메뉴 건너뛰기




Volumn 27, Issue 36, 2009, Pages 4883-4890

Adjuvant activities of saponins from traditional Chinese medicinal herbs

Author keywords

Adjuvant; Medicinal herb; Saponin; Traditional Chinese medicine (TCM)

Indexed keywords

ANTIGEN; ASTRAGALOSIDE I; ASTRAGALOSIDE II; ASTRAGALOSIDE IV; ASTRAGALOSIDE VII; BRACHYOISIDE A; BRACHYOISIDE B; BRACHYOISIDE C; CYCLOCEPHALOSIDE I; CYCLOCEPHALOSIDE II; CYTOKINE; DNA VACCINE; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GINSENOSIDE RG 3; GINSENOSIDE RH 1; GINSENOSIDE RH 4; GLYCYRRHIZIC ACID; IMMUNOLOGICAL ADJUVANT; NOTOGINSENOSIDE; NOTOGINSENOSIDE R1; NOTOGINSENOSIDE R2; RECOMBINANT VACCINE; SAPONIN DERIVATIVE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 67650470867     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.06.033     Document Type: Review
Times cited : (126)

References (82)
  • 1
    • 0037686586 scopus 로고    scopus 로고
    • Recent advances in veterinary vaccine adjuvants
    • Singh M., and O'Hagan D.T. Recent advances in veterinary vaccine adjuvants. Int J Parasitol 33 May (5-6) (2003) 469-478
    • (2003) Int J Parasitol , vol.33 , Issue.May 5-6 , pp. 469-478
    • Singh, M.1    O'Hagan, D.T.2
  • 2
    • 0034826521 scopus 로고    scopus 로고
    • Recent developments in adjuvants for vaccines against infectious diseases
    • O'Hagan D.T., MacKichan M.L., and Singh M. Recent developments in adjuvants for vaccines against infectious diseases. Biomol Eng 18 October (3) (2001) 69-85
    • (2001) Biomol Eng , vol.18 , Issue.October 3 , pp. 69-85
    • O'Hagan, D.T.1    MacKichan, M.L.2    Singh, M.3
  • 3
    • 0030666222 scopus 로고    scopus 로고
    • Innate immunity: the virtues of a nonclonal system of recognition
    • Medzhitov R., and Janeway Jr. C.A. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91 October (3) (1997) 295-298
    • (1997) Cell , vol.91 , Issue.October 3 , pp. 295-298
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 4
    • 0029166358 scopus 로고
    • The nutritional and biological significance of saponins
    • Milgate J., and Roberts D.C.K. The nutritional and biological significance of saponins. Nutr Res 15 8 (1995) 1223-1248
    • (1995) Nutr Res , vol.15 , Issue.8 , pp. 1223-1248
    • Milgate, J.1    Roberts, D.C.K.2
  • 6
    • 0029987783 scopus 로고    scopus 로고
    • Structure-function relationship among Quillaja saponins serving as excipients for nasal and ocular delivery of insulin
    • Pillion D.J., Amsden J.A., Kensil C.R., and Recchia J. Structure-function relationship among Quillaja saponins serving as excipients for nasal and ocular delivery of insulin. J Pharm Sci 85 May (5) (1996) 518-524
    • (1996) J Pharm Sci , vol.85 , Issue.May 5 , pp. 518-524
    • Pillion, D.J.1    Amsden, J.A.2    Kensil, C.R.3    Recchia, J.4
  • 7
    • 0141889064 scopus 로고    scopus 로고
    • Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity
    • Marciani D.J. Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity. Drug Discov Today 8 October (20) (2003) 934-943
    • (2003) Drug Discov Today , vol.8 , Issue.October 20 , pp. 934-943
    • Marciani, D.J.1
  • 8
    • 0030249914 scopus 로고    scopus 로고
    • Covalent chemical events in immune induction: fundamental and therapeutic aspects
    • Rhodes J. Covalent chemical events in immune induction: fundamental and therapeutic aspects. Immunol Today 17 September (9) (1996) 436-441
    • (1996) Immunol Today , vol.17 , Issue.September 9 , pp. 436-441
    • Rhodes, J.1
  • 9
    • 0025310910 scopus 로고
    • Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs
    • Takahashi H., Takeshita T., Morein B., Putney S., Germain R.N., and Berzofsky J.A. Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs. Nature 344 April (6269) (1990) 873-875
    • (1990) Nature , vol.344 , Issue.April 6269 , pp. 873-875
    • Takahashi, H.1    Takeshita, T.2    Morein, B.3    Putney, S.4    Germain, R.N.5    Berzofsky, J.A.6
  • 10
    • 0028800377 scopus 로고
    • Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function
    • Soltysik S., Wu J.Y., Recchia J., Wheeler D.A., Newman M.J., Coughlin R.T., et al. Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function. Vaccine 13 15 (1995) 1403-1410
    • (1995) Vaccine , vol.13 , Issue.15 , pp. 1403-1410
