Secretin and vasoactive intestinal peptide receptors: Members of a unique family of G protein-coupled receptors

Gastroenterology

Volumn 114, Issue 2, 1998, Pages 382-397

  Ulrich II, C D ^a   Holtmann, M ^a   Miller, L J ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; CALCITONIN; CALCITONIN GENE RELATED PEPTIDE; COMPLEMENTARY DNA; CORTICOTROPIN RELEASING FACTOR RECEPTOR; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE; GROWTH HORMONE RELEASING FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; PARATHYROID HORMONE; RHODOPSIN; SECRETIN; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR;

BINDING AFFINITY; DESENSITIZATION; DISULFIDE BOND; HORMONAL REGULATION; LIGAND BINDING; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; RECEPTOR BINDING; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 0031936197     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70491-3     Document Type: Article

References (147)

1. GV Segre SR Goldring Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone–releasing hormone, and glucagon belong to a newly discovered G-protein–linked receptor family Trends Endocrinol Metab 4 1993 309 314
2. D Spengler C Waeber C Pantaloni F Holsboer J Bockaert PH Seeberg L Journot Differential signal transduction by five splice variants of the PACAP receptor Nature 365 1993 170 175
3. TB Usdin É Mezey DC Button MJ Brownstein TI Bonner Gastric inhibitory polypeptide receptor, a member of the secretin–vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain Endocrinology 133 1993 2861 2870
4. LJ Jelinek S Lok GB Rosenberg RA Smith FJ Grant S Biggs PA Bensch JL Kuijper PO Sheppard CA Sprecher PJ O'Hara D Foster KM Walker LHJ Chen PA McKernan W Kindsvogel Expression cloning and signaling properties of the rat glucagon receptor Science 259 1993 1614 1616
5. B Thorens Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1 Proc Natl Acad Sci USA 89 1992 8641 8645
6. HY Lin TL Harris MS Flannery A Aruffo EH Kaji A Gorn LF Kolakowski HF Lodish SR Goldring Expression cloning of an adenylate cyclase–coupled calcitonin receptor Science 254 1991 1022 1026
7. N Aiyar K Rand NA Elshourbagy ZZ Zeng JE Adamou DJ Bergsma Y Li A cDNA encoding the calcitonin gene-related peptide type 1 receptor J Biol Chem 271 1996 11325 11329
8. H Juppner A Abou-Samra M Freeman XF Kong E Schipani J Richards LF Kolakowski J Hock JT Potts HM Kronenbeurg GV Segre A G protein–linked receptor for parathyroid hormone and parathyroid hormone–related peptide Science 254 1991 1024 1026
9. P Godfrey JO Rahal WG Beamer NG Copeland NA Jenkins KE Mayo GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function Nat Genet 4 1993 227 232
10. CP Chang RV Pearse S O'Connell MG Rosenfeld Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain Neuron 11 1993 1187 1195
11. JD Reagan Expression cloning of an insect diuretic hormone receptor. A member of the calcitonin/secretin receptor family J Biol Chem 269 1994 9 12
12. WM Bayliss EH Starling On the causation of the so-called “peripheral reflex secretion” of the pancreas Proc R Soc Lond 69 1902 352 353
13. RJ Lefkowitz S Cotecchia P Samama T Costa Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins Trends Pharmacol Sci 14 1993 303 307
14. T Kenakin The classification of seven transmembrane receptors in recombinant expression systems Pharmacol Rev 48 1996 413 463
15. BF Roettger RU Rentsch D Pinon E Holicky E Hadac JM Larkin LJ Miller Dual pathways of internalization of the cholecystokinin receptor J Cell Biol 128 1995 1029 1042
16. BF Roettger RU Rentsch EM Hadac EH Hellen TP Burghardt LJ Miller Insulation of a G protein–coupled receptor on the plasmalemmal surface of the pancreatic acinar cell J Cell Biol 130 1995 579 590
17. RV Rao BF Roettger EM Hadac LJ Miller Roles of cholecystokinin receptor phosphorylation in agonist-stimulated desensitization of pancreatic acinar cells and receptor-bearing Chinese hamster ovary cholecystokinin receptor cells Mol Pharmacol 51 1997 185 192
