Molecular signatures of phytol-derived immunostimulants in the context of chemokine-cytokine microenvironment and enhanced immune response

Cellular Immunology

Volumn 271, Issue 2, 2011, Pages 227-238

  Aachoui, Youssef ^a   Chowdhury, Roshni Roy ^a   Fitch, Richard W ^a   Ghosh, Swapan K ^a  

^a INDIANA STATE UNIVERSITY   (United States)

Author keywords

Chemokine cytokine signatures; Inflammasome; Nod like receptors; Phytol based immunostimulant

Indexed keywords

CD30 LIGAND; CXCL1 CHEMOKINE; CYTOKINE; EOTAXIN; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GAMMA INTERFERON; IMMUNOSTIMULATING AGENT; INFLAMMASOME; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 9; MACROPHAGE INFLAMMATORY PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 1; PHIS 01; PHIS 02; PHIS 03; PHYTANOL; PHYTANYL AMNE; PHYTANYL MANNOSE; PHYTOL; RANTES; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELL MOTILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SOLUBILITY; FEMALE; GENE EXPRESSION REGULATION; HUMORAL IMMUNITY; IMMUNOSTIMULATION; MICROARRAY ANALYSIS; MICROENVIRONMENT; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PERITONEAL FLUID; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ASCITIC FLUID; CARRIER PROTEINS; CELLULAR MICROENVIRONMENT; CHEMOKINES; CYTOKINES; FEMALE; IMMUNITY, INNATE; INFLAMMASOMES; MICE; MICE, INBRED BALB C; PHYTOL; PROTEIN ARRAY ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTIONAL ACTIVATION;

MUS;

EID: 80054019355     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2011.07.001     Document Type: Article

References (47)