    • Soltysik, S.1    Wu, J.Y.2    Recchia, J.3    Wheeler, D.A.4    Newman, M.J.5    Coughlin, R.T.6
  • 11
    • 0026033441 scopus 로고
    • Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex
    • Kensil C.R., Patel U., Lennick M., and Marciani D. Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex. J Immunol 146 2 (1991) 431-437
    • (1991) J Immunol , vol.146 , Issue.2 , pp. 431-437
    • Kensil, C.R.1    Patel, U.2    Lennick, M.3    Marciani, D.4
  • 12
    • 2942585110 scopus 로고    scopus 로고
    • Protective vaccination against murine visceral leishmaniasis using aldehyde-containing Quillaja saponaria sapogenins
    • Palatnik de Sousa C.B., Santos W.R., Casas C.P., Paraguai de Souza E., Tinoco L.W., da Silva B.P., et al. Protective vaccination against murine visceral leishmaniasis using aldehyde-containing Quillaja saponaria sapogenins. Vaccine 22 19 (2004) 2470-2479
    • (2004) Vaccine , vol.22 , Issue.19 , pp. 2470-2479
    • Palatnik de Sousa, C.B.1    Santos, W.R.2    Casas, C.P.3    Paraguai de Souza, E.4    Tinoco, L.W.5    da Silva, B.P.6
  • 13
    • 33845222410 scopus 로고    scopus 로고
    • Assessment of the monoterpene, glycidic and triterpene-moieties' contributions to the adjuvant function of the CP05 saponin of Calliandra pulcherrima Benth during vaccination against experimental visceral leishmaniasis
    • Nico D., Santos F.N., Borja-Cabrera G.P., Palatnik M., and Palatnik de Sousa C.B. Assessment of the monoterpene, glycidic and triterpene-moieties' contributions to the adjuvant function of the CP05 saponin of Calliandra pulcherrima Benth during vaccination against experimental visceral leishmaniasis. Vaccine 25 January (4) (2007) 649-658
    • (2007) Vaccine , vol.25 , Issue.January 4 , pp. 649-658
    • Nico, D.1    Santos, F.N.2    Borja-Cabrera, G.P.3    Palatnik, M.4    Palatnik de Sousa, C.B.5
  • 14
    • 11144258881 scopus 로고    scopus 로고
    • Pulcherrimasaponin, from the leaves of Calliandra pulcherrima, as adjuvant for immunization in the murine model of visceral leishmaniasis
    • Silva B.P., Soares J.B., Souza E.P., Palatnik M., Sousa C.B., and Parente J.P. Pulcherrimasaponin, from the leaves of Calliandra pulcherrima, as adjuvant for immunization in the murine model of visceral leishmaniasis. Vaccine 23 January (8) (2005) 1061-1071
    • (2005) Vaccine , vol.23 , Issue.January 8 , pp. 1061-1071
    • Silva, B.P.1    Soares, J.B.2    Souza, E.P.3    Palatnik, M.4    Sousa, C.B.5    Parente, J.P.6
  • 15
    • 0035898945 scopus 로고    scopus 로고
    • Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21
    • Waite D.C., Jacobson E.W., Ennis F.A., Edelman R., White B., Kammer R., et al. Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21. Vaccine 19 July (8-29) (2001) 3957-3967
    • (2001) Vaccine , vol.19 , Issue.July 8-29 , pp. 3957-3967
    • Waite, D.C.1    Jacobson, E.W.2    Ennis, F.A.3    Edelman, R.4    White, B.5    Kammer, R.6
  • 16
    • 0026655265 scopus 로고
    • Vaccination of dogs against Babesia canis infection using parasite antigens from in vitro culture
    • Schetters T.P., Kleuskens J., Scholtes N., and Bos H.J. Vaccination of dogs against Babesia canis infection using parasite antigens from in vitro culture. Parasite Immunol 14 May (3) (1992) 295-305
    • (1992) Parasite Immunol , vol.14 , Issue.May 3 , pp. 295-305
    • Schetters, T.P.1    Kleuskens, J.2    Scholtes, N.3    Bos, H.J.4
  • 17
    • 33846625531 scopus 로고    scopus 로고
    • Immunity against Babesia rossi infection in dogs vaccinated with antigens from culture supernatants
    • Schetters T.P., Strydom T., Crafford D., Kleuskens J.A., van de Crommert J., and Vermeulen A.N. Immunity against Babesia rossi infection in dogs vaccinated with antigens from culture supernatants. Vet Parasitol 144 March (1-2) (2007) 10-19
    • (2007) Vet Parasitol , vol.144 , Issue.March 1-2 , pp. 10-19
    • Schetters, T.P.1    Strydom, T.2    Crafford, D.3    Kleuskens, J.A.4    van de Crommert, J.5    Vermeulen, A.N.6
  • 18
    • 0035106036 scopus 로고    scopus 로고
    • Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins
    • Marciani D.J., Pathak A.K., Reynolds R.C., Seitz L., and May R.D. Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins. Int Immunopharmacol 1 April (4) (2001) 813-818
