The anatomy of mood disorders - Review of structural neuroimaging studies

Biological Psychiatry

Volumn 41, Issue 1, 1997, Pages 86-106

  Soares, Jair C ^a   Mann, J John ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

computed tomography; magneti cresonance imaging; mood disorders; neuroanatomy; neuroimaging; pathophysiology; structural

Indexed keywords

BASAL GANGLION; BRAIN VENTRICLE; COMPUTER ASSISTED TOMOGRAPHY; FRONTAL LOBE; HUMAN; HYPOTHALAMUS; MOOD; NUCLEAR MAGNETIC RESONANCE IMAGING; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; WHITE MATTER;

ATROPHY; BIPOLAR DISORDER; BRAIN; BRAIN MAPPING; DEPRESSIVE DISORDER; DIAGNOSTIC IMAGING; HUMANS; MAGNETIC RESONANCE IMAGING; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0031023930     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(96)00006-6     Document Type: Review

References (218)

1. Aasly J, Storsaeter O, Nilsen G, Smevik O, Rinck P (1993): Minor structural brain changes in young drug abusers. Acta Neurol Scand 87:210-214.
2. Abas MA, Sahakian BJ, Levy R (1990): Neuropsychological deficits and CT scan changes in elderly depressives. Psychol Med 20:507-520.
3. Agrell B, Dehlin O (1994): Depression in stroke patients with left and right hemisphere lesions. A study in geriatric rehabilitation in-patients. Aging Clin Exp Res 6:49-56.
4. Alexander GE, DeLong MR, Strick PL (1986): Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Ann Rev Neurosci 9:357-381.
5. Alexander GE, Crutcher MD, DeLong MR (1990): Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Prog Brain Res 85:119-146.
6. Alexopoulos GS, Young RC, Shindledecker RD (1992): Brain computed tomography findings in geriatric depression and primary degenerative dementia. Biol Psychiatry 31:591-599.
7. Allen LS, Gorski RA (1990): Sex difference in the bed nucleus of the stria terminalis of the human brain. J Comp Neurol 302:697-706.
8. Allen LS, Richey MF, Chai YM, Gorski RA (1991): Sex differences in the corpus callosum of the living human brain. J Neurosci 11:933-942.
9. Altshuler LL, Conrad A, Hauser P, et al (1991): Reduction of temporal lobe volume in bipolar disorder: A preliminary report of magnetic resonance imaging. Arch Gen Psychiatry 48:482-483.
10. Altshuler LL, Curran JG, Hauser P, Mintz J, Denicoff K, Post R (1995): T2 hyperintensities in bipolar disorder: Magnetic resonance imaging comparison and literature meta-analysis. Am J Psychiatry 152:1139-1144.
11. Ames D, Dolan R, Mann A (1990): The distinction between depression and dementia in the very old. Int J Geriat Psychiatry 5:193-198.
12. Amsterdam JD, Marinelli DL, Arger P, Winokur A (1987): Assessment of adrenal gland volume by computed tomography in depressed patients and healthy volunteers: A pilot study. Psychiatry Res 21:189-197.
13. Andersen G, Vestergaard K, Ingemann-Nielsen M, Lauritzen L (1995): Risk factors for post-stroke depression. Acta Psychiatr Scand 92:193-198.
14. Andreasen NC, Swayze V, Flaum M, Alliger R, Cohen G (1990): Ventricular abnormalities in affective disorder: Clinical and demographic correlates. Am J Psychiatry 147:893-900.
15. Astrom M, Adolfsson R, Asplund K (1993): Major depression in stroke patients - A 3-year longitudinal study. Stroke 24:976-982.
16. Austin MP, Mitchell P (1995): Editorial - The anatomy of melancholia: Does frontal-subcortical pathophysiology underpin its psychomotor and cognitive manifestations? Psychol Med 25:665-672.
17. Axelson DA, Doraiswamy PM, Boyko OB, et al (1992): In vivo assessment of pituitary volume with magnetic resonance imaging and systematic stereology: Relationship to dexamethasone suppression test results in patients. Psychiatry Res 44:63-70.
18. Axelson DA, Doraiswamy PM, McDonald WM, et al (1993): Hypercortisolemia and hippocampal changes in depression. Psychiatry Res 47:163-173.
19. Aylward EH, Roberts-Twillie JV, Barta PE, et al (1994): Basal ganglia volumes and white matter hyperintensities in patients with bipolar disorder. Am J Psychiatry 151:687-693.
20. Awad IA, Spetzler RF, Hodak JA, Awad CA, Carey R (1986a): Incidental subcortical lesions identified on magnetic resonance imaging in the elderly: I. Correlation with age and cerebrovascular risk factors. Stroke 17:1084-1089.
21. Awad IA, Johnson PC, Spetzler RF, Hodak JA (1986b): Incidental subcortical lesions identified on magnetic resonance imaging in the elderly: II. Postmortem pathologic correlations. Stroke 17:1090-1097.
22. Bachneff SA (1991): Positron emission tomography and magnetic resonance imaging: A review and a local circuit neurons hypo(dys)function hypothesis of schizophrenia. Biol Psychiatry 30:857-886.
23. Baxter LR (1991): PET studies of cerebral function in major depression and obsessive-compulsive disorder - The emerging prefrontal cortex consensus. Ann Clin Psychiatry 3:103-109.
