Phytoconstituents and therapeutic potential of allium cepa linn.- A Review

Pharmacognosy Reviews

Volumn 3, Issue 5, 2009, Pages 170-180

  Bora, Kundan ^a   Sharma, Anupam ^b  

^a LR Institute of Pharmacy   (India)

^b PANJAB UNIVERSITY   (India)

Author keywords

Allium cepa; Anticancer; Antioxidant; Flavonoids; S cysteine sulphoxides

Indexed keywords

EID: 84873602798     PISSN: 09737847     EISSN: 09762787     Source Type: Journal    
DOI: None     Document Type: Review

References (150)

1. P. Rose, M. Whiteman, P.K. Moore and Z.Y.I. Zhun. Bioactive Salk (en)yl cysteine sulphoxide metabolites in the genus Allium: The chemistry of potential therapeutic agents. Nat Prod Rep. 22: 351-368 (2005). (Pubitemid 40885716)
2. G.R. Fenwick and A.B. Hanley. The genus Allium- part I. Crit Rev Food Sci Nutr. 22: 199-271 (1985).
3. E. Strasburger, P. Sitte, E.W. Weiler, J.W. Kadereit, A. Bresinsky and C. Korner. Gustav Fischer Verlag Stuttgart (New York, 1978) 855.
4. K.R. Kirtikar and B.D. Basu. Indian meditional plants. Edi II, Vol IV (Lalit mohan basu, 1993) 2511-2513.
5. Anonymous, WHO monographs on selected medicinal plants, Vol I, (World Health Organization, Geneva, 1999) 5-15.
6. R. Hegnauer. Chemotaxonomie der Pflanzen, Vol II, (Birkhauser Verlag Basel, Stuttgart, 1963) 45.
7. R.M. Dahlgren, T. Clifford and P. Yeo. The families of the monocotyledons (Springer-Verlag, Berlin, Heidelberg, New York, 1985) 58.
8. G. Griffiths, L. Trueman, T. Crowther, B. Thomas and B. Smith. Onions- A global benefit to health. Phytother Res. 16: 603-615 (2002).
9. FAOSTAT. Agriculture data, Food balance sheets, URL. http://apps.fao.org, 2002. Through, EJEAF Chem. 2: 519-524 (2003).
10. M. Mazelis and L. Crews. Purification of alliin lyase of garlic, Allium sativum L. Biochem J. 108: 725-730 (1968).
11. M. Mazelis and R.K. Creveling. Purification and properties of S-Alkyl- L-cysteine lysase from seedlings of Acacia farnesiana wild. Biochem J. 147: 485-491 (1975).
12. L.P. Nock and M. Mazelis. The C-S lyases of higher plants. Direct comparision of the physical properties of homogeneous allinase of garlic (Allium sativum) and onion (Allium cepa). Plant Physiol. 85: 1079-1083 (1987).
13. J. Landshuter, E.M. Lohmuller and K. Knobloch. Purification and characterization of a C-S-lyase from Ramson, and wild garlic, Allium ursinum. Planta Med. 60: 343-347 (1994). (Pubitemid 24255929)
14. E.M. Lohmuller, J. Landshuter and K. Knobloch. On the isolation and characterization of a C-S-lyase preparation from Leek (Allium porrum). Planta Med. 60: 337-342 (1994). (Pubitemid 24255928)
15. J.E. Lancaster and H.A. Collin. Presence of alliinase in isolated vacuoles and of alkyl cysteine sulphoxides in. the cytoplasm of bulbs of onion (Allium cepa). Plant Sci Lett. 22: 169-176 (1981).
16. M.H. Brodnitz and J.V. Pascale. Thiopropanal S-Oxide: A Lachrymatory Factor in Onions. J Agri Food Chem. 19: 269-272 (1971).
17. E. Steinegger, O. Sticher and R. Hansel. Pharmakognosie, Phytopharmazie, 6 (AuflSpringer Verlag, Berlin, Heidelberg, New York, 1999) 939.