18. U Rausch P Vasiloudes K Rudiger HF Kern In vivo stimulation of rat pancreatic acinar cells by infusion of secretin. I. Changes in enzyme content, pancreatic fine structure and total rate of protein synthesis Cell Tissue Res 242 1985 633 639
19. + and pepsin secretion and on urinary electrolyte excretion in man Scand J Gastroenterol 16 1981 999 1004
20. Y Lu C Owyang Secretin at physiological doses inhibits gastric motility via a vagal afferent pathway Am J Physiol 268 1995 G1012 G1016
21. P Biancani JH Walsh J Behar Vasoactive intestinal polypeptide. A neurotransmitter for lower esophageal sphincter relaxation J Clin Invest 73 1984 963 967
22. P Biancani JH Walsh J Behar Vasoactive intestinal polypeptide. A neurotransmitter for relaxation of the rabbit internal anal sphincter Gastroenterology 89 1985 867 874
23. J Fahrenkrug Transmitter role of vasoactive intestinal peptide Pharmacol Toxicol 72 1993 354 363
24. J-G Jin S Katsoulis WE Schmidt JR Grider Inhibitory transmission in tenia coli mediated by distinct vasoactive intestinal peptide and apamin-sensitive pituitary adenylate cyclase activating peptide receptors J Pharmacol Exp Ther 270 1994 433 439
25. M Costa JB Furness The origins, pathways and terminations of neurons with VIP-like immunoreactivity in the guinea pig small intestine Neuroscience 8 1983 665 676
26. JR Grider KS Murthy G-F Jin GM Makhlouf Stimulation of nitric oxide from muscle cells by VIP: prejunctional enhancement of VIP release Am J Physiol 262 1992 G774 G778
27. JJ Holst J Fahrenkrug S Knuhtsen SL Jensen SS Poulsen OV Nielsen Vasoactive intestinal peptide (VIP) in the pig pancreas: role of VIPergic nerves in the control of fluid and bicarbonate secretion Regul Pept 8 1984 245 259
28. P Robberecht TP Conlon JD Gardner Interaction of porcine vasoactive intestinal peptide with dispersed pancreatic acinar cells from the guinea pig. Structural requirements for effects of vasoactive intestinal peptide and secretin on cellular adenosine 3':5'-monophosphate J Biol Chem 251 1976 4635 4639
29. GJ Krejs JS Fordtran Effect of VIP infusion on water and ion transport in human jejunum Gastroenterology 78 1980 722 727
30. E Hollande M Fanjul S Claret ME Forgue-Lafitte J Bara Effects of VIP on the regulation of mucin secretion in cultured human pancreatic cell (Capan-1) In Vitro Cell Dev Biol 92 1995 143 149
31. JA Waschek Vasoactive intestinal peptide: an important trophic factor and developmental regulator Dev Neurosci 17 1995 1 7
32. 125I-secretin to identify and characterize high-affinity secretin receptors on pancreatic acini Am J Physiol 245 1983 G186 G195
33. BM Bissonnette MJ Collen H Adachi RT Jensen JD Gardner Receptors for vasoactive intestinal peptide and secretin on rat pancreatic acini Am J Physiol 246 1984 G710 G717
34. P Robberecht NP De M Waelbroeck JC Camus JL Scemama D Fourmy L Pradayrol N Vayasse J Christophe Secretin receptors in human pancreatic membranes Pancreas 3 1988 529 535
35. MH Holtmann EM Hadac CD Ulrich LJ Miller Molecular basis and species specificity of high affinity binding of vasoactive intestinal polypeptide by the rat secretin receptor J Pharmacol Exp Ther 279 1996 555 560
36. D Gossen P Poloczek M Svoboda J Christophe Molecular architecture of secretin receptors: the specific covalent labelling of a 51 kDa peptide after cross-linking of iodosecretin to intact rat pancreatic acini FEBS Lett 243 1989 205 208
37. CD Ulrich II DI Pinon EM Hadac EL Holicky A Chang-Miller LK Gates LJ Miller Intrinsic photoaffinity labeling of native and recombinant rat pancreatic secretin receptors Gastroenterology 105 1993 1534 1543
38. HB Muller Der einfluss kupferarmer kost auf das pankreas. Lichtmikroskopische untersuchungen am exokrinen teil der bauchspeicheldrusen weisser ratten Virchows Arch A Pathol Anat Histopathol 350 1970 353 367