1. Zanin-Zhorov A., Tal-Lapidot G., Cahalon L., Cohen-Sfady M., Pevsner-Fischer M., Lider O., Cohen I.R. Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signaling. J. Immunol. 2007, 179:41-44.
2. Baldridge J.R., McGowan P., Evans J.T., Cluff C., Mossman S., Johnson D., Persing D. Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents. Expert Opini. Biological Therapy 2004, 4:1129-1138.
3. Benko S., Philpott D.J., Girardin S.E. The microbial and danger signals that activate Nod-like receptors. Cytokine 2008, 43:368-373.
4. Ishii K.J., Akira S. Toll or toll-free adjuvant path toward the optimal vaccine development. J. Clin. Immunol. 2007, 27:363-371.
5. Kool M., Pétrilli V., De Smedt T., Rolaz A., Hammad H., van Nimwegen M., Bergen I.M., Castillo R., Lambrecht B.N., Tschopp J. Cutting edge: Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J. Immunol. 2008, 181:3755-3759.
6. Seubert A., Monaci E., Pizza M., O'Hagan D.T., Wack A. The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells. J. Immunol. 2008, 180:5402-5412.
7. Morel S., Didierlaurent A., Bourguignon P., Delhaye S., Baras B., Jacob V., Planty C., Elouahabi A., Harvengt P., Carlsen H., Kielland A., Chomez P., Garçon N., Van Mechelen M. Adjuvant System AS03 containing [alpha]-tocopherol modulates innate immune response and leads to improved adaptive immunity. Vaccine 2011, 29:2461-2473.
8. Kool M., Soullie T., van Nimwegen M., Willart M.A., Muskens F., Jung S., Hoogsteden H.C., Hammad H., Lambrecht B.N. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J. Exp. Med. 2008, 205:869-882.
9. Mosca F., Tritto E., Muzzi A., Monaci E., Bagnoli F., Iavarone C., O'Hagan D., Rappuoli R., De Gregorio E. Molecular and cellular signatures of human vaccine adjuvants. Proc. Nat. Acad. Sci. 2008, 105:10501-10506.
10. Calabro S., Tortoli M., Baudner B.C., Pacitto A., Cortese M., O'Hagan D.T., De Gregorio E., Seubert A., Wack A. Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes. Vaccine 2011, 29:1812-1823.
11. Jellum E., Eldjarn L., Try K. Conversion of phytol into dihydrophytol and phytanic acid. Acta Chem. Scand. 1966, 20:2535-2538.
12. Bendavid A., Burns C.J., Field L.D., Hashimoto K., Ridley D.D., Sandanayake K.R., Wieczorek L. Solution- and solid-phase synthesis of components for tethered bilayer membranes. J. Org. Chem. 2001, 66:3709-3716.
13. Schmidt RR M.J. Facile synthesis of α- and β-0-glycosyl imidates. Preparation of glycosides and disaccharides'. Angew. Chem. Int. Ed. Engl. 1980, 19:731-732.
14. S.K. Ghosh, Phytol-derived immunoadjuvants and their use in vaccine formulations, US patent Application #11/295131.
15. Lim S.Y., Meyer M., Kjonaas R.A., Ghosh S.K. Phytol-based novel adjuvants in vaccine formulation: 1. Assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses. J. Immune Based Ther. Vaccines 2006, 4:6.
16. Lim S.Y., Bauermeister A., Kjonaas R.A., Ghosh S.K. Phytol-based novel adjuvants in vaccine formulation: 2. Assessment of efficacy in the induction of protective immune responses to lethal bacterial infections in mice. J. Immune Based Ther. Vaccines 2006, 4:5.
17. Y. Aachoui, M. Schulte, R. Fitch, and, S. Ghosh,. Synthetic adjuvants for vaccine formulations: Evaluation of new phytol derivatives in induction and persistence of specific immune response, Cell. Immund., in press.
18. Abramoff M.D., Magelhaes P.J., Ram S.J. Image processing with Image. J Biophotonics Int. 2004, 11:36-42.
19. Sallusto F., Baggiolini M. Chemokines and leukocyte traffic. Nat. Immunol. 2008, 9:949-952.
20. Ansel K.M., Harris R.B.S., Cyster J.G. CXCL13 is required for B1 cell homing. Natural antibody production, and body cavity immunity. Immunity 2002, 16:67-76.
21. Shimizu M., Tomoo T. Anti-inflammatory constituents of topically applied crude drugs V. Constituents and anti-inflammatory effect of Aoki, Aucuba japonica Thunb. Biol. Pharm. Bull. 1994, 17:665-667.
22. Mackie J.T., Atshaves B.P., Payne H.R., McIntosh A.L., Schroeder F., Kier A.B. Phytol-induced hepatotoxicity in mice. Toxicol. Pathol. 2009, 37:201-208.
23. Aachoui Y., Ghosh S.K. Novel phytol-based adjuvants in vaccine formulations: Evaluation of safety and efficacy in induction and persistence of specific immune responses. J. Immunol. 2009, 182:41-64.
24. Boring L., Gosling J., Chensue S.W., Kunkel S.L., Farese R.V., Broxmeyer H.E., Charo I.F. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Invest. 1997, 100:2552-2561.
25. Lu B., Rutledge B.J., Gu L., Fiorillo J., Lukacs N.W., Kunkel S.L., North R., Gerard C., Rollins B.J. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J. Exp. Med. 1998, 187:601-608.
26. Stanley E.R., Berg K.L., Einstein D.B., Lee P.S., Yeung Y.G. The biology and action of colony stimulating factor-1. Stem Cells 1994, 12(Suppl. 1):15-24. (discussion 25).
27. Metcalf D. The granulocyte-macrophage colony-stimulating factors. Science 1985, 229:16-22.
28. Conti L., Cardone M., Varano B., Puddu P., Belardelli F., Gessani S. Role of the cytokine environment and cytokine receptor expression on the generation of functionally distinct dendritic cells from human monocytes. Eur. J. Immunol. 2008, 38:750-762.
29. Chomarat P., Banchereau J., Davoust J., Palucka A.K. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat. Immunol. 2000, 1:510-514.
30. Fearon D.T. Seeking wisdom in innate immunity. Nature 1997, 388:323-324.
31. Fearon D.T., Locksley R.M. The instructive role of innate immunity in the acquired immune response. Science 1996, 272:50-54.
32. Medzhitov R., Janeway C.A. Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997, 91:295-298.
33. Dauer M., Obermaier B., Herten J., Haerle C., Pohl K., Rothenfusser S., Schnurr M., Endres S., Eigler A. Mature dendritic cells derived from human monocytes within 48h: a novel strategy for dendritic cell differentiation from blood precursors. J. Immunol. 2003, 170:4069-4076.
34. McKee A.S., Munks M.W., MacLeod M.K.L., Fleenor C.J., Van Rooijen N., Kappler J.W., Marrack P. Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J. Immunol. 2009, 183:4403-4414.
35. Ellebedy A.H., Lupfer C., Ghoneim H.E., DeBeauchamp J., Kanneganti T.-D., Webby R.J. Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59. Proc. Nat. Acad. Sci. 2011, 108:2927-2932.
36. Zhou R., Tardivel A., Thorens B., Choi I., Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 2010, 11:136-140.
37. Hornung V., Bauernfeind F., Halle A., Samstad E.O., Kono H., Rock K.L., Fitzgerald K.A., Latz E. Silica crystals aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 2008, 9:847-856.
38. Chae J.J., Wood G., Masters S.L., Richard K., Park G., Smith B.J., Kastner D.L. The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1β production. Proc. Nat. Acad. Sci. 2006, 103:9982-9987.
39. Chae J.J., Wood G., Richard K., Jaffe H., Colburn N.T., Masters S.L., Gumucio D.L., Shoham N.G., Kastner D.L. The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment. Blood 2008, 112:1794-1803.
40. Cassel S.L., Joly S., Sutterwala F.S. The NLRP3 inflammasome: A sensor of immune danger signals. Semin. Immunol. 2009, 21:194-198.
41. Li H., Ambade A., Re F. Cutting edge: necrosis activates the NLRP3 inflammasome. J. Immunol. 2009, 183:1528-1532.
42. Saleh M., Mathison J.C., Wolinski M.K., Bensinger S.J., Fitzgerald P., Droin N., Ulevitch R.J., Green D.R., Nicholson D.W. Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature 2006, 440:1064-1068.
43. Williams K.L., Lich J.D., Duncan J.A., Reed W., Rallabhandi P., Moore C., Kurtz S., Coffield V.M., Accavitti-Loper M.A., Su L., Vogel S.N., Braunstein M., Ting J.P. The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J. Biol. Chem. 2005, 280:39914-39924.
44. Jeru I., Duquesnoy P., Fernandes-Alnemri T., Cochet E., Yu J.W., Lackmy-Port-Lis M., Grimprel E., Landman-Parker J., Hentgen V., Marlin S., McElreavey K., Sarkisian T., Grateau G., Alnemri E.S., Amselem S. Mutations in NALP12 cause hereditary periodic fever syndromes. Proc. Natl. Acad. Sci. USA 2008, 105:1614-1619.
45. Pras E., Aksentijevich I., Gruberg L., Balow J.E., Prosen L., Dean M., Steinberg A.D., Pras M., Kastner D.L. Mapping of a gene causing familial Mediterranean fever to the short arm of chromosome 16. N. Engl. J. Med. 1992, 326:1509-1513.
46. Cell 1997, 90:797-807. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium.
47. Gallucci S., Lolkema M., Matzinger P. Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 1999, 5:1249-1255.