18. W.M. Randle, J.E. Lancaster, M.L. Shaw, K.H. Sutton, R.L. Hay and M.L. Bussard. Quantifying onion flavour compounds responding to sulphur fertility-Sulphur increases levels of alk(en)yl cysteine sulphoxides and biosynthetic intermediates. J Amer Soci Hort Sci. 120: 1075-1081 (1995). (Pubitemid 3003467)
19. W.M. Randle. Increasing nitrogen concentration in hydroponic solutions affects onion flavour and bulb quality. J Amer Soci Hort Sci. 125: 254-259 (2000). (Pubitemid 30104988)
20. W.M. Randle and J.E. Lancaster. Sulphur compounds in Alliums in relation to flavour quality. In: H.D. Rabinowitch, and L. Currah ed. Allium Crop Science: Recent Advances. CAB International, Wallingford, UK; 329-356 (2002).
21. T.W. Coolong and W.M. Randle. Sulphur and nitrogen availability interact to affect the flavour biosynthetic pathway in onion. J Amer Soci Hortic Sci. 128: 776-783 (2003). (Pubitemid 36941415)
22. K.T. Augusti. Therapeutic values of onion and garlic. Ind J Exp Biol. 34: 634-640 (1996).
23. J.E. Lancaster, B.J. Callion and M.L. Shaw. The dynamics of the flavour precursors, the S-alk (en)yl-L-cysteine sulphoxides, during leaf blade and scale development in the onion (Allium cepa). Physiologia Plantarum. 66: 293-297 (1986).
24. W. Breu. Allium cepa L. (onion) part 1. Chemistry and analysis. Phytomed. 3: 293-306 (1996). (Pubitemid 126504572)
25. S. Imani, S. Tsuge, M. Tomotake, Y. Nagatome, H. Sawada and T. Nagata. An onion enzyme that makes the eyes water. Nature. 419: 685 (2002). (Pubitemid 35177945)
26. A. Crozier, M.E.Z. Lean, M.S. Donald and C. Black. Quantitative analysis of the flavonoids content of commercial tomatoes, onion, lettuce and celery. J Agri Food Chem. 45: 590-595 (1997). (Pubitemid 127483672)
27. J.B. Harborne. Nature, distribution and function of plant flavonoids: In V.E. Cody, Middleton, J.R. and J.B. Harborne ed. Progress in Clinical and Biological Res, Vol CCXIII. Alan R. Liss, New York. Through, Texas J Agri Nat Reso. 16: 24-28 (2003).
28. A. Bilyk, P.L. Cooper and G.M. Sapers. Varietal differences in distribution of quercetin and kaempferol in onion (Allium cepa L.) tissues. J Agri Food Chem. 32: 274-276 (1984).
29. M.J.C. Rhodes and K.R. Price. Analytical problems in the study of flavonoid compounds in onions. Food Chem. 57: 113-117 (1996). (Pubitemid 26345084)
30. C.A. Rice-Evans, N.J. Miller, P.G. Bolwell, P.M. Bremley and J.B. Pridham. The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Radi Res. 22: 375-383 (1995).
31. T. Leighton, C. Ginther, L. Fluss, W.K. Harter, J. Cansado and V. Notario. Molecular characterization of quercetin and quercetin glycosides in Allium vegetables phenolic compounds in food and their effects on health II. ACS Symposium Series. 507: 220-238 (1992).
32. B. Patil, L. Pike and B. Hamilton. Changes in quercetin concentration in onion owing to location, growth stage and soil type. New Phytol. 130: 349-355 (1995).
33. B.S. Patil and L.M. Pike. Distribution of quercetin contents in different rings various coloured onion (Allium cepa L.) cultivars. J Hort Sci. 70: 643- 650 (1995).
34. V. Lambard, E. Geoffriau and E. Peffley. Flavonoid quantification in onion (Allium cepa L.) by spectrophotometric and HPLC analyses. Hort Sci. 37: 682-685 (2002). (Pubitemid 34812689)
35. V. Tsushida and M. Suzuki M. Content of flavonol glucosides and some properties of enzymes metabolizing the glucosides in onion. Nippon Shokuhin Kougyo Gakkaishi. 43: 642-649 (1996).
36. S. Hirota, T. Shimoda and U. Takahama. Tissue and spatial distribution of flavonol and peroxidase in onion bulbs and stability of flavonol glucosides during boiling of the scales. J Agri Food Chem. 46: 3497-3502 (1998). (Pubitemid 128488156)
37. U. Takahama and S. Hirota. Deglucosidation of quercetin glucosides to the aglycone and formation of antifungal agents by peroxidase dependent oxidation of quercetin on browning of onion scales. Plant Cell Physiol. 41: 1021-1029 (2000).
