메뉴 건너뛰기




Volumn 20, Issue 1, 2013, Pages 79-103

Novel therapies in asthma: Leukotriene antagonists, biologic agents, and beyond

Author keywords

asthma; bronchial thermoplasty; leukotriene antagonists; montelukast; omalizumab; zafirlukast

Indexed keywords

ALTRAKINCEPT; ANRUKINZUMAB; BECLOMETASONE; BIOLOGICAL PRODUCT; BUDESONIDE; CROMOGLYCATE DISODIUM; DACLIZUMAB; FLUNISOLIDE; FLUTICASONE; FLUTICASONE PROPIONATE PLUS SALMETEROL; LEBRIKIZUMAB; LEUKOTRIENE RECEPTOR AFFECTING AGENT; MOMETASONE FUROATE; MONTELUKAST; OMALIZUMAB; PASCOLIZUMAB; PIOGLITAZONE; PITRAKINRA; PLACEBO; PREDNISONE; ROSIGLITAZONE; SALBUTAMOL; SALMETEROL; TRALOKINUMAB; TRIAMCINOLONE ACETONIDE; UNINDEXED DRUG; WARFARIN; ZAFIRLUKAST; ZILEUTON;

EID: 84872895158     PISSN: 10752765     EISSN: 15363686     Source Type: Journal    
DOI: 10.1097/MJT.0b013e31826915c2     Document Type: Article
Times cited : (23)

References (243)
  • 3
    • 76149146032 scopus 로고    scopus 로고
    • Identification of asthma phenotypes using cluster analysis in the severe asthma research program
    • Moore WC, Meyers DA, Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the severe asthma research program. Am J Respir Crit Care Med. 2010;181:315-323
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 315-323
    • Moore, W.C.1    Meyers, D.A.2    Wenzel, S.E.3
  • 4
    • 34247862197 scopus 로고    scopus 로고
    • Inhalation therapy: An historical review
    • DOI 10.3132/pcrj.2007.00017
    • Sanders M. Inhalation therapy: An historical review. Prim Care Respir J. 2007;16:71-81 (Pubitemid 46698770)
    • (2007) Primary Care Respiratory Journal , vol.16 , Issue.2 , pp. 71-81
    • Sanders, M.1
  • 6
    • 79959344460 scopus 로고    scopus 로고
    • Expert panel report 3 (EPR-3): Guidelines for the diagnosis and management of asthma-summary report 2007
    • Program NAEAP. Suppl
    • Program, NAEAP. Expert panel report 3 (EPR-3): Guidelines for the diagnosis and management of asthma-summary report 2007. J Allergy Clin Immunol. 2007;120(5 Suppl):S94-S138
    • (2007) J Allergy Clin Immunol , vol.120 , Issue.5
  • 7
    • 0020408633 scopus 로고
    • Bronchial asthma in the medical literature of Greek antiquity
    • Marketos SG, Ballas CN. Bronchial asthma in themedical literature of Greek antiquity. J Asthma. 1982;19:263-269 (Pubitemid 13180816)
    • (1982) Journal of Asthma Research , vol.19 , Issue.4 , pp. 263-269
    • Marketos, S.G.1    Ballas, C.N.2
  • 9
    • 77954071334 scopus 로고    scopus 로고
    • A brief history of asthma and its mechanisms to modern concepts of disease pathogenesis
    • Holgate ST. A brief history of asthma and its mechanisms to modern concepts of disease pathogenesis. Allergy Asthma Immunol Res. 2010;2:165-171
    • (2010) Allergy Asthma Immunol Res , vol.2 , pp. 165-171
    • Holgate, S.T.1
  • 10
    • 79953293200 scopus 로고    scopus 로고
    • Current asthma prevalence - United states 2006- 2008
    • Suppl
    • Moorman JE, Zahran H, Truman BI, et al. Current asthma prevalence - United states, 2006-2008. MMWR Surveill Summ. 2011;60(Suppl):84-86
    • (2011) MMWR Surveill Summ , vol.60 , pp. 84-86
    • Moorman, J.E.1    Zahran, H.2    Truman, B.I.3
  • 11
    • 79551480908 scopus 로고    scopus 로고
    • The burden of adult asthma in the United States: Evidence from the Medical Expenditure Panel Survey
    • Sullivan PW, Ghushchyan VH, Slejko JF, et al. The burden of adult asthma in the United States: Evidence from the Medical Expenditure Panel Survey. J Allergy Clin Immunol. 2011;127:363-369. e1-e3
    • (2011) J Allergy Clin Immunol , vol.127 , Issue.363-369
    • Sullivan, P.W.1    Ghushchyan, V.H.2    Slejko, J.F.3
  • 12
    • 33746269756 scopus 로고    scopus 로고
    • Classifying asthma
    • DOI 10.1378/chest.130.1-suppl.13S
    • Graham LM. Classifying asthma-. Chest. 2006. 130(1 Suppl):13S-20S. (Pubitemid 44107232)
    • (2006) Chest , vol.130 , Issue.1 SUPPL.
