation. J. Surg. Res., 15:313-318.
    • (1973) J. Surg. Res , vol.15 , pp. 313-318
    • Gosalvez, M.1    Castillo Olivares, J.2    De Miguel, E.3    Blanco, M.4    Figuera, D.5
  • 112
    • 0019468233 scopus 로고
    • Effects of hyperbaric oxygenation on spermatozoan motility driven by mitochondrial respiration
    • Bar-Sagie, D., A. Mayevsky, B. Bartoov, 1981. Effects of hyperbaric oxygenation on spermatozoan motility driven by mitochondrial respiration. J. Appl. Physiol., 50:531-537.
    • (1981) J. Appl. Physiol , vol.50 , pp. 531-537
    • Bar-Sagie, D.1    Mayevsky, A.2    Bartoov, B.3
  • 113
    • 33644873010 scopus 로고    scopus 로고
    • Involvement of the mitochondrial ATP-sensitive potassium channel in the neuroprotective effect of hyperbaric oxygenation after cerebral ischemia
    • Lou, M., Y. Chen, M. Ding, C.C. Eschenfelder, G. Deuschl, 2006. Involvement of the mitochondrial ATP-sensitive potassium channel in the neuroprotective effect of hyperbaric oxygenation after cerebral ischemia. Brain Res. Bull., 69:109-116.
    • (2006) Brain Res. Bull , vol.69 , pp. 109-116
    • Lou, M.1    Chen, Y.2    Ding, M.3    Eschenfelder, C.C.4    Deuschl, G.5
  • 115
    • 33744739160 scopus 로고    scopus 로고
    • Hyperbaric oxygen therapy may improve symptoms in autistic children
    • Rossignol, D.A., L.W. Rossignol, 2006. Hyperbaric oxygen therapy may improve symptoms in autistic children. Med. Hypotheses, 67:216-228.
    • (2006) Med. Hypotheses , vol.67 , pp. 216-228
    • Rossignol, D.A.1    Rossignol, L.W.2


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