The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies

Blood

Volumn 113, Issue 14, 2009, Pages 3276-3286

  Nahimana, Aimable ^a   Attinger, Antoine ^b   Aubry, Dominique ^a   Greaney, Peter ^b   Ireson, Christopher ^b   Thougaard, Annemette V ^b   Tjørnelund, Jette ^b   Dawson, Keith M ^b   Dupuis, Marc ^b   Duchosal, Michel A ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b BioAlliance Pharma   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; APO 886; CASPASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG; ACRYLAMIDE DERIVATIVE; CYTOKINE; N (4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL) 3 (PYRIDIN 3 YL)ACRYLAMIDE; N-(4-(1-BENZOYLPIPERIDIN-4-YL)BUTYL)-3-(PYRIDIN-3-YL)ACRYLAMIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE, HUMAN; PIPERIDINE DERIVATIVE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; BURKITT LYMPHOMA; CANCER CELL; CANCER INHIBITION; CELL DEATH; CHRONIC LYMPHATIC LEUKEMIA; CLONOGENIC ASSAY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CYTOTOXICITY; DRUG SENSITIVITY; FEMALE; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA; LYMPHOBLASTOMA; MANTLE CELL LYMPHOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; T CELL LYMPHOMA; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD DISEASE; CELL STRAIN HL 60; CELL STRAIN K 562; CELL STRAIN U937; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; LEUKEMIA CELL LINE; METABOLISM; NUDE MOUSE; TUMOR CELL CULTURE;

ACRYLAMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMATOLOGIC NEOPLASMS; HL-60 CELLS; HUMANS; JURKAT CELLS; K562 CELLS; MICE; MICE, INBRED BALB C; MICE, NUDE; NAD; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PIPERIDINES; TUMOR CELLS, CULTURED; U937 CELLS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 65149084441     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-08-173369     Document Type: Article

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