    • Graham, L.M.1
  • 13
    • 53049084809 scopus 로고    scopus 로고
    • A new perspective on concepts of asthma severity and control
    • Taylor DR, Bateman ED, Boulet L-P, et al. A new perspective on concepts of asthma severity and control. Eur Respir J. 2008;32:545-554
    • (2008) Eur Respir J , vol.32 , pp. 545-554
    • Taylor, D.R.1    Bateman, E.D.2    Boulet, L.-P.3
  • 15
    • 77956026534 scopus 로고    scopus 로고
    • Single maintenance and reliever therapy (SMART) of asthma: A critical appraisal
    • Chapman KR, Barnes NC, Greening AP, et al. Single maintenance and reliever therapy (SMART) of asthma: A critical appraisal. Thorax. 2010;65:747-752
    • (2010) Thorax , vol.65 , pp. 747-752
    • Chapman, K.R.1    Barnes, N.C.2    Greening, A.P.3
  • 16
    • 33144476873 scopus 로고    scopus 로고
    • The salmeterol multicenter asthma research trial: A comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol
    • DOI 10.1378/chest.129.1.15
    • Nelson HS, Weiss ST, Bleecker ER, et al. The Salmeterol Multicenter Asthma Research Trial: A comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest. 2006;129:15-26 (Pubitemid 43265239)
    • (2006) Chest , vol.129 , Issue.1 , pp. 15-26
    • Nelson, H.S.1    Weiss, S.T.2    Bleecker, E.K.3    Yancey, S.W.4    Dorinsky, P.M.5
  • 17
    • 77953163429 scopus 로고    scopus 로고
    • Salmeterol use and risk of hospitalization among emergency department patients with acute asthma
    • Liao MM, Ginde AA, Clark S, et al. Salmeterol use and risk of hospitalization among emergency department patients with acute asthma. Ann Allergy Asthma Immunol. 2010;104:478-484
    • (2010) Ann Allergy Asthma Immunol , vol.104 , pp. 478-484
    • Liao, M.M.1    Ginde, A.A.2    Clark, S.3
  • 18
    • 33745306721 scopus 로고    scopus 로고
    • Meta-analysis: Effect of long-acting β-agonists on severe asthma exacerbations and asthma-related deaths
    • Salpeter SR, Buckley NS, Ormiston TM, et al. Metaanalysis: Effect of long-Acting beta-Agonists on severe asthma exacerbations and asthma-related deaths. Ann Allergy Asthma Immunol. 2006;144:904-912 (Pubitemid 46768131)
    • (2006) Annals of Internal Medicine , vol.144 , Issue.12 , pp. 904-912
    • Salpeter, S.R.1    Buckley, N.S.2    Ormiston, T.M.3    Salpeter, E.E.4
  • 19
    • 77950481806 scopus 로고    scopus 로고
    • The FDA and safe use of long-Acting beta-Agonists in the treatment of asthma
    • Chowdhury BA, Dal Pan G. The FDA and safe use of long-Acting beta-Agonists in the treatment of asthma. N Engl J Med. 2010;362:1169-1171
    • (2010) N Engl J Med , vol.362 , pp. 1169-1171
    • Chowdhury, B.A.1    Dal Pan, G.2
  • 20
    • 84872961804 scopus 로고    scopus 로고
    • Wilmington DE AstraZeneca Pharmaceuticals LP
    • Accolate, [Package Insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2009
    • (2009) Accolate, [Package Insert
  • 21
    • 0030866313 scopus 로고    scopus 로고
    • Zafirlukast: The first leukotriene-receptor antagonist approved for the treatment of asthma
    • Kelloway JS. Zafirlukast: The first leukotriene-receptor antagonist approved for the treatment of asthma. Ann Pharmacother. 1997;31:1012-1021 (Pubitemid 27390959)
    • (1997) Annals of Pharmacotherapy , vol.31 , Issue.9 , pp. 1012-1021
    • Kelloway, J.S.1
  • 23
    • 36749035792 scopus 로고    scopus 로고
    • Singulair, [Package Insert NJ: Merck and Co. Inc
    • Singulair, [Package Insert]. Whitehouse Station, NJ: Merck and Co., Inc; 2009
    • (2009) Whitehouse Station
  • 24
    • 80051922654 scopus 로고    scopus 로고
    • Advair, [Package Insert NC: Glaxo SmithKIine
    • Advair, [Package Insert]. Research Triangle Park, NC: Glaxo SmithKIine; 2010
    • (2010) Research Triangle Park
  • 25
    • 0020597565 scopus 로고
    • Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation
    • Samuelsson B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science. 1983;220:568-575 (Pubitemid 13130140)
    • (1983) Science , vol.220 , Issue.4597 , pp. 568-575
    • Samuelsson, B.1
  • 27
    • 77952823941 scopus 로고    scopus 로고
    • Cysteinyl leukotrienes and their receptors: Molecular and functional characteristics
    • Singh RK, Gupta S, Dastidar S, et al. Cysteinyl leukotrienes and their receptors: Molecular and functional characteristics. Pharmacology. 2010;85:336-349
    • (2010) Pharmacology , vol.85 , pp. 336-349
    • Singh, R.K.1    Gupta, S.2    Dastidar, S.3
  • 32
    • 0142042430 scopus 로고    scopus 로고
    • Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis
    • DOI 10.1046/j.1365-2222.2003.01786.x
    • Figueroa DJ, Borish L, Baramki D, et al. Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis. Clin Exp Allergy. 2003;33:1380-1388 (Pubitemid 37289934)
    • (2003) Clinical and Experimental Allergy , vol.33 , Issue.10 , pp. 1380-1388
    • Figueroa, D.J.1    Borish, L.2    Baramki, D.3    Philip, G.4    Austin, C.P.5    Evans, J.F.6
  • 36
    • 0034730638 scopus 로고    scopus 로고
    • Characterization of the human cysteinyl leukotriene 2 receptor
    • Heise CE, O'Dowd BF, Figueroa DJ, et al. Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem. 2000;275:30531-30536
    • (2000) J Biol Chem , vol.275 , pp. 30531-30536
    • Heise, C.E.1    O'Dowd, B.F.2    Figueroa, D.J.3
  • 37
    • 28144448369 scopus 로고    scopus 로고
    • Interferon-γ up-regulates expression of cysteinyl leukotriene type 2 receptors on eosinophils in asthmatic patients
    • DOI 10.1378/chest.128.5.3148
    • FujiiM, Tanaka H, Abe S. Interferon-gamma up-regulates expression of cysteinyl leukotriene type 2 receptors on eosinophils in asthmatic patients. Chest. 2005;128: 3148-3155 (Pubitemid 41698634)
    • (2005) Chest , vol.128 , Issue.5 , pp. 3148-3155
    • Fujii, M.1    Tanaka, H.2    Abe, S.3
  • 38
    • 77951683063 scopus 로고    scopus 로고
    • Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor
    • Wunder F, Tinel H, Kast R, et al. Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. Br J Pharmacol. 2010;160:399-409
    • (2010) Br J Pharmacol , vol.160 , pp. 399-409
    • Wunder, F.1    Tinel, H.2    Kast, R.3
  • 39
    • 0031037332 scopus 로고    scopus 로고
    • Pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors in the management of asthma
    • Drazen JM. Pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors in the management of asthma. Pharmacotherapy. 1997;17(1 pt 2):22S-30S. (Pubitemid 27057110)
    • (1997) Pharmacotherapy , vol.17 , Issue.1 SUPPL.
