The food contaminant and nephrotoxin ochratoxin A enhances Wnt1 inducible signaling protein 1 and tumor necrosis factor-α expression in human primary proximal tubule cells

Molecular Nutrition and Food Research

Volumn 56, Issue 9, 2012, Pages 1375-1384

  Hennemeier, Isabell ^a   Humpf, Hans Ulrich ^b   Gekle, Michael ^a   Schwerdt, Gerald ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Gene expression; Mycotoxin; Ochratoxin A; Proximal tubule; Tubulointerstitial nephritis

Indexed keywords

CCN PROTEIN; OCHRATOXIN; ONCOPROTEIN; TUMOR NECROSIS FACTOR ALPHA; WISP1 PROTEIN, HUMAN;

ARTICLE; CELL LINE; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; FIBROBLAST; FOOD CONTAMINATION; GENETICS; HUMAN; KIDNEY PROXIMAL TUBULE; METABOLISM; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION;

CCN INTERCELLULAR SIGNALING PROTEINS; CELL LINE; EPITHELIAL CELLS; FIBROBLASTS; FOOD CONTAMINATION; HUMANS; KIDNEY TUBULES, PROXIMAL; MAP KINASE SIGNALING SYSTEM; OCHRATOXINS; PROTO-ONCOGENE PROTEINS; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84865702908     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200164     Document Type: Article

References (38)

