Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil

Oncology Reports

Volumn 26, Issue 5, 2011, Pages 1251-1257

  Bi, Tie Qiang ^a   Che, Xiang Ming ^a   Liao, Xin Hua ^a   Zhang, Dan Jie ^a   Long, Hou Long ^a   Li, Hai Jun ^a   Zhao, Wei ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Apoptosis; FK866; Gastric cancer; Migration; Nicotinamide phosphoribosyltransferase; Proliferation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; DAPORINAD; FLUOROURACIL; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; VASCULOTROPIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL ASSAY; CELL DEATH; CELL MIGRATION; CELL PROLIFERATION; CHEMOSENSITIVITY; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STOMACH CANCER; TUMOR GENE; WESTERN BLOTTING;

ACRYLAMIDES; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG SYNERGISM; FLUOROURACIL; HUMANS; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PIPERIDINES; RNA, MESSENGER; STOMACH NEOPLASMS;

EID: 80053142651     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1378     Document Type: Article

References (28)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
2. Glimelius B, Ekström K, Hoffman K, et al: Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer. Ann Oncol 8: 163-168, 1997. (Pubitemid 27112884)
3. Bi TQ and Che XM: Nampt/PBEF/visfatin and cancer. Cancer Biol Ther 10: 119-125, 2010.
4. Gallí M, Van Gool F, Rongvaux A, Andris F and Leo O: The nicotinamide phosphoribosyltransferase: a molecular link between metabolism, inflammation, and cancer. Cancer Res 70: 8-11, 2010.
5. Samal B, Sun Y, Stearns G, Xie C, Suggs S and McNiece I: Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol 14: 1431-1437, 1994.
6. Fukuhara A, Matsuda M, Nishizawa M, et al: Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 307: 426-430, 2005. (Pubitemid 40139988)
7. Rajamohan SB, Pillai VB, Gupta M, et al: SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol Cell Biol 29: 4116-4129, 2009.
8. Wang B, Hasan MK, Alvarado E, Yuan H, Wu H and Chen WY: NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response. Oncogene 30: 907-921, 2011.
9. Hufton SE, Moerkerk PT, Brandwijk R, De Bruïne AP, Arends JW and Hoogenboom HR: A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization. FEBS Lett 463: 77-82, 1999. (Pubitemid 30001722)
10. Van Beijnum JR, Moerkerk PT, Gerbers AJ, De Bruïne AP, Arends JW, Hoogenboom HR and Hufton SE: Target validation for genomics using peptide-specific phage antibodies: a study of five gene products overexpressed in colorectal cancer. Int J Cancer 101: 118-127, 2002. (Pubitemid 34970903)
11. Nakajima TE, Yamada Y, Hamano T, et al: Adipocytokine levels in gastric cancer patients: resistin and visfatin as biomarkers of gastric cancer. J Gastroenterol 44: 685-690, 2009.
12. Nakajima TE, Yamada Y, Hamano T, et al: Adipocytokines as new promising markers of colorectal tumors: adiponectin for colorectal adenoma, and resistin and visfatin for colorectal cancer. Cancer Sci 101: 1286-1291, 2010.
13. Hasmann M and Schemainda I: FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res 63: 7436-7442, 2003. (Pubitemid 37413486)
14. Nahimana A, Attinger A, Aubry D, et al: The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies. Blood 113: 3276-3286, 2009.
15. Holen K, Saltz LB, Hollywood E, Burk K and Hanauske AR: The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor. Invest New Drugs 26: 45-51, 2008.
16. Reddy PS, Umesh S, Thota B, et al: PBEF1/NAmPRTase/Visfatin: a potential malignant astrocytoma/glioblastoma serum marker with prognostic value. Cancer Biol Ther 7: 663-668, 2008.
17. Adya R, Tan BK, Chen J and Randeva HS: Nuclear factor-kappaB induction by visfatin in human vascular endothelial cells: its role in MMP-2/9 production and activation. Diabetes Care 31: 758-760, 2008.
18. Wang P, Xu TY, Guan YF, Su DF, Fan GR and Miao CY: Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide. Cardiovasc Res 81: 370-380, 2009.
19. Lee WJ, Wu CS, Lin H, et al: Visfatin-induced expression of inflammatory mediators in human endothelial cells through the NF-kappaB pathway. Int J Obes (Lond) 33: 465-472, 2009.
20. Fan Y, Meng S, Wang Y, Cao J and Wang C: Visfatin/PBEF/Nampt induces EMMPRIN and MMP-9 production in macrophages via the NAMPT-MAPK (p38, ERK1/2)-NF-κB signaling pathway. Int J Mol Med 27: 607-615, 2011.
21. Mino K, Ozaki M, Nakanishi K, et al: Inhibition of nuclear factor-kappaB suppresses peritoneal dissemination of gastric cancer by blocking cancer cell adhesion. Cancer Sci 102: 1052-1058, 2011.
22. Karin M and Greten FR: NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5: 749-759, 2005. (Pubitemid 41400849)
23. Bacac M and Stamenkovic I: Metastatic cancer cell. Annu Rev Pathol 3: 221-247, 2008. (Pubitemid 351488281)
24. Patel ST, Mistry T, Brown JE, Digby JE, Adya R, Desai KM and Randeva HS: A novel role for the adipokine visfatin/pre-B cell colony-enhancing factor 1 in prostate carcinogenesis. Peptides 31: 51-57, 2010.
25. Folgueira MA, Carraro DM, Brentani H, et al: Gene expression profile associated with response to doxorubicin-based therapy in breast cancer. Clin Cancer Res 11: 7434-7443, 2005. (Pubitemid 41507704)
26. + levels dictate cell survival. Cell 130: 1095-1107, 2007.
27. Pogrebniak A, Schemainda I, Azzam K, Pelka-Fleischer R, Nüssler V and Hasmann M: Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents. Eur J Med Res 11: 313-321, 2006. (Pubitemid 44390171)
28. Herceg Z and Wang ZQ: Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. Mutat Res 477: 97-110, 2001. (Pubitemid 32480193)