    • Drazen, J.M.1
  • 41
  • 42
    • 71749095907 scopus 로고    scopus 로고
    • Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis
    • Philip G, van Adelsberg J, Loeys T, et al. Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis. J Allergy Clin Immunol. 2009;124:942-948. e1-e9
    • (2009) J Allergy Clin Immunol , vol.124 , Issue.942-948
    • Philip, G.1    Van Adelsberg, J.2    Loeys, T.3
  • 43
    • 79958800973 scopus 로고    scopus 로고
    • Association between leukotriene-modifying agents and suicide: What is the evidence?
    • Schumock GT, Lee TA, Joo MJ, et al. Association between leukotriene-modifying agents and suicide: What is the evidence? Drug Saf. 2011;34:533-544
    • (2011) Drug Saf , vol.34 , pp. 533-544
    • Schumock, G.T.1    Lee, T.A.2    Joo, M.J.3
  • 44
    • 84864491309 scopus 로고    scopus 로고
    • Risk of suicide attempt in asthmatic children and young adults prescribed leukotriene-modifying agents: A nested case-control study
    • Schumock GT, Stayner LT, Valuck RJ, et al. Risk of suicide attempt in asthmatic children and young adults prescribed leukotriene-modifying agents: A nested case-control study. J Allergy Clin Immunol. 2012;130:368-375
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 368-375
    • Schumock, G.T.1    Stayner, L.T.2    Valuck, R.J.3
  • 47
    • 68849090036 scopus 로고    scopus 로고
    • Churgstrauss syndrome in patients treated with omalizumab
    • Wechsler ME, Wong DA, Miller MK, et al. Churgstrauss syndrome in patients treated with omalizumab. Chest. 2009;136:507-518
    • (2009) Chest , vol.136 , pp. 507-518
    • Wechsler, M.E.1    Wong, D.A.2    Miller, M.K.3
  • 48
    • 76549137094 scopus 로고    scopus 로고
    • Association between leukotriene receptor antagonist therapy and Churg-Strauss syndrome: An analysis of the FDA AERS database
    • Bibby S, Healy B, Steele R, et al. Association between leukotriene receptor antagonist therapy and Churg-Strauss syndrome: An analysis of the FDA AERS database. Thorax. 2010;65:132-138
    • (2010) Thorax , vol.65 , pp. 132-138
    • Bibby, S.1    Healy, B.2    Steele, R.3
  • 49
    • 0029155630 scopus 로고
    • Formes frustes of Churg-Strauss syndrome
    • Churg A, Brallas M, Cronin SR, et al. Formes frustes of Churg-Strauss syndrome. Chest. 1995;108:320-323
    • (1995) Chest , vol.108 , pp. 320-323
    • Churg, A.1    Brallas, M.2    Cronin, S.R.3
  • 51
    • 74949090750 scopus 로고    scopus 로고
    • Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: A multicenter, randomized, doubleblind, sham-controlled clinical trial
    • Castro M, Rubin AS, Laviolette M, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: A multicenter, randomized, doubleblind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2009;181:116-124
    • (2009) Am J Respir Crit Care Med , vol.181 , pp. 116-124
    • Castro, M.1    Rubin, A.S.2    Laviolette, M.3
  • 52
    • 53649097422 scopus 로고    scopus 로고
    • Churg-Strauss syndrome and leukotriene antagonist use: A respiratory perspective
    • Nathani N, Little MA, Kunst H, et al. Churg-Strauss syndrome and leukotriene antagonist use: A respiratory perspective. Thorax. 2008;63:883-888
    • (2008) Thorax , vol.63 , pp. 883-888
    • Nathani, N.1    Little, M.A.2    Kunst, H.3
  • 53
    • 49149105615 scopus 로고    scopus 로고
    • The leucotriene receptor antagonist montelukast and the risk of Churg-Strauss syndrome: A case-crossover study
    • Hauser T, Mahr A, Metzler C, et al. The leucotriene receptor antagonist montelukast and the risk of Churg-Strauss syndrome: A case-crossover study. Thorax. 2008;63:677-682
    • (2008) Thorax , vol.63 , pp. 677-682
    • Hauser, T.1    Mahr, A.2    Metzler, C.3