38. G. Corea, E. Fattorosso and V. Lanzotti. Antispasmodic saponins from bulbs of red onon, Allium cepa L. Var. Tropea. J Agri Food Chem. 35: 935- 940 (2005). (Pubitemid 40270379)
39. G.J. Meriel, H. Jill, T. Angela, M. Jonothan, A. Brian and A.C. Hamish. Biosynthesis of the flavour precursors of onion and garlic. J Exp Botany. 55: 1903-1918 (2004).
40. B.K. Watt and A.L. Merrill. Composition of foods, raw, processed, prepared, Agricultural handbook No 8 (U.S. Department of Agriculture, Washington, 1963) 1056.
41. W. Dorsch. Allium cepa L. (onion) part 2: Chemistry, analysis and pharmacology. Phytomed. 3: 391-397 (1996).
42. K.K. Sharma, R.K. Gupta, S. Gupta and K.C. Samuel. Antihyperglycemic effect of onion: Effect on fasting blood sugar and induced hyperglycemia in man. Ind J medical Res. 65: 422-429 (1977). (Pubitemid 8205653)
43. W. Dorsch, J. Scharff, T. Bayer and H. Wagner. Antiasthmatic effects of onions: Prevention of platelet-activating factor induced bronchial hyper reactivity to histamine in guinea pigs by diphenylthiosulfinate. Int Arch Aller Appl Immunol. 88: 228-230 (1989). (Pubitemid 19100645)
44. W. Dorsch and H. Wagner. New antiasthmatic drugs from traditional Medicines? Int Arch Aller Appl Immunol. 94: 262-265 (1991).
45. P.T. Mathew and K.T. Augusti. Hypoglycemic effects of onion (Allium cepa Linn). On diabetes mellitus: a preliminary report. Ind J physio Pharmacol. 9: 213-217 (1975).
46. Y. Kimura and K. Yamamoto. Cytological effect of chemicals on tumors. XXIII. Influence of crude extracts from Garlic and some related species on M.K.T sarcoma III. Gann. 55: 325 (1964).
47. J.P. Perchellet, E.M. Perchellet and S. Belman. Inhibition of DMBA induced mouse skin tumorigenesis by garlic oil and inhibition of two tumor-promotion stages by garlic and onion oil. Nutr Cancer. 14: 183-193 (1990).
48. S. Belman, A. Shellakumar, M.C. Bosland, K. Savarese and R.D. Tensen. Papilloma and carcinoma production in DMBA initiated, onion oil promoted mouse skin. Nutr Cancer. 4: 141-148 (1990). (Pubitemid 20294129)
49. C.M. Gao, T. Takezaki, J.H. Ding, M.S. Li and K. Tajima. Protective effect of Allium vegetables against both esophageal and stomach cancer: A simultaneous casereferent study of a high-epidemic area in Jiangsu province, China. Jpn J Cancer Res. 90: 614-621 (1999). (Pubitemid 29332919)
50. J. Hu, C. Vecchia, E. Negri, L. Chatenoud, C. Bosetti, X. Jia and R. Liu. Diet and brain cancer in adults: a case-control study in northeast China. Int J Cancer. 81: 20-23 (1999). (Pubitemid 29124190)
51. E. Dorant, P.A. Van Den Breandt, R.A. Goldbohm and F. Sturmans. Consumption of onions and a reduced risk of stomach carcinoma. Gastroenterology. 110: 12-20 (1996). (Pubitemid 26021599)
52. M. Hertog and M. Katan. Quercetin in foods, cardiovascular disease, and cancer. In: Flavonoids in Health and Disease; 447-467 (1998).