24. Beats BC (1991): Structural imaging in affective disorder. Int J Geriat Psychiatry 6:419-422.
25. Beats B, Levy R, Forstl H (1991): Ventricular enlargement and caudate hyperdensity in elderly depressives. Biol Psychiatry 30:452-458.
26. Becker T, Retz W, Hofmann E, Becker G, Teichmann E, Gsell W (1995): Some methodological issues in neuroradiological research in psychiatry. J Neural Transm 99:7-54.
27. Berton GG, Torello MW (1982): The paleocerebellum and the integration of behavioral function. Physiol Psychol 10:1-12.
28. Bolla-Wilson K, Robinson RG, Starkstein SE, Boston J, Price TR (1989): Lateralization of dementia of depression in stroke patients. Am J Psychiatry 146:627-634.
29. Botteron KN, Figiel GS, Wetzel MW, Hudziak J, van Eeerdewegh M (1992): MRI abnormalities in adolescent bipolar affective disorder. J Am Acad Child Adolesc Psychiatry 31:258-261.
30. Brady KT, Sonne SC (1995): The relationship between substance abuse and bipolar disorder. J Clin Psychiatry 56(suppl 3):19-24.
31. Brown FW, Lewine RJ, Hudgins PA, Risch SC (1992): White matter hyperintensity signals in psychiatric and nonpsychiat-ric subjects. Am J Psychiatry 149:620-625.
32. Brun A, Englund E (1986): A white matter disorder in dementia of the Alzheimer's type: A pathoanatomical study. Ann Neurol 19:253-262.
33. Buchsbaum MS (1986): Brain imaging in the search for biological markers in affective disorder. J Clin Psychiatry 47(suppl):7-10.
34. Caine ED, Shoulson I (1983): Psychiatric syndrome in Huntington's disease. Am J Psychiatry 140:728-733.
35. Charnes ME (1993): Brain lesions in alcoholics. Alcohol Clin Exp Res 17:2-11.
36. Chimowitz MI, Estes ML, Furlan AJ, Awad IA (1992): Further observations on the pathology of subcortical lesions identified on magnetic resonance imaging. Arch Neurol 49:747-752.
37. Churchill CM, Priolo CV, Nemeroff CB, Krishnan KRR, Breitner JCS (1991): Occult subcortical magnetic resonance findings in elderly depressives. Int J Geriat Psychiatry 6:213-216.
38. Cleghorn JM, Zipursky RB, List SJ (1991): Structural and functional brain imaging in schizophrenia. J Psychiatry Neurosci 16:53-74.
39. Coffey CE, Hinkle PE, Weiner RD, et al (1987): Electroconvulsive therapy of depression in patients with white matter hyperintensity. Biol Psychiatry 122:629-636.
40. Coffey CE, Figiel GS, Djang WT, Cress M, Saunders WB, Weiner RD (1988): Leukoencephalopathy in elderly depressed patients referred for ECT. Biol Psychiatry 24:143-161.
41. Coffey CE, Figiel GS, Djang WT, Saunders WB, Weiner RD (1989): White matter hyperintensity on magnetic resonance imaging: Clinical and neuroanatomic correlates in the depressed elderly. J Neuropsychiatry Clin Neurosci 1:135-144.
42. Coffey CE, Figiel GS, Djang WT, Weiner RD (1990): Subcortical hyperintensity on magnetic resonance imaging: A comparison of normal and depressed elderly subjects. Am J Psychiatry 147:187-189.
43. Coffey CE, Wilkinson WE, Weiner RD, et al (1993a): Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study. Arch Gen Psychiatry 50:7-16.
44. Coffey CE, Wilkinson WE, Weiner RD, Ritchie JC, Aque M (1993b): The dexamethasone suppression test and quantitative cerebral anatomy in depression. Biol Psychiatry 33:442-449.
45. Coffman JA, Bornstein RA, Olson SC, Schwarzkopf SB, Nasrallah HA (1990): Cognitive impairment and cerebral structure by MRI in bipolar disorder. Biol Psychiatry 27:1188-1196.
46. Cohen G, Andreasen NC, Alliger R, et al (1992): Segmentation techniques for the classification of brain tissue using magnetic resonance imaging. Psychiatry Res: Neuroimaging 45: 33-51.
47. Conlon P, Trimble MR (1987): Magnetic resonance imaging in psychiatry. Can J Psychiatry 32:702-712.
48. Cummings JL (1993): The neuroanatomy of depression. J Clin Psychiatry 54(suppl):14-20.
49. Cummings JL, Mendez MF (1984): Secondary mania with focal cerebrovascular lesions. Am J Psychiatry 141:1084-1087.
50. DeLisi LE, Stritzke P, Riordan H, et al (1992): The timing of brain morphological changes in schizophrenia and their relationship to clinical outcome. Biol Psychiatry 31:241-254.
51. Dewan MJ, Haldipur CV, Lane EE, Ispahani A, Boucher MF, Major LF (1988a): Bipolar affective disorder: I. Comprehensive quantitative computed tomography. Acta Psychiatr Scand 77:670-676.
52. Dewan MJ, Haldipur CV, Boucher MF, Ramachandran T, Major LF (1988b): Bipolar affective disorder: II. EEG, neuropsychological, and clinical correlates of CT abnormality. Acta Psychiatr Scand 77:677-682.