  • 54
    • 0001409324 scopus 로고    scopus 로고
    • Effect of zafirlukast on prothrombin time and area under the curve of warfarin
    • Abstract
    • Vargo DL, Y C, Lasseter K, et al. Effect of zafirlukast on prothrombin time and area under the curve of warfarin. J Clin Pharmacol. 1997;37:870. Abstract
    • (1997) J Clin Pharmacol , vol.37 , pp. 870
    • Vargo, D.L.Y.C.1    Lasseter, K.2
  • 57
    • 33745727121 scopus 로고    scopus 로고
    • Montelukast and zafirlukast do not affect the pharmacokinetics of the CYP2C8 substrate pioglitazone
    • Jaakkola T, Backman JT, Neuvonen M, et al. Montelukast and zafirlukast do not affect the pharmacokinetics of the CYP2C8 substrate pioglitazone. Eur J Clin Pharmacol. 2006;62:503-509
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 503-509
    • Jaakkola, T.1    Backman, J.T.2    Neuvonen, M.3
  • 58
    • 33846995662 scopus 로고    scopus 로고
    • Effect of multiple doses of montelukast on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in humans
    • Kim KA, Park P-W, Kim KR, et al. Effect of multiple doses of montelukast on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in humans. Br J Clin Pharmacol. 2007;63:339-345
    • (2007) Br J Clin Pharmacol , vol.63 , pp. 339-345
    • Kim, K.A.1    Park, P.-W.2    Kim, K.R.3
  • 61
    • 78650887498 scopus 로고    scopus 로고
    • Costeffectiveness analysis of fluticasone versus montelukast in children with mild-To-moderate persistent asthma in the pediatric asthma controller trial
    • 166 e1
    • Wang L, Hollenbeak CS, Mauger DT, et al. Costeffectiveness analysis of fluticasone versus montelukast in children with mild-To-moderate persistent asthma in the Pediatric Asthma Controller Trial. J Allergy Clin Immunol. 2011;127:161-166. 166 e1
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 161-166
    • Wang, L.1    Hollenbeak, C.S.2    Mauger, D.T.3
  • 62
    • 19544388923 scopus 로고    scopus 로고
    • Short-term and long-term asthma control in patients with mild persistent asthma receiving montelukast or fluticasone: A randomized controlled trial
    • DOI 10.1016/j.amjmed.2005.03.003, PII S0002934305001749
    • Zeiger RS, Bird SR, Kaplan MS, et al. Short-Term and long-Term asthma control in patients with mild persistent asthma receiving montelukast or fluticasone: A randomized controlled trial. Am J Med. 2005;118:649-657 (Pubitemid 40732705)
    • (2005) American Journal of Medicine , vol.118 , Issue.6 , pp. 649-657
    • Zeiger, R.S.1    Bird, S.R.2    Kaplan, M.S.3    Schatz, M.4    Pearlman, D.S.5    Orav, E.J.6    Hustad, C.M.7    Edelman, J.M.8
  • 65
    • 18944364933 scopus 로고    scopus 로고
    • Long-Acting beta2-Agonists versus anti-leukotrienes as add-on therapy to inhaled corticosteroids for chronic asthma
    • Ram FS, Cates CJ, Ducharme FM. Long-Acting beta2-Agonists versus anti-leukotrienes as add-on therapy to inhaled corticosteroids for chronic asthma. Cochrane Database Syst Rev. 2005;CD003137
    • (2005) Cochrane Database Syst Rev
    • Ram, F.S.1    Cates, C.J.2    Ducharme, F.M.3
  • 66
    • 79959501692 scopus 로고    scopus 로고
    • Addition to inhaled corticosteroids of long-Acting beta2-Agonists versus anti-leukotrienes for chronic asthma
    • Ducharme FM, Lasserson TJ, Cates CJ. Addition to inhaled corticosteroids of long-Acting beta2-Agonists versus anti-leukotrienes for chronic asthma. Cochrane Database Syst Rev. 2011;CD003137
    • (2011) Cochrane Database Syst Rev
    • Ducharme, F.M.1    Lasserson, T.J.2    Cates, C.J.3
  • 68
    • 27144496334 scopus 로고    scopus 로고
    • Long-acting bronchodilator or leukotriene modifier as add-on therapy to inhaled corticosteroids in persistent asthma?
