Welsh onion (Allium fistulosum L.) Extracts alter vascular responses in rat aortae

Journal of Cardiovascular Pharmacology

Volumn 33, Issue 4, 1999, Pages 515-520

  Chen, Jia Huey ^a,c   Tsai, Shun Jen ^b   Chen, Hsiun Ing ^c  

^a CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Blood vessels; Endothelium derived nitric oxide; Flavonoids; Sulfur containing compounds; Welsh onion

Indexed keywords

7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; N(G) NITROARGININE; NITRIC OXIDE; ONION EXTRACT; TETRYLAMMONIUM; THROMBOXANE A2;

ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; HEATING; MALE; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; RAT; THORACIC AORTA; VASCULAR RING;

ALLIUM FISTULOSUM;

EID: 0032957247     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199904000-00001     Document Type: Article

References (35)

1. Moncada S, Palmer RMJ. Endothelium-dependent relaxation and the discovery of the L-arginine-NO pathway. In: Ryan US, Rubanyi GM, eds. Endothelial regulation of vascular tone. New York: Marcel Dekker, 1992:21-36.
2. Moncada S, Herman AG, Vanhoutte PM. Endothelium derived relaxing factor is identified as nitric oxide. TIPS 1987;8:365-8.
3. Nagao T, Vanhoutte PM. Endothelium-derived hyperpolarizing factor and endothelium-dependent relaxations. Am J Respir Cell Mol Biol 1993;8:1-6.
4. 2 by layers of the arterial wall: an explanation for the anti-thrombotic properties of vascular endothelium. Thromb Res 1977;11:323-44.
5. Katusic ZS, Vanhoutte PM. Superoxide anion is an endothelium-derived contracting factor. Am J Physiol 1989;255:H207-12.
6. Vanhoutte PM. Endothelial dysfunction in hypertension. J Hypertens 1996;14:S83-9.
7. Fenwick GR, Hanley AB. The genus Allium: Part 1. CRC Crit Rev Food Sci Nutr 1985;22:199-271.
8. Loeper M, Debray M. Hypotensive effect of tincture of garlic. Prog Med 1921;36:391-2.
9. Estrada CA, Young MJ. Patient preferences for novel therapy: an N-of-1 trial of garlic in the treatment for hypertension. J Gen Intern Med 1993;8:619-21.
10. McMahon FG, Vargas R. Can garlic lower blood pressure? A pilot study. Pharmacotherapy 1993;13:406-7.
11. Kiesewetter H, Jung F, Jung EM, et al. Effect of garlic coated tablets in peripheral arterial occlusive disease. Clin Invest 1993; 71:383-6.
12. Silagy CA, Neil HAW. A meta-analysis of the effect of garlic on blood pressure. J Hypertens 1994;12:463-8.
13. Martin N, Bardisa L, Pantoja C, Roman R, Vargas M. Experimental cardiovascular depressant effects of garlic (Allium sativum) dialysate. J Ethnopharmacol 1992;37:145-9.
14. Ozturk Y, Aydin S, Kosar M, Husnu K, Baser C. Endothelium-dependent and independent effects of garlic on rat aorta. J Ethnopharmacol 1994;44:109-16.
15. Chen HI, Li HT. Physical conditioning can modulate endothelium-dependent vasorelaxation in rabbits. Arterioscler Thromb 1993;13: 852-6.
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin reagent. J Biol Chem 1951;193:265-75.
17. Fitzpatrick DF, Hirschfield SL, Ricci T, Jantzen P, Coffey RG. Endothelium-dependent vasorelaxation caused by various plant extracts. J Cardiovasc Pharmacol 1995;26:90-5.
18. Das I, Khan NS, Sooranna SR. Potent activation of nitric oxide synthase by garlic: a basis for its therapeutic applications. Curr Med Res Opin 1995;13:257-63.
19. Das I, Khan NS, Sooranna SR. Nitric oxide synthase activation is a unique mechanism of garlic action. Biochem Soc Trans 1995;23: 1365.
20. Sooranna SR, Hirani J, Das I. Garlic can induce both GTP cyclohydrolase and nitric oxide synthase activity in choriocarcinoma cells. Biochem Soc Trans 1995;23:543S.
21. Matikkala EJ, Virtanen AI. On the quantitative determination of the amino acids and gamma-glutamyl peptides of onions. Acta Chem Scand 1967;21:2891-6.
22. Das I, Hirani J, Sooranna S. Arginine is not responsible for the activation of nitric oxide synthase by garlic. J Ethnopharmacol 1996; 53:5-9.
23. Fenwick GR, Hanley AB. The genus Allium: part 2. CRC Crit Rev Food Sci Nutri 1985;22:273-7.
24. Myers PR, Minor RL, Guerra R, Bates JN, Harrison DG. Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature 1990; 345:1161-3.
25. Aqel MB, Gharaibah MN, Salhab AS. Direct relaxant effects of garlic juice on smooth and cardiac muscles. J Ethnopharmacol 1991;33:13-9.
26. Wood KS, Buga GM, Byrns RE, Ignarro LJ. Vascular smooth muscle-derived relaxing factor (MDRF) and its close similarity to nitric oxide. Biochem Biophys Res Commun 1990;170:80-8.
27. Ignarro LJ, Wood KS, Fukuto JM. Continuous basal formation of endothelium-derived relaxing factor and muscle-derived relaxing factor, both of which are nitric oxide. J Cardiovasc Pharmacol 1991;17(suppl 3):S229-33.
28. Formica JV, Regelson W. Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol 1995;33:1061-80.
29. Duarte J, Perez-Vizcaino F, Zarzuelo A, Jimenez J, Tamargo J. Vasodilator effects of quercetin in isolated rat vascular smooth muscle. Eur J Pharmacol 1993;239:1-7.
30. Girard P, Sercombe R, Sercombe C, Lem GL, Seylaz J, Potier P. A new synthetic flavonoid protects endothelium-derived relaxing factor-induced relaxation in rabbit arteries in vitro: evidence for superoxide scavenging. Biochem Pharmacol 1995;49:1533-9.
31. Kim SJ, Han D, Park MH, Rhee JS. Screening for superoxide dismutase-like compound and its activators in extracts of foods and vegetables. Biosci Biotech Biochem 1994;58:2263-5.
32. Shryock JC, Belardinelli L. Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology. Am J Cardiol 1997;79:2-10.
33. Melzig MF, Krause E, Franke S. Inhibition of adenosine deaminase activity of aortic endothelial cells by extracts of garlic (Allium sativum L.). Pharmazie 1995;50:359-61.
34. Hamberg M, Svensson J, Samuelsson B. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci USA 1975;72: 2994-8.
35. 2 in blood vessel and its physiological significance: relevance to thrombosis and hypertension. Prosraglandins Med 1980;4:431-8.