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Volumn 3, Issue MAR, 2012, Pages

Phytolderived novel isoprenoid immunostimulants

Author keywords

Activation of innate immunity; AntibodyandCTLresponse; Cytokinemicroenvironment; Immunostimulants; Inflammasome; Isoprenoid adjuvants; Phytol derivatives; Vaccine fficacy

Indexed keywords


EID: 84873076814     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00049     Document Type: Review
Times cited : (31)

References (107)
  • 2
    • 80054025404 scopus 로고    scopus 로고
    • Synthetic adjuvants for vaccine formulations: evaluation of new phytol derivatives in induction and persistence of specific immune response
    • Aachoui, Y., Schulte, M. L., Fitch, R. W., and Ghosh, S. K. (2011a). Synthetic adjuvants for vaccine formulations: evaluation of new phytol derivatives in induction and persistence of specific immune response. Cell. Immunol. 271, 308-318.
    • (2011) Cell. Immunol. , vol.271 , pp. 308-318
    • Aachoui, Y.1    Schulte, M.L.2    Fitch, R.W.3    Ghosh, S.K.4
  • 3
    • 80054019355 scopus 로고    scopus 로고
    • Ghosh molecular signatures of phytolderived immunostimulants in the context of chemokinecytokine microenvironment and enhanced immune response
    • Aachoui, Y., Chowdhury, R. R., Fitch, R. W., and Ghosh, S. K. (2011b). Ghosh molecular signatures of phytolderived immunostimulants in the context of chemokinecytokine microenvironment and enhanced immune response. Cell. Immunol. 271, 227-238.
    • (2011) Cell. Immunol. , vol.271 , pp. 227-238
    • Aachoui, Y.1    Chowdhury, R.R.2    Fitch, R.W.3    Ghosh, S.K.4
  • 4
    • 42649144443 scopus 로고    scopus 로고
    • Vaccines: explaining alum: immunologists' dirty little secret
    • Allan, S. (2008). Vaccines: explaining alum: immunologists' dirty little secret. Nat. Rev. Immunol. 8, 320.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 320
    • Allan, S.1
  • 5
    • 0033974771 scopus 로고    scopus 로고
    • Antibodies to squalene in Gulf War syndrome
    • Asa,P. B.,Cao,Y.,and Garry,R. F. (2000). Antibodies to squalene in Gulf War syndrome. Exp. Mol. Pathol. 68, 55-64.
    • (2000) Exp. Mol. Pathol. , vol.68 , pp. 55-64
    • Asa, P.B.1    Cao, Y.2    Garry, R.F.3
  • 6
    • 0026564321 scopus 로고
    • Synthetic immunoadjuvants: application to nonspecific host stimulation and potentiation of vaccine immunogenicity
    • Azuma, I. (1992). Synthetic immunoadjuvants: application to nonspecific host stimulation and potentiation of vaccine immunogenicity.Vaccine 10, 1000-1006.
    • (1992) Vaccine , vol.10 , pp. 1000-1006
    • Azuma, I.1
  • 9
    • 58149328924 scopus 로고    scopus 로고
    • MF59-adjuvanted vaccines for seasonal and pandemic influenza prophylaxis. Influenza Other Respi
    • Banzhoff, A., Pellegrini, M., Del Giu-Dice, G., Fragapane, E., Groth, N., and Podda, A. (2008). MF59-adjuvanted vaccines for seasonal and pandemic influenza prophylaxis. Influenza Other Respi. Viruses 2, 243-249.
    • (2008) Viruses , vol.2 , pp. 243-249
    • Banzhoff, A.1    Pellegrini, M.2    Del Giu-Dice, G.3    Fragapane, E.4    Groth, N.5    Podda, A.6
  • 11
    • 0014330683 scopus 로고
    • Absorption of chlorophyll phytol in normal man and in patients with Refsum's disease
    • Baxter, J. H. (1968). Absorption of chlorophyll phytol in normal man and in patients with Refsum's disease. J. Lipid Res. 9, 636-641.
    • (1968) J. Lipid Res. , vol.9 , pp. 636-641
    • Baxter, J.H.1
  • 13
    • 23044507603 scopus 로고    scopus 로고
    • Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis
    • Bifulco, M. (2005). Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis. Life Sci. 77, 1740-1749.
    • (2005) Life Sci , vol.77 , pp. 1740-1749
    • Bifulco, M.1
  • 14
    • 0035217962 scopus 로고    scopus 로고
    • Modes of action of Freund's adjuvants in experimental models of autoimmune diseases
    • Billiau, A., and Matthys, P. (2001). Modes of action of Freund's adjuvants in experimental models of autoimmune diseases. J. Leukoc. Biol. 70, 849-860.
    • (2001) J. Leukoc. Biol. , vol.70 , pp. 849-860
    • Billiau, A.1    Matthys, P.2
  • 15
    • 0008896416 scopus 로고
    • Durée du séjour de l'antigène dans l'organisme et immunité
    • Blagowechensky, N. (1938). Durée du séjour de l'antigène dans l'organisme et immunité. Rev. Immunol. 4, 161.