    • DOI 10.1378/chest.128.4.2954
    • Currie GP, Lee DK, Srivastava P. Long-Acting bronchodilator or leukotriene modifier as add-on therapy to inhaled corticosteroids in persistent asthma? Chest. 2005;128:2954-2962 (Pubitemid 41507655)
    • (2005) Chest , vol.128 , Issue.4 , pp. 2954-2962
    • Currie, G.P.1    Lee, D.K.C.2    Srivastava, P.3
  • 69
    • 43949129790 scopus 로고    scopus 로고
    • Montelukast as add-on therapy to inhaled corticosteroids in the treatment of mild to moderate asthma: A systematic review
    • DOI 10.1136/thx.2007.081596
    • Joos S, Miksch A, Szecsenyi J, et al. Montelukast as addon therapy to inhaled corticosteroids in the treatment of mild to moderate asthma: A systematic review. Thorax. 2008;63:453-462 (Pubitemid 351698876)
    • (2008) Thorax , vol.63 , Issue.5 , pp. 453-462
    • Joos, S.1    Miksch, A.2    Szecsenyi, J.3    Wieseler, B.4    Grouven, U.5    Kaiser, T.6    Schneider, A.7
  • 70
    • 79955716906 scopus 로고    scopus 로고
    • Leukotriene antagonists as first-line or add-on asthma-controller therapy
    • Price D, Musgrave SD, Shepstone L, et al. Leukotriene antagonists as first-line or add-on asthma-controller therapy. N Engl J Med. 2011;364:1695-1707
    • (2011) N Engl J Med , vol.364 , pp. 1695-1707
    • Price, D.1    Musgrave, S.D.2    Shepstone, L.3
  • 71
    • 0034793255 scopus 로고    scopus 로고
    • Oral montelukast versus inhaled beclomethasone in 6- to 11-year-old children with asthma: Results of an open-label extension study evaluating long-term safety, satisfaction, and adherence with therapy
    • DOI 10.1185/030079901317010739
    • Maspero JF, Duenas-Meza E, Volovitz B, et al. Oral montelukast versus inhaled beclomethasone in 6- to 11-year-old children with asthma: Results of an openlabel extension study evaluating long-Term safety, satisfaction, and adherence with therapy. Curr Med Res Opin. 2001;17:96-104 (Pubitemid 32964000)
    • (2001) Current Medical Research and Opinion , vol.17 , Issue.2 , pp. 96-104
    • Maspero, J.F.1    Duenas-Meza, E.2    Volovitz, B.3    Daza, C.P.4    Kosa, L.5    Leff, F.6    Vrijens, J.A.7
  • 72
    • 77951620096 scopus 로고    scopus 로고
    • Add-on montelukast in inadequately controlled asthma patients in a 6-month open-label study: The montelukast in chronic asthma (monica) study
    • Virchow JC, Mehta A, Ljungblad L, et al. Add-on montelukast in inadequately controlled asthma patients in a 6-month open-label study: The MONtelukast in Chronic Asthma (MONICA) study. Respir Med. 2010; 104:644-651
    • (2010) Respir Med , vol.104 , pp. 644-651
    • Virchow, J.C.1    Mehta, A.2    Ljungblad, L.3
  • 74
    • 0037441916 scopus 로고    scopus 로고
    • A randomized controlled trial of intravenous montelukast in acute asthma
    • Camargo CA Jr, Smithline HA, Malice MP, et al. A randomized controlled trial of intravenous montelukast in acute asthma.AmJ Respir Crit Care Med. 2003;167:528-533
    • (2003) AmJ Respir Crit Care Med , vol.167 , pp. 528-533
    • Camargo Jr., C.A.1    Smithline, H.A.2    Malice, M.P.3
  • 75
    • 75849157844 scopus 로고    scopus 로고
    • A randomized placebo-controlled study of intravenous montelukast for the treatment of acute asthma
    • Camargo CA Jr, Gurner DM, Smithline HA, et al. A randomized placebo-controlled study of intravenous montelukast for the treatment of acute asthma. J Allergy Clin Immunol. 2010;125:374-380
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 374-380
    • Camargo Jr., C.A.1    Gurner, D.M.2    Smithline, H.A.3
  • 76
    • 76649089020 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study of intravenous montelukast in children with acute asthma
    • Morris CR, Becker AB, Pinieiro A, et al. A randomized, placebo-controlled study of intravenous montelukast in children with acute asthma. Ann Allergy Asthma Immunol. 2010;104:161-171
    • (2010) Ann Allergy Asthma Immunol , vol.104 , pp. 161-171
    • Morris, C.R.1    Becker, A.B.2    Pinieiro, A.3
  • 77
    • 38549156035 scopus 로고    scopus 로고
    • Pilot study of oral montelukast added to standard therapy for acute asthma exacerbations in children aged 6 to 14 years
    • DOI 10.1097/pec.0b013e31815f3968
    • Nelson KA, Smith SR, Trinkaus K, et al. Pilot study of oral montelukast added to standard therapy for acute asthma exacerbations in children aged 6 to 14 years. Pediatr Emerg Care. 2008;24:21-27 (Pubitemid 351158763)
    • (2008) Pediatric Emergency Care , vol.24 , Issue.1 , pp. 21-27
    • Nelson, K.A.1    Smith, S.R.2    Trinkaus, K.3    Jaffe, D.M.4
  • 78
    • 77953787641 scopus 로고    scopus 로고
    • Effect of addition of single dose of oral montelukast to standard treatment in acute moderate to severe asthma in children between 5 and 15 years of age: A randomised, doubleblind, placebo controlled trial
    • Todi VK, Lodha R, Kabra SK. Effect of addition of single dose of oral montelukast to standard treatment in acute moderate to severe asthma in children between 5 and 15 years of age: A randomised, doubleblind, placebo controlled trial. Arch Dis Child. 2010;95: 540-543
    • (2010) Arch Dis Child , vol.95 , pp. 540-543
    • Todi, V.K.1    Lodha, R.2    Kabra, S.K.3
  • 79
    • 73949109264 scopus 로고    scopus 로고
    • Can montelukast shorten prednisolone therapy in children with mild to moderate acute asthma? A randomized controlled trial
    • Schuh S, Willan AR, Stephens D, et al. Can montelukast shorten prednisolone therapy in children with mild to moderate acute asthma? A randomized controlled trial. J Pediatr. 2009;155:795-800