53. Dewan MJ, Haldipur CV, Boucher M, Major LF (1988c): Is CT ventriculomegaly related to hypercortisolemia? Acta Psychiatr Scand 77:230-231.
54. Dolan RJ, Calloway SP, Mann AH (1985): Cerebral ventricular size in depressed subjects. Psychol Med 15:873-878.
55. Dolan RJ, Calloway SP, Thacker PF, Mann AH (1986): The cerebral cortical appearance in depressed subjects. Psychol Med 16:775-779.
56. Dolan RJ, Poynton AM, Bridges PK, Trimble MR (1990): Altered magnetic resonance white-matter Tl values in patients with affective disorder. Br J Psychiatr 157:107-110.
57. Drevets WC, Videen TO, Price JL, Preskorn SH, Carmichael ST, Raichle ME (1992): A functional anatomical study of unipolar depression. J Neurosci 12:3628-3641.
58. Dupont RM, Jernigan TL, Gillin JC, Butters N, Delis DC, Hesselink JR (1987): Subcortical signal hyperintensities in bipolar patients detected by MRI. Psychiatry Res 21:357-358.
59. Dupont RM, Jernigan TL, Butters N, et al (1990): Subcortical abnormalities detected in bipolar affective disorder using magnetic resonance imaging. Arch Gen Psychiatry 47:55-59.
60. Dupont RM, Jernigan TL, Heindel W, et al (1995): Magnetic resonance imaging and mood disorders-Localization of white matter and other subcortical abnormalities. Arch Gen Psychiatry 52:747-755.
61. Eastwood MR, Rifat SL, Nobbs H, Ruderman J (1989): Mood disorder following cerebrovascular accident. Br J Psychiatry 154:195-200.
62. El-Guebaly N (1975): Manic-depressive psychosis and drug abuse. Can J Psychiatry 20:595-598.
63. Elkis H, Friedman L, Wise A, Meltzer HY (1995): Meta-analyses of studies of ventricular enlargement and cortical sulcal prominence in mood disorders - Comparisons with controls or patients with schizophrenia. Arch Gen Psychiatry 52:735-746.
64. Englund E, Brun A, Persson B (1987): Correlations between histopathologic white matter changes and proton MR relaxation times in dementia. Alzheimer's Dis Assoc Disord 1:156-170.
65. Erkinjuntti T, Sipponen JT, livanainem M, Ketonen L, Sulkava R, Sepponen RE (1984): Cerebral NMR and CT imaging in dementia. J Comput Assist Tomogr 8:614-618.
66. Escalona PR, McDonald WM, Doraiswamy PM, et al (1991): In vivo stereological assessment of human cerebellar volume: Effects of gender and age. Am J Neuroradiol 12:927-929.
67. Escalona PR, Early B, McDonald WM, et al (1993): Reduction of cerebellar volume in major depression: A controlled MRI study. Depression 1:156-158.
68. Figiel GS, Coffey CE, Weiner RD (1989a): Brain magnetic resonance imaging in elderly depressed patients receiving electroconvulsive therapy. Convuls Ther 5:26-34.
69. Figiel GS, Krishnan KR, Breitner JC, Nemeroff CB (1989b): Radiologic correlates of antidepressant-induced delirium: The possible significance of basal-ganglia lesions. J Neuropsychiatry Clin Neurosci 1:188-190.
70. Figiel GS, Krishnan KR, Doraiswamy PM (1990a): Subcortical structural changes in ECT-induced delirium. J Geriat Psychiatry Neurol 3:172-176.
71. Figiel GS, Coffey CE, Djang WT, Hoffman G Jr, Doraiswamy PM (1990b): Brain magnetic resonance imaging findings in ECT-induced delirium. J Neuropsychiatry Clin Neurosci 2:53-58.
72. Figiel GS, Krishnan KRR, Doraiswamy PM, Rao VP, Nemeroff CB, Boyko OB (1991a): Subcortical hyperintensities on brain magnetic resonance imaging: A comparison between late age onset and early onset elderly depressed subjects. Neurobiol Aging 26:245-247.
73. Figiel GS, Krishnan KRR, Rao VP, et al (1991b): Subcortical hyperintensities on brain magnetic resonance imaging: A comparison of normal and bipolar subjects. J Neuropsychiatry Clin Neurosci 3:18-22.
74. Figiel GS, Krishnan KRR, Doraiswamy PM, Nemeroff CB (1991c): Caudate hyperintensities in elderly depressed patients with neuroleptic-induced parkinsonism. J Geriatr Psychiatry Neurol 4:86-89.
75. Filipek PA, Kennedy DN, Caviness VS, Rossnick SL, Spraggins TA, Starewicz PM (1989): Magnetic resonance imagingbased brain morphometry: Development and application to normal subjects. Ann Neurol 25:61-67.
76. Folstein MF, Maiberger R, McHugh PR (1977): Mood disorder as a specific complication of stroke. J Neurol Neurosurg Psychiatry 40:1018-1020.
77. Forrest DV (1982): Bipolar illness after right hemispherectomy. Arch Gen Psychiatry 39:817-819.
78. Fujikawa T, Yamawaki S, Touhouda Y (1993): Incidence of silent cerebral infarction in patients with major depression. Stroke 24:1631-1634.