    • (2001) Int Immunopharmacol , vol.1 , Issue.April 4 , pp. 813-818
    • Marciani, D.J.1    Pathak, A.K.2    Reynolds, R.C.3    Seitz, L.4    May, R.D.5
  • 19
    • 33846972027 scopus 로고    scopus 로고
    • Safety trial using the Leishmune vaccine against canine visceral leishmaniasis in Brazil
    • Parra L.E., Borja-Cabrera G.P., Santos F.N., Souza L.O., Palatnik-de-Sousa C.B., and Menz I. Safety trial using the Leishmune vaccine against canine visceral leishmaniasis in Brazil. Vaccine 25 March (12) (2007) 2180-2186
    • (2007) Vaccine , vol.25 , Issue.March 12 , pp. 2180-2186
    • Parra, L.E.1    Borja-Cabrera, G.P.2    Santos, F.N.3    Souza, L.O.4    Palatnik-de-Sousa, C.B.5    Menz, I.6
  • 20
    • 33845595321 scopus 로고    scopus 로고
    • Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice
    • Sun J., Hu S., and Song X. Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice. Vaccine 25 January (6) (2007) 1114-1120
    • (2007) Vaccine , vol.25 , Issue.January 6 , pp. 1114-1120
    • Sun, J.1    Hu, S.2    Song, X.3
  • 21
    • 0021684153 scopus 로고
    • Immunomodulatory effects of Panax ginseng C.A. Meyer in the mouse
    • Jie Y.H., Cammisuli S., and Baggiolini M. Immunomodulatory effects of Panax ginseng C.A. Meyer in the mouse. Agents Actions 15 October (3-4) (1984) 386-391
    • (1984) Agents Actions , vol.15 , Issue.October 3-4 , pp. 386-391
    • Jie, Y.H.1    Cammisuli, S.2    Baggiolini, M.3
  • 22
    • 0025681804 scopus 로고
    • Immunomodulating activity of ginsenoside Rg1 from Panax ginseng
    • Kenarova B., Neychev H., Hadjiivanova C., and Petkov V.D. Immunomodulating activity of ginsenoside Rg1 from Panax ginseng. Jpn J Pharmacol 54 December (4) (1990) 447-454
    • (1990) Jpn J Pharmacol , vol.54 , Issue.December 4 , pp. 447-454
    • Kenarova, B.1    Neychev, H.2    Hadjiivanova, C.3    Petkov, V.D.4
  • 23
    • 0037427999 scopus 로고    scopus 로고
    • Ginseng extract in aluminium hydroxide adjuvanted vaccines improves the antibody response of pigs to porcine parvovirus and Erysipelothrix rhusiopathiae
    • Rivera E., Daggfeldt A., and Hu S. Ginseng extract in aluminium hydroxide adjuvanted vaccines improves the antibody response of pigs to porcine parvovirus and Erysipelothrix rhusiopathiae. Vet Immunol Immunopathol 91 January (10) (2003) 19-27
    • (2003) Vet Immunol Immunopathol , vol.91 , Issue.January 10 , pp. 19-27
    • Rivera, E.1    Daggfeldt, A.2    Hu, S.3
  • 24
    • 2942541216 scopus 로고    scopus 로고
    • Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken
    • Kong X., Hu Y., Rui R., Wang D., and Li X. Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken. Int Immunopharmacol 4 July (7) (2004) 975-982
    • (2004) Int Immunopharmacol , vol.4 , Issue.July 7 , pp. 975-982
    • Kong, X.1    Hu, Y.2    Rui, R.3    Wang, D.4    Li, X.5
  • 25
    • 0037424160 scopus 로고    scopus 로고
    • Ginseng and aluminium hydroxide act synergistically as vaccine adjuvants
    • Rivera E., Hu S., and Concha C. Ginseng and aluminium hydroxide act synergistically as vaccine adjuvants. Vaccine 21 March (11-12) (2003) 1149-1157
    • (2003) Vaccine , vol.21 , Issue.March 11-12 , pp. 1149-1157
    • Rivera, E.1    Hu, S.2    Concha, C.3
  • 26
    • 40449126802 scopus 로고    scopus 로고
    • Rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB/c mice
    • Sun J., Song X., Hu S., and Ginsenoside. Rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB/c mice. Clin Vaccine Immunol 15 February (2) (2008) 303-307
    • (2008) Clin Vaccine Immunol , vol.15 , Issue.February 2 , pp. 303-307
    • Sun, J.1    Song, X.2    Hu, S.3    Ginsenoside4
  • 27
    • 0037428002 scopus 로고    scopus 로고
    • Adjuvant effect of ginseng extracts on the immune responses to immunisation against Staphylococcus aureus in dairy cattle
    • Hu S., Concha C., Lin F., and Persson Waller K. Adjuvant effect of ginseng extracts on the immune responses to immunisation against Staphylococcus aureus in dairy cattle. Vet Immunol Immunopathol 91 January (1) (2003) 29-37
    • (2003) Vet Immunol Immunopathol , vol.91 , Issue.January 1 , pp. 29-37
    • Hu, S.1    Concha, C.2    Lin, F.3    Persson Waller, K.4
  • 28
    • 56949095962 scopus 로고    scopus 로고