39. CD Ulrich EM Hadac G Alpini NF LaRusso LJ Miller Molecular characterization of a high affinity secretin-binding protein in rat pancreatic ducts (abstr) Gastroenterology 104 1993 A341
40. − channels in bile duct epithelial cells through a cAMP-dependent mechanism Am J Physiol 266 1994 G731 G736
41. RT Fremeau RT Jensen CG Charlton RL Miller TL O'Donohue TW Moody Secretin: specific binding to rat brain membranes J Neurosci 3 1983 1620 1625
42. ER Trimble R Bruzzone TJ Biden CJ Meehan D Andreu RB Merrifield Secretin stimulates cyclic AMP and inositol trisphosphate production in rat pancreatic acinar tissue by two fully independent mechanisms Proc Natl Acad Sci USA 84 1987 3146 3150
43. J Christophe P Chatelain G Taton M Delhaye M Waelbroeck P Robberecht Comparison of VIP-secretin receptors in rat and human lung Peptides 2 Suppl 2 1981 253 258
44. DP Taylor CB Pert Vasoactive intestinal polypeptide: specific binding to rat brain membranes Proc Natl Acad Sci USA 76 1979 660 664
45. MJ Raymond SA Rosenzweig Vasoactive intestinal peptide receptors on AR42J rat pancreatic acinar cells Biochem Biophys Res Commun 179 1991 176 182
46. T Voisin A Couvineau L Guijarro M Laburthe VIP receptors from porcine liver: high yield solubilization in a GTP-insensitive form Life Sci 48 1991 135 141
47. M Laburthe B Breant C Rouyer-Fessard Molecular identification of receptors for vasoactive intestinal peptide in rat intestinal epithelium by covalent cross-linking. Evidence for two classes of binding sites with different structural and functional properties Eur J Biochem 139 1984 181 187
48. P Robberecht M Waelbroeck JC Camus P De Neef J Christophe Importance of disulfide bonds in receptors for vasoactive intestinal peptide and secretin in rat pancreatic plasma membranes Biochim Biophys Acta 773 1984 271 278
49. RP Zimmerman TS Gates CR Mantyh SR Vigna ML Welton EP Passaro Jr PW Mantyh Vasoactive intestinal polypeptide receptor binding sites in the human gastrointestinal tract: localization by autoradiography Neuroscience 31 1989 771 783
50. JC Reubi In vitro identification of vasoactive intestinal peptide receptors in human tumors: implications for tumor imaging J Nucl Med 36 1995 1846 1853
51. JC Kermode AW DeLuca A Zilberman J Valliere SM Shreeve Evidence for the formation of a functional complex between vasoactive intestinal peptide, its receptor, and Gs in lung membranes J Biol Chem 267 1992 3382 3388
52. + channels in endothelial cells J Pharmacol Exp Ther 276 1996 690 696
53. KS Murthy GM Makhlouf Vasoactive intestinal peptide/pituitary adenylate cyclase–activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin–sensitive Gi1-2 J Biol Chem 269 1994 15977 15980
54. 1 receptors expressed by stable transfectants couple to two distinct signaling pathways Biochem Biophys Res Commun 203 1994 141 148
55. D Gossen A Vandermeers M-C Vandermeers-Piret J Rathe A Cauvin P Robberecht J Christophe Isolation and primary structure of rat secretin Biochem Biophys Res Commun 160 1989 862 867
56. 1H-NMR study of the solution conformation of secretin. Resonance assignment and secondary structure FEBS Lett 215 1987 88 94
57. M Clore M Nilges A Brunger AM Gronenborn Determination of the backbone conformation of secretin by restrained molecular dynamics on the basis of interproton distance data Eur J Biochem 171 1988 479 484
58. M Bodanszky A Bodanszky Conformation of peptides of the secretin-VIP-glucagon family in solution Peptides 7 Suppl 1 1986 43 48
59. GM Makhlouf M Bodanszky ML Fink M Schebalin Pancreatic secretory activity of secretin and substituted analogues Gastroenterology 74 1978 44 48
60. JD Gardner AJ Rottman S Natarajan M Bodanszky Interaction of secretin-5-27 and its analogues with hormone receptors on pancreatic acini Biochim Biophys Acta 583 1979 491 503
61. W Konig M Bickel K Karch V Teetz R Uhmann Analogues and fragments of secretin Peptides 5 1984 189 193
