Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by1H-decoupled-31P magnetic resonance spectroscopy

Clinical Cancer Research

Volumn 11, Issue 9, 2005, Pages 3503-3513

  Muruganandham, Manickam ^a   Alfieri, Alan A ^a   Matei, Cornelia ^a   Chen, Yuchun ^a   Sukenick, George ^a   Schemainda, Isabel ^b   Hasmann, Max ^b,c   Saltz, Leonard B ^a   Koutcher, Jason A ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Fujisawa GmbH   (Germany)

^c ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FK 866; GUANOSINE PHOSPHATE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE INHIBITOR; PERCHLORIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CYTOFLUOROMETRY; DRUG EFFECT; GLYCOLYSIS; LEUKEMIA; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RADIOSENSITIVITY; TUMOR CELL LINE; TUMOR XENOGRAFT;

ACRYLAMIDES; ANIMALS; ANNEXIN A5; APOPTOSIS; CELL CYCLE; GLYCOLYSIS; GUANINE NUCLEOTIDES; HYDROGEN-ION CONCENTRATION; INTRACELLULAR MEMBRANES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MEMBRANE POTENTIALS; MICE; MICE, INBRED C3H; MITOCHONDRIA; MITOSIS; NAD; NADP; NEOPLASM TRANSPLANTATION; PENTOSYLTRANSFERASES; PHOSPHOLIPIDS; PIPERIDINES; PROTEIN BINDING; TIME FACTORS;

EID: 18244376911     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-04-1399     Document Type: Article

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