메뉴 건너뛰기




Volumn 10, Issue 1, 2013, Pages 29-38

Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia

Author keywords

Akt; Alzheimer's disease; Amyloid; CCN4; Microglia; MTOR; P70S6K; PI 3 k; TSC2; Tuberin; WISP1

Indexed keywords

AMYLOID; CELL NUCLEUS DNA; CYTOCHROME C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PHOSPHATIDYLSERINE; PROTEIN KINASE B; REGULATOR PROTEIN; S6 KINASE; TUBEROUS SCLEROSIS PROTEIN 2; UNCLASSIFIED DRUG; WNT1 INDUCIBLE SIGNALING PATHWAY PROTEIN 1;

EID: 84873052754     PISSN: 15672026     EISSN: 18755739     Source Type: Journal    
DOI: 10.2174/156720213804806007     Document Type: Article
Times cited : (49)

References (56)
  • 1
    • 80054848108 scopus 로고    scopus 로고
    • Multi-target-directed ligands in Alzheimer's disease treatment
    • Nov 1
    • Bajda M, Guzior N, Ignasik M, Malawska B. Multi-target-directed ligands in Alzheimer's disease treatment. Curr Med Chem. 2011 Nov 1;18(32):4949-75.
    • (2011) Curr Med Chem. , vol.18 , Issue.32 , pp. 4949-4975
    • Bajda, M.1    Guzior, N.2    Ignasik, M.3    Malawska, B.4
  • 2
    • 76749087751 scopus 로고    scopus 로고
    • New strategies for Alzheimer's disease and cognitive impairment
    • Nov-Dec
    • Maiese K, Chong ZZ, Hou J, Shang YC. New strategies for Alzheimer's disease and cognitive impairment. Oxid Med Cell Longev. 2009 Nov-Dec;2(5):279-89.
    • (2009) Oxid Med Cell Longev , vol.2 , Issue.5 , pp. 279-289
    • Maiese, K.1    Chong, Z.Z.2    Hou, J.3    Shang, Y.C.4
  • 4
    • 57649232697 scopus 로고    scopus 로고
    • The CCN family of genes: A perspective on CCN biology and therapeutic potential
    • Dec.
    • Yeger H, Perbal B. The CCN family of genes: a perspective on CCN biology and therapeutic potential. J Cell Commun Signal. 2007 Dec;1(3-4):159-64.
    • (2007) J Cell Commun Signal , vol.1 , Issue.3-4 , pp. 159-164
    • Yeger, H.1    Perbal, B.2
  • 5
    • 4344643927 scopus 로고    scopus 로고
    • WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair
    • Sep
    • French DM, Kaul RJ, D'Souza AL, Crowley CW, Bao M, Frantz GD, et al. WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. Am J Pathol. 2004 Sep;165(3):855-67.
    • (2004) Am J Pathol , vol.165 , Issue.3 , pp. 855-867
    • French, D.M.1    Kaul, R.J.2    D'souza, A.L.3    Crowley, C.W.4    Bao, M.5    Frantz, G.D.6
  • 6
    • 84865702908 scopus 로고    scopus 로고
    • The food contaminant and nephrotoxin ochratoxin A enhances Wnt1 inducible signaling protein 1 and tumor necrosis factor-alpha expression in human primary proximal tubule cells
    • Sep
    • Hennemeier I, Humpf HU, Gekle M, Schwerdt G. The food contaminant and nephrotoxin ochratoxin A enhances Wnt1 inducible signaling protein 1 and tumor necrosis factor-alpha expression in human primary proximal tubule cells. Molecular nutrition & food research. 2012 Sep;56(9):1375-84.
    • (2012) Molecular Nutrition & Food Research , vol.56 , Issue.9 , pp. 1375-1384
    • Hennemeier, I.1    Humpf, H.U.2    Gekle, M.3    Schwerdt, G.4
  • 7
    • 0036141112 scopus 로고    scopus 로고
    • WISP-1 attenuates p53- mediated apoptosis in response to DNA damage through activation of the Akt kinase
    • Jan 1
    • Su F, Overholtzer M, Besser D, Levine AJ. WISP-1 attenuates p53- mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev. 2002 Jan 1;16(1):46-57.