    • Ginseng stem-leaf saponins (GSLS) and mineral oil act synergistically to enhance the immune responses to vaccination against foot-and-mouth disease in mice
    • Song X., Bao S., Wu L., and Hu S. Ginseng stem-leaf saponins (GSLS) and mineral oil act synergistically to enhance the immune responses to vaccination against foot-and-mouth disease in mice. Vaccine 27 January (1) (2009) 51-55
    • (2009) Vaccine , vol.27 , Issue.January 1 , pp. 51-55
    • Song, X.1    Bao, S.2    Wu, L.3    Hu, S.4
  • 29
    • 27644546643 scopus 로고    scopus 로고
    • The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response
    • Rivera E., Ekholm Pettersson F., Inganas M., Paulie S., and Gronvik K.O. The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response. Vaccine 23 November (46-47) (2005) 5411-5419
    • (2005) Vaccine , vol.23 , Issue.November 46-47 , pp. 5411-5419
    • Rivera, E.1    Ekholm Pettersson, F.2    Inganas, M.3    Paulie, S.4    Gronvik, K.O.5
  • 30
    • 9644300893 scopus 로고    scopus 로고
    • Effects of triterpene saponins from Astragalus species on in vitro cytokine release
    • Yesilada E., Bedir E., Calis I., Takaishi Y., and Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J Ethnopharmacol 96 January (1-2) (2005) 71-77
    • (2005) J Ethnopharmacol , vol.96 , Issue.January 1-2 , pp. 71-77
    • Yesilada, E.1    Bedir, E.2    Calis, I.3    Takaishi, Y.4    Ohmoto, Y.5
  • 31
    • 25144454868 scopus 로고    scopus 로고
    • Haemolytic activities and adjuvant effect of Astragalus membranaceus saponins (AMS) on the immune responses to ovalbumin in mice
    • Yang Z.G., Sun H.X., and Fang W.H. Haemolytic activities and adjuvant effect of Astragalus membranaceus saponins (AMS) on the immune responses to ovalbumin in mice. Vaccine 23 October (44) (2005) 5196-5203
    • (2005) Vaccine , vol.23 , Issue.October 44 , pp. 5196-5203
    • Yang, Z.G.1    Sun, H.X.2    Fang, W.H.3
  • 32
    • 0031414682 scopus 로고    scopus 로고
    • Immunomodulating activity of Chinese medicinal herbs and Oldenlandia diffusa in particular
    • Yoshida Y., Wang M.Q., Liu J.N., Shan B.E., and Yamashita U. Immunomodulating activity of Chinese medicinal herbs and Oldenlandia diffusa in particular. Int J Immunopharmacol 19 July (7) (1997) 359-370
    • (1997) Int J Immunopharmacol , vol.19 , Issue.July 7 , pp. 359-370
    • Yoshida, Y.1    Wang, M.Q.2    Liu, J.N.3    Shan, B.E.4    Yamashita, U.5
  • 33
    • 0033914963 scopus 로고    scopus 로고
    • Immunostimulatory effects of cycloartane-type triterpene glycosides from astragalus species
    • Bedir E., Pugh N., Calis I., Pasco D.S., and Khan I.A. Immunostimulatory effects of cycloartane-type triterpene glycosides from astragalus species. Biol Pharm Bull 23 July (7) (2000) 834-837
    • (2000) Biol Pharm Bull , vol.23 , Issue.July 7 , pp. 834-837
    • Bedir, E.1    Pugh, N.2    Calis, I.3    Pasco, D.S.4    Khan, I.A.5
  • 34
    • 0037296911 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats
    • Xu Q.F., Fang X.L., and Chen D.F. Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats. J Ethnopharmacol 84 February (2-3) (2003) 187-192
    • (2003) J Ethnopharmacol , vol.84 , Issue.February 2-3 , pp. 187-192
    • Xu, Q.F.1    Fang, X.L.2    Chen, D.F.3
  • 36
    • 4444310289 scopus 로고    scopus 로고
    • Adjuvant effect of Panax notoginseng saponins on the immune responses to ovalbumin in mice
    • Sun H.X., Ye Y.P., Pan H.J., and Pan Y.J. Adjuvant effect of Panax notoginseng saponins on the immune responses to ovalbumin in mice. Vaccine 22 September (29-30) (2004) 3882-3889
    • (2004) Vaccine , vol.22 , Issue.September 29-30 , pp. 3882-3889
    • Sun, H.X.1    Ye, Y.P.2    Pan, H.J.3    Pan, Y.J.4
  • 37
    • 18844433862 scopus 로고    scopus 로고
    • Immunological-Adjuvant Saponins from the Roots of Panax notoginseng
    • Sun H., Ye Y., and Pan H.J. Immunological-Adjuvant Saponins from the Roots of Panax notoginseng. Chem Biodivers 2 April (4) (2005) 510-515
    • (2005) Chem Biodivers , vol.2 , Issue.April 4 , pp. 510-515
    • Sun, H.1    Ye, Y.2    Pan, H.J.3
  • 38
    • 28444457369 scopus 로고    scopus 로고
    • biological activity of protopanaxatriol-type saponins from the roots of Panax notoginseng