    • (2009) J Pediatr , vol.155 , pp. 795-800
    • Schuh, S.1    Willan, A.R.2    Stephens, D.3
  • 81
    • 78149423165 scopus 로고    scopus 로고
    • A subgroup analysis MONICA study: A 12-month, open-label study add-on montelukast treatment asthma patients
    • Virchow JC, Mehta A, Ljungblad L, et al. A subgroup analysis MONICA study: A 12-month, open-label study add-on montelukast treatment asthma patients. J Asthma. 2010;47:986-993
    • (2010) J Asthma , vol.47 , pp. 986-993
    • Virchow, J.C.1    Mehta, A.2    Ljungblad, L.3
  • 82
    • 0026357245 scopus 로고
    • Urinary leukotriene E4 levels after allergen and exercise challenge in bronchial asthma
    • Smith CM, Christie PE, Hawksworth RJ, et al. Urinary leukotriene E4 levels after allergen and exercise challenge in bronchial asthma. Am Rev Respir Dis. 1991; 144:1411-1413
    • (1991) Am Rev Respir Dis , vol.144 , pp. 1411-1413
    • Smith, C.M.1    Christie, P.E.2    Hawksworth, R.J.3
  • 83
    • 0026644731 scopus 로고
    • Urinary excretion of leukotriene E4 and 11-dehydro-Thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics
    • Kumlin M, Dahlen B, Bjorck T, et al. Urinary excretion of leukotriene E4 and 11-dehydro-Thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics. Am Rev Respir Dis. 1992;146:96-103
    • (1992) Am Rev Respir Dis , vol.146 , pp. 96-103
    • Kumlin, M.1    Dahlen, B.2    Bjorck, T.3
  • 84
    • 80052438246 scopus 로고    scopus 로고
    • An official ATS clinical practice guideline: Interpretation of exhaled nitric oxide levels (FENO) for clinical applications
    • Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: Interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011;184:602-615
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 602-615
    • Dweik, R.A.1    Boggs, P.B.2    Erzurum, S.C.3
  • 85
    • 77956378266 scopus 로고    scopus 로고
    • Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
    • e1-e4
    • Rabinovitch N, Graber NJ, Chinchilli VM, et al. Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma. J Allergy Clin Immunol. 2010;126:545-551. e1-e4
    • (2010) J Allergy Clin Immunol , vol.126 , pp. 545-551
    • Rabinovitch, N.1    Graber, N.J.2    Chinchilli, V.M.3
  • 86
    • 84872923083 scopus 로고    scopus 로고
    • Xolair, [Package Insert CA: Genentech Inc
    • Xolair, [Package Insert]. South San Fransisco, CA: Genentech, Inc; 2007
    • (2007) South San Fransisco
  • 87
    • 77953377656 scopus 로고    scopus 로고
    • Omalizumab in the management of patients with allergic (IgE-mediated) asthma
    • Sandstrom T. Omalizumab in the management of patients with allergic (IgE-mediated) asthma. J Asthma Allergy. 2009;2:49-62
    • (2009) J Asthma Allergy , vol.2 , pp. 49-62
    • Sandstrom, T.1
  • 88
    • 0025871907 scopus 로고
    • Hydrocortisone and IL-4 induce IgE isotype switching in human B cells
    • Jabara HH, Ahern DJ, Vercelli D, et al. Hydrocortisone and IL-4 induce IgE isotype switching in human B cells. J Immunol. 1991;147:1557-1560
    • (1991) J Immunol , vol.147 , pp. 1557-1560
    • Jabara, H.H.1    Ahern, D.J.2    Vercelli, D.3
  • 89
    • 4444232912 scopus 로고    scopus 로고
    • Effects of treatment with anti-immunoglobulin e antibody omalizumab on airway inflammation in allergic asthma
    • Djukanovic R. Effects of treatment with anti-immunoglobulin e antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med. 2004; 170:583-593
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 583-593
    • Djukanovic, R.1
  • 90
    • 34548145543 scopus 로고    scopus 로고
    • Anti-immunoglobulin E therapy with omalizumab for asthma
    • DOI 10.1345/aph.1K005
    • Hendeles L, Sorkness CA. Anti-immunoglobulin E therapy with omalizumab for asthma. Ann Pharmacother. 2007;41:1397-1410 (Pubitemid 47311360)
    • (2007) Annals of Pharmacotherapy , vol.41 , Issue.9 , pp. 1397-1410
    • Hendeles, L.1    Sorkness, C.A.2
  • 91
    • 78649673636 scopus 로고    scopus 로고
    • Efficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to corticosteroids for children and adults with asthma: A systematic review
    • Rodrigo GJ, Neffen H, Castro-Rodriguez JA. Efficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to corticosteroids for children and adults with asthma: A systematic review. Chest. 2011; 139:28-35
    • (2011) Chest , vol.139 , pp. 28-35
    • Rodrigo, G.J.1    Neffen, H.2    Castro-Rodriguez, J.A.3
  • 92
    • 79959821554 scopus 로고    scopus 로고
    • American Academy of allergy, asthma & Immunology/American College of allergy, asthma & immunology omalizumabassociated anaphylaxis joint task force follow-up report
    • Cox L, Lieberman P, Wallace D, et al. American Academy of allergy, asthma & Immunology/American College of allergy, asthma & immunology omalizumabassociated anaphylaxis joint task force follow-up report. J Allergy Clin Immunol. 2011;128:210-212
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 210-212
    • Cox, L.1    Lieberman, P.2    Wallace, D.3
  • 93
    • 33846464598 scopus 로고    scopus 로고
    • Safety of anti-immunoglobulin E therapy with omalizumab in allergic patients at risk of geohelminth infection
    • DOI 10.1111/j.1365-2222.2007.02650.x
    • Cruz AA, Lima F, Sarinho E, et al. Safety of antiimmunoglobulin E therapy with omalizumab in allergic patients at risk of geohelminth infection. Clin Exp Allergy J. 2007;37:197-207 (Pubitemid 46148277)
