Structure-activity relationship studies on chalcone derivatives: The potent inhibition of chemical mediators release

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 1, 2003, Pages 105-111

  Ko, Horng Huey ^a   Tsao, Lo Ti ^b   Yu, Kun Lung ^c   Liu, Cheng Tsung ^c   Wang, Jih Pyang ^b   Lin, Chun Nan ^c  

^a YUNG TA INSTITUTE OF TECHNOLOGY AND COMMERCE   (Taiwan)

^b TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2',2 DITHIENYLCHALCONE; 2',5' DIHYDROXY 3 THIENYLCHALCONE; 2',5' DIMETHOXY 4 HYDROXYCHALCONE; 3,4 DICHLORO 2' HYDROXY 5' PROPOXYCHALCONE; 3,4 DICHLORO 2',5' DIETHOXYCHALCONE; 3,4 DICHLORO 2',5' DIHYDROXYCHALCONE; 3,4 DICHLORO 2',5' DIMETHOXYCHALCONE; 4 BROMO 2',5' DIMETHOXYCHALCONE; ACETOPHENONE DERIVATIVE; ALDEHYDE; ANTIINFLAMMATORY AGENT; BETA GLUCURONIDASE; CHALCONE DERIVATIVE; CYTOCHALASIN B; FORMYLMETHIONYLLEUCYLPHENYLALANINE; ISOENZYME; LYSOZYME; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL LINE; CELL STIMULATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME RELEASE; MACROPHAGE; MAST CELL; MEDIATOR RELEASE; MICROGLIA; NEUTROPHIL; NONHUMAN; POLYMERIZATION; PROTEIN EXPRESSION; RAT; SEPTIC SHOCK; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CHALCONE; CYTOCHALASIN B; GLUCURONIDASE; HISTAMINE RELEASE; MACROPHAGES; MAST CELLS; MICE; MICROGLIA; MURAMIDASE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDES;

EID: 0037413347     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00312-7     Document Type: Article

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