RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects

British Journal of Pharmacology

Volumn 168, Issue 4, 2013, Pages 1001-1014

  Wang, Zhen Zhen ^a   Zhang, Yi ^b   Liu, Yan Qin ^a   Zhao, Nan ^a   Zhang, You Zhi ^a   Yuan, Li ^a   An, Lei ^a   Li, Jing ^a   Wang, Xiao Yun ^a   Qin, Juan Juan ^a   Wilson, Steven P ^c   O'Donnell, James M ^d   Zhang, Han Ting ^d   Li, Yun Feng ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

antidepressant; cAMP; cognition; dendritic complexity; phosphodiesterase 4D; RNA interference

Indexed keywords

CYCLIC AMP; LENTIVIRUS VECTOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IVD; PHOSPHODIESTERASE IVD4; PHOSPHODIESTERASE IVD5; ROLIPRAM; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; COGNITION; CONTROLLED STUDY; DENDRITE; DOWN REGULATION; EXPERIMENTAL TEST; FLUORESCENCE RESONANCE ENERGY TRANSFER; FORCED SWIMMING TEST; IN VITRO STUDY; IN VIVO STUDY; MALE; MAZE TEST; MORRIS WATER MAZE TEST; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBJECT RECOGNITION TEST; PREFRONTAL CORTEX; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TAIL SUSPENSION TEST; WESTERN BLOTTING;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; COGNITION; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DEPRESSION; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; HEK293 CELLS; HUMANS; LENTIVIRUS; MALE; MAZE LEARNING; MICE; PHOSPHODIESTERASE 4 INHIBITORS; PREFRONTAL CORTEX; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; VOMITING;

EID: 84872956039     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02225.x     Document Type: Article

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