    • Sun H., Yang Z., Ye Y., and Structure. biological activity of protopanaxatriol-type saponins from the roots of Panax notoginseng. Int Immunopharmacol 6 January (1) (2006) 14-25
    • (2006) Int Immunopharmacol , vol.6 , Issue.January 1 , pp. 14-25
    • Sun, H.1    Yang, Z.2    Ye, Y.3    Structure4
  • 39
    • 27744578514 scopus 로고    scopus 로고
    • Relationship between haemolytic and adjuvant activity and structure of protopanaxadiol-type saponins from the roots of Panax notoginseng
    • Sun H.X., Qin F., and Ye Y.P. Relationship between haemolytic and adjuvant activity and structure of protopanaxadiol-type saponins from the roots of Panax notoginseng. Vaccine 23 December (48-49) (2005) 5533-5542
    • (2005) Vaccine , vol.23 , Issue.December 48-49 , pp. 5533-5542
    • Sun, H.X.1    Qin, F.2    Ye, Y.P.3
  • 40
    • 0021978923 scopus 로고
    • Studies on the constituents of Momordica cochinchinensis SPRENG. II: Isolation and characterization of the root saponins, momordins I, II and III
    • Iwamoto M., Okabe H., and Yamauchi T. Studies on the constituents of Momordica cochinchinensis SPRENG. II: Isolation and characterization of the root saponins, momordins I, II and III. Chem Pharm Bull 33 1 (1985) 1-7
    • (1985) Chem Pharm Bull , vol.33 , Issue.1 , pp. 1-7
    • Iwamoto, M.1    Okabe, H.2    Yamauchi, T.3
  • 41
    • 34250617059 scopus 로고    scopus 로고
    • Adjuvant effect of an extract from Cochinchina momordica seeds on the immune responses to ovalbumin in mice
    • Xiao C.W., Hu S., and Rajput Z.I. Adjuvant effect of an extract from Cochinchina momordica seeds on the immune responses to ovalbumin in mice. Front Agric China 1 1 (2007) 90-95
    • (2007) Front Agric China , vol.1 , Issue.1 , pp. 90-95
    • Xiao, C.W.1    Hu, S.2    Rajput, Z.I.3
  • 42
    • 38049077896 scopus 로고    scopus 로고
    • Enhancement of serological immune responses to foot-and-mouth disease vaccine by a supplement made of extract of Cochinchina momordica seeds
    • Xiao C., Rajput Z.I., Liu D., and Hu S. Enhancement of serological immune responses to foot-and-mouth disease vaccine by a supplement made of extract of Cochinchina momordica seeds. Clin vaccine Immunol: CVI 14 12 (2007) 1634-1639
    • (2007) Clin vaccine Immunol: CVI , vol.14 , Issue.12 , pp. 1634-1639
    • Xiao, C.1    Rajput, Z.I.2    Liu, D.3    Hu, S.4
  • 43
    • 32544439349 scopus 로고    scopus 로고
    • Immunological adjuvant effect of Glycyrrhiza uralensis saponins on the immune responses to ovalbumin in mice
    • Sun H.X., and Pan H.J. Immunological adjuvant effect of Glycyrrhiza uralensis saponins on the immune responses to ovalbumin in mice. Vaccine 24 March (11) (2006) 1914-1920
    • (2006) Vaccine , vol.24 , Issue.March 11 , pp. 1914-1920
    • Sun, H.X.1    Pan, H.J.2
  • 44
    • 33645242521 scopus 로고    scopus 로고
    • Adjuvant effect of Achyranthes bidentata saponins on specific antibody and cellular response to ovalbumin in mice
    • Sun H.X. Adjuvant effect of Achyranthes bidentata saponins on specific antibody and cellular response to ovalbumin in mice. Vaccine 24 April (17) (2006) 3432-3439
    • (2006) Vaccine , vol.24 , Issue.April 17 , pp. 3432-3439
    • Sun, H.X.1
  • 45
    • 46149092981 scopus 로고    scopus 로고
    • A promising balanced Th1 and Th2 directing immunological adjuvant, saponins from the root of Platycodon grandiflorum
    • Xie Y., Pan H., Sun H., and Li D. A promising balanced Th1 and Th2 directing immunological adjuvant, saponins from the root of Platycodon grandiflorum. Vaccine 26 July (31) (2008) 3937-3945
    • (2008) Vaccine , vol.26 , Issue.July 31 , pp. 3937-3945
    • Xie, Y.1    Pan, H.2    Sun, H.3    Li, D.4
  • 47
    • 0026504109 scopus 로고
    • Recent advances on ginseng research in China
    • Liu C.X., and Xiao P.G. Recent advances on ginseng research in China. J Ethnopharmacol 36 February (1) (1992) 27-38
    • (1992) J Ethnopharmacol , vol.36 , Issue.February 1 , pp. 27-38
    • Liu, C.X.1    Xiao, P.G.2
  • 48
    • 0019413728 scopus 로고
    • Ginseng: a pharmacological profile
    • Owen R.T. Ginseng: a pharmacological profile. Drugs Today 8 (1981) 343-351
    • (1981) Drugs Today , vol.8 , pp. 343-351
    • Owen, R.T.1
  • 49
    • 0030330575 scopus 로고    scopus 로고
    • Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold [corrected]
