Regional cerebral blood flow in children with autism spectrum disorders: A quantitative 99mTc-ECD brain SPECT study with statistical parametric mapping evaluation

Chinese Medical Journal

Volumn 124, Issue 9, 2011, Pages 1362-1366

  Yang, Wen han ^a   Jing, Jin ^a   Xiu, Li juan ^b   Cheng, Mu hua ^a   Wang, Xin ^a   Bao, Peng ^a   Wang, Qing xiong ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU WOMEN AND CHILDREN S MEDICAL CENTER   (China)

Author keywords

Autism spectrum disorders; Regional cerebral blood flow; Single photon emission computed tomography

Indexed keywords

CYSTEINE ETHYL ESTER TC 99M;

ARTICLE; ASPERGER SYNDROME; AUTISM; BASAL AMYGDALA; BASAL GANGLION; BRAIN ASYMMETRY; BRAIN BLOOD FLOW; BRAIN REGION; CEREBELLUM; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; FRONTAL GYRUS; FRONTAL LOBE; HUMAN; LEGUMINA NUCLEUS; MALE; PARIETAL LOBE; PERFUSION; PRESCHOOL CHILD; QUANTITATIVE ANALYSIS; SCHOOL CHILD; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STATISTICAL PARAMETERS; TEMPORAL LOBE; THALAMENCEPHALON;

CEREBROVASCULAR CIRCULATION; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CHILD, PRESCHOOL; CYSTEINE; FEMALE; HUMANS; MALE; ORGANOTECHNETIUM COMPOUNDS; REGIONAL BLOOD FLOW; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 79955942263     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2011.09.017     Document Type: Article

References (29)