53. S. Hatono, A. Jimenez and M. Wargovich. Chemopreventive effect of Sallylcysteine and the relationship to the detoxification enzyme glutathione S-transferase. Carcinogenesis. 17: 1041-1044 (1996). (Pubitemid 26158402)
54. S. Fukushima, N. Takada, T. Hori and H. Wanibuchi. Cancer prevention by organosulphur compounds from garlic and onion. J Cell Biochem Supp. 27: 100-105 (1997). (Pubitemid 28222125)
55. M. Richter, R. Ebermann and B. Marian. Quercetin-induced apoptosis in colourectal tumor cells: possible role of EGF receptor signaling. Nutr Cancer. 34: 88-99 (1999). (Pubitemid 29382921)
56. P. Miodini, L. Gioravanti, G. Di Fronzo and V. Cappelletti. The two phyto-oestogens genistein and quercetin exert different effects on oestrogen receptor function. Br J Cancer. 80: 1150-1155 (1999). (Pubitemid 29264073)
57. P.A. Steerenberg, J. Garssen, P. Dortant, P.C. Hollman, G.M. Alink and M. Dekker. Protection of UV-induced suppression of skin contact hypersensitivity: A common feature of flavonoids after oral administration? Photochem Photobiol. 67: 456-461 (1998). (Pubitemid 128472702)
58. S. Fukushima, N. Takada, H. Wanibuchi, T. Hori, W. Min and M. Ogawa. Suppression of chemical carcinogenesis by water-soluble organosulphur compounds. J Nutr. 131: 1049s-1053s (2001). (Pubitemid 32195005)
59. C. Malaveille, A. Hautefeuille, B. Pignatelli, G. Talaska, P. Vineis and H. Bartsch. Dietary phenolics as anti-mutagens and inhibitory of tobacco related DNA adduction in the urothelium of smokers. Carcinogenesis. 17: 2193-2200 (1996). (Pubitemid 26372058)
60. F. Levi, C. La Vecchia, C. Gulie and E. Negri. Dietary factors and breast cancer risk in Vaud, Switzerland. Nutr Cancer. 19: 327-335 (1993). (Pubitemid 23204849)
61. B. Challier, J. Pernau and J. Viel. Garlic, onion and cereal fibre as protective for breast cancer: A French case study. Europ J Epidemiol. 14: 739-774 (1998).
62. F. Shen, M. Herenyiova and G. Weber. Synergistic down-regulation of signal transduction and cytotoxicity by tiazofurin and quercetin in human ovarian carcinoma cells. Life Sci. 64: 1869-1876 (1999). (Pubitemid 29215188)
63. W.D. Guo, M.S. Linet, W.H. Chow, J.Y. Li and W.J. Blot. Diet and serum markers in relation to primary brain tumor risk in China. Nutr Cancer. 22: 143-150 (1994). (Pubitemid 24310122)
64. N.R. Shenoy, A.S. Choughuley. Inhibitory effect of diet related sulphydryl compounds in the formation of carcinogenic nitrosamines. Cancer Lett. 65: 227-232 (1992).
65. A. Law, J. Wu, L.H. Zeng, T.W. Wu. Aortic endothelial cells damaged by a nitric oxide donor and protected by flavonoids. Life Sci. 64: 199-204 (1999).
66. Z. Shutenko, Y. Henry, E. Pinard, J. Seylaz, P. Potier and F. Berthet. Influence of the antioxidant quercetin in vivo on the level of nitric oxide determined by electron paramagnetic resonance in rat brain during global ischemia and reperfusion. Biochem Pharmacol. 57: 199-208 (1999). (Pubitemid 29056182)
67. H.D. Brahmachari and K.T. Augusti. Effect of orally effective hypoglycemic agents from plants on alloxan-induced diabetes. J Phar Pharmacol. 14: 617 (1962).
68. K.T. Augusti. Studies on the effects of a hypoglycemic principle from Allium cepa L. Ind J Med Res. 1: 1066-1071 (1973).
69. R.C. Jain, C.R. Vyas. Hypoglycemic action of onion on rabbits. Br Med J. 2: 730 (1974).
70. B.O. Bever and G.R. Zahnd. Plant with oral hypoglycemic action. Quart J Crude Drug Res. 17: 139-196 (1979).
71. E.T. Ashwah, R.M. EI-Allawy, F.S. EI-Hashimy and M.H. Ibrahim. The hypoglycemic activity of onion extracts "Allium cepa" influenced by adrenaline-induced hyperglycemia. J Drug Res. 13: 61-68 (1981).
72. R. Roman-Ramos, J.L. Flores-Scaenz and F.J. Alarcon-aguilar. Antihyperglycemic effect of some edible plants. J Ethnopharmacol. 84: 25-32 (1995).
73. C.G. Sheela and K.T Augusti. Antiperoxide effects of S-allyl cysteine sulphoxide isolated from Allium sativum Linn and gugulipid in cholesterol diet fed rats. Ind J Exp Biol. 33: 337-341 (1995).
74. M. Lean, M. Noroozi, I. Kelly, J. Burns, D. Talwar and N. Satter. Dietary flavonoids protect diabetic human lymphocytes against oxidant damage to DNA. Diabetes. 48: 176-178 (1999).