    • (1938) Rev. Immunol. , vol.4 , pp. 161
    • Blagowechensky, N.1
  • 16
    • 0032756730 scopus 로고    scopus 로고
    • Aluminium hydroxide adjuvant initiates strong antigenspecific Th2 responses in the absence of IL-4-or IL-13-mediated signaling
    • Brewer, J. M., Conacher, M., Hunter, C. A., Mohrs, M., Brombacher, F., andAlexander,J. (1999).Aluminium hydroxide adjuvant initiates strong antigenspecific Th2 responses in the absence of IL-4-or IL-13-mediated signaling. J. Immunol. 163, 6448-6454.
    • (1999) J. Immunol. , vol.163 , pp. 6448-6454
    • Brewer, J.M.1    Conacher, M.2    Hunter, C.A.3    Mohrs, M.4    Brombacher, F.5    Alexander, J.6
  • 17
    • 0014676267 scopus 로고
    • Advantages of aluminium hydroxide adsorbed combined diphtheria, tetanus, and pertussis vaccines for the immunization of infants
    • Butler, N. R., Voyce, M. A., Burland, W. L., and Hilton, M. L. (1969). Advantages of aluminium hydroxide adsorbed combined diphtheria, tetanus, and pertussis vaccines for the immunization of infants. Br. Med. J. 1, 663-666.
    • (1969) Br. Med. J. , vol.1 , pp. 663-666
    • Butler, N.R.1    Voyce, M.A.2    Burland, W.L.3    Hilton, M.L.4
  • 18
    • 0031984194 scopus 로고    scopus 로고
    • Use of licensed vaccines for active immunization of the immunocompromised host
    • Casadevall,A.,and Pirofski,L.A. (1998). Use of licensed vaccines for active immunization of the immunocompromised host. Clin. Microbiol. Rev. 11, 1-26.
    • (1998) Clin. Microbiol. Rev. , vol.11 , pp. 1-26
    • Casadevall, A.1    Pirofski, L.A.2
  • 22
    • 0016341233 scopus 로고
    • Structure of Freund's complete and incomplete adjuvants Relation of adjuvanticity to structure
    • Dvorak,A. M.,and Dvorak,H. F. (1974). Structure of Freund's complete and incomplete adjuvants. Relation of adjuvanticity to structure. Immunology 27, 99-114.
    • (1974) Immunology , vol.27 , pp. 99-114
    • Dvorak, A.M.1    Dvorak, H.F.2
  • 23
    • 0028245392 scopus 로고
    • The chemoprevention of cancer by mevalonatederived constituents of fruits and vegetables
    • Elson, C. E., and Yu, S. G. (1994). The chemoprevention of cancer by mevalonatederived constituents of fruits and vegetables. J. Nutr. 124, 607-614.
    • (1994) J. Nutr. , vol.124 , pp. 607-614
    • Elson, C.E.1    Yu, S.G.2
  • 24
    • 0031819540 scopus 로고    scopus 로고
    • Adjuvant action of Chenopodium quinoa saponins on the induction of antibody responses to intragastric and intranasal administered antigens in mice
    • Estrada, A., Li, B., and Laarveld, B. (1998). Adjuvant action of Chenopodium quinoa saponins on the induction of antibody responses to intragastric and intranasal administered antigens in mice. Comp. Immunol. Microbiol. Infect. Dis. 21, 225-236.
    • (1998) Comp. Immunol. Microbiol. Infect. Dis. , vol.21 , pp. 225-236
    • Estrada, A.1    Li, B.2    Laarveld, B.3
  • 25
    • 70449367314 scopus 로고    scopus 로고
    • Mitochondrial dysfunction, impaired oxidativereduction activity, degeneration, and death in human neuronal and fetal cells induced by lowlevel exposure to thimerosal and other metal compounds
    • Geiera, D. A., King, P. G., and Geierc, M. R. (2009). Mitochondrial dysfunction, impaired oxidativereduction activity, degeneration, and death in human neuronal and fetal cells induced by lowlevel exposure to thimerosal and other metal compounds. Toxicol. Environ. Chem. 91, 735-749.
    • (2009) Toxicol. Environ. Chem. , vol.91 , pp. 735-749
    • Geiera, D.A.1    King, P.G.2    Geierc, M.R.3
  • 26
    • 84892601686 scopus 로고    scopus 로고
    • Phytol derived immunoadjuvants and their use in vaccine formulations
    • Ghosh, S. K. (2012). Phytol derived immunoadjuvants and their use in vaccine formulations. United States Patent 8088395.
    • (2012) United States Patent 8088395
    • Ghosh, S.K.1
  • 27
    • 80054816241 scopus 로고    scopus 로고
    • Immune enhancement by novel vaccine adjuvants in autoimmuneprone NZB/W F1 mice: relative efficacy and safety
    • doi:10.1186/1471-2172-12-61
    • Ghosh, S. K., and Aachoui, Y. (2011). Immune enhancement by novel vaccine adjuvants in autoimmuneprone NZB/W F1 mice: relative efficacy and safety. BMC Immunol. 12, 61. doi:10.1186/1471-2172-12-61
    • (2011) BMC Immunol , vol.12 , pp. 61
    • Ghosh, S.K.1    Aachoui, Y.2
  • 28
    • 0025277259 scopus 로고
    • Prenyl proteins in eukaryotic cells: a new type of membrane anchor
    • Glomset, J. A., Gelb, M. H., and Farnsworth, C. C. (1990). Prenyl proteins in eukaryotic cells: a new type of membrane anchor. Trends Biochem. Sci. 15, 139-142.