62. D Gossen M Tastenoy P Robberecht J Christophe Secretin receptors in the neuroglioma hybrid cell line NG108-15. Characterization and regulation of their expression Eur J Biochem 193 1990 149 154
63. H Kofod P Thams JJ Holst Differential effects of secretin-fragments imply a dual mechanism of action for secretin Int J Pept Protein Res 37 1991 134 139
64. M Waelbroeck P Robberecht P De Neef P Chatelain J Christophe Binding of vasoactive intestinal peptide and its stimulation of adenylate cyclase through two classes of receptors in rat liver membranes. Effects of 12 secretin analogues and 2 secretin fragments Biochim Biophys Acta 678 1981 83 90
65. JP Christophe TP Conlon JD Gardner Interaction of porcine vasoactive intestinal peptide with dispersed pancreatic acinar cells from the guinea pig. Binding of radioiodinated peptide J Biol Chem 251 1976 4629 4634
66. MA Hefford H Kaplan Chemical properties of the histidine residue of secretin: evidence for a specific intramolecular interaction Biochim Biophys Acta 998 1989 267 270
67. RS Izzo M Praissman Effect of N-terminal iodination on the biological, immunological and receptor binding properties of secretion. A role for the alpha-amino group of histidine in stabilizing hormone-receptor interactions Int J Pept Protein Res 23 1984 292 299
68. BM Haffar SJ Hocart DH Coy S Mantey HCV Chiang RT Jensen Reduced peptide bond pseudopeptide analogues of secretin a new class of secretin receptor antagonists J Biol Chem 266 1991 316 322
69. ME Presti JD Gardner Receptor antagonists for gastrointestinal peptides Am J Physiol 264 1993 G399 G406
70. A Arimura Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research Regul Pept 37 1992 287 303
71. K Tatemoto PHI—a new brain-gut peptide Peptides 5 1984 151 154
72. JP Dehaye J Winand C Damien P Poloczek M Svoboda J Christophe Stimulatory effects of Gila monster venom on rat pancreatic acini Peptides 5 1984 333 337
73. DS Parker JP Raufman TL O'Donohue M Bledsoe H Yoshida JJ Pisano Amino acid sequences of helospectins, new members of the glucagon superfamily, found in Gila monster venom J Biol Chem 259 1984 11751 11755
74. JP Raufman L Singh J Eng Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal polypeptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39)amide, a specific exendin receptor antagonist J Biol Chem 266 1991 2897 2902
75. RM Campbell CG Scanes Evolution of the growth hormone–releasing factor (GRF) family of peptides Growth Regul 2 1992 175 191
76. TM Biedzinski D Bataille MA Devaux H Sarles The effect of oxyntomodulin (glucagon 37) and glucagon on exocrine pancreatic secretion in the conscious rat Peptides 8 1987 967 972
77. KEJ Dickinson M Schachter CMM Miles DH Coy PS Sever Characterization of vasoactive intestinal peptide receptors in mammalian lung Peptides 7 1986 791 800
78. T Ishihara S Nakamura Y Kaziro T Takahashi K Takahashi S Nagata Molecular cloning and expression of a cDNA encoding the secretin receptor EMBO J 10 1991 1635 1641
79. JP Vilardaga E Ciccarelli C Dubeaux P De Neef A Bollen P Robberecht Properties and regulation of the coupling to adenylate cyclase of secretin receptors stably transfected in Chinese hamster ovary cells Mol Pharmacol 45 1994 1022 1028
80. G Alpini C Ulrich S Roberts JO Phillips Y Ueno PV Podila O Colegio GD LeSage LJ Miller NF LaRusso Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation Am J Physiol 272 1997 G289 G297
81. S Jiang C Ulrich Molecular cloning and functional expression of a human pancreatic secretin receptor Biochem Biophys Res Commun 207 1995 883 890
82. S Jiang RH Bell CD Ulrich Characterization of a human pancreatic secretin receptor and its expression in human ductal pancreatic adenocarcinomas (abstr) Gastroenterology 108 1995 A978
83. L Marino C Cotton Immortalization of bovine pancreatic duct epithelial cells Am J Physiol 270 1996 G676 G683