75. K. Kumari, B.M. Mathew and K.T. Augusti. Antidiabetic and hypolipidemic effects of S-Mehyl cysteine sulphoxide isolated from Allium cepa L. Ind J Biochem Biophysics. 32: 49-54 (1995).
76. M.S. Karawya, S.M. Abde, M.M. EI-Olemy and N.M. Farrag. Diphenylamine, an antihyperglycemic agent from onion and tea. J Natural Prod. 47: 775-780 (1984). (Pubitemid 15222628)
77. B. Hughes and L. Lawson. Antimicrobial effects of Allium sativum L. (garlic), Allium ampeloprasum L. (elephant garlic), and Allium cepa L. (onion), garlic compounds and commercial garlic supplement products. Phytother Res. 5: 154-158 (1991).
78. D.E. Conner and L.R. Beuchat. Effects of essential oils from plants on growth of food spoilage yeasts. J Food Sci. 49: 429-434 (1984).
79. A. Zohri, K. Abdel-Gawad and S. Saber. Antibacterial, antidermatophytic and antitioxigenic activities of onion (Allium cepa) oil. Microbiol Res. 150: 167-172 (1995).
80. N. Didry, M. Pinkas and L. Dubreuil. Activite antibacterienne d'especes du genre Allium. Pharmazie. 42: 687-688 (1987).
81. K. Arunachalam. Antimicrobial activity of garlic, onion, and honey. Geobios. 7: 46-47 (1980).
82. J. Fan and J. Chen. Inhibition of aflatoxin producing fungi by Welsh onion extracts. J Food Prote. 62: 414-417 (1999). (Pubitemid 29174927)
83. J. Kim. Anti-bacterial action of onion extracts against oral pathogenic bacteria. Nihon Uni Sch Dent. 39: 136-141 (1997).
84. G.R. Gibson. Dietary modulation of the human gut microflora using prebiotics. Br J Nutr. 80: S209-S212 (1998). (Pubitemid 28510689)
85. J. Yang, K.J. Meyers, J.V. Heide and R.H. Liu. Varietal differences in phenolic content and antioxidant and antiproliferative activities of onions. J Agri Food Chem. 52: 6787-6793 (2004).
86. H. De Groot and U. Rauen. Tissue injury by reactive oxygen species and the protective effects of flavonoids. Fundam Clin Pharmacol. 12: 249-255 (1998). (Pubitemid 28261368)
87. Y. Suzuki, I. Masashi, T. Segami and M. Ito. Antiulcer effects of antioxidant, quecetin, a-tocopherol, nifedipine and tetracycline in rats. Jpn J Pharmacol. 78: 435-441 (1998). (Pubitemid 29052065)
88. H.J. Suh, J.M. Lee, J.S. Cho, Y.S. Kim and S.H.E Chaug. Radical scavenging compounds in onion skin. Food Res Int. 32: 659-664 (1999). (Pubitemid 30112833)
89. A.M. Nuutila, R. Puupponen-Pimia, M. Aarni and K.M. Oksman-Caldentey. Comparison of antioxidant activities of onion and garlic extracts by inhibition of lipid peroxidation and radical scavenging activity. Food Chem. 81: 485-493 (2003). (Pubitemid 36411757)
90. S. Kawaii, Y. Tomono, E. Katase, K. Ogawa and M. Yano. Antiproliferative activity of flavonoids on several cancer cell lines. Biosci Biotech Biochem. 63: 896-899 (1999). (Pubitemid 129562768)
91. J. Sanderson, W. Mclauchlin and G. Williamson. Quercetin inhibits hydrogen peroxide-induced oxidization of the rat lens. Free Radi Biol Med. 26: 639-645 (1999). (Pubitemid 29146266)
92. L. Fremont, M.T. Gozzelino, M.P. Franchi and A. Linard. Dietary flavonoids reduce lipid peroxidation in rats fed polyunsaturated or monounsaturated fat diets. J Nutr. 128: 1495-1502 (1998). (Pubitemid 28399947)
93. M. Aviram, M. Rosenblat, S. Billecke, J. Erogul, R. Sorenson and C.L. Bisgaier Human serum paraoxonase (PON1) is inactivated by oxidized low-density liporotein and preserved by antioxidants. Free Radi Biol Med. 26: 892-904 (1999). (Pubitemid 29198362)
94. T. Kaneko and N. Baba. Protective effect of flavonoids on endothelial cells against linoleic acid hydroperoxide-induced toxicity. Biosci Biotechnol Biochem. 63: 323-328 (1999). (Pubitemid 129548678)
95. D. Jurdi-Haldeman, J. Mac-Neil and D. Yared. Antioxidant activity of onion and garlic juices in stored cooked ground lamb. J Food Prote. 50: 411-413 (1987).