    • (1990) Trends Biochem. Sci. , vol.15 , pp. 139-142
    • Glomset, J.A.1    Gelb, M.H.2    Farnsworth, C.C.3
  • 29
    • 0030976101 scopus 로고    scopus 로고
    • MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine
    • Granoff, D. M., McHugh, Y. E., Raff, H. V., Mokatrin, A. S., and Van Nest, G. A. (1997). MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine. Infect. Immun. 65, 1710-1715.
    • (1997) Infect. Immun. , vol.65 , pp. 1710-1715
    • Granoff, D.M.1    McHugh, Y.E.2    Raff, H.V.3    Mokatrin, A.S.4    Van Nest, G.A.5
  • 31
    • 0003724933 scopus 로고    scopus 로고
    • Natural terpenoids as messengers. A multidisciplinary study of their production, biological functions and practical applications
    • Harrewijn, P., van Oosten, A. M., and Piron, P. G. M. (2001). Natural terpenoids as messengers. A multidisciplinary study of their production, biological functions and practical applications. Ann. Bot. 90, 299-300
    • (2001) Ann. Bot. , vol.90 , pp. 299-300
    • Harrewijn, P.1    van Oosten, A.M.2    Piron, P.G.M.3
  • 32
    • 45749091342 scopus 로고    scopus 로고
    • Effective induction of type 1 helper IgG2a and cytotoxic T-cell responses in mice following immunization with human papillomavirus type 16 E2 in MF59
    • Heinemann, L., Woodfield, L., Amer, M., and Hibma, M. (2008). Effective induction of type 1 helper IgG2a and cytotoxic T-cell responses in mice following immunization with human papillomavirus type 16 E2 in MF59. Viral Immunol. 21, 225-233.
    • (2008) Viral Immunol , vol.21 , pp. 225-233
    • Heinemann, L.1    Woodfield, L.2    Amer, M.3    Hibma, M.4
  • 33
    • 3042738406 scopus 로고    scopus 로고
    • Adjuvant oil induces waves of arthritogenic lymph node cells prior to arthritis onset
    • Holm, B. C., Lorentzen, J. C., and Bucht, A. (2004). Adjuvant oil induces waves of arthritogenic lymph node cells prior to arthritis onset. Clin. Exp. Immunol. 137, 59-64.
    • (2004) Clin. Exp. Immunol. , vol.137 , pp. 59-64
    • Holm, B.C.1    Lorentzen, J.C.2    Bucht, A.3
  • 35
    • 30844438912 scopus 로고    scopus 로고
    • Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world
    • Isman, M. B. (2006). Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. Annu. Rev. Entomol. 51, 45-66.
    • (2006) Annu. Rev. Entomol. , vol.51 , pp. 45-66
    • Isman, M.B.1
  • 36
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway, C. (1989). Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54, 1-13.
    • (1989) Cold Spring Harb. Symp. Quant. Biol. , vol.54 , pp. 1-13
    • Janeway, C.1
  • 37
    • 0032928669 scopus 로고    scopus 로고
    • Phytol is a novel tumor promoter on ICR mouse skin
    • Kagoura, M., Matsui, C., and Moro-Hashi, M. (1999). Phytol is a novel tumor promoter on ICR mouse skin. Jpn. J. Cancer Res. 4, 377-384.
    • (1999) Jpn. J. Cancer Res. , vol.4 , pp. 377-384
    • Kagoura, M.1    Matsui, C.2    Moro-Hashi, M.3
  • 38
    • 77949264892 scopus 로고    scopus 로고
    • Squalenebased oilinwater emulsion adjuvants perturb metabolism of neutral lipids and enhance lipid droplet formation
    • Kalvodova, L. (2010). Squalenebased oilinwater emulsion adjuvants perturb metabolism of neutral lipids and enhance lipid droplet formation. Biochem. Biophys. Res. Commun. 393, 350-355.
    • (2010) Biochem. Biophys. Res. Commun. , vol.393 , pp. 350-355
    • Kalvodova, L.1
  • 39
    • 29144529161 scopus 로고    scopus 로고
    • Targeting protein kinase C and "nonkinase" phorbol ester receptors: emerging concepts and therapeutic implications
    • Kazanietz, M. (2005). Targeting protein kinase C and "nonkinase" phorbol ester receptors: emerging concepts and therapeutic implications. Biochim. Biophys. Acta 1754, 296-304.
    • (2005) Biochim. Biophys. Acta , vol.1754 , pp. 296-304
    • Kazanietz, M.1
  • 40
    • 0031661414 scopus 로고    scopus 로고
    • QS-21: a watersoluble triterpene glycoside adjuvant
    • Kensil, C. R., and Kammer, R. (1998). QS-21: a watersoluble triterpene glycoside adjuvant. Expert Opin. Investig. Drugs 7, 1475-1482.
    • (1998) Expert Opin. Investig. Drugs , vol.7 , pp. 1475-1482
    • Kensil, C.R.1    Kammer, R.2
  • 41
    • 84892623609 scopus 로고    scopus 로고
    • Effects of QS21 on innate and adaptive immune responses
    • Kensil, C. R., Liu, G., Anderson, C., and Storey, J. (2006). Effects of QS21 on innate and adaptive immune responses. Vaccin. Adjuvants 221-234.