    • (2002) Genes Dev. , vol.16 , Issue.1 , pp. 46-57
    • Su, F.1    Overholtzer, M.2    Besser, D.3    Levine, A.J.4
  • 8
    • 77951886107 scopus 로고    scopus 로고
    • WNT1-inducible signaling pathway protein-1activates diverse cell survival pathways and blocks doxorubicininduced cardiomyocyte death
    • May
    • Venkatesan B, Prabhu SD, Venkatachalam K, Mummidi S, Valente AJ, Clark RA, et al. WNT1-inducible signaling pathway protein-1activates diverse cell survival pathways and blocks doxorubicininduced cardiomyocyte death. Cell Signal. 2010 May;22(5):809-20.
    • (2010) Cell Signal , vol.22 , Issue.5 , pp. 809-820
    • Venkatesan, B.1    Prabhu, S.D.2    Venkatachalam, K.3    Mummidi, S.4    Valente, A.J.5    Clark, R.A.6
  • 9
    • 79955967161 scopus 로고    scopus 로고
    • Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity
    • May 20
    • Heise RL, Stober V, Cheluvaraju C, Hollingsworth JW, Garantziotis S. Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity. J Biol Chem. 2011 May 20;286(20):17435-44.
    • (2011) J Biol Chem. , vol.286 , Issue.20 , pp. 17435-17444
    • Heise, R.L.1    Stober, V.2    Cheluvaraju, C.3    Hollingsworth, J.W.4    Garantziotis, S.5
  • 10
    • 84863230670 scopus 로고    scopus 로고
    • Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling involving Bad, Bax, Bim, and Bcl-xL
    • Feb
    • Wang S, Chong ZZ, Shang YC, Maiese K. Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling involving Bad, Bax, Bim, and Bcl-xL. Curr Neurovasc Res. 2012 Feb;9(1):20-31.
    • (2012) Curr Neurovasc Res. , vol.9 , Issue.1 , pp. 20-31
    • Wang, S.1    Chong, Z.Z.2    Shang, Y.C.3    Maiese, K.4
  • 11
    • 84860738503 scopus 로고    scopus 로고
    • WISP1 (CCN4) autoregulates its expression and nuclear trafficking of beta-catenin during oxidant stress with limited effects upon neuronal autophagy
    • Apr 4
    • Wang S, Chong ZZ, Shang YC, Maiese K. WISP1 (CCN4) autoregulates its expression and nuclear trafficking of beta-catenin during oxidant stress with limited effects upon neuronal autophagy. Curr Neurovasc Res. 2012 Apr 4;9(2):89-99.
    • (2012) Curr Neurovasc Res. , vol.9 , Issue.2 , pp. 89-99
    • Wang, S.1    Chong, Z.Z.2    Shang, Y.C.3    Maiese, K.4
  • 12
    • 84873046988 scopus 로고    scopus 로고
    • WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1
    • Nov 12, in press
    • Wang S, Chong ZZ, Shang YC, Maiese K. WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1. Curr Neurovasc Res. 2012 Nov 12;(in press).
    • (2012) Curr Neurovasc Res.
    • Wang, S.1    Chong, Z.Z.2    Shang, Y.C.3    Maiese, K.4
  • 13
    • 84868662619 scopus 로고    scopus 로고
    • WNT1 inducible signaling pathway protein 1 (WISP1) targets PRAS40 to govern beta-amyloid apoptotic injury of microglia
    • Aug 6
    • Shang YC, Chong ZZ, Wang S, Maiese K. WNT1 Inducible Signaling Pathway Protein 1 (WISP1) Targets PRAS40 to Govern beta-Amyloid Apoptotic Injury of Microglia. Curr Neurovasc Res. 2012 Aug 6;9(4):239-49.