96. B. Juurlink and P. Paterson. Review of oxidative stress in brain and spinal cord injury. Spinal Cord Med. 21: 309-334 (1998).
97. E.L. Da Silva, T. Tsushida and J. Terao. Inhibition of mammalian 15- lipoxygenase-dependent lipoprotein by quercetin and quercetin monoglucosides. Arch Biochem Biophy. 49: 313-320 (1998). (Pubitemid 28368676)
98. C. Yuting, Z. Rongliang, J. Zhongjian and J. Yong. Flavonoids as superoxide scavengers and antioxidants. Free Radi Biol Medic. 9: 19-2 (1990).
99. P. Sestili, A. Guidarelli, M. Dacha and O. Cantoni. Quecetin prevents DNA single strand breakage and cytotoxicity caused by tertbutylhydroperoxide: Free radical scavenging versus iron chelating mechanism. Free Radi Biol Med. 25: 196-200 (1998). (Pubitemid 28293154)
100. A. Negre-Salvayre and R. Salvayre. Quercetin prevents the cytotoxicity of oxidized LDL of lymphoid cell lines. Free Radi Biol Med. 12: 101-106 (1992).
101. G.T. Mc-Anlis, J. Mc-Eneny, J. Pearce and I.S. Young. Absorption and antioxidant effects of quercetin from onions, in man. Eur J Clin Nutr. 53: 92-96 (1999). (Pubitemid 29082526)
102. G. Gazzani, A. Papetti, M. Daglia, F. Berte and C. Gregotti. Protective activity of water-soluble components of some common diet vegetable on rat liver microsome and the effects of the thermal treatment. J Agri Food Chem. 46: 4123-4127 (1998). (Pubitemid 128488503)
103. G. Gazzani, A. Papetti, G. Massolini and M. Daglia. Anti- and prooxidant activity of water-soluble components of some common diet vegetables and the effect of thermal treatment. J Agri Food Chem. 46: 4118-4122 (1998). (Pubitemid 128488502)
104. M. Yin and W. Heng. Antioxidant activity of several Allium members. J Agri Food Chem. 46: 4097-4101 (1998). (Pubitemid 128488498)
105. G. Block, B. Patterson and A. Subar. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutr Cancer. 18: 1- 29 (1992).
106. G. Cao, E. Sofic and R.L. Prior. Antioxidant capacity of tea and common vegetables. J Agri Food Chem. 44: 3426-3431 (1996). (Pubitemid 126454726)
107. J.H.M. De Vries, P.C.H. Hollman, S. Meyboom, M.N.C.P. Buysman, P.L. Zock and W.A. Van Staveren. Plasma concentrations and urinary excretion of the antioxidant flavonoids quercetin and kaempferol as biomarkers for dietary intake. Am J Clin Nutr. 68: 60-65(1998). (Pubitemid 28307655)
108. S. Widder S, S. Luentzel, T. Dittner and W. Pickenhagen. 3-Mercapto-2- methylpentan-1-ol, a new powerful aroma compound. J Agri Food Chem. 48: 418-423 (2000). (Pubitemid 30120376)
109. P. Rose, S. Widder, J. Looft, W. Pickenhagen, C.N. Ong and M. Whiteman. Inhibition of peroxynitrite-mediated cellular toxicity, tyrosine nitration, and 1-antiproteinase inactivation by 3-mercapto-2- methylpentan-1-ol, a novel compound isolated from Allium cepa. Biochem Biophysi Res Communications. 302: 397-402 (2003). (Pubitemid 36397936)
110. S. Lata, K.K. Saxena, V. Bhasin, R.S. Saxena, A. Kumar and N.K. Srivastava. Beneficial effects Alliums sativa, Alliums cape, and Commiphora mukul on experimental hyperlipidemia and atherosclerosis: A comparative evaluation. J Postgra Medic. 37: 132-135 (1991).
111. G.S. Sainani, D.B. Desai and P. Sainine. Onion in prevention of atherosclerosis. J Ind Medical Associ. 71: 109 (1978).
