Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita

Journal of Dermatological Science

Volumn 51, Issue 3, 2008, Pages 151-157

  Leachman, Sancy A ^a   Hickerson, Robyn P ^b   Hull, Peter R ^c   Smith, Frances J D ^d   Milstone, Leonard M ^e   Lane, E Birgitte ^f   Bale, Sherri J ^g   Roop, Dennis R ^h   McLean, W H Irwin ^d   Kaspar, Roger L ^b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b TransDerm Inc   (United States)

^c ROYAL UNIVERSITY HOSPITAL   (Canada)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^g GENEDX   (United States)

^h UNIVERSITY OF COLORADO   (United States)

Author keywords

Gene therapy; Genodermatoses; Keratin; Pachyonychia congenita; RNAi; siRNA

Indexed keywords

KERATIN; SMALL INTERFERING RNA;

ALLELE; ANTISENSE THERAPY; CALLUS; CELL AGGREGATION; CLINICAL TRIAL; CONGENITAL PACHYONYCHIA; DRUG EFFICACY; GENE IDENTIFICATION; GENE MUTATION; GENETIC DISORDER; GENOME; HUMAN; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHYSICIAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; RNA INTERFERENCE; SKIN DISEASE;

ANIMALS; CLINICAL TRIALS AS TOPIC; DISEASE MODELS, ANIMAL; GENE THERAPY; HUMANS; KERATIN-6; MODELS, GENETIC; PACHYONYCHIA CONGENITA; POINT MUTATION; RNA, SMALL INTERFERING; SKIN DISEASES, GENETIC;

EID: 48049103228     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2008.04.003     Document Type: Review

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