79. George MS (1994): Introduction: The emerging neuroanatomy of depression. Psychiatr Ann 24:635-636.
80. George AE, deLeon M, Gentes C, et al (1986): Leukoencephalopathy in normal and pathological aging: 1. CT of brain lucencies. AJNR Am J Neuroradiol 7:561-566.
81. George MS, Ketter TA, Post RM (1993): SPECT and PET imaging in mood disorders. J Clin Psychiatry 54(suppl):613.
82. George MS, Ketter TA, Post RM (1994): Prefrontal cortex dysfunction in clinical depression. Depression 2:59-72.
83. Grafton ST, Sumi SM, Stimac GK, Alvord EC, Shaw CM, Nochlin D (1991): Comparison of postmortem magnetic resonance imaging and neuropathologic findings in the cerebral white matter. Arch Neurol 48:293-298.
84. Gupta SR, Naheedy MH, Young JC, Ghobrial M, Rubino FA, Hindo W (1988): Periventricular white matter changes and dementia: Clinical, neuropsychological, radiological, and pathological correlation. Arch Neurol 45:637-641.
85. Gur RE, Pearlson GD (1993): Neuroimaging in schizophrenia research. Schizophr Bull 19:337-353.
86. Guze BH, Gitlin M (1994): the neuropathologic basis of major affective disorders: Neuroanatomic insights. J Neuropsychiatry Clin Neurosci 6:114-121.
87. Guze BH, Szuba MP (1992): Leukoencephalopathy and major depression: A preliminary report. Psychiatry Res 45:169-175.
88. Harrel LE, Duvall E, Folks DG, et al (1991): The relationship of high-intensity signals on magnetic resonance images to cognitive and psychiatric state in Alzheimer's disease. Arch Neurol 48:1136-1140.
89. Harvey I, Persaud R, Ron MA, Baker B, Murray RM (1994): Volumetric MRI measurements in bipolars compared with schizophrenics and healthy controls. Psychol Med 24:689-699.
90. Hasin D, Endicott J, Lewis C (1985): Alcohol and drug abuse in patients with affective syndromes. Compr Psychiatry 26:283-295.
91. Hauser P, Altshuler LL, Berrettini W, Dauphinais ID, Gelernter J, Post RM (1989a): Temporal lobe measurement in primary affective disorder by magnetic resonance imaging. J Neuropsychiatry Clin Neurosci 1:128-134.
92. Hauser P, Dauphinais D, Berrettini W, DeLisi LE, Gelernter J, Post RM (1989b): Corpus callosum dimensions measured by magnetic resonance imaging in bipolar affective disorder and schizophrenia. Biol Psychiatry 26:659-668.
93. Herrmann M, Bartels C, Wallesch CW (1993): Depression in acute and chronic aphasia: Symptoms, pathoanatomical-clinical correlations and functional implications. J Neurol Neurosurg Psychiatry 56:672-678.
94. Hickie I, Scott E, Mitchell P, Wilhelm K, Austin MP, Bennett B (1995): Subcortical hyperintensities on magnetic resonance imaging: Clinical correlates and prognostic significance in patients with severe depression. Biol Psychiatry 37:151-160.
95. House A, Dennis M, Warlow C, Hawton K, Molyneux A (1990): Mood disorders after stroke and their relation to lesion location. Brain 113:1113-1129.
96. Howard RJ, Beats B, Forstl H, Graves P, Bingham J, Levy R (1993): White matter changes in late onset depression: A magnetic resonance imaging study. Int J Geriat Psychiatry 8:183-185.
97. Husain MM, McDonald WM, Doraiswamy PM, et al (199la): A magnetic resonance imaging study of putamen nuclei in major depression. Psychiatry Res 40:95-99.
98. Husain MM, Knight DL, Doraiswamy PM, et al (1991b): Platelet [3H]-imipramine binding and leukoencephalopathy in geriatric depression. Biol Psychiatry 29:665-670.
99. Iacono WG, Smith GN, Moreau M, et al (1988): Ventricular and sulcal size at the onset of psychosis. Am J Psychiatry 145:820-824.
100. Irle E, Peper M, Wowra B, Kunze S (1994): Mood changes after surgery for tumors of the cerebral cortex. Arch Neurol 51:164-174.
101. Jacoby RJ, Levi R (1980): Computed tomography in the elderly: 3. Affective disorder. Br J Psychiatry 136:270-275.
102. Jacoby RJ, Levy R, Bird JM (1981): Computed tomography and the outcome of affective disorder: A follow-up study of elderly patients. Br J Psychiatry 139:288-292.
103. Jernigan TL, Butters N, DiTraglia G, et al (1991): Reduced cerebral grey matter observed in alcoholics using magnetic resonance imaging. Alcohol Clin Exp Res 15:418-427.
104. Jeste DV, Lohr JB, Goodwin FK (1988): Neuroanatomical studies of major affective disorders: A review and suggestions for further research. Br J Psychiatry 153:444-459.
105. Johnson BA, Campbell LB (1990): Mood disorder, "pre-ictal" psychosis and temporal lobe damage. Br J Psychiatry 157: 441-444.
106. Johnstone EC, Owens DGC, Crow TJ, et al (1986): Hypothyroidism as a correlate of lateral ventricular enlargement in manic-depressive and neurotic illness. Br J Psychiatry 148: 317-321.