    • (2006) Vaccin. Adjuvants , pp. 221-234
    • Kensil, C.R.1    Liu, G.2    Anderson, C.3    Storey, J.4
  • 42
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the immune system to danger
    • Kono, H., and Rock, K. L. (2008). How dying cells alert the immune system to danger. Nat. Rev. Immunol. 8, 279-289.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 279-289
    • Kono, H.1    Rock, K.L.2
  • 43
    • 0033957435 scopus 로고    scopus 로고
    • Archaeosome vaccine adjuvants induce strong humoral, cellmediated, and memory responses: comparison to conventional liposomes and alum
    • Krishnan, L., Dicaire, C. J., Patel, G. B., and Sprott, G. D. (2000). Archaeosome vaccine adjuvants induce strong humoral, cellmediated, and memory responses: comparison to conventional liposomes and alum. Infect. Immun. 68, 54-63.
    • (2000) Infect. Immun. , vol.68 , pp. 54-63
    • Krishnan, L.1    Dicaire, C.J.2    Patel, G.B.3    Sprott, G.D.4
  • 45
    • 0019152173 scopus 로고
    • Synthetic immunostimulants derived from the bacterial cell wall
    • Lederer, E. (1980). Synthetic immunostimulants derived from the bacterial cell wall. J. Med. Chem. 8, 819-825.
    • (1980) J. Med. Chem. , vol.8 , pp. 819-825
    • Lederer, E.1
  • 46
    • 80053076885 scopus 로고    scopus 로고
    • NKT cells are required for complete Freund's adjuvantmediated protection from autoimmune diabetes
    • Lee, I. F., van den Elzen, P., Tan, R., and Priatel, J. J. (2011). NKT cells are required for complete Freund's adjuvantmediated protection from autoimmune diabetes. J. Immunol. 187, 2898-2904.
    • (2011) J. Immunol. , vol.187 , pp. 2898-2904
    • Lee, I.F.1    van den Elzen, P.2    Tan, R.3    Priatel, J.J.4
  • 47
    • 34548548460 scopus 로고    scopus 로고
    • Improvement of adjuvant systems to obtain a costeffectiveproductionofhighlevelsof specific IgY
    • Lévesque, S., Martinez, G., and Fair-Brother, J. M. (2007). Improvement of adjuvant systems to obtain a costeffectiveproductionofhighlevelsof specific IgY. Poult. Sci. 86, 630-635.
    • (2007) Poult. Sci. , vol.86 , pp. 630-635
    • Lévesque, S.1    Martinez, G.2    Fair-Brother, J.M.3
  • 49
    • 47849087075 scopus 로고    scopus 로고
    • Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3
    • Li, H., Willingham, S. B., Ting, J. P., and Re, F. (2008). Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J. Immunol. 181, 17-21.
    • (2008) J. Immunol. , vol.181 , pp. 17-21
    • Li, H.1    Willingham, S.B.2    Ting, J.P.3    Re, F.4
  • 50
    • 0037244587 scopus 로고    scopus 로고
    • Freund adjuvant induces TLR2 but not TLR4 expression in the liver of mice
    • Lim, S.-K. (2003). Freund adjuvant induces TLR2 but not TLR4 expression in the liver of mice. Int. Immunopharmacol. 3, 115-118.
    • (2003) Int. Immunopharmacol. , vol.3 , pp. 115-118
    • Lim, S.-K.1
  • 51
    • 0346851874 scopus 로고    scopus 로고
    • Autoreactive responses to an environmental factor: 1 phthalate induces antibodies exhibiting anti-DNA specificity
    • Lim, S. Y., and Ghosh, S. K. (2003). Autoreactive responses to an environmental factor: 1 phthalate induces antibodies exhibiting anti-DNA specificity. Immunology 110, 482-492.
    • (2003) Immunology , vol.110 , pp. 482-492
    • Lim, S.Y.1    Ghosh, S.K.2
  • 52
    • 22444442542 scopus 로고    scopus 로고
    • Autoreactive responses to environmental factors: 3 Mouse strainspecific differences in induction and regulation of anti-DNA antibody responses due to phthalateisomers
    • Lim, S. Y., and Ghosh, S. K. (2004). Autoreactive responses to environmental factors: 3. Mouse strainspecific differences in induction and regulation of anti-DNA antibody responses due to phthalateisomers. J. Autoimmun. 25, 33-45.
    • (2004) J. Autoimmun. , vol.25 , pp. 33-45
    • Lim, S.Y.1    Ghosh, S.K.2
  • 53
    • 33750693040 scopus 로고    scopus 로고
    • Phytolbased novel adjuvants in vaccine formulation 1 assessment of safety and efficacy during stimulation of humoral and cellmediated immune responses
    • Lim, S. Y., Meyer, M., Kjonaas, R. A., and Ghosh, S. K. (2006a). Phytolbased novel adjuvants in vaccine formulation 1 assessment of safety and efficacy during stimulation of humoral and cellmediated immune responses. J. Immune Based Ther. Vaccines 4, 5.
    • (2006) J. Immune Based Ther. Vaccines , vol.4 , pp. 5
    • Lim, S.Y.1    Meyer, M.2    Kjonaas, R.A.3    Ghosh, S.K.4
  • 54
    • 33750693040 scopus 로고    scopus 로고
    • Phytolbased novel adjuvants in vaccine formulation: 2 assessment of efficacy in the induction of protective immune responses to lethal bacterial infections in mice
    • Lim, S. Y., Bauermeister, A., Kjonaas, R. A.,and Ghosh,S. K. (2006b). Phytolbased novel adjuvants in vaccine formulation: 2 assessment of efficacy in the induction of protective immune responses to lethal bacterial infections in mice. J. Immune Based Ther. Vaccines 4, 5.