    • (2007) Clinical and Experimental Allergy , vol.37 , Issue.2 , pp. 197-207
    • Cruz, A.A.1    Lima, F.2    Sarinho, E.3    Ayre, G.4    Martin, C.5    Fox, H.6    Cooper, P.J.7
  • 95
    • 33749325937 scopus 로고    scopus 로고
    • Clinical data do not suggest a causal relationship between omalizumab therapy and cancer
    • Fernandez CBW, Reisner C, Gupta N, et al. Clinical data do not suggest a causal relationship between omalizumab therapy and cancer. Proc Am Thorac Soc. 2005;2: A359
    • (2005) Proc Am Thorac Soc , vol.2
    • Fernandez, C.B.W.1    Reisner, C.2    Gupta, N.3
  • 98
    • 0035434688 scopus 로고    scopus 로고
    • Treatment of childhood asthma with anti-immunoglobulin e antibody (Omalizumab
    • Milgrom H, Berger W, Nayak A, et al. Treatment of childhood asthma with anti-immunoglobulin e antibody (Omalizumab). Pediatrics. 2001;108:e36
    • (2001) Pediatrics , vol.108
    • Milgrom, H.1    Berger, W.2    Nayak, A.3
  • 99
    • 71249102935 scopus 로고    scopus 로고
    • Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma
    • Lanier B, Bridges T, Kulus M, et al. Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma. J Allergy Clin Immunol. 2009;124:1210-1216
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 1210-1216
    • Lanier, B.1    Bridges, T.2    Kulus, M.3
  • 101
    • 42549154437 scopus 로고    scopus 로고
    • An evaluation of the cost-effectiveness of omalizumab for the treatment of severe allergic asthma
    • DOI 10.1111/j.1398-9995.2008.01723.x
    • Sullivan SD, Turk F. An evaluation of the cost-effectiveness of omalizumab for the treatment of severe allergic asthma. Allergy. 2008;63:670-684 (Pubitemid 351591863)
    • (2008) Allergy: European Journal of Allergy and Clinical Immunology , vol.63 , Issue.6 , pp. 670-684
    • Sullivan, S.D.1    Turk, F.2
  • 102
    • 4344622274 scopus 로고    scopus 로고
    • Cost-effectiveness analysis of omalizumab in adults and adolescents with moderate-to-severe allergic asthma
    • DOI 10.1016/j.jaci.2004.05.049, PII S0091674904015635
    • Oba Y, Salzman GA. Cost-effectiveness analysis of omalizumab in adults and adolescents with moderate-Tosevere allergic asthma. J Allergy Clin Immunol. 2004; 114:265-269 (Pubitemid 39119022)
    • (2004) Journal of Allergy and Clinical Immunology , vol.114 , Issue.2 , pp. 265-269
    • Oba, Y.1    Salzman, G.A.2
  • 103
    • 35648974285 scopus 로고    scopus 로고
    • Cost-effectiveness of omalizumab in adults with severe asthma: Results from the Asthma Policy Model
    • DOI 10.1016/j.jaci.2007.07.055, PII S009167490701456X
    • Wu AC, Paltiel AD, Kuntz KM, et al. Cost-effectiveness of omalizumab in adults with severe asthma: Results from the Asthma Policy Model. J Allergy Clin Immunol. 2007;120:1146-1152 (Pubitemid 350029901)
    • (2007) Journal of Allergy and Clinical Immunology , vol.120 , Issue.5 , pp. 1146-1152
    • Wu, A.C.1    Paltiel, A.D.2    Kuntz, K.M.3    Weiss, S.T.4    Fuhlbrigge, A.L.5
  • 105
    • 3442891695 scopus 로고    scopus 로고
    • Predicting response to omalizumab, an anti-IgE antibody, in patients with allergic asthma
    • DOI 10.1378/chest.125.4.1378
    • Bousquet J, Wenzel S, Holgate S, et al. Predicting response to omalizumab, an anti-IgE antibody, in patients with allergic asthma-. Chest. 2004;125:1378-1386 (Pubitemid 38501353)
    • (2004) Chest , vol.125 , Issue.4 , pp. 1378-1386
    • Bousquet, J.1    Wenzel, S.2    Holgate, S.3    Lumry, W.4    Freeman, P.5    Fox, H.6
  • 106
    • 6444236644 scopus 로고    scopus 로고
    • Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: Preliminary investigations
    • DOI 10.1183/09031936.04.00054604
    • Cox PG, Miller J, Mitzner W, et al. Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: Preliminary investigations. Eur Respir J. 2004; 24:659-663 (Pubitemid 39406141)
    • (2004) European Respiratory Journal , vol.24 , Issue.4 , pp. 659-663
    • Cox, P.G.1    Miller, J.2    Mitzner, W.3    Leff, A.R.4
  • 107
    • 79751533768 scopus 로고    scopus 로고
    • Long-Term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial
    • Thomson NC, Rubin AS, Niven RM, et al. Long-Term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial. BMC Pulm Med. 2011;11:8
    • (2011) BMC Pulm Med , vol.11 , pp. 8
    • Thomson, N.C.1    Rubin, A.S.2    Niven, R.M.3
  • 108
    • 84860732536 scopus 로고    scopus 로고
    • 5-Year safety of bronchial thermoplasty demonstrated in patients with severe refractory asthma: Research in severe asthma (RISA) trial
    • 1meeting abstracts
    • Pavord ID. 5-Year safety of bronchial thermoplasty demonstrated in patients with severe refractory asthma: Research in severe asthma (RISA) trial. Am J Respir Crit Care Med. 2011;183(1-meeting abstracts):A6382
    • (2011) Am J Respir Crit Care Med , vol.183
    • Pavord, I.D.1
  • 109
    • 74949090750 scopus 로고    scopus 로고
    • Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: A multicenter, randomized, doubleblind, sham-controlled clinical trial
    • Castro M, Rubin AS, Laviolette M, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: A multicenter, randomized, doubleblind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2010;181:116-124
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 116-124
    • Castro, M.1    Rubin, A.S.2    Laviolette, M.3
  • 112
    • 74949094510 scopus 로고    scopus 로고
    • Bronchial thermoplasty has the promise been met?