107. Johnstone EC, Owens DGC, Crow TJ, et al (1989): Temporal lobe structure as determined by nuclear magnetic resonance in schizophrenia and bipolar affective disorder. J Neurol Neurosurg Psychiatry 52:736-741.
108. Jones P, Murray RM (1991): The genetics of schizophrenia is the genetics of neurodevelopment. Br J Psychiatry 158:615-623.
109. Jorge RE, Robinson RG, Arndt SV, Forrester AW, Geister F, Starkstein SE (1993): Comparison between acute-and delayed-onset depression following traumatic brain injury. J Neuropsychiatry Clin Neurosci 5:43-49.
110. Junque C, Pujot T, Vendrell P, et al (1990): Leukoaraiosis on magnetic resonance imaging and speed of mental processing. Arch Neurol 47:151-156.
111. Jurjus GJ, Nasrallah HA, Olson SC, Schwarzkopf SB (1993): Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls: A magnetic resonance imaging study. Psychol Med 23:319-322.
112. Kaplan MJ, Lazoff M, Kelly K, Lukin R, Garver DL (1990): Enlargement of cerebral third ventricle in psychotic patients with delayed response to neuroleptics. Biol Psychiatry 27: 205-214.
113. Kellner CH, Rubinow DR, Gold PW, Post RM (1983): Relationship of cortisol hypersecretion to brain CT scan alterations in depressed patients. Psychiatry Res 8:191-197.
114. Kemmerer M, Nasrallah HA, Sharma S, Olson SC, Martin R, Lynn MB (1994): Increased hippocampal volume in bipolar disorder [abstract]. Biol Psychiatry 35:626.
115. Keshavan MS, Anderson S, Pettegrew JW (1994): Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited. J Psychiatr Res 28:239-265.
116. Ketter TA, George MS, Ring HA, et al (1994): Primary mood disorders: Structural and resting functional studies. Psychiatr Ann 24:637-642.
117. Kolbeinsson H, Arnaldsson OS, Petursson H, Skulason S (1986): Computed tomographic scans in ECT-patients. Acta Psychiatr Scand 73:28-32.
118. Krieg JC, Pirke KM, Lauer C, Backmund H (1988): Endocrine, metabolic, and cranial computed tomographic findings in anorexia nervosa. Biol Psychiatry 23:377-387.
119. Krishnan KRR (1993): Pituitary and adrenal changes in depression. Psychiatr Ann 23:671-675.
120. Krishnan KR, Doraiswamy PM, Figiel GS, et al (1991a): Hippocampal abnormalities in depression. J Neuropsychiatry Clin Neurosci 3:387-391.
121. Krishnan KR, Doraiswamy PM, Lurie SN, et al (1991b): Pituitary size in depression. J Clin Endocrinol Metabol 72:256-259.
122. Krishnan KR, McDonald WM, Escalona PR, et al (1992): Magnetic resonance imaging of the caudate nuclei in depression. Preliminary observations. Arch Gen Psychiatry 49:553-557.
123. Krishnan KRR, Boyko OB, McDonald WM, et al (1993a): Magnetic-resonance morphometry: Image-analysis methodology development for affective disorder. Depression 1:159-171.
124. Krishnan KRR, McDonald WM, Doraiswamy PM, et al (1993b): Neuroanatomical substrates of depression in the elderly. Eur Arch Psychiatry Clin Neurosci 243:41-46.
125. Lader MH, Ron M, Petursson H (1984): Computed axial brain tomography in long-term benzodiazepine users. Psychol Med 14:203-206.
126. Lammers GS, Doraiswamy PM, Husain MM, Figiel GS, Lurie SN, Boyko OB, Ellinwood EH Jr, Nemeroff CB, Krishnan KRR (1991): MRJ of the corpus callosum and septum pellucidum in depression. Biol Psychiatry 29:295-308.
127. Leifer D, Buonanno FS, Richardson EP Jr (1990): Clinicopathologic correlations of cranial magnetic resonance imaging of periventricular white matter. Neurology 40:911-918.
128. Lesser IM, Miller BL, Boone KB, Hill-Gutierrez E, Mehringer CM, Wong K, Mena I (1991): Brain injury and cognitive function in late-onset psychotic depression. J Neuropsychiatry Clin Neurosci 3:33-40.
129. Lesser IM, Jeste DV, Boone KB, et al (1992): Late-onset psychotic disorder, not otherwise specified: Clinical and neuroimaging findings. Biol Psychiatry 31:419-423.
130. Lesser IM, Hill-Gutierrez E, Miller BL, Boone KB (1993): Late-onset depression with white matter lesions. Psychosomatics 34:364-367.
131. Leuchter AF, Dunkin JJ, Lufkin RB, Anzai Y, Cook IA, Newton TF (1994): Effect of white matter disease on functional connections in the aging brain. J Neurol Neurosurg Psychiatry 57:1347-1354.
132. Lewine RRJ, Risch C, Risby E, et al (1991): Lateral ventriclebrain ratio and balance between CSF HVA and 5-HIAA in schizophrenia. Am J Psychiatry 148:1189-1194.
133. Lippman S, Manshadi M, Baldwin H, et al (1985): Cerebral cat scan imaging in schizophrenic and bipolar patients. J Kentucky Med Assoc January: 13-15.
134. Lipsey JR, Robinson RG, Pearlson GD, Rao K, Price TR (1983): Mood change following bilateral hemisphere brain injury. Br J Psychiatry 143:266-273.
