The orthosteric agonist-binding pocket in the prototypic class B G-protein-coupled secretin receptor

Biochemical Society Transactions

Volumn 41, Issue 1, 2013, Pages 154-158

  Miller, Laurence J ^a   Dong, Maoqing ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

GPCR (G protein coupled receptor); Ligand binding; Receptor conformation

Indexed keywords

ALANINE; G PROTEIN COUPLED RECEPTOR; SECRETIN;

AGONIST; ALPHA HELIX; BINDING AFFINITY; CONFERENCE PAPER; CRYSTAL STRUCTURE; FLUORESCENCE ANALYSIS; MOLECULAR INTERACTION; MOLECULAR MODEL; MUTAGENESIS; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

BINDING SITES; MUTAGENESIS; PHOTOAFFINITY LABELS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GASTROINTESTINAL HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873102925     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20120204     Document Type: Conference Paper

References (33)

1. Granier, S. and Kobilka, B. (2012) A new era of GPCR structural and chemical biology. Nat. Chem. Biol. 8, 670-673
2. Grace, C. R., Perrin, M. H., Gulyas, J., Digruccio, M. R., Cantle, J. P., Rivier, J. E., Vale, W. W. and Riek, R. (2007) Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand. Proc. Natl. Acad. Sci. U. S. A. 104, 4858-4863 (Pubitemid 47186141)
3. Parthier, C., Kleinschmidt, M., Neumann, P., Rudolph, R., Manhart, S., Schlenzig, D., Fanghanel, J., Rahfeld, J. U., Demuth, H. U. and Stubbs, M. T. (2007) Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor. Proc. Natl. Acad. Sci. U. S. A. 104, 13942-13947 (Pubitemid 350003317)
4. Pioszak, A. A., Parker, N. R., Suino-Powell, K. and Xu, H. E. (2008) Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. J. Biol. Chem. 283, 32900-32912
5. Pioszak, A. A. and Xu, H. E. (2008) Molecular recognition of parathyroid hormone by its G protein-coupled receptor. Proc. Natl. Acad. Sci. U. S. A. 105, 5034-5039 (Pubitemid 351738505)
6. Runge, S., Thogersen, H., Madsen, K., Lau, J. and Rudolph, R. (2008) Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J. Biol. Chem. 283, 11340-11347
7. Sun, C., Song, D., Davis-Taber, R. A., Barrett, L. W., Scott, V. E., Richardson, P. L., Pereda-Lopez, A., Uchic, M. E., Solomon, L. R., Lake, M. R. et al. (2007) Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. Proc. Natl. Acad. Sci. U. S. A. 104, 7875-7880 (Pubitemid 47185844)
8. ter Haar, E., Koth, C. M., Abdul-Manan, N., Swenson, L., Coll, J. T., Lippke, J. A., Lepre, C. A., Garcia-Guzman, M. and Moore, J. M. (2010) Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure 18, 1083-1093
9. Underwood, C. R., Garibay, P., Knudsen, L. B., Hastrup, S., Peters, G. H., Rudolph, R. and Reedtz-Runge, S. (2010) Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor. J. Biol. Chem. 285, 723-730
10. Dong, M. and Miller, L. J. (2002) Molecular pharmacology of the secretin receptor. Recept. Channels 8, 189-200
11. Gronenborn, A. M., Bovermann, G. and Clore, G. M. (1987) A 1H-NMR study of the solution conformation of secretin. Resonance assignment and secondary structure. FEBS Lett. 215, 88-94 (Pubitemid 17099144)
12. Hofmann, M., Gondol, D., Bovermann, G. and Nilges, M. (1989) Conformation of secretin in dimethyl sulfoxide solution. NMR studies and restrained molecular dynamics. Eur. J. Biochem. 186, 95-103 (Pubitemid 20015131)
13. Neumann, J. M., Couvineau, A., Murail, S., Lacapere, J. J., Jamin, N. and Laburthe, M. (2008) Class-B GPCR activation: is ligand helix-capping the key? Trends Biochem. Sci. 33, 314-319
14. Watkins, H. A., Au, M. and Hay, D. L (2012) The structure of secretin family GPCR peptide ligands: implications for receptor pharmacology and drug development. Drug Discovery Today 17, 1006-1014
15. Mayo, K. E., Miller, L. J., Bataille, D., Dalle, S., Goke, B., Thorens, B. and Drucker, D. J. (2003) International Union of Pharmacology. XXXV. The glucagon receptor family. Pharmacol. Rev. 55, 167-194 (Pubitemid 36268402)