    • (2012) Curr Neurovasc Res. , vol.9 , Issue.4 , pp. 239-249
    • Shang, Y.C.1    Chong, Z.Z.2    Wang, S.3    Maiese, K.4
  • 14
    • 80052843006 scopus 로고    scopus 로고
    • The role of CNI-1493 in the function of primary microglia with respect to amyloid-beta
    • Jan 1
    • Bach JP, Mengel D, Wahle T, Kautz A, Balzer-Geldsetzer M, Al- Abed Y, et al. The Role of CNI-1493 in the Function of Primary Microglia with Respect to Amyloid-beta. J Alzheimers Dis. 2011 Jan 1;26(1):69-80.
    • (2011) J Alzheimers Dis. , vol.26 , Issue.1 , pp. 69-80
    • Bach, J.P.1    Mengel, D.2    Wahle, T.3    Kautz, A.4    Balzer-Geldsetzer, M.5    Al-, A.Y.6
  • 16
    • 0034814056 scopus 로고    scopus 로고
    • Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease
    • Nov-Dec
    • Rogers J, Lue LF. Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease. Neurochem Int. 2001 Nov-Dec;39(5-6):333- 40.
    • (2001) Neurochem Int. , vol.39 , Issue.5-6 , pp. 333-340
    • Rogers, J.1    Lue, L.F.2
  • 17
    • 67649432436 scopus 로고    scopus 로고
    • Siglec receptors and hiding plaques in Alzheimer's disease
    • Jul
    • Salminen A, Kaarniranta K. Siglec receptors and hiding plaques in Alzheimer's disease. J Mol Med. 2009 Jul;87(7):697-701.
    • (2009) J Mol Med. , vol.87 , Issue.7 , pp. 697-701
    • Salminen, A.1    Kaarniranta, K.2
  • 18
    • 61849085876 scopus 로고    scopus 로고
    • The forkhead transcription factor FoxO3a controls microglial inflammatory activation and eventual apoptotic injury through caspase 3
    • Feb
    • Shang YC, Chong ZZ, Hou J, Maiese K. The forkhead transcription factor FoxO3a controls microglial inflammatory activation and eventual apoptotic injury through caspase 3. Curr Neurovasc Res. 2009 Feb;6(1):20-31.
    • (2009) Curr Neurovasc Res. , vol.6 , Issue.1 , pp. 20-31
    • Shang, Y.C.1    Chong, Z.Z.2    Hou, J.3    Maiese, K.4
  • 19
    • 84860704035 scopus 로고    scopus 로고
    • Prevention of betaamyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL
    • Mar 3
    • Shang YC, Chong ZZ, Wang S, Maiese K. Prevention of betaamyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL. Aging (Albany NY). 2012 Mar 3;4(3):187-201.
    • (2012) Aging (Albany NY) , vol.4 , Issue.3 , pp. 187-201
    • Shang, Y.C.1    Chong, Z.Z.2    Wang, S.3    Maiese, K.4
  • 21
    • 80052699957 scopus 로고    scopus 로고
    • Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation
    • Dec
    • Reddy VS, Valente AJ, Delafontaine P, Chandrasekar B. Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation. J Cell Physiol. 2011 Dec;226(12):3303-15.
    • (2011) J Cell Physiol. , vol.226 , Issue.12 , pp. 3303-3315
    • Reddy, V.S.1    Valente, A.J.2    Delafontaine, P.3    Chandrasekar, B.4
  • 22
    • 84868646977 scopus 로고    scopus 로고
    • A critical kinase cascade in neurological disorders: PI 3-K, Akt, and mTOR
    • Chong ZZ, Shang YC, Wang S, Maiese K. A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR. Future Neurol. 2012;7(6):733-48.