84. T Takahashi MP Moyer C Martin QJ Wang TE Adrian CP Mountjoy W Sanger H Sugiura H Katoh PM Pour Establishment and characterization of a new spontaneously immortalized, pancreatic ductal cell line from the Syrian golden hamster Cell Tissue Res 282 1995 163 174
85. C Tang I Biemond M Appel C Visser R Wouterson C Lamers Gut peptide receptors in pancreata of BOP-treated and normal control hamsters (abstr) Gastroenterology 110 1996 A436
86. T Ishihara R Shigemoto K Mori K Takahashi S Nagata Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide Neuron 8 1992 811 819
87. SP Sreedharan DR Patel J-X Huang EJ Goetzl Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor Biochem Biophys Res Commun 193 1993 546 553
88. S Jiang E Kopras M McMicheal RH Bell CD Ulrich Vasoactive intestinal peptide (VIP) stimulates in vitro growth of VIP-1 receptor–bearing human pancreatic adenocarcinoma–derived cells Cancer Res 57 1997 1475 1480
89. A Couvineau C Rouyer-Fessard D Darmoul J-J Maoret I Carrero E Ogier-Denis M Laburthe Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains Biochem Biophys Res Commun 200 1994 769 776
90. 2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide FEBS Lett 334 1993 3 8
91. JE Adamou N Aiyar S Van Horn NA Elshourbagy Cloning and functional characterization of the human vasoactive intestinal peptide (VIP)-2 receptor Biochem Biophys Res Commun 209 1995 385 392
92. TB Usdin TI Bonner É Mezey Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions Endocrinology 135 1994 2662 2680
93. JG Jin KS Murthy M Al-Essa JR Grider GM Makhlouf ANP-clearance receptor (NPR-C) mediates VIP/PACAP-induced activation of smooth muscle eNOS (abstr) Gastroenterology 112 1997 A1159
94. D Donnelly JBC Findlay Seven-helix receptors: structure and modelling Curr Opin Struct Biol 4 1994 582 589
95. CD Strader TM Fong MR Tota D Underwood RAF Dixon Structure and function of G protein–coupled receptors Annu Rev Biochem 63 1994 101 132
96. MH Holtmann EM Hadac LJ Miller Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors J Biol Chem 270 1995 14394 14398
97. J-P Vilardaga P De Neef E Di Paolo A Bollen M Waelbroeck P Robberecht Properties of chimeric secretin and VIP receptor proteins indicate the importance of the N-terminal domain for ligand discrimination Biochem Biophys Res Commun 211 1995 885 891
98. Y-J Cao G Gimpl F Fahrenholz The amino-terminal fragment of the adenylate cyclase activating polypeptide (PACAP) receptor functions as a high affinity PACAP binding domain Biochem Biophys Res Commun 212 1995 673 680
99. P Gaudin A Couvineau J-J Maoret C Rouyer-Fessard M Laburthe Mutational analysis of cysteine residues within the extracellular domains of the human vasoactive intestinal peptide (VIP) 1 receptor identifies seven mutants that are defective in VIP binding Biochem Biophys Res Commun 211 1995 901 908
100. MH Holtmann S Ganguli EM Hadac V Dolu LJ Miller Multiple extracellular loop domains contribute critical determinants for agonist binding and activation of the secretin receptor J Biol Chem 271 1996 14944 14949
101. CG Unson AM Cypress CR Wu PK Goldsmith RB Merrifield Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding Proc Natl Acad Sci USA 93 1996 310 315
102. A Couvineau C Fabre P Gaudin JJ Maoret M Laburthe Mutagenesis of N-glycosylation sites in the human vasoactive intestinal peptide 1 receptor. Evidence that asparagine 58 or 69 is crucial for correct delivery of the receptor to plasma membrane Biochemistry 35 1996 1745 1752
103. S Houssami DM Findlay CL Brady DE Myers TJ Martin PM Sexton Isoforms of the rat calcitonin receptor: consequences for ligand binding and signal transduction Endocrinology 135 1994 183 190
104. C Bergwitz TJ Gardella MR Flannery JT Potts Jr HM Kronenberg SR Goldring H Jüppner Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin—evidence for a common pattern of ligand-receptor interaction J Biol Chem 271 1996 26469 26472