1. Kanner L. Autistic disturbances of affective contact. Acta Paedopsychiatr 1968; 35: 100-136.
2. Lainhart JE. Advances in autism neuroimaging research for the clinician and geneticist. Am J Med Genet C Semin Med Genet 2006; 142C: 33-39.
3. Verhoeven JS, De Cock P, Lagae L, Sunaert S. Neuroimaging of autism. Neuroradiology 2010; 52: 3-14.
4. Baron-Cohen S, Ring HA, Wheelwright S, Bullmore ET, Brammer MJ, Simmons A, et al. Social intelligence in the normal and autistic brain: an fMRI study. Eur J Neurosci 1999; 11: 1891-1898.
5. Brun CC, Nicolson R, Lepore N, Chou YY, Vidal CN, DeVito TJ, et al. Mapping brain abnormalities in boys with autism. Hum Brain Mapp 2009; 30: 3887-3900.
6. Chiron C, Leboyer M, Leon F, Jambaque I, Nuttin C, Syrota A. SPECT of the brain in childhood autism: evidence for a lack of normal hemispheric asymmetry. Dev Med Child Neurol 1995; 37: 849-860.
7. Degirmenci B, Miral S, Kaya GC, Iyilikci L, Arslan G, Baykara A, et al. Durak H. Technetium-99m HMPAO brain SPECT in autistic children and their families. Psychiatry Res 2008; 162: 236-243.
8. 99mTc-ECD SPECT in high-functioning autism-3-dimensional stereotactic ROI template analysis of brain SPECT. J Med Invest 2005; 52: 49-56.
9. 99mTc-HMPAO brain SPECT and the scores of real life rating scale in autistic children. Brain Dev 2002; 24: 77-81.
10. Makkonen I, Riikonen R, Kokki H, Airaksinen MM, Kuikka JT. Serotonin and dopamine transporter binding in children with autism determined by SPECT. Dev Med Child Neurol 2008; 50: 593-597.
11. McAlonan GM, Cheung V, Cheung C, Suckling J, Lam GY, Tai KS, et al. Mapping the brain in autism. A voxel-based MRI study of volumetric differences and intercorrelations in autism. Brain 2005; 128: 268-276.
12. Mountz JM, Tolbert LC, Lill DW, Katholi CR, Liu HG. Functional deficits in autistic disorder: characterization by technetium-99m-HMPAO and SPECT. J Nucl Med 1995; 36: 1156-1162.
13. Zilbovicius M, Boddaert N, Belin P, Poline JB, Remy P, Mangin JF, et al. Temporal lobe dysfunction in childhood autism: a PET study. Positron emission tomography. Am J Psychiatry 2000; 157: 1988-1993.
14. Machado MG, Oliveira HA, Cipolotti R, Santos CA, de Oliveira EF, Donald RM, et al. Anatomical and functional abnormalities of central nervous system in autistic disorder: a MRI and SPECT study. Arq Neuropsiquiatr 2003; 61: 957-961.
15. Gupta SK, Ratnam BV. Cerebral perfusion abnormalities in children with autism and mental retardation: a segmental quantitative SPECT study. Indian Pediatr 2009; 46: 161-164.
16. Gendry MI, Zilbovicius M, Boddaert N, Robel L, Philippe A, Sfaello I, et al. Autism severity and temporal lobe functional abnormalities. Ann Neurol 2005; 58: 466-469.
17. Baron-Cohen S, Ring H, Moriarty J, Schmitz B, Costa D, Ell P. Recognition of mental state terms. Clinical findings in children with autism and a functional neuroimaging study of normal adults. Br J Psychiatry 1994; 165: 640-649.
18. Castelli F, Frith C, Happe F, Frith U. Autism, asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain 2002; 125: 1839-1849.
19. Cheung C, Chua SE, Cheung V, Khong PL, Tai KS, Wong TK, et al. White matter fractional anisotrophy differences and correlates of diagnostic symptoms in autism. J Child Psychol Psychiatry 2009; 50: 1102-1112.
20. Frith U. Mind blindness and the brain in autism. Neuron 2001; 32: 969-979.
21. Zilbovicius M, Boddaert N, Belin P, Poline JB, Remy P, Mangin JF, et al. Temporal lobe dysfunction in childhood autism: a PET study. Positron emission tomography. Am J Psychiatry 2000; 157: 1988-1993.
22. Pierce K, Muller RA, Ambrose J, Allen G, Courchesne E. Face processing occurs outside the fusiform "face area" in autism: evidence from functional MRI. Brain 2001; 124: 2059-2073.
23. Wada Y, Yamamoto T. Selective impairment of facial recognition due to a haematoma restricted to the right fusiform and lateral occipital region. J Neurol Neurosurg Psychiatry 2001; 71: 254-257.
24. Dawson G, Meltzoff AN, Osterling J, Rinaldi J, Brown E. Children with autism fail to orient to naturally occurring social stimuli. J Autism Dev Disord 1998; 28: 479-485.
25. Eigsti IM, Shapiro T. A systems neuroscience approach to autism: biological, cognitive, and clinical perspectives. Ment Retard Dev Disabil Res Rev 2003; 9: 205-215.
26. Ohnishi T, Matsuda H, Hashimoto T, Kunihiro T, Nishikawa M, Uema T, et al. Abnormal regional cerebral blood flow in childhood autism. Brain 2000; 123: 1838-1844.
27. Toal F, Daly EM, Page L, Deeley Q, Hallahan B, Bloemen O, et al. Clinical and anatomical heterogeneity in autistic spectrum disorder: a structural MRI study. Psychol Med 2010; 40: 1171-1181.
28. Kwon H, Ow AW, Pedatella KE, Lotspeich LJ, Reiss AL. Voxel-based morphometry elucidates structural neuroanatomy of high-functioning autism and Asperger syndrome. Dev Med Child Neurol 2004; 46: 760-764.
29. McAlonan GM, Cheung V, Cheung C, Chua SE, Murphy DG, Suckling J, et al. Mapping brain structure in attention deficit-hyperactivity disorder: a voxel-based MRI study of regional grey and white matter volume. Psychiatry Res 2007; 154: 171-180.