    • (2012) Future Neurol , vol.7 , Issue.6 , pp. 733-748
    • Chong, Z.Z.1    Shang, Y.C.2    Wang, S.3    Maiese, K.4
  • 23
    • 84870703044 scopus 로고    scopus 로고
    • Oxidant stress and signal transduction in the nervous system with the PI 3-K, Akt, and mTOR cascade
    • Maiese K, Chong ZZ, Wang S, Shang YC. Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade. International journal of molecular sciences. 2012;13(11):13830-66.
    • (2012) International Journal of Molecular Sciences , vol.13 , Issue.11 , pp. 13830-13866
    • Maiese, K.1    Chong, Z.Z.2    Wang, S.3    Shang, Y.C.4
  • 24
    • 84862179773 scopus 로고    scopus 로고
    • Mammalian target of rapamycin signaling in diabetic cardiovascular disease
    • Chong ZZ, Maiese K. Mammalian Target of Rapamycin Signaling in Diabetic Cardiovascular Disease. Cardiovasc Diabetol. 2012;11(1):45.
    • (2012) Cardiovasc Diabetol , vol.11 , Issue.1 , pp. 45
    • Chong, Z.Z.1    Maiese, K.2
  • 26
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002;4(9):648-57.
    • (2002) Nat Cell Biol. , vol.4 , Issue.9 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 27
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3- kinase/akt pathway
    • Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3- kinase/akt pathway. Mol Cell. 2002;10(1):151-62.
    • (2002) Mol Cell. , vol.10 , Issue.1 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 28
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter CJ, Pedraza LG, Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol. 2002;4(9):658-65.
    • (2002) Nat Cell Biol. , vol.4 , Issue.9 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 29
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • 26
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003 26;115(5):577-90.
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 30
    • 21744459535 scopus 로고    scopus 로고
    • Regulation of mTOR and cell growth in response to energy stress by REDD1
    • Sofer A, Lei K, Johannessen CM, Ellisen LW. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol. 2005;25(14):5834-45.
    • (2005) Mol Cell Biol. , vol.25 , Issue.14 , pp. 5834-5845
    • Sofer, A.1    Lei, K.2    Johannessen, C.M.3    Ellisen, L.W.4
  • 31
    • 29044433048 scopus 로고    scopus 로고
    • Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity
    • Chong ZZ, Li F, Maiese K. Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity. Curr Neurovasc Res. 2005;2(5):387-99.
    • (2005) Curr Neurovasc Res. , vol.2 , Issue.5 , pp. 387-399
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 32
    • 34147100616 scopus 로고    scopus 로고
    • Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways
    • Chong ZZ, Li F, Maiese K. Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways. Cell Signal. 2007;19(6):1150-62.
    • (2007) Cell Signal , vol.19 , Issue.6 , pp. 1150-1162
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 33
    • 0037016065 scopus 로고    scopus 로고
    • Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
    • Chong ZZ, Kang JQ, Maiese K. Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation. 2002;106(23):2973- 9.
    • (2002) Circulation , vol.106 , Issue.23 , pp. 2973-2979
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 34
    • 0037365196 scopus 로고    scopus 로고
    • Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways
    • Chong ZZ, Kang JQ, Maiese K. Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways. Br J Pharmacol. 2003;138(6):1107-18.
    • (2003) Br J Pharmacol , vol.138 , Issue.6 , pp. 1107-1118
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 35
    • 77951818902 scopus 로고    scopus 로고
    • Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation
    • Hou J, Chong ZZ, Shang YC, Maiese K. Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation. Curr Neurovasc Res. 2010;7(2):95-112.
    • (2010) Curr Neurovasc Res. , vol.7 , Issue.2 , pp. 95-112
    • Hou, J.1    Chong, Z.Z.2    Shang, Y.C.3    Maiese, K.4
  • 36
    • 80051534214 scopus 로고    scopus 로고
    • Erythropoietin employs cell longevity pathways of sirt1 to foster endothelial vascular integrity during oxidant stress
    • Hou J, Wang S, Shang YC, Chong ZZ, Maiese K. Erythropoietin Employs Cell Longevity Pathways of SIRT1 to Foster Endothelial Vascular Integrity During Oxidant Stress. Curr Neurovasc Res. 2011;8(3):220-35.