105. P Gourlet A Vandermeers MC Vandermeers-Piret P De Neef P Robberecht Addition of the (28-38) peptide sequence of PACAP to the VIP sequence modifies peptide selectivity and efficacy Int J Pept Protein Res 48 1996 391 396
106. P Gourlet JP Vilardaga P De Neef M Waelbroeck A Vandermeers P Robberecht The C-terminus ends of secretin and VIP interact with the N-terminal domains of their receptors Peptides 17 1996 825 829
107. RJ Bold J Ishizuka CM Townsend Jr JC Thompson Secretin potentiates cholecystokinin-stimulated amylase release by AR4-2J cells via a stimulation of phospholipase C J Cell Physiol 165 1995 172 176
108. A Fatatis LA Holtzclaw R Avidor DE Brenneman JT Russell Vasoactive intestinal peptide increases intracellular calcium in astroglia: synergism with α-adrenergic receptors Proc Natl Acad Sci USA 91 1994 2036 2040
109. MJ Collen VE Sutliff GZ Pan JD Gardner Postreceptor modulation of action of VIP and secretin on pancreatic enzyme secretion by secretagogues that mobilize cellular calcium Am J Physiol 242 1982 G423 G428
110. DG Lambright J Sondek A Bohm NP Skiba HE Hamm The 2.0 A crystal structure of a heterotrimeric G protein Nature 379 1996 311 319
111. J Sondek A Bohm DG Lambright HE Hamm PB Sigler Crystal structure of a G protein dimer at 2.1 angstrom resolution Nature 379 1996 369 374
112. MB Mixon E Lee DE Coleman AM Berghuis AG Gilman SR Sprang Tertiary and quaternary structure of structural changes in Giα1 induced by GTP hydrolysis Science 270 1995 954 960
113. J Guiramand JP Montmayeur J Ceraline M Bhatia E Borrelia Alternate splicing of the dopamine D2 receptor directs specificity of coupling to G proteins J Biol Chem 270 1995 7354 7358
114. EE Moore RE Kuestner SD Stroop FJ Grant SL Matthewes CL Brady PM Sexton DM Findlay Functionally different isoforms of the human calcitonin receptor result from alternative splicing of the gene transcript Mol Endocrinol 9 1995 959 968
115. M Sato R Kataoka J Dingus M Wilcox JD Hildebrandt SM Lanier Factors determining specificity of signal transduction by G-protein–coupled receptors. Regulation of signal transfer from receptor to G-protein J Biol Chem 270 1995 15269 15276
116. PF Pollack JG Wood T Solomon Effect of secretin on growth of stomach, small intestine, and pancreas of developing rats Dig Dis Sci 35 1990 749 758
117. E Bhattacharyya A Panchal TJ Wilkins J De Ondarza SR Hootman Insulin, transforming growth factors, and substrates modulate growth of guinea pig pancreatic duct cells in vitro Gastroenterology 109 1995 944 952
118. G Lilling Y Wollman MN Goldstein S Rubinraut M Fridkin DE Brenneman I Gozes Inhibition of human neuroblastoma growth by a specific VIP antagonist J Mol Neurosci 5 1995 231 239
119. TW Moody F Zia M Draoui DE Brenneman M Fridkin A Davidson I Gozes A vasoactive intestinal peptide antagonist inhibits non–small cell lung cancer growth Proc Natl Acad Sci USA 90 1993 4345 4349
120. L Gamet JC Murat A Remuary C Remesy P Valet H Paris C Denis-Pouxviel Vasoactive intestinal peptide and forskolin regulate proliferation of the HT29 human colon adenocarcinoma cell line J Cell Physiol 150 1992 501 509
121. K Maruno SI Said Small-cell lung carcinoma: inhibition of proliferation by vasoactive intestinal peptide and helodermin and enhancement of inhibition by anti-bombesin antibody Life Sci 52 1993 PL267 PL271
122. Z Olah C Lehel WB Anderson DE Brenneman DV Agoston Subnanomolar concentration of VIP induces the nuclear translocation of protein kinase C in neonatal rat cortical astrocytes J Neurosci 39 1994 355 363
123. G Berrozpe J Schaeffer MA Peinado FX Real M Perucho Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer Int J Cancer 58 1994 185 191
124. J Axelson I Ihse R Håkanson Pancreatic cancer: the role of cholecystokinin Scand J Gastroenterol 27 1992 993 998
125. M Sharif N Sasakawa MR Hanley Malignant transformation by G protein–coupled hormone receptors Mol Cell Endocrinol 100 1994 115 119