    • Scaglione F., Cattaneo G., Alessandria M., and Cogo R. Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold [corrected]. Drugs Exp Clin Res 22 2 (1996) 65-72
    • (1996) Drugs Exp Clin Res , vol.22 , Issue.2 , pp. 65-72
    • Scaglione, F.1    Cattaneo, G.2    Alessandria, M.3    Cogo, R.4
  • 51
    • 0025173264 scopus 로고
    • Panax ginseng as a potential immunomodulator: studies in mice
    • Kim J.Y., Germolec D.R., and Luster M.I. Panax ginseng as a potential immunomodulator: studies in mice. Immunopharmacol Immunotoxicol 12 2 (1990) 257-276
    • (1990) Immunopharmacol Immunotoxicol , vol.12 , Issue.2 , pp. 257-276
    • Kim, J.Y.1    Germolec, D.R.2    Luster, M.I.3
  • 52
    • 4844220475 scopus 로고    scopus 로고
    • Ginseng modulates the immune response by induction of interleukin-12 production
    • Larsen M.W., Moser C., Hoiby N., Song Z., and Kharazmi A. Ginseng modulates the immune response by induction of interleukin-12 production. APMIS 112 June (6) (2004) 369-373
    • (2004) APMIS , vol.112 , Issue.June 6 , pp. 369-373
    • Larsen, M.W.1    Moser, C.2    Hoiby, N.3    Song, Z.4    Kharazmi, A.5
  • 53
    • 0023497782 scopus 로고
    • Effect of red ginseng on natural killer cell activity in mice with lung adenoma induced by urethan and benzo(a)pyrene
    • Yun Y.S., Moon H.S., Oh Y.R., Jo S.K., Kim Y.J., and Yun T.K. Effect of red ginseng on natural killer cell activity in mice with lung adenoma induced by urethan and benzo(a)pyrene. Cancer Detect Prev Suppl 1 (1987) 301-309
    • (1987) Cancer Detect Prev Suppl , vol.1 , pp. 301-309
    • Yun, Y.S.1    Moon, H.S.2    Oh, Y.R.3    Jo, S.K.4    Kim, Y.J.5    Yun, T.K.6
  • 54
    • 0020600642 scopus 로고
    • Combined treatment of mice with Panax ginseng extract and interferon inducer. Amplification of host resistance to Semliki forest virus
    • Singh V.K., George C.X., Singh N., Agarwal S.S., and Gupta B.M. Combined treatment of mice with Panax ginseng extract and interferon inducer. Amplification of host resistance to Semliki forest virus. Planta Med 47 April (4) (1983) 234-236
    • (1983) Planta Med , vol.47 , Issue.April 4 , pp. 234-236
    • Singh, V.K.1    George, C.X.2    Singh, N.3    Agarwal, S.S.4    Gupta, B.M.5
  • 55
    • 0030581154 scopus 로고    scopus 로고
    • Sensitive high-performance liquid chromatographic method for the determination of a benzonaphthazepine antipsychotic agent, SCH, 39166 and its active metabolite SCH, 40853, in human plasma and its cross-validation with a gas chromatographic method
    • Lin C.C., Kim H.K., and Parker D. Sensitive high-performance liquid chromatographic method for the determination of a benzonaphthazepine antipsychotic agent, SCH, 39166 and its active metabolite SCH, 40853, in human plasma and its cross-validation with a gas chromatographic method. J Chromatogr B Biomed Appl 682 July (2) (1996) 309-313
    • (1996) J Chromatogr B Biomed Appl , vol.682 , Issue.July 2 , pp. 309-313
    • Lin, C.C.1    Kim, H.K.2    Parker, D.3
  • 57
    • 0030797894 scopus 로고    scopus 로고
    • A review of the pharmacology and toxicology of Astragalus
    • Rios J.L., and Waterman P.G. A review of the pharmacology and toxicology of Astragalus. Phytother Res 11 (1997) 411-418
    • (1997) Phytother Res , vol.11 , pp. 411-418
    • Rios, J.L.1    Waterman, P.G.2
  • 59
    • 0035209698 scopus 로고    scopus 로고
    • Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation
    • Verotta L., Guerrini M., El-Sebakhy N.A., Asaad A.M., Toaima S.M., Abou-Sheer M.E., et al. Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation. Fitoterapia 72 December (8) (2001) 894-905
    • (2001) Fitoterapia , vol.72 , Issue.December 8 , pp. 894-905
    • Verotta, L.1    Guerrini, M.2    El-Sebakhy, N.A.3    Asaad, A.M.4    Toaima, S.M.5    Abou-Sheer, M.E.6
  • 61
    • 0041703042 scopus 로고    scopus 로고
    • Isolation of dammarane saponins from Panax notoginseng by high-speed counter-current chromatography
    • Du Q., Jerz G., Waibel R., and Winterhalter P. Isolation of dammarane saponins from Panax notoginseng by high-speed counter-current chromatography. J Chromatogr A 1008 August (2) (2003) 173-180
    • (2003) J Chromatogr A , vol.1008 , Issue.August 2 , pp. 173-180
    • Du, Q.1    Jerz, G.2    Waibel, R.3    Winterhalter, P.4