112. K.K. Sharma, N.K. Chowdhury and A.L. Sharma. Studies on hypocholesterolaemic activity of onion. II. Effect on serum cholesterol in rabbits maintained on high cholesterol diet. Ind J Nutr. Diet. 12: 388- 391 (1975).
113. I. Adamu, P.K. Joseph and K.T. Augusti. Hypolipidemic action of onion and garlic unsaturated oils in sucrose fed rats over a two-month period. Expentia. 38: 899-901 (1982). (Pubitemid 13249295)
114. T.M. Vatsala, M. Singh and R.G. Murugesan. Effects of onion in induced atherosclerosis in rabbits: In Reduction of arterial lesions and lipid levels. Artery. 7: 519-530 (1980).
115. A. Bobboi, K.T. Augusti and P.K. Joseph. Hypolipidemic effects of onion oil and garlic oil in ethanol-fed rats. Ind J Biochem Biophys. 21: 211- 21 (1984).
116. P. Ahluwalia and A. Mohindroo. Effect of oral ingestion of different fractions of Allium cepa on the blood and erythrocyte membrane lipids and certain membrane-bound enzymes in rats. J Nutr Sci Vitaminol. 35: 155-161 (1989). (Pubitemid 19159750)
117. R.C. Jain and C.R. Vyas. Onion and Garlic in atherosclerotic heart disease. Medikon. 6: 12-14 (1977).
118. K.K. Sharma and S.P. Sharma. Effect of onion on blood cholesterol, fibrinogen and fibrinolytic activity in normal subjects. Ind J Pharmacol. 8: 231-233 (1976).
119. K.K. Sharma and S.P. Sharma. Effect of onion and garlic on serum cholesterol on normal subjects. Mediscope. 22: 134-136 (1979).
120. Y. Itokawa, K. Inoue, S. Sasagawa and M. Fujiwara. Effect of Smethylcysteine sulphoxide, S-allylcysteine sulphoxide and related sulfurcontaining amino acids on lipid metabolism of experimental hypercholesterolemic rats. J Nutr. 103: 88-92 (1973).
121. K.T. Augusti and P.T. Mathew. Effect of long-term feeding of the aqueous extracts of onion (Allium cepa L.) and garlic (Allium sativum L.) on normal rats. Ind J Medi Res. 11: 239-241 (1973).
122. B.F. Wilcox, P.K. Joseph and K.T. Augusti. Effects of allylpropyl disulphide isolated from Allium cepa Linn on high-fat fed rats. Ind J Biochem Biophys. 21: 214-216 (1984). (Pubitemid 15218721)
123. D. Farya, I.A. Goji, P.K. Joseph and K.T. Augusti. Effects of garlic oil on streptozotocin-diabetic rats maintained on normal and high fat diets. Ind J Biochem Biophys. 23: 24-27 (1986). (Pubitemid 16092353)
124. K. Kumari and B.C. Mathew. Antidiabetic and hypolipidemic effects of S-Mehyl cysteine sulphoxide isolated from Allium cepa L. Ind J Biochem Biophys. 32: 49-54 (1995).
125. K. Janssen, R.P. Mensink, F.J.J. Cox, J.L. Harryvan, R. Hovenior and P.C.H. Hollman. Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study. Am J Clin Nutr. 67: 255-262 (1998). (Pubitemid 28076717)
126. K.C. Srivastava. Aqueous extracts of onion, garlic and ginger inhibit platelet aggregation and alter arachidonic acid metabolism. Biomedica Biochimica Acta. 43: 335-346 (1984).
127. A.N. Makheja, J.Y. Vanderhoek and J.M. Bailey. Inhibition of platelet aggregation and thromboxane synthesis by onion and garlic. Lancet. 1: 781 (1979). (Pubitemid 9160677)
128. T. Ariga and S. Oshiba. Effects of the essential oil components of garlic cloves on rabbit platelet aggregation. Igakuto Seibutsugaku. 102: 169-174 (1981).
129. H. Weissenberger. Isolation and identification of the platelet aggregation inhibitor present in onion (Allium cepa). FEBS Lett. 26: 105-108 (1972).
130. J.Y. Vanderhoek, A.N. Makheja and J.M. Bailey. Inhibition of fatty acid oxygenases by onion and garlic oils. Evidence for the mechanism by which these oils inhibit platelet aggregation. Biochem Pharmacol. 29: 3169- 3173 (1980).