126. B Marquardt D Frith S Stabel Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro Oncogene 9 1994 3213 3218
127. M Faure TA Voyno-Yasenetskaya HR Bourne cAMP and β subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells J Biol Chem 269 1994 7851 7854
128. P Roger S Reuse C Maenhaut J Dumont Multiple facets of the modulation of growth by cAMP Vitam Horm 51 1995 59 191
129. D Ways C Kukoly J deVente JL Hooker WO Bryant KJ Posekany DJ Fletcher PP Cook PJ Parker MCF-7 breast cancer cells transfected with protein kinase C-α exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype J Clin Invest 95 1995 1906 1915
130. MH Holtmann BF Roettger DI Pinon LJ Miller Role of receptor phosphorylation in desensitization and internalization of the secretin receptor J Biol Chem 271 1996 23566 23571
131. 1B-adrenergic receptor J Biol Chem 271 1996 5049 5058
132. W Bawab E Chastre C Gespach Functional and structural characterization of the secretin receptors in rat gastric glands: desensitization and glycoprotein nature Biosci Rep 11 1991 33 42
133. MJ Carmen C Hueso LG Guijarro JC Prieto Cholesterol modulation of membrane fluidity and VIP receptor/effector system in rat prostatic epithelial cells Regul Pept 33 1991 287 297
134. J Abello C Damien P Robberecht R Hooghe A Vandermeers MC Vandermeers-Piret J Christophe Homologous and heterologous regulation of the helodermin/vasoactive-intestinal-peptide response in the murine radiation leukemia-virus–induced lymphoma cell line BL/VL3 Eur J Biochem 183 1989 269 274
135. C Boissard JC Marie G Hejblum C Gespach G Rosselin Vasoactive intestinal peptide receptor regulation and reversible desensitization in human colonic carcinoma cells in culture Cancer Res 46 1986 4406 4413
136. JT Turner DW Bollinger ML Toews Vasoactive intestinal peptide receptor/adenylate cyclase system: differences between agonist- and protein kinase C–mediated desensitization and further evidence for receptor internalization J Pharm Exp Ther 247 1988 417 423
137. JP Vincent P Kitabgi Phorbol ester induces loss of VIP stimulation of adenylate cylcase and VIP-binding sites in HT29 cells FEBS Lett 211 1987 151 154
138. JM Backer CR Kahn DA Cahill A Ullrich MF White Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit J Biol Chem 265 1990 16450 16454
139. W Hunziker C Fumey A di-leucine motif mediates endocytosis and basolateral sorting of macrophage IgG Fc receptors in MDCK cells EMBO J 13 1994 2963 2969
140. 1 angiotensin receptor J Biol Chem 269 1994 31378 31382
141. S Katsushima H Adachi T Honda S Sato T Kusui S Onishi E Aoki M Noguchi J Konishi Cholecystokinin downregulates receptors for vasoactive intestinal peptide and secretin in rat pancreatic acini Am J Physiol 258 1990 G395 G403
142. H-G Schneider F Raue A Koppold W Ruf R Ziegler Homologous desensitization of calcitonin receptors and calcitonin-dependent adenylate cyclase in T47D cells Acta Endocrinol 128 1993 373 378
143. Z Huang Y Chen RA Nissenson The cytoplasmic tail of the G-protein–coupled receptor for parathyroid hormone and parathyroid hormone–related protein contains positive and negative signals for endocytosis J Biol Chem 270 1995 151 156
144. S Fukayama E Schipani H Jüppner B Lanske HM Kronenberg A-B Abou-Samra FR Bringhurst Role of protein kinase–A in homologous down-regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in human osteoblast-like SaOS-2 cells Endocrinology 134 1994 1851 1858
145. J Gromada S Dissing P Rorsman Desensitization of glucagon-like peptide 1 receptors in insulin-secreting βTC3 cells: role of PKA-independent mechanisms Br J Pharmacol 118 1996 769 775
146. AB Abou Samra H Juppner T Force MW Freeman XF Kong E Schipani P Urena J Richards JV Bonventre JT Potts Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone–related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium Proc Natl Acad Sci USA 89 1992 2732 2736
147. 2+/inositol phosphate signaling pathways Mol Endocrinol 6 1992 551 556