A preclinical study on the rescue of normal tissue by nicotinic acid in high-dose treatment with APO866, a specific nicotinamide phosphoribosyltransferase inhibitor

Molecular Cancer Therapeutics

Volumn 9, Issue 6, 2010, Pages 1609-1617

  Olesen, Uffe Høgh ^a,b   Thougaard, Annemette V ^b   Jensen, Peter Buhl ^b   Sehested, Maxwell ^a,b  

^a University of Copenhagen   (Denmark)

^b BioAlliance Pharma   (France)

Author keywords

[No Author keywords available]

Indexed keywords

N [4 (1 BENZOYL 4 PIPERIDINYL)BUTYL] 3 (3 PYRIDINYL)ACRYLAMIDE; NICOTINATE PHOSPHORIBOSYLTRANSFERASE; NICOTINIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD TOXICITY; CANCER CELL CULTURE; CANCER SURVIVAL; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; DRUG MEGADOSE; EXPERIMENTAL NEOPLASM; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; MALE; MAXIMUM TOLERATED DOSE; MONOTHERAPY; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE; SURVIVAL TIME; TUMOR MODEL; TUMOR XENOGRAFT;

ACRYLAMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL DEATH; CELL LINE, TUMOR; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MAXIMUM TOLERATED DOSE; MICE; NAD; NIACIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; ORGAN SPECIFICITY; PIPERIDINES; RNA, MESSENGER; SUBSTRATE SPECIFICITY; TUMOR MARKERS, BIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77953408297     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-09-1130     Document Type: Article

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