    • (2006) J. Immune Based Ther. Vaccines , vol.4 , pp. 5
    • Lim, S.Y.1    Bauermeister, A.2    Kjonaas, R.A.3    and Ghosh, S.K.4
  • 56
    • 0037308432 scopus 로고    scopus 로고
    • Stabilization of alumadjuvanted vaccine dry powder formulations: mechanism and application
    • Maa, Y. F., Zhao, L., Payne, L. G., and Chen, D. (2002). Stabilization of alumadjuvanted vaccine dry powder formulations: mechanism and application. J. Pharm. Sci. 92, 319-332.
    • (2002) J. Pharm. Sci. , vol.92 , pp. 319-332
    • Maa, Y.F.1    Zhao, L.2    Payne, L.G.3    Chen, D.4
  • 57
    • 34250697565 scopus 로고    scopus 로고
    • Modern synthetic efforts toward biologically active terpenes
    • Maimone, T. J., and Baran, P. S. (2007). Modern synthetic efforts toward biologically active terpenes. Nat. Chem. Biol. 3, 396-407.
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 396-407
    • Maimone, T.J.1    Baran, P.S.2
  • 58
    • 0019865489 scopus 로고
    • Instrumental neutron activation analysis of brain aluminum in Alzheimer disease and aging
    • Marchkesbery, W. R., Ehmann, W. D., Hossain, T. I., Alauddin, M., and Goodin, D. T. (1981). Instrumental neutron activation analysis of brain aluminum in Alzheimer disease and aging. Ann. Neurol. 10, 511-516.
    • (1981) Ann. Neurol. , vol.10 , pp. 511-516
    • Marchkesbery, W.R.1    Ehmann, W.D.2    Hossain, T.I.3    Alauddin, M.4    Goodin, D.T.5
  • 59
    • 0035106036 scopus 로고    scopus 로고
    • Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins
    • Marciani, D. J., Pathak, A. K., Reynolds, R. C., Seitz, L., and May, R. D. (2001). Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins. Int. Immunopharmacol. 1, 813-818.
    • (2001) Int. Immunopharmacol. , vol.1 , pp. 813-818
    • Marciani, D.J.1    Pathak, A.K.2    Reynolds, R.C.3    Seitz, L.4    May, R.D.5
  • 61
    • 63149126030 scopus 로고    scopus 로고
    • Towards an understanding of the adjuvant action of aluminium
    • Marrack, P., McKee, A. S., and Munks, M. W. (2009). Towards an understanding of the adjuvant action of aluminium. Nat. Rev. Immunol. 9, 287-293.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 287-293
    • Marrack, P.1    McKee, A.S.2    Munks, M.W.3
  • 63
    • 0033567960 scopus 로고    scopus 로고
    • Enhanced autoimmune arthritis in IFN-gamma receptordeficient mice is conditioned by mycobacteria in Freund's adjuvant and by increased expansion of Mac-1+ myeloid cells
    • Matthys, P., Vermeire, K., Mitera, T., Heremans, H., Huang, S., Schols, D., De Wolf-Peeters, C., and Billiau, A. (1999). Enhanced autoimmune arthritis in IFN-gamma receptordeficient mice is conditioned by mycobacteria in Freund's adjuvant and by increased expansion of Mac-1+ myeloid cells. J. Immunol. 163, 3503-3510.
    • (1999) J. Immunol. , vol.163 , pp. 3503-3510
    • Matthys, P.1    Vermeire, K.2    Mitera, T.3    Heremans, H.4    Huang, S.5    Schols, D.6    De Wolf-Peeters, C.7    Billiau, A.8
  • 64
    • 79953746668 scopus 로고    scopus 로고
    • Alum's adjuvant action: grease is the word
    • Mbow, M. L., De Gregorio, E., and Ulmer, J. B. (2011). Alum's adjuvant action: grease is the word. Nat. Med. 17, 415-416.
    • (2011) Nat. Med. , vol.17 , pp. 415-416
    • Mbow, M.L.1    De Gregorio, E.2    Ulmer, J.B.3
  • 65
    • 0025853517 scopus 로고
    • Prevention of insulitis and diabetes onset by treatment with complete Freund's adjuvant in NOD mice
    • McInerney, M. F., Pek, S. B., and Thomas, D. W. (1991). Prevention of insulitis and diabetes onset by treatment with complete Freund's adjuvant in NOD mice. Diabetes 40, 715-725.
    • (1991) Diabetes , vol.40 , pp. 715-725
    • McInerney, M.F.1    Pek, S.B.2    Thomas, D.W.3
  • 66
    • 77950652380 scopus 로고    scopus 로고
    • Immune mechanisms of protection: can adjuvants rise to the challenge?