    • (2011) Curr Neurovasc Res. , vol.8 , Issue.3 , pp. 220-235
    • Hou, J.1    Wang, S.2    Shang, Y.C.3    Chong, Z.Z.4    Maiese, K.5
  • 37
    • 77953718207 scopus 로고    scopus 로고
    • Wnt1, FoxO3a, and NFkappaB oversee microglial integrity and activation during oxidant stress
    • Shang YC, Chong ZZ, Hou J, Maiese K. Wnt1, FoxO3a, and NFkappaB oversee microglial integrity and activation during oxidant stress. Cell Signal. 2010;22(9):1317-29.
    • (2010) Cell Signal , vol.22 , Issue.9 , pp. 1317-1329
    • Shang, Y.C.1    Chong, Z.Z.2    Hou, J.3    Maiese, K.4
  • 38
    • 77951254898 scopus 로고    scopus 로고
    • FoxO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling
    • Hou J, Chong ZZ, Shang YC, Maiese K. FoxO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling. Mol Cell Endocrinol. 2010;321(2):194-206.
    • (2010) Mol Cell Endocrinol , vol.321 , Issue.2 , pp. 194-206
    • Hou, J.1    Chong, Z.Z.2    Shang, Y.C.3    Maiese, K.4
  • 39
    • 82155166743 scopus 로고    scopus 로고
    • Erythropoietin and Wnt1 govern pathways of mtor, apaf-1, and xiap in inflammatory microglia
    • Shang YC, Chong ZZ, Wang S, Maiese K. Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia. Curr Neurovasc Res. 2011;8(4):270-85.
    • (2011) Curr Neurovasc Res. , vol.8 , Issue.4 , pp. 270-285
    • Shang, Y.C.1    Chong, Z.Z.2    Wang, S.3    Maiese, K.4
  • 40
    • 0028802451 scopus 로고
    • The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain
    • Pearson RB, Dennis PB, Han JW, Williamson NA, Kozma SC, Wettenhall RE, et al. The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. Embo J. 1995;14(21):5279-87.
    • (1995) Embo J. , vol.14 , Issue.21 , pp. 5279-5287
    • Pearson, R.B.1    Dennis, P.B.2    Han, J.W.3    Williamson, N.A.4    Kozma, S.C.5    Wettenhall, R.E.6
  • 41
    • 84867897183 scopus 로고    scopus 로고
    • Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin
    • Chong ZZ, Shang YC, Wang S, Maiese K. Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin. Prog Neurobiol. 2012;99(2):128-48.
    • (2012) Prog Neurobiol , vol.99 , Issue.2 , pp. 128-148
    • Chong, Z.Z.1    Shang, Y.C.2    Wang, S.3    Maiese, K.4
  • 43
    • 80053387765 scopus 로고    scopus 로고
    • Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress
    • Ng S, Wu YT, Chen B, Zhou J, Shen HM. Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress. Autophagy. 2011;7(10):1173-86.
    • (2011) Autophagy , vol.7 , Issue.10 , pp. 1173-1186
    • Ng, S.1    Wu, Y.T.2    Chen, B.3    Zhou, J.4    Shen, H.M.5
  • 44
    • 79955979597 scopus 로고    scopus 로고
    • Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration
    • Reith RM, Way S, McKenna J, Haines K, Gambello MJ. Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration. Neurobiol Dis. 2011;43(1):113-22.
    • (2011) Neurobiol Dis. , vol.43 , Issue.1 , pp. 113-122
    • Reith, R.M.1    Way, S.2    McKenna, J.3    Haines, K.4    Gambello, M.J.5
  • 45
    • 18844434370 scopus 로고    scopus 로고
    • Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease
    • Chong ZZ, Li F, Maiese K. Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol. 2005;75(3):207-46.