135. Lishman WA (1990): Alcohol and the brain. Br J Psychiatry 156:635-644.
136. Luchins DJ, Lewine RRJ, Meltzer HY (1984): Lateral ventricular size, psychopathology, and medication response in the psychosis. Biol Psychiatry 19:29-44.
137. Mayberg HS (1994): Frontal lobe dysfunction in secondary depression. J Neuropsychiatry Clin Neurosci 6:428-442.
138. Mayberg HS, Lewis PJ, Regenold W, Wagner HN Jr (1994): Paralimbic hypoperfusion in unipolar depression. J Nucl Med 35:929-934.
139. McDonald WM, Krishnan KRR (1992): Magnetic resonance in patients with affective illness. Eur Arch Psychiatry Clin Neurosci 241:283-290.
140. McDonald WM, Krishnan KRR, Doraiswamy PM, Blazer DG (1991): Occurrence of subcortical hyperintensities in elderly subjects with mania. Psychiatry Res: Neuroimaging 40:211-220.
141. Mega MS, Cummings JL (1994): Frontal-subcortical circuits and neuropsychiatric disorders. J Neuropsychiatry Clin Neurosci 6:358-370.
142. Meltzer HY, Tong C, Luchins DJ (1984): Serum dopamine-betahydroxylase activity and lateral ventricular size in affective disorders and schizophrenia. Biol Psychiatry 19:1395-1402.
143. Mendez MF, Lewandowski KS (1989): Neurobehavioral changes with caudate lesions. Neurology 39:1410-1411.
144. Morris P, Rapoport SI (1990): Neuroimaging and affective disorder in late life: A review. Can J Psychiatry 35:347-354.
145. Nasrallah HA (1991): Neurodevelopmental aspects of bipolar affective disorder. Biol Psychiatry 29:1-2.
146. Nasrallah HA, McCalley-Whitters M, Jacoby CG (1982a): Cerebral ventricular enlargement in young manic males - A controlled CT study. J Affect Disord 4:15-19.
147. Nasrallah HA, McCalley-Whitters M, Jacoby CG (1982b): Cortical atrophy in schizophrenia and mania: A comparative CT study. J Clin Psychiatry 43:439-441.
148. Nasrallah HA, Coffman JA, Olson SC (1989): Structural brainimaging findings in affective disorders: An overview. J Neuropsychiatry Clin Neurosci 1:21-26.
149. Ng KC, Chan KL, Straughan PT (1995): A study of post-stroke depression in a rehabilitative center. Acta Psychiatr Scand 92:75-79.
150. Pearlson GD, Veroff AE (1981): Computerized tomographic scan changes in manic-depressive illness. Lancet 2(8244), August 29:470.
151. Pearlson GD, Garbacz DJ, Breakey WR, Ahn HS, DePaulo JR (1984a): Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder. Psychiatry Res 12:1-9.
152. Pearlson GD, Garbacz DJ, Tompkins RH, et al (1984b): Clinical correlates of lateral ventricular enlargement in bipolar affective disorder. Am J Psychiatry 141:253-256.
153. Pearlson GD, Rabins PV, Kim WS, et al (1989): Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia ("pseudodementia"). Psychol Med 19:573-584.
154. Pfefferbaum A, Lim KO, Zipursky RB, et al (1992): Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: A quantitative MRI study. Alcohol Clin Exp Res 16:1078-1089.
155. Pfefferbaum A, Mathalon DH, Sullivan EV, Rawles JM, Zipursky RB, Lim KO (1994): A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol 51:874-887.
156. Pilowsky LS, Kerwin RW, Murray RM (1993): Schizophrenia: A neurodevelopmental perspective. Neuropsychopharmacology 9:83-91.
157. Rabins PV, Pearlson GD, Aylward E, Kumar AJ, Dowell K (1991): Cortical magnetic resonance imaging changes in elderly inpatients with major depression. Am J Psychiatry 148:617-620.
158. Rangel-Guerra RA, Perez-Payan H, Minkoff L, Todd LE (1983): Nuclear magnetic resonance in bipolar affective disorders. AJNR Am J Neuroradiol 4:229-231.
159. Rao VP, Krishnan KR, Goli V, et al (1989): Neuroanatomical changes and hypothalamo-pituitary-adrenal axis abnormalities. Biol Psychiatry 26:729-732.
160. Raz S (1993): Structural cerebral pathology in schizophrenia: regional or diffuse? J Abnorm Psychol 102:445-452.
161. Raz S, Raz N (1990): Structural brain abnormalities in the major psychoses: A quantitative review of the evidence from computerized imaging. Psychol Bull 108:93-108.
162. Reich LH, Davies RK, Himmelhoch JM (1974): Excessive alcohol use in manic-depressive illness. Am J Psychiatry 131:83-86.
163. Rieder RO, Mann LS, Weinberger DR, van Kammen DP, Post RM (1983): Computed tomographic scans in patients with schizophrenia, schizoaffective, and bipolar affective disorder. Arch Gen Psychiatry 40:735-739.
164. Risen SC, Lewine RJ, Kalin NH, et al (1992): Limbic-hypothalamic-pituitary-adrenal axis activity and ventricular-to-brain ratio studies in affective illness and schizophrenia. Neuropsychopharmacology 6:95-100.
