Effect of lyophilization and freeze-thawing on the stability of siRNA-liposome complexes

AAPS PharmSciTech

Volumn 9, Issue 2, 2008, Pages 335-341

  Yadava, Preeti ^a   Gibbs, Melissa ^a   Castro, Carlos ^a   Hughes, Jeffrey A ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

DLS; FACS; Freeze thaw; Liposomes; Lyophilization; siRNA

Indexed keywords

GREEN FLUORESCENT PROTEIN; LIPOPLEX; LIPOSOME; SMALL INTERFERING RNA; SUGAR; 1,2 DIOLEOYL GLYCERO 3 PHOSPHATIDYL ETHANOLAMINE; 1,2 DIOLEOYLOXY 3 (TRIMETHYLAMMONIUM)PROPANE; 1,2-DIOLEOYL-GLYCERO-3-PHOSPHATIDYL ETHANOLAMINE; 1,2-DIOLEOYLOXY-3-(TRIMETHYLAMMONIUM)PROPANE; CARBOHYDRATE; CRYOPROTECTIVE AGENT; FLUORESCENT DYE; GLUCOSE; LACTOSE; LIPID; MONOUNSATURATED FATTY ACID; ORGANIC COMPOUND; PHOSPHATIDYLETHANOLAMINE; QUATERNARY AMMONIUM DERIVATIVE; SUCROSE; SYBR GREEN I; TREHALOSE;

ANIMAL CELL; ARTICLE; CELL TRANSPORT; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACCUMULATION; DRUG FORMULATION; DRUG STABILITY; FREEZE DRYING; FREEZE THAWING; GENETIC TRANSFECTION; LIPOSOMAL GENE DELIVERY SYSTEM; NONHUMAN; PARTICLE SIZE; ANIMAL; CHEMISTRY; FREEZING; METABOLISM; MOUSE; RNA STABILITY; TUMOR CELL LINE;

ANIMALS; CARBOHYDRATES; CELL LINE, TUMOR; CRYOPROTECTIVE AGENTS; FATTY ACIDS, MONOUNSATURATED; FLUORESCENT DYES; FREEZE DRYING; FREEZING; GLUCOSE; LACTOSE; LIPIDS; LIPOSOMES; MICE; ORGANIC CHEMICALS; PARTICLE SIZE; PHOSPHATIDYLETHANOLAMINES; QUATERNARY AMMONIUM COMPOUNDS; RNA STABILITY; RNA, SMALL INTERFERING; SUCROSE; TRANSFECTION; TREHALOSE;

EID: 51449095971     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-007-9000-1     Document Type: Article

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