    • doi:10.1186/1741-7007-8-37
    • McKee, A. S., MacLeod, M. K., Kappler, J. W., and Marrack, P. (2010). Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biol. 8, 37. doi:10.1186/1741-7007-8-37
    • (2010) BMC Biol , vol.8 , pp. 37
    • McKee, A.S.1    MacLeod, M.K.2    Kappler, J.W.3    Marrack, P.4
  • 67
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathwaydependent blockade of CD4+CD25+ T cellmediated suppression by dendritic cells
    • Medzhitov, R., and Pasare, C. (2003). Toll pathwaydependent blockade of CD4+CD25+ T cellmediated suppression by dendritic cells. Science 299, 1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Medzhitov, R.1    Pasare, C.2
  • 68
    • 3042736080 scopus 로고    scopus 로고
    • Studies of the isoprenoidmediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention
    • Mo, H., and Elson, C. E. (2004). Studies of the isoprenoidmediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention. Exp. Biol. Med. (Maywood) 229, 567-585.
    • (2004) Exp. Biol. Med. (Maywood) , vol.229 , pp. 567-585
    • Mo, H.1    Elson, C.E.2
  • 71
    • 77649095742 scopus 로고    scopus 로고
    • Prophylactic Administration of bacterially derived immunomodulators improves the outcome of influenza virus infection in a murine model
    • Norton, E. B., Clements, J. D., Voss, T. G., and Cárdenas-Freytag, L. (2010). Prophylactic Administration of bacterially derived immunomodulators improves the outcome of influenza virus infection in a murine model. J. Virol. 84, 2983-2995.
    • (2010) J. Virol. , vol.84 , pp. 2983-2995
    • Norton, E.B.1    Clements, J.D.2    Voss, T.G.3    Cárdenas-Freytag, L.4
  • 72
    • 0343114291 scopus 로고    scopus 로고
    • Adjuvant and haemolytic activities of 47 saponins derived from medicinal and food plants
    • Oda, K., Matsuda, H., Murakami, T., Katayama, S., Ohgitani, T., and Yoshikawa, M. (2000). Adjuvant and haemolytic activities of 47 saponins derived from medicinal and food plants. Biol. Chem. 381, 67-74.
    • (2000) Biol. Chem. , vol.381 , pp. 67-74
    • Oda, K.1    Matsuda, H.2    Murakami, T.3    Katayama, S.4    Ohgitani, T.5    Yoshikawa, M.6
  • 73
    • 33644892176 scopus 로고    scopus 로고
    • Lowdose intraperitoneal Freund's adjuvant: toxicity and immunogenicity in mice using an immunogen targeting amyloid-β peptide
    • Oscherwitz, J., Hankenson, F. C., Yu, F., and Cease, K. B. (2006). Lowdose intraperitoneal Freund's adjuvant: toxicity and immunogenicity in mice using an immunogen targeting amyloid-β peptide. Vaccine 24, 3018-3025.
    • (2006) Vaccine , vol.24 , pp. 3018-3025
    • Oscherwitz, J.1    Hankenson, F.C.2    Yu, F.3    Cease, K.B.4
  • 75
    • 8444245925 scopus 로고    scopus 로고
    • Tolldependent control mechanisms of CD4 T cell activation
    • Pasare, C., and Medzhitov, R. (2004). Tolldependent control mechanisms of CD4 T cell activation. Immunity 21, 733-741.
    • (2004) Immunity , vol.21 , pp. 733-741
    • Pasare, C.1    Medzhitov, R.2
  • 76
    • 0030953632 scopus 로고    scopus 로고
    • Roles of interferongamma and interleukin-4 in murine lupus
    • Peng, S. L., Moslehi, J., and Craft, J. (1997). Roles of interferongamma and interleukin-4 in murine lupus. J. Clin. Invest. 99, 1936-1946.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1936-1946
    • Peng, S.L.1    Moslehi, J.2    Craft, J.3
  • 77
    • 7044263390 scopus 로고    scopus 로고
    • Vaccine adjuvants: current state and future trends
    • Petrovsky, N., and Aguilar, J. C. (2004). Vaccine adjuvants: current state and future trends. Immunol. Cell Biol. 82, 488-496.
    • (2004) Immunol. Cell Biol. , vol.82 , pp. 488-496
    • Petrovsky, N.1    Aguilar, J.C.2
  • 78
    • 0021055623 scopus 로고
    • Wild potato repels aphids by release of aphid alarm pheromone
    • Pickett, J. A., and Gibson, R. W. (1983). Wild potato repels aphids by release of aphid alarm pheromone. Nature 302, 608-609.
    • (1983) Nature , vol.302 , pp. 608-609
    • Pickett, J.A.1    Gibson, R.W.2
  • 79
    • 3242758909 scopus 로고    scopus 로고
    • Complete Freunds adjuvantinduced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS
    • Raghavendra, V., Tanga, F. Y., and DeLeo, J. A. (2004). Complete Freunds adjuvantinduced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS. Eur. J. Neurosci. 20, 467-473.
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 467-473
    • Raghavendra, V.1    Tanga, F.Y.2    DeLeo, J.A.3
  • 81
    • 71649103780 scopus 로고    scopus 로고
    • Squalene: a natural triterpene for use in disease management and therapy
    • Reddy, L. H., and Couvreur, P. (2009). Squalene: a natural triterpene for use in disease management and therapy. Adv. Drug Deliv. Rev. 61, 1412-1426.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 1412-1426
    • Reddy, L.H.1    Couvreur, P.2
  • 82
    • 68949183471 scopus 로고    scopus 로고
    • Induction of autoimmunity by pristane and other naturallyoccurring hydrocarbons
    • Reeves, W. H., Lee, P. Y., Weinstein, J. S., Satoh, M., and Lu, L. (2009). Induction of autoimmunity by pristane and other naturallyoccurring hydrocarbons. Trends Immunol. 30, 455-464.