165. Robinson RG, Kubos KL, Starr LB, Rao K, Price TR (1984a): Mood disorders in stroke patients: Importance of location of lesion. Brain 107:81-93.
166. Robinson RG, Starr LB, Lipsey JR, Rao K, Price TR (1984b): A two-year longitudinal study of post-stroke mood disorders: Dynamic changes in associated variables over the first six months of follow-up. Stroke 15:510-517.
167. Robinson RG, Boston JD, Starkstein SE, Price TR (1988): Comparison of mania and depression after brain injury: Causal factors. Am J Psychiatry 145:172-178.
168. Rogus D, Lees AJ, Smith E, Trinkle M, Stern GM (1987): Bradyphrenia in Parkinson's disease and psychomotor illness. Brain 110:761-776.
169. Rossi A, Stratta P, Petruzzi C, De Donatis M, Nistico R, Casacchia M (1987): A computerized tomographic study in DSM-III affective disorders. J Affect Disord 12:259-262.
170. Rossi A, Stratta P, di Michele V, et al (1989): A computerized tomographic study in patients with depressive disorder: A comparison with schizophrenic patients and controls. Acta Psychiatr Belg 89:56-61.
171. Rossi A, Stratta P, Di Michele V, et al (1991): Temporal lobe structure by magnetic resonance in bipolar affective disorders and schizophrenia. J Affect Disord 21:19-22.
172. Rothschild AJ, Benes F, Hebben N, et al (1989): Relationships between brain CT scan findings and cortisol in psychotic and nonpsychotic depressed patients. Biol Psychiatry 26:565-575.
173. Roy-Byrne PP, Post RM, Kellner CH, Joffe RT, Uhde TW (1988): Ventricular-brain ratio and life course of illness in patients with affective disorder. Psychiatry Res 23:277-284.
174. Rubin RT, Phillips JJ, Sadow TF, McCracken JT (1995): Adrenal gland volume in major depression. Increase during the depressive episode and decrease with successful treatment. Arch Gen Psychiatry 52:213-218.
175. Salloway S, Cummings J (1994): Subcortical disease and neuropsychiatrie illness. J Neuropsychiatry Clin Neurosci 6:93-99.
176. Sapolsky RM, McEwen BS (1988): Why dexamethasone resistance? Two possible neuroendocrine mechanisms in the hypothalamic pituitary adrenal axis. In Schatzberg AF, Nemeroff CB (eds), Psychology, Pathophysiology and Psychiatric Implications. New York: Raven Press, 155-169.
177. Scheltens P, Barkhof F, Leys D, Wolters EC, Ravid R, Kamphorst W (1995): Histopathologic correlates of white matter changes on MRI in Alzheimer's disease and normal aging. Neurology 45:883-888.
178. Schlaepfer TE, Harris GJ, Tien AY, et al (1994): Decreased regional cortical gray matter volume in schizophrenia. Am J Psychiatry 151:842-848.
179. Schlaepfer TE, Harris GJ, Tien AY, Peng L, Lee S, Pearlson GD (1995): Structural differences in the cerebral cortex of healthy female and male subjects: A magnetic resonance imaging study. Psychiatry Res: Neuroimaging 61:129-135.
180. Schlegel S, Kretzschmar K (1987): Computed tomography in affective disorders: Part I. Ventricular and sulcal measurements. Biol Psychiatry 22:4-14.
181. Schlegel S, Maier W, Philipp M, et al (1989a): Computed tomography in depression: Association between ventricular size and psychopathology. Psychiatry Res 29:221-230.
182. Schlegel S, von Bardeleben U, Wiedemann K, Frommberger U, Holsboer F (1989b): Computerized brain tomography measures compared with spontaneous and suppressed plasma cortisol levels in major depression. Psychoneuroendocrinology 14:209-216.
183. Schmidt R, Fazekas F, Offenbacher H, et al (1991): Magnetic resonance imaging white matter lesions and cognitive impairment in hypertensive individuals. Arch Neurol 48:417-420.
184. Scott ML, Golden CJ, Ruedrich SL, Bishop RJ (1983): Ventricular enlargement in major depression. Psychiatry Res 8:91-93.
185. Shah SA, Doraiswamy PM, Husain MM, et al (1992): Posterior fossa abnormalities in major depression: A controlled magnetic resonance imaging study. Acta Psychiatr Scand 85: 474-479.
186. Sharpe M, Hawton K, House A, et al (1990): Mood disorders in long-term survivors of stroke: Associations with brain lesion location and volume. Psychol Med 20:815-828.
187. Shear PK, Jernigan TL, Butters N (1994): Volumetric magnetic resonance imaging quantification of longitudinal brain changes in abstinent alcoholics. Alcohol Clin Exp Res 18: 172-176.
188. Shima S, Shikano T, Kitamura T, et al (1984): Depression and ventricular enlargement. Acta Psychiatr Scand 70:275-277.
189. Shiraishi H, Koizumi J, Hori M, et al (1992): A computerized tomographic study in patients with delusional and nondelusional depression. Jpn J Psychiatry Neurol 46:99-105.
190. Sinyor D, Jacques P, Kaloupek DG, Becker R, Goldenberg M, Coopersmith H (1986): Poststroke depression and lesion location. An attempted replication. Brain 109:537-546.
191. Snider SR, Snider RS (1977): Alterations in forebrain catecholamine metabolism produced by cerebellar lesions in the rat. J Neural Transm 40:115-128.