    • (2005) Prog Neurobiol , vol.75 , Issue.3 , pp. 207-246
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 46
    • 42749086593 scopus 로고    scopus 로고
    • OutFOXOing disease and disability: The therapeutic potential of targeting FoxO proteins
    • Maiese K, Chong ZZ, Shang YC. OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins. Trends Mol Med. 2008;14(5):219-27.
    • (2008) Trends Mol Med. , vol.14 , Issue.5 , pp. 219-227
    • Maiese, K.1    Chong, Z.Z.2    Shang, Y.C.3
  • 48
    • 78049520114 scopus 로고    scopus 로고
    • The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Muller glia proliferation and cone cell regeneration in the lightdamaged zebrafish retina
    • Bailey TJ, Fossum SL, Fimbel SM, Montgomery JE, Hyde DR. The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Muller glia proliferation and cone cell regeneration in the lightdamaged zebrafish retina. Exp Eye Res. 2010;91(5):601-12.
    • (2010) Exp Eye Res. , vol.91 , Issue.5 , pp. 601-612
    • Bailey, T.J.1    Fossum, S.L.2    Fimbel, S.M.3    Montgomery, J.E.4    Hyde, D.R.5
  • 49
    • 77956914523 scopus 로고    scopus 로고
    • Phosphatidylserine targeting for diagnosis and treatment of human diseases
    • Schutters K, Reutelingsperger C. Phosphatidylserine targeting for diagnosis and treatment of human diseases. Apoptosis. 2010;15(9):1072-82.
    • (2010) Apoptosis , vol.15 , Issue.9 , pp. 1072-1082
    • Schutters, K.1    Reutelingsperger, C.2
  • 50
    • 84859354721 scopus 로고    scopus 로고
    • Nicotinamide attenuates the decrease of astrocytic phosphoprotein PEA-15 in focal cerebral ischemic injury
    • Koh PO. Nicotinamide attenuates the decrease of astrocytic phosphoprotein PEA-15 in focal cerebral ischemic injury. J Vet Med Sci. 2012;74(3):377-80.
    • (2012) J Vet Med Sci. , vol.74 , Issue.3 , pp. 377-380
    • Koh, P.O.1
  • 51
    • 36448967502 scopus 로고    scopus 로고
    • Sly as a FOXO : New paths with Forkhead signaling in the brain
    • Maiese K, Chong ZZ, Shang YC. "Sly as a FOXO": New paths with Forkhead signaling in the brain. Curr Neurovasc Res. 2007;4(4):295-302.
    • (2007) Curr Neurovasc Res. , vol.4 , Issue.4 , pp. 295-302
    • Maiese, K.1    Chong, Z.Z.2    Shang, Y.C.3
  • 54
    • 77956305343 scopus 로고    scopus 로고
    • Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
    • Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, et al. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One. 2010;5(4):e9979.
    • (2010) PLoS One. , vol.5 , Issue.4
    • Spilman, P.1    Podlutskaya, N.2    Hart, M.J.3    Debnath, J.4    Gorostiza, O.5    Bredesen, D.6
  • 55
    • 65949106140 scopus 로고    scopus 로고
    • Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTORdependent manner
    • Di Nardo A, Kramvis I, Cho N, Sadowski A, Meikle L, Kwiatkowski DJ, et al. Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTORdependent manner. J Neurosci. 2009;29(18):5926-37.
    • (2009) J Neurosci , vol.29 , Issue.18 , pp. 5926-5937
    • Di, N.A.1    Kramvis, I.2    Cho, N.3    Sadowski, A.4    Meikle, L.5    Kwiatkowski, D.J.6
  • 56
    • 64549109015 scopus 로고    scopus 로고
    • Targeted therapy of human osteosarcoma with 17AAG or rapamycin: Characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways
    • Gazitt Y, Kolaparthi V, Moncada K, Thomas C, Freeman J. Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. Int J Oncol. 2009;34(2):551-61.
    • (2009) Int J Oncol. , vol.34 , Issue.2 , pp. 551-561
    • Gazitt, Y.1    Kolaparthi, V.2    Moncada, K.3    Thomas, C.4    Freeman, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.