Fluorescence resonance energy transfer analysis of secretin docking to its receptor: Mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues

Journal of Biological Chemistry

Volumn 282, Issue 45, 2007, Pages 32834-32843

  Harikumar, Kaleeckal G ^a   Lam, Polo C H ^b   Dong, Maoqing ^a   Sexton, Patrick M ^c   Abagyan, Ruben ^b   Miller, Laurence J ^a,d  

^a MAYO GRADUATE SCHOOL   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c MONASH UNIVERSITY   (Australia)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENERGY TRANSFER; FLUORESCENCE; MATHEMATICAL MODELS; PROTEINS;

EXTRACELLULAR LOOP; FLUORESCENCE RESONANCE ENERGY TRANSFER; PHARMACOPHORE; PHOTOAFFINITY LABELING;

BIOCHEMISTRY;

ASPARAGINE; ASPARTIC ACID; CARBON TETRACHLORIDE; DOCKING PROTEIN; G PROTEIN COUPLED RECEPTOR; LIGAND; TRYPTOPHAN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENCE SPECTROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE MAPPING; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GASTROINTESTINAL HORMONE; SECRETIN;

EID: 36349035022     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M704563200     Document Type: Article

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