Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept

Journal of Controlled Release

Volumn 166, Issue 3, 2013, Pages 211-219

  Chong, Rosalind H E ^a,b   Gonzalez Gonzalez, Emilio ^c   Lara, Maria F ^d   Speaker, Tycho J ^d   Contag, Christopher H ^c   Kaspar, Roger L ^c,d   Coulman, Sion A ^a   Hargest, Rachel ^b   Birchall, James C ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TransDerm Inc   (United States)

Author keywords

Coating; Keratinocytes; Lipoplex; Microneedles; RNA interference; Self delivery siRNA

Indexed keywords

KERATINOCYTES; LIPOPLEXES; MICRONEEDLES; RNA INTERFERENCE; SELF-DELIVERY SIRNA;

COATINGS; GENE EXPRESSION; GENETIC ENGINEERING; LIPOSOMES; LOADING; MAMMALS; MOLECULAR BIOLOGY; RNA;

NEEDLES;

GREEN FLUORESCENT PROTEIN; HERMES ANTIGEN; LAMIN A; LAMIN C; LIPOPLEX; LUCIFERASE; MESSENGER RNA; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; IN VIVO GENE TRANSFER; KERATINOCYTE; MATERIAL COATING; MICRONEEDLE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PAW EDEMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; RNA INTERFERENCE;

ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; GENE SILENCING; GREEN FLUORESCENT PROTEINS; HUMANS; KERATINOCYTES; LAMIN TYPE A; MICE; MICE, TRANSGENIC; MICROINJECTIONS; NEEDLES; RNA, MESSENGER; RNA, SMALL INTERFERING; SKIN; SKIN DISEASES; STAINLESS STEEL; TRANSFECTION;

EID: 84873481790     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.12.030     Document Type: Article

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