  • 62
    • 0043022050 scopus 로고    scopus 로고
    • Analysis of saponins in raw and steamed Panax notoginseng using high-performance liquid chromatography with diode array detection
    • Lau A.J., Woo S.O., and Koh H.L. Analysis of saponins in raw and steamed Panax notoginseng using high-performance liquid chromatography with diode array detection. J Chromatogr A 1011 September (1-2) (2003) 77-87
    • (2003) J Chromatogr A , vol.1011 , Issue.September 1-2 , pp. 77-87
    • Lau, A.J.1    Woo, S.O.2    Koh, H.L.3
  • 64
    • 67650474255 scopus 로고    scopus 로고
    • Mu Bie Zi (Semen momordicae)
    • Gao X.M. (Ed), Traditional Chinese Materia Medica Press, Beijing
    • Gao X.M. Mu Bie Zi (Semen momordicae). In: Gao X.M. (Ed). Chinese materia medicia (2005), Traditional Chinese Materia Medica Press, Beijing 601-602
    • (2005) Chinese materia medicia , pp. 601-602
    • Gao, X.M.1
  • 65
    • 0037449105 scopus 로고    scopus 로고
    • Relationship between adjuvant activity and amphipathic structure of soyasaponins
    • Oda K., Matsuda H., Murakami T., Katayama S., Ohgitani T., and Yoshikawa M. Relationship between adjuvant activity and amphipathic structure of soyasaponins. Vaccine 21 May (17-18) (2003) 2145-2151
    • (2003) Vaccine , vol.21 , Issue.May 17-18 , pp. 2145-2151
    • Oda, K.1    Matsuda, H.2    Murakami, T.3    Katayama, S.4    Ohgitani, T.5    Yoshikawa, M.6
  • 66
    • 0343114291 scopus 로고    scopus 로고
    • Adjuvant and haemolytic activities of 47 saponins derived from medicinal and food plants
    • Oda K., Matsuda H., Murakami T., Katayama S., Ohgitani T., and Yoshikawa M. Adjuvant and haemolytic activities of 47 saponins derived from medicinal and food plants. Biol Chem 381 January (1) (2000) 67-74
    • (2000) Biol Chem , vol.381 , Issue.January 1 , pp. 67-74
    • Oda, K.1    Matsuda, H.2    Murakami, T.3    Katayama, S.4    Ohgitani, T.5    Yoshikawa, M.6
  • 68
    • 0033522941 scopus 로고    scopus 로고
    • Influence of antigenic forms and adjuvants on the IgG subclass antibody response to Aujeszky's disease virus in mice
    • Katayama S., Oda K., Ohgitani T., Hirahara T., and Shimizu Y. Influence of antigenic forms and adjuvants on the IgG subclass antibody response to Aujeszky's disease virus in mice. Vaccine 17 June (20-21) (1999) 2733-2739
    • (1999) Vaccine , vol.17 , Issue.June 20-21 , pp. 2733-2739
    • Katayama, S.1    Oda, K.2    Ohgitani, T.3    Hirahara, T.4    Shimizu, Y.5
  • 69
    • 18444365935 scopus 로고    scopus 로고
    • Medicinal foodstuffs. XIII. Saponin constituents with adjuvant activity from hyacinth bean, the seeds of Dolichos lablab L. (2): structures of lablabosides D, E, and F
    • Komatsu H., Murakami T., Matsuda H., and Yoshikawa M. Medicinal foodstuffs. XIII. Saponin constituents with adjuvant activity from hyacinth bean, the seeds of Dolichos lablab L. (2): structures of lablabosides D, E, and F. Heterocycles 48 4 (1998) 703-710
    • (1998) Heterocycles , vol.48 , Issue.4 , pp. 703-710
    • Komatsu, H.1    Murakami, T.2    Matsuda, H.3    Yoshikawa, M.4
  • 70
    • 0035860609 scopus 로고    scopus 로고
    • Onjisaponins, from the root of Polygala tenuifolia Willdenow, as effective adjuvants for nasal influenza and diphtheria-pertussis-tetanus vaccines
    • Nagai T., Suzuki Y., Kiyohara H., Susa E., Kato T., Nagamine T., et al. Onjisaponins, from the root of Polygala tenuifolia Willdenow, as effective adjuvants for nasal influenza and diphtheria-pertussis-tetanus vaccines. Vaccine 19 September (32) (2001) 4824-4834
    • (2001) Vaccine , vol.19 , Issue.September 32 , pp. 4824-4834
    • Nagai, T.1    Suzuki, Y.2    Kiyohara, H.3    Susa, E.4    Kato, T.5    Nagamine, T.6
  • 71
    • 0037150482 scopus 로고    scopus 로고
    • QS-21 structure/function studies: effect of acylation on adjuvant activity
    • Liu G., Anderson C., Scaltreto H., Barbon J., and Kensil C.R. QS-21 structure/function studies: effect of acylation on adjuvant activity. Vaccine 20 June (21-22) (2002) 2808-2815
    • (2002) Vaccine , vol.20 , Issue.June 21-22 , pp. 2808-2815
    • Liu, G.1    Anderson, C.2    Scaltreto, H.3    Barbon, J.4    Kensil, C.R.5
  • 72
    • 0036444201 scopus 로고    scopus 로고
    • Discovery of immunopotentiatory drugs: current and future strategies