    • (2009) Trends Immunol , vol.30 , pp. 455-464
    • Reeves, W.H.1    Lee, P.Y.2    Weinstein, J.S.3    Satoh, M.4    Lu, L.5
  • 83
    • 0029083716 scopus 로고
    • Therapeutic potentiation of the immune system by costimulatory Schiffbaseforming drugs
    • Rhodes, J., Chen, H., Hall, S. R., Beesley, J. E., Jenkins, D. C., Collins, P., and Zheng, B. (1995). Therapeutic potentiation of the immune system by costimulatory Schiffbaseforming drugs. Nature 377, 71-75.
    • (1995) Nature , vol.377 , pp. 71-75
    • Rhodes, J.1    Chen, H.2    Hall, S.R.3    Beesley, J.E.4    Jenkins, D.C.5    Collins, P.6    Zheng, B.7
  • 84
    • 0025710317 scopus 로고
    • Prenylated proteins: the structure of the isoprenoid group
    • Rilling, H. C., Breunger, E., Epstein, W. W., and Crain, P. F. (1990). Prenylated proteins: the structure of the isoprenoid group. Science 247, 318-320.
    • (1990) Science , vol.247 , pp. 318-320
    • Rilling, H.C.1    Breunger, E.2    Epstein, W.W.3    Crain, P.F.4
  • 85
    • 0030857865 scopus 로고    scopus 로고
    • Lipopolysaccharide and monophosphoryl lipid A differentially regulate interleukin-12, gamma interferon, and interleukin-10 mRNA production in murine macrophages
    • Salkowski, C. A., Detore, G. R., and Vogel, S. N. (1997). Lipopolysaccharide and monophosphoryl lipid A differentially regulate interleukin-12, gamma interferon, and interleukin-10 mRNA production in murine macrophages. Infect. Immun. 65, 3239.
    • (1997) Infect. Immun. , vol.65 , pp. 3239
    • Salkowski, C.A.1    Detore, G.R.2    Vogel, S.N.3
  • 88
    • 45949083618 scopus 로고    scopus 로고
    • The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells
    • Seubert, A., Monaci, E., Pizza, M., O'Hagan, D. T., and Wack,A. (2008). The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells. J. Immunol. 180, 5402-5412.
    • (2008) J. Immunol. , vol.180 , pp. 5402-5412
    • Seubert, A.1    Monaci, E.2    Pizza, M.3    O'Hagan, D.T.4    Wack, A.5
  • 89
    • 0028948167 scopus 로고
    • Differential protein kinase C ligand regulation detected in vivo by a phenotypic Chowdhury and Ghosh Phytolderived novel isoprenoid immunostimulants yeast assay
    • Shieh, H. L., Hansen, H., Zhu, J., and Riedel, H. (1995). Differential protein kinase C ligand regulation detected in vivo by a phenotypic Chowdhury and Ghosh Phytolderived novel isoprenoid immunostimulants yeast assay. Mol. Carcinog. 12, 166-176.
    • (1995) Mol. Carcinog. , vol.12 , pp. 166-176
    • Shieh, H.L.1    Hansen, H.2    Zhu, J.3    Riedel, H.4
  • 90
    • 33748795114 scopus 로고    scopus 로고
    • Saponinadjuvanted particulate vaccines for clinical use
    • Skene, C. D., and Sutton, P. (2006). Saponinadjuvanted particulate vaccines for clinical use. Methods 40, 53-59.
    • (2006) Methods , vol.40 , pp. 53-59
    • Skene, C.D.1    Sutton, P.2
  • 91
    • 3242792378 scopus 로고    scopus 로고
    • In vivo generated Th1 cells can migrate to B cell follicles to support B cell responses
    • Smith, K. M., Brewer, J. M., Rush, C. M., Riley, J., and Garside, P. (2004). In vivo generated Th1 cells can migrate to B cell follicles to support B cell responses. J. Immunol. 173, 1640-1646.
    • (2004) J. Immunol. , vol.173 , pp. 1640-1646
    • Smith, K.M.1    Brewer, J.M.2    Rush, C.M.3    Riley, J.4    Garside, P.5
  • 92
    • 0028800377 scopus 로고
    • Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function
    • Soltysik, S., Wu, J. Y., Recchia, J., Wheeler, D. A., Newman, M. J., Coughlin, R. T., and Kensil, C. R. (1995). Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function. Vaccine 13, 1403-1410.
    • (1995) Vaccine , vol.13 , pp. 1403-1410
    • Soltysik, S.1    Wu, J.Y.2    Recchia, J.3    Wheeler, D.A.4    Newman, M.J.5    Coughlin, R.T.6    Kensil, C.R.7
  • 93
    • 67650470867 scopus 로고    scopus 로고
    • Adjuvant activities of saponins from traditional Chinese medicinal herbs
    • Song, X., and Hu, S. (2009). Adjuvant activities of saponins from traditional Chinese medicinal herbs. Vaccine 27, 4883-4890.