131. A. Makheja and J. Baily. Antiplatelet constituents of garlic and onion. Agents and Actions. 29: 360-363 (1990). (Pubitemid 20098466)
132. W. Breu and W. Dorsch. Allium cepa L. (Onion): Chemistry, analysis and pharmacology. In: H. Wagner, N.R. Farnsworth, ed. Economic and Medicinal plants Research, London, Academic Press; 115-147 (1994).
133. Anonymous. Quercetin. Alter Med Revi. 3: 140-143 (1998).
134. M.K. Kuhlmann, G. Burkhardt, E. Horsch, M. Wagner and H. Kohler. Inhibition of oxidant-induced lipid peroxidation in cultured renal tubular epithelial cells (LLC-PK1) by quercetin. Free Radi Res. 29: 451- 460 (1998). (Pubitemid 29048003)
135. K. Uchida, M. Shiraishi, Y. Naito, Y. Torii, Y. Nakamura and T. Osawa. Activation of stress signaling pathways by the end of lipid peroxidation. J Biol Chem. 274: 2234-2242 (1999).
136. M. Ali, T. Bordia and T. Mustafa. Effect of raw versus boiled aqueous extract of garlic and onion on platelet aggregation. Prosta Leuko Esse Fatty Acids. 60: 43-47 (1999). (Pubitemid 29182164)
137. T. Bordia, N. Mohammed, M. Thompson and M. Ali. An evaluation of garlic and onion as antithrombotic agents. Prosta Leuko Esse Fatty Acids. 54: 183-186 (1996). (Pubitemid 26146859)
138. J.H. Chen, S.J. Tsai and H. Chen. Welsh onion (Allium fistulosum L.) extracts alter vascular responses in rat aortae. J Cardiovas Pharmacol. 33: 515-520 (1999). (Pubitemid 29164812)
139. I.L. Goldman, M. Kopelberg, J.E.P. Debaene and B.S. Schwartz. Antiplatelet activity in onion (Allium cepa) is sulfur dependent. Thrombos Haemostas. 76: 450-452 (1996). (Pubitemid 26373542)
140. A. Spector. Oxidative stress-induces cataract. Mechanism of action. FASEB J. 9: 1173-1182 (1995).
141. J.M. Robertson, A.P. Donner and J.R. Trevithick. A possible role for vitamin C and E in cataract prevention. Am J Clin Nutr. 53: 346S-351S (1991).
142. I.S. Menon, R.Y. Kendal, H.A. Dewar and D.J. Newell. Effect of onions on blood fibrinolytic activity. Br Med J. 3: 351-352 (1968).
143. R.K. Agarwal, H.A. Dewar, D.J Newell and B. Das. Controlled trial of the effect of cycloalliin on the fibrinolytic activity of venous blood. Atherosclerosis. 27: 347-351 (1977). (Pubitemid 8123200)
144. I.S. Menon. Onion and blood fibrinolysis. Ind Practi. 32: 72-76 (1979).
145. M. Chisty, R. Quddus, B. Islam and B. Khan. Effect of onion extract on immune response in rabbits. Bangladesh Med Res. Counc Bull. 22: 81-85 (1996).
146. D.A. Shoskes. Effect of bioflavonoids quercetin and curcumin on ischemic renal injury. Transplan. 66: 147-152 (1998).
147. R. Shri and K.S. Bora. Neuroprotective effect of methanolic extracts of Allium cepa L. on ischemia and reperfusion-induced cerebral injury. Fitoterapia. 79: 86-96 (2008). (Pubitemid 351192241)
148. D.S. Vyas, R.P. Acharya, A.P. Dadhich, J.L. Godhwani and V.S. Purohit. Effect of Allium cepa (onion) on immune response in rats. Ind J Physio Pharmacol. 27: 259-260 (1983).
149. I.A. Ross. Meditional Plants of the World. Chemical constituents, traditional and modern Medicinal uses, Vol II, (Humana press, Totowa, New Jersey, 2001) 1-35.
150. W. Dorsch, E. Schneider, T. Bayer, W. Breu and H. Wagner. Antiinflammatory effects of onions: inhibition of chemotaxis of human polymorphonuclear leukocytes by thiosulfinates and cepaenes. Int Arch Aller Appl Immunol. 92: 39-42 (1990). (Pubitemid 20359725)