192. Sonne SC, Brady KT, Morton WA (1994): Substance abuse and bipolar affective disorder. J Nerv Ment Dis 182:349-352.
193. Standish-Barry HMAS, Hale AS, Honig A, Bouras N, Bridges PK, Bartlett JR (1985): Ventricular size, the dexamethasone suppression test and outcome of severe endogenous depression following psychosurgery. Acta Psychiatr Scand 72:166-171.
194. Standish-Barry HMAS, Bouras N, Hale AS, Bridges PK, Bartlett JR (1986): Ventricular size and CSF transmitter metabolite concentrations in severe endogenous depression. Br J Psychiatry 148:386-392.
195. Starkman MN, Gebarski SS, Berent S, Schteingart DE (1992): Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome. Biol Psychiatry 32:756-765.
196. Starkstein SE, Robinson RG (1989): Affective disorders and cerebral vascular disease. Br J Psychiatry 154:170-182.
197. Starkstein SE, Robinson RG, Price TR (1987): Comparison of cortical and subcortical lesions in the production of poststroke mood disorders. Brain 110:1045-1059.
198. Starkstein SE, Robinson RG, Price TR (1988): Comparison of patients with and without poststroke major depression matched for size and location of lesion. Arch Gen Psychiatry 45:247-252.
199. Starkstein SE, Mayberg HS, Berthier ML, et al (1990): Mania after brain injury: Neuroradiological and metabolic findings. Ann Neurol 27:652-659.
200. Starkstein SE, Fedoroff P, Berthier ML, Robinson RG (1991):
201. Steiner RE, Bydder GM (1984): Clinical nuclear magnetic resonance imaging. In Dawson AM, Compston ND, Besser GM (eds), Recent Advances in Medicine, No. 19. London, Churchill-Livingstone, pp 39-56.
202. Steingart A, Lau C, Fox A, Diaz F, Fisman M, Hachinski V (1986): The significance of white matter lucencies on CT scan in relation to cognitive impairment. Can J Neurol Sci 13:383-384.
203. Steingart A, Hachinski V, Lau C, et al (1987): Cognitive and neurologic findings in subjects with diffuse white matter lucencies on CT scan. Arch Neurol 44:36-39.
204. Strakowski SM, Wilson DR, Tohen M, Woods BT, Douglass AW, Stoll AL (1993a): Structural brain abnormalities in first-episode mania. Biol Psychiatry 33:602-609.
205. Strakowski SM, Woods BT, Tohen M, Wilson DR, Douglass AW, Stoll AL (1993b): MRI subcortical signal hyperintensities in mania at first hospitalization. Biol Psychiatry 33:204-206.
206. Swayze VW, Andreasen NC, Alliger RJ, Ehrhardt JC, Yuh WTC (1990): Structural brain abnormalities in bipolar affective disorder. Ventricular enlargement and focal signal hyperintensities. Arch Gen Psychiatry 47:1054-1059.
207. Swayze VW, Andreasen NC, Alliger RJ, Yuh WTC, Ehrhardt JC (1992): Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study. Biol Psychiatry 31:221-240.
208. Tanaka Y, Hazama H, Fukuhara T, Tsutsui T (1982): Computerized tomography of the brain in manic-depressive patients - A controlled study. Folia Psychiatr Neurol Jpn 36:137-144.
209. Targum SD, Rosen LN, DeLisi LE, Weinberger DR, Citrin CM (1983): Cerebral ventricular size in major depressive disorder: Association with delusional symptoms. Biol Psychiatry 18:329-336.
210. van den Bossche B, Macs M, Brussaard C, et al (1991): Computed tomography of the brain in unipolar depression. J Affect Disord 21:67-74.
211. Weinberger DR (1993): A connectionist approach to the prefrontal cortex. J Neuropsychiatry Clin Neurosci 5:241-253.
212. Weinberger D, DeLisi LE, Perman GP, Targum S, Wyatt RJ (1982): Computed tomography in schizophreniform disorder and other acute psychiatric disorders. Arch Gen Psychiatry 39:778-783.
213. Woods BT, Yurgelun-Todd D, Benes FM, Frankenburg FR, Pope HG Jr, McSparren J (1990): Progressive ventricular enlargement in schizophrenia: Comparison to bipolar affective disorder and correlation with clinical course. Biol Psychiatry 27:341-352.
214. Wright P, Gill M, Murray RM (1993): Schizophrenia: Genetics and the maternal imune response to viral infection. Am J Med Genet 48:40-46.
215. Wu JC, Buchsbaum MS, Johnson JC, et al (1993): Magnetic resonance and positron emission tomography imaging of the corpus callosum: Size, shape and metabolic rate in unipolar depression. J Affect Disord 28:15-25.
216. Wurthmann C, Bogerts B, Falkai P (1995): Brain morphology assessed by computed tomography in patients with geriatric depression, patients with degenerative dementia, and normal control subjects. Psychiatry Res: Neuroimaging 61:103-111.
217. Yates WR, Jacoby CG, Andreasen NC (1987): Cerebellar atro-phy in schizophrenia and affective disorder. Am J Psychiatry 144:465-467.
218. Zubenko GS, Sullivan P, Nelson JP, Belle SH, Huff J, Wolf G (1990): Brain imaging abnormalities in mental disorders of late life. Arch Neurol 47:1107-1111.