    • (2009) Vaccine , vol.27 , pp. 4883-4890
    • Song, X.1    Hu, S.2
  • 95
    • 4344587843 scopus 로고    scopus 로고
    • Biological activities and distribution of plant saponins
    • Sparg, S. G., Light, M. E., and van Staden, J. (2004). Biological activities and distribution of plant saponins. J. Ethnopharmacol. 94, 219-243.
    • (2004) J. Ethnopharmacol. , vol.94 , pp. 219-243
    • Sparg, S.G.1    Light, M.E.2    van Staden, J.3
  • 96
    • 0033562987 scopus 로고    scopus 로고
    • IL-1 Is an effective adjuvant for mucosal and systemic immune responses when coadministered with protein immunogens
    • Staats, H. F., and Ennis, F. A. Jr. (1999). IL-1 Is an effective adjuvant for mucosal and systemic immune responses when coadministered with protein immunogens. J. Immunol. 162, 6141-6147.
    • (1999) J. Immunol. , vol.162 , pp. 6141-6147
    • Staats, H.F.1    Ennis Jr., F.A.2
  • 97
    • 21044455622 scopus 로고    scopus 로고
    • Adjuvants and antibody production: dispelling the myths associated with Freund's complete and other adjuvants
    • Stills, H. F. Jr. (2005). Adjuvants and antibody production: dispelling the myths associated with Freund's complete and other adjuvants. ILAR J. 46, 280-293.
    • (2005) ILAR J , vol.46 , pp. 280-293
    • Stills Jr., H.F.1
  • 98
    • 0021847717 scopus 로고
    • Comparison of tissue reactions produced by Haemophilus pleuropneumoniae vaccines made with six different adjuvants in swine
    • Straw, B. E., MacLachlan, N. J., Cor-Bett, W. T., Carter, P. B., and Schey, H. M. (1985). Comparison of tissue reactions produced by Haemophilus pleuropneumoniae vaccines made with six different adjuvants in swine. Can. J. Comp. Med. 49, 149-151.
    • (1985) Can. J. Comp. Med. , vol.49 , pp. 149-151
    • Straw, B.E.1    MacLachlan, N.J.2    Cor-Bett, W.T.3    Carter, P.B.4    Schey, H.M.5
  • 99
    • 36248970136 scopus 로고    scopus 로고
    • Bacterial cell walls, innate immunity and immunoadjuvants
    • Strominger, J. L. (2007). Bacterial cell walls, innate immunity and immunoadjuvants. Nat. Immunol. 8, 1269-1271.
    • (2007) Nat. Immunol. , vol.8 , pp. 1269-1271
    • Strominger, J.L.1
  • 100
    • 61349084783 scopus 로고    scopus 로고
    • Advances in saponinbased adjuvants
    • Sun, H. X., Xie, Y., and Ye, Y. P. (2009). Advances in saponinbased adjuvants. Vaccine 27, 1787-1796.
    • (2009) Vaccine , vol.27 , pp. 1787-1796
    • Sun, H.X.1    Xie, Y.2    Ye, Y.P.3
  • 102
    • 84861024238 scopus 로고    scopus 로고
    • Terpenoids as potential chemopreventive and therapeutic agents in liver cancer
    • Thoppil, R. J., and Bishayee, A. (2011). Terpenoids as potential chemopreventive and therapeutic agents in liver cancer. WorldJ.Hepatol.3, 228-249.
    • (2011) WorldJ. Hepatol , vol.3 , pp. 228-249
    • Thoppil, R.J.1    Bishayee, A.2
  • 103
    • 0029852624 scopus 로고    scopus 로고
    • MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates
    • Traquina, P., Morandi, M., Contorni, M., and Van Nest, G. (1996). MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates. J. Infect. Dis. 174, 1168-1175.
    • (1996) J. Infect. Dis. , vol.174 , pp. 1168-1175
    • Traquina, P.1    Morandi, M.2    Contorni, M.3    Van Nest, G.4
  • 104
    • 0038087616 scopus 로고
    • Vaccine potentiation by emulsification with pure hydrocarbon compounds
    • Wilner, B. I., Evers, M. A., Troutman, H. D., Trader, F. W., and Mclean, I. W. (1963). Vaccine potentiation by emulsification with pure hydrocarbon compounds. J. Immunol. 91, 210-229.
    • (1963) J. Immunol. , vol.91 , pp. 210-229
    • Wilner, B.I.1    Evers, M.A.2    Troutman, H.D.3    Trader, F.W.4    Mclean, I.W.5
  • 106
    • 0034075607 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide acts as an adjuvant to induce autoimmune arthritis in mice
    • Yoshino, S., Sasatomi, E., and Ohsawa, M. (2000). Bacterial lipopolysaccharide acts as an adjuvant to induce autoimmune arthritis in mice. Immunology 4, 607-614.
    • (2000) Immunology , vol.4 , pp. 607-614
    • Yoshino, S.1    Sasatomi, E.2    Ohsawa, M.3
  • 107
    • 77950529044 scopus 로고    scopus 로고
    • Plant terpenoids: applications and future potentials
    • Zwenger, S., and Basu, C. (2008). Plant terpenoids: applications and future potentials. Biotechnol. Mol. Biol. Rev. 3, 1-7.
    • (2008) Biotechnol. Mol. Biol. Rev. , vol.3 , pp. 1-7
    • Zwenger, S.1    Basu, C.2


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