    • Rhodes J. Discovery of immunopotentiatory drugs: current and future strategies. Clin Exp Immunol 130 December (3) (2002) 363-369
    • (2002) Clin Exp Immunol , vol.130 , Issue.December 3 , pp. 363-369
    • Rhodes, J.1
  • 73
    • 33646135059 scopus 로고    scopus 로고
    • Acylated and deacylated saponins of Quillaja saponaria mixture as adjuvants for the FML-vaccine against visceral leishmaniasis
    • Oliveira-Freitas E., Casas C.P., Borja-Cabrera G.P., Santos F.N., Nico D., Souza L.O., et al. Acylated and deacylated saponins of Quillaja saponaria mixture as adjuvants for the FML-vaccine against visceral leishmaniasis. Vaccine 24 May (18) (2006) 3909-3920
    • (2006) Vaccine , vol.24 , Issue.May 18 , pp. 3909-3920
    • Oliveira-Freitas, E.1    Casas, C.P.2    Borja-Cabrera, G.P.3    Santos, F.N.4    Nico, D.5    Souza, L.O.6
  • 74
    • 0141882443 scopus 로고    scopus 로고
    • Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100
    • Marciani D.J., Reynolds R.C., Pathak A.K., Finley-Woodman K., and May R.D. Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100. Vaccine 21 September (25-26) (2003) 3961-3971
    • (2003) Vaccine , vol.21 , Issue.September 25-26 , pp. 3961-3971
    • Marciani, D.J.1    Reynolds, R.C.2    Pathak, A.K.3    Finley-Woodman, K.4    May, R.D.5
  • 75
    • 27144439257 scopus 로고    scopus 로고
    • Antioxidative effect of a chymotrypsin inhibitor from Momordica cochinchinensis (Cucurbitaceae) seeds in a primary rat hepatocyte culture
    • Tsoi A.Y., Ng T.B., and Fong W.P. Antioxidative effect of a chymotrypsin inhibitor from Momordica cochinchinensis (Cucurbitaceae) seeds in a primary rat hepatocyte culture. J Pept Sci 11 October (10) (2005) 665-668
    • (2005) J Pept Sci , vol.11 , Issue.October 10 , pp. 665-668
    • Tsoi, A.Y.1    Ng, T.B.2    Fong, W.P.3
  • 76
    • 37049052069 scopus 로고
    • Action of saponins on biological membranes
    • Glaueri A.M., Dingle J.T., and Lucy J.A. Action of saponins on biological membranes. Nature 196 (1962) 953
    • (1962) Nature , vol.196 , pp. 953
    • Glaueri, A.M.1    Dingle, J.T.2    Lucy, J.A.3
  • 77
    • 0035925595 scopus 로고    scopus 로고
    • Immune responses to ISCOM formulations in animal and primate models
    • Sjolander A., Drane D., Maraskovsky E., Scheerlinck J.P., Suhrbier A., Tennent J., et al. Immune responses to ISCOM formulations in animal and primate models. Vaccine 19 March (17-19) (2001) 2661-2665
    • (2001) Vaccine , vol.19 , Issue.March 17-19 , pp. 2661-2665
    • Sjolander, A.1    Drane, D.2    Maraskovsky, E.3    Scheerlinck, J.P.4    Suhrbier, A.5    Tennent, J.6
  • 78
    • 1342330633 scopus 로고    scopus 로고
    • Panax ginseng induces production of proinflammatory cytokines via toll-like receptor
    • Nakaya T.A., Kita M., Kuriyama H., Iwakura Y., and Imanishi J. Panax ginseng induces production of proinflammatory cytokines via toll-like receptor. J Interf Cytok Res 24 February (2) (2004) 93-100
    • (2004) J Interf Cytok Res , vol.24 , Issue.February 2 , pp. 93-100
    • Nakaya, T.A.1    Kita, M.2    Kuriyama, H.3    Iwakura, Y.4    Imanishi, J.5
  • 79
    • 0037435928 scopus 로고    scopus 로고
    • Liposomes and ISCOMs
    • Kersten G.F., and Crommelin D.J. Liposomes and ISCOMs. Vaccine 21 February (9-10) (2003) 915-920
    • (2003) Vaccine , vol.21 , Issue.February 9-10 , pp. 915-920
    • Kersten, G.F.1    Crommelin, D.J.2
  • 80
    • 9244230047 scopus 로고    scopus 로고
    • ISCOMATRIX adjuvant for antigen delivery
    • Pearse M.J., and Drane D. ISCOMATRIX adjuvant for antigen delivery. Adv Drug Deliv Rev 57 January (3) (2005) 465-474
    • (2005) Adv Drug Deliv Rev , vol.57 , Issue.January 3 , pp. 465-474
    • Pearse, M.J.1    Drane, D.2
  • 82
    • 33746931698 scopus 로고    scopus 로고
    • On the preparation, microscopic investigation and application of ISCOMs
    • Myschik J., Lendemans D.G., McBurney W.T., Demana P.H., Hook S., and Rades T. On the preparation, microscopic investigation and application of ISCOMs. Micron 37 8 (2006) 724-734
    • (2006) Micron , vol.37 , Issue.8 , pp. 724-734
    • Myschik, J.1    Lendemans, D.G.2    McBurney, W.T.3    Demana, P.H.4    Hook, S.5    Rades, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.