1. Stoev, S. D., Gundasheva, D., Zarkov, I., Mircheva, T. et al., Experimental mycotoxic nephropathy in pigs provoked by a mouldy diet containing ochratoxin A and fumonisin B1. Exp. Toxicol. Pathol. 2011, DOI: 10.1016/j.etp.2011.01.008.
2. Stoev, S. D., Hald, B., Mantle, P. G., Porcine nephropathy in Bulgaria: a progressive syndrome of complex or uncertain (mycotoxin) aetiology. Vet. Rec. 1998, 142, 190-194.
3. Stoev, S. D., The role of ochratoxin A as a possible cause of Balkan endemic nephropathy and its risk evaluation. Vet. Hum. Toxicol. 1998, 40, 352-360.
4. Palli, D., Miraglia, M., Saieva, C., Masala, G. et al., Serum levels of ochratoxin A in healthy adults in Tuscany: correlation with individual characteristics and between repeat measurements. Cancer Epidemiol. Biomarkers Prev. 1999, 8, 265-269.
5. Ozcelik, N., Ko, ar, A., Soysal, D., Ochratoxin A in human serum samples collected in Isparta-Turkey from healthy individuals and individuals suffering from different urinary disorders. Toxicol. Lett. 2001, 121, 9-13.
6. Skaug, M. A., Levels of ochratoxin A and IgG against conidia of Penicillium verrucosum in blood samples from healthy farm workers. Ann. Agric. Environ. Med. 2003, 10, 73-77.
7. Karima, H. K., Ridha, G., Zied, A., Chekib, M. et al., Estimation of ochratoxin A in human blood of healthy Tunisian population. Exp. Toxicol. Pathol. 2010, 62, 539-542.
8. Zaied, C., Bouaziz, C., Azizi, I., Bensassi, F. et al., Presence of ochratoxin A in Tunisian blood nephropathy patients. Exposure level to OTA. Exp. Toxicol. Pathol. 2011, 63, 613-618.
9. Schwerdt, G., Holzinger, H., Sauvant, C., Königs, M. et al., Long-term effects of ochratoxin A on fibrosis and cell death in human proximal tubule or fibroblast cells in primary culture. Toxicology 2007, 232, 57-67.
10. Schwerdt, G., Holzinger, H., Königs, M., Humpf, H. U. et al., Effect of ochratoxin A on cell survival and collagen homeostasis in human mesangial cells in primary culture. Food Chem. Toxicol. 2009, 47, 209-213.
11. Gekle, M., Sauvant, C., Schwerdt, G., Ochratoxin A at nanomolar concentrations: a signal modulator in renal cells. Mol. Nutr. Food Res. 2005, 49, 118-130.
12. Vrabcheva, T., Petkova-Bocharova, T., Grosso, F., Nikolov, I. et al., Analysis of ochratoxin A in foods consumed by inhabitants from an area with balkan endemic nephropathy: a 1 month follow-up study. J. Agric. Food Chem. 2004, 52, 2404-2410.
13. Anzai, N., Jutabha, P., Endou, H., Molecular mechanism of ochratoxin a transport in the kidney. Toxins 2010, 2, 1381-1398.
14. Wohlfarth, V., Drumm, K., Mildenberger, S., Freudinger, R. et al., Protein uptake disturbs collagen homeostasis in proximal tubule-derived cells. Kidney Int. Suppl. 2003, S103-S109.
15. Sauvant, C., Holzinger, H., Gekle, M., The nephrotoxin ochratoxin A induces key parameters of chronic interstitial nephropathy in renal proximal tubular cells. Cell Physiol. Biochem. 2005, 15, 125-134.
16. Schwerdt, G., Freudinger, R., Mildenberger, S., Silbernagl, S. et al., The nephrotoxin ochratoxin A induces apoptosis in cultured human proximal tubule cells. Cell Biol. Toxicol. 1999, 15, 405-415.
17. Gekle, M., Schwerdt, G., Freudinger, R., Mildenberger, S. et al., Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J. Pharmacol. Exp. Ther. 2000, 293, 837-844.
18. Boor, P., Ostendorf, T., Floege, J., Renal fibrosis: novel insights into mechanisms and therapeutic targets. Nat. Rev. Nephrol. 2010, 6, 643-656.
19. Venkatachalam, K., Venkatesan, B., Valente, A. J., Melby, P. C. et al., WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death. J. Biol. Chem. 2009, 284, 14414-14427.
20. Colston, J. T., de la Rosa, S. D., Koehler, M., Gonzales, K. et al., Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor. Am. J. Physiol. Heart Circ. Physiol. 2007, 293, H1839-H1846.
21. Pennica, D., Swanson, T. A., Welsh, J. W., Roy, M. A. et al., WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc. Natl. Acad. Sci. USA 1998, 95, 14717-14722.
22. Berschneider, B., Königshoff, M., WNT1 inducible signaling pathway protein 1 (WISP1): a novel mediator linking development and disease. Int. J. Biochem. Cell Biol. 2011, 43, 306-309.
23. Calvisi, D. F., Conner, E. A., Ladu, S., Lemmer, E. R. et al., Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer. J. Hepatol. 2005, 42, 842-849.
24. Margalit, O., Eisenbach, L., Amariglio, N., Kaminski, N. et al., Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines. Br. J. Cancer 2003, 89, 314-319.
25. Königshoff, M., Kramer, M., Balsara, N., Wilhelm, J. et al., WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J. Clin. Invest. 2009, 119, 772-787.
26. Venkatesan, B., Prabhu, S. D., Venkatachalam, K., Mummidi, S. et al., WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte death. Cell Signal. 2010, 22, 809-820.
27. Xu, L., Corcoran, R. B., Welsh, J. W., Pennica, D. et al., WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. Genes Dev. 2000, 14, 585-595.
28. Schwerdt, G., Königs, M., Holzinger, H., Humpf, H. U. et al., Effects of the mycotoxin FB1 on cell death in human kidney cells and human lung fibroblasts in primary culture. J. Appl. Toxicol. 2009, 29, 174-182.
29. Klöckner, U., Rueckschloss, U., Grossmann, C., Ebelt, H. et al., Differential reduction of HCN channel activity by various types of lipopolysaccharide. J. Mol. Cell Cardiol. 2011, 51, 226-235.
30. Lam, A. P., Gottardi, C. J., beta-catenin signaling: a novel mediator of fibrosis and potential therapeutic target. Curr. Opin. Rheumatol. 2011, 23, 562-567.
31. Schwerdt, G., Bauer, K., Gekle, M., Silbernagl, S., Accumulation of ochratoxin A in rat kidney in vivo and in cultivated renal epithelial cells in vitro. Toxicology 1996, 114, 177-185.
32. Wang, J., Zhang, G. Y., Li, X. H., Effect of indomethacin on Bfl-1, WISP-1 and proliferating cell nuclear antigen in colon cancer cell line HCT116 cells. Chin. J. Dig. Dis. 2006, 7, 219-224.
33. Katula, K. S., Heinloth, A. N., Paules, R. S., Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J. Nutr. Biochem. 2007, 18, 541-552.
34. Benton, M. A., Rager, J. E., Smeester, L., Fry, R. C., Comparative genomic analyses identify common molecular pathways modulated upon exposure to low doses of arsenic and cadmium. BMC. Genomics 2011, 12, 173
35. Marin-Kuan, M., Nestler, S., Verguet, C., Bezencon, C. et al., MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma. Toxicol. Appl. Pharmacol. 2007, 224, 174-181.
36. Schramek, H., Wilflingseder, D., Pollack, V., Freudinger, R. et al., Ochratoxin A-induced stimulation of extracellular signal-regulated kinases 1/2 is associated with Madin-Darby canine kidney-C7 cell dedifferentiation. J. Pharmacol. Exp. Ther. 1997, 283, 1460-1468.
37. Gekle, M., Gassner, B., Freudinger, R., Mildenberger, S. et al., Characterization of an ochratoxin-A-dedifferentiated and cloned renal epithelial cell line. Toxicol. Appl. Pharmacol. 1998, 152, 282-291.
38. Reddy, V. S., Valente, A. J., Delafontaine, P., Chandrasekar, B., Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation. J. Cell Physiol. 2011, 226, 3303-3315.