16. Robberecht, P., Conlon, T. P. and Gardner, J. D. (1976) Interaction of porcine vasoactive intestinal peptide with dispersed pancreatic acinar cells from the guinea pig. Structural requirements for effects of vasoactive intestinal peptide and secretin on cellular adenosine 3 ':5'-monophosphate. J. Biol. Chem. 251, 4635-4639
17. Turner, J. T., Jones, S. B. and Bylund, D. B. (1986) A fragment of vasoactive intestinal peptide, VIP (10-28), is an antagonist of VIP in the colon carcinoma cell line, HT29. Peptides 7, 849-854 (Pubitemid 17182353)
18. Chesnut, 3rd, C. H., Azria, M., Silverman, S., Engelhardt, M., Olson, M. and Mindeholm, L (2008) Salmon calcitonin: a review of current and future therapeutic indications. Osteoporosis Int. 19, 479-491
19. Gentilella, R., Bianchi, C, Rossi, A. and Rotella, CM. (2009) Exenatide: a review from pharmacology to clinical practice. Diabetes, Obes. Metab. 11, 544-556
20. Ishihara, T., Nakamura, S., Kaziro, Y., Takahashi, T., Takahashi, K. and Nagata, S. (1991) Molecular cloning and expression of a cDNA encoding the secretin receptor. EMBOJ. 10, 1635-1641 (Pubitemid 21905629)
21. Ulrich, 2nd, CD., Holtmann, M. and Miller, L. J. (1998) Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors. Gastroenterology 114, 382-397 (Pubitemid 28093547)
22. Parthier, C, Reedtz-Runge, S., Rudolph, R. and Stubbs, M. T. (2009) Passing the baton in class B GPCRs: peptide hormone activation via helix induction? Trends Biochem. Sci. 34, 303-310
23. Chey, W. Y. and Chang, T. M. (2003) Secretin, 100 years later. J. Gastroenterol. 38, 1025-1035 (Pubitemid 38016361)
24. Dong, M., Le, A., Te, J. A., Pinon, D. I., Bordner, A. J. and Miller, L. J. (2011) Importance of each residue within secretin for receptor binding and biological activity. Biochemistry 50, 2983-2993
25. Dong, M., Lam, P. C, Pinon, D. I., Hosohata, K., Orry, A., Sexton, P. M., Abagyan, R. and Miller, L. J. (2011) Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore. J. Biol. Chem. 286, 23888-23899
26. Dong, M., Lam, P. C, Pinon, D. I., Sexton, P. M., Abagyan, R. and Miller, L. J. (2008) Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding. Mol. Pharmacol. 74, 413-422
27. Dong, M., Li, Z., Pinon, D. I., Lybrand, T. P. and Miller, L. J. (2004) Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor. J. Biol. Chem. 279, 2894-2903 (Pubitemid 38114281)
28. Hoare, S. R. (2005) Mechanisms of peptide and nonpeptide ligand binding to class B G-protein-coupled receptors. Drug Discovery Today 10, 417-427 (Pubitemid 40450272)
29. Dong, M., Te, J. A., Xu, X., Wang, J., Pinon, D. I., Storjohann, L, Bordner, A. J. and Miller, L. J. (2011) Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist. Biochemistry 50, 8181-8192
30. Harikumar, K. G., Lam, P. C, Dong, M., Sexton, P. M., Abagyan, R. and Miller, L. J. (2007) Fluorescence resonance energy transfer analysis of secretin docking to its receptor: mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues. J. Biol. Chem. 282, 32834-32843 (Pubitemid 350159279)
31. Murage, E. N., Gao, G., Bisello, A. and Ahn, J. M. (2010) Development of potent glucagon-like peptide-1 agonists with high enzyme stability via introduction of multiple lactam bridges. J. Med. Chem. 53, 6412-6420
32. Miranda, A., Lahrichi, S. L., Gulyas, J., Koerber, S. C., Craig, A. G., Corrigan, A., Rivier, C., Vale, W. and Rivier, J. (1997) Constrained corticotropin-releasing factor antagonists with i-(i + 3) Glu-Lys bridges. J. Med. Chem. 40, 3651-3658 (Pubitemid 27465097)
33. Te, J. A., Dong, M., Miller, L. J. and Bordner, A. J. (2012) Predicting the effects of amino acid replacements in peptide hormones on their binding affinities for class B GPCRs and application to the design of secretin receptor antagonists. J. Comput.-Aided Mol. Des. 26, 835-845