    • Bel EH. Bronchial thermoplasty: Has the promise been met? Am J Respir Crit Care Med. 2010;181:101-102
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 101-102
    • Bel, E.H.1
  • 113
    • 79959771521 scopus 로고    scopus 로고
    • Persistence of effectiveness of bronchial thermoplasty in patients with severe asthma
    • Castro M, Rubin A, Laviolette M, et al. Persistence of effectiveness of bronchial thermoplasty in patients with severe asthma. Ann Allergy Asthma Immunol. 2011;107: 65-70
    • (2011) Ann Allergy Asthma Immunol , vol.107 , pp. 65-70
    • Castro, M.1    Rubin, A.2    Laviolette, M.3
  • 114
    • 80052681125 scopus 로고    scopus 로고
    • Point: Efficacy of bronchial thermoplasty for patients with severe asthma. Is there sufficient evidence?
    • Shifren A, Chen A, Castro M. Point: Efficacy of bronchial thermoplasty for patients with severe asthma. Is there sufficient evidence? Yes. Chest. 2011;140:573-575
    • (2011) Yes. Chest , vol.140 , pp. 573-575
    • Shifren, A.1    Chen, A.2    Castro, M.3
  • 115
    • 84555208680 scopus 로고    scopus 로고
    • Counterpoint: Efficacy of bronchial thermoplasty for patients with severe asthma.Is there sufficient evidence? Not Yet
    • Michaud G, Ernst A. Counterpoint: Efficacy of bronchial thermoplasty for patients with severe asthma.Is There Sufficient Evidence? Not Yet. Chest. 2011;140:576-577
    • (2011) Chest , vol.140 , pp. 576-577
    • Michaud, G.1    Ernst, A.2
  • 116
    • 77954033984 scopus 로고    scopus 로고
    • New therapies for asthma: Is there any progress?
    • Barnes PJ. New therapies for asthma: Is there any progress? Trends Pharmacol Sci. 2010;31:335-343
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 335-343
    • Barnes, P.J.1
  • 117
    • 80053330950 scopus 로고    scopus 로고
    • Novel cytokine-directed therapies for asthma
    • Walsh GM. Novel cytokine-directed therapies for asthma. Discov Med. 2011;11:283-291
    • (2011) Discov Med , vol.11 , pp. 283-291
    • Walsh, G.M.1
  • 118
    • 58149311297 scopus 로고    scopus 로고
    • Novel targets of therapy in asthma
    • Holgate ST. Novel targets of therapy in asthma. Curr Opin Pulm Med. 2009;15:63-71
    • (2009) Curr Opin Pulm Med , vol.15 , pp. 63-71
    • Holgate, S.T.1
  • 120
    • 79952291528 scopus 로고    scopus 로고
    • Interleukins, from 1 to 37, and interferon-gamma: Receptors, functions, and roles in diseases
    • 701-721
    • Akdis M, Burgler S, Crameri R, et al. Interleukins, from 1 to 37, and interferon-gamma: Receptors, functions, and roles in diseases. J Allergy Clin Immunol. 2011;127:701-721. e1-e70
    • (2011) J Allergy Clin Immunol , vol.127
    • Akdis, M.1    Burgler, S.2    Crameri, R.3
  • 121
    • 57349179165 scopus 로고    scopus 로고
    • Daclizumab improves asthma control in patients with moderate to severe persistent asthma: A randomized, controlled trial
    • Busse WW, Israel E, Nelson HS, et al. Daclizumab improves asthma control in patients with moderate to severe persistent asthma: A randomized, controlled trial. Am J Respir Crit Care Med. 2008;178:1002-1008
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 1002-1008
    • Busse, W.W.1    Israel, E.2    Nelson, H.S.3
  • 125
    • 0036379740 scopus 로고    scopus 로고
    • Preclinical efficacy and safety of pascolizumab (SB 240683): A humanized anti-interleukin-4 antibody with therapeutic potential in asthma
    • Hart TK, Blackburn MN, Brigham-Burke M, et al. Preclinical efficacy and safety of pascolizumab (SB 240683): A humanized anti-interleukin-4 antibody with therapeutic potential in asthma. Clin Exp Immunol. 2002;130: 93-100
    • (2002) Clin Exp Immunol , vol.130 , pp. 93-100
    • Hart, T.K.1    Blackburn, M.N.2    Brigham-Burke, M.3
  • 126
    • 78650405860 scopus 로고    scopus 로고
    • Pitrakinra, a dual IL-4/IL-13 antagonist for the potential treatment of asthma and eczema
    • Antoniu SA. Pitrakinra, a dual IL-4/IL-13 antagonist for the potential treatment of asthma and eczema. Curr Opin Investig Drugs. 2010;11:1286-1294
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1286-1294
    • Antoniu, S.A.1
  • 127
    • 35348909044 scopus 로고    scopus 로고
    • Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies
    • DOI 10.1016/S0140-6736(07)61600-6, PII S0140673607616006
    • Wenzel S, Wilbraham D, Fuller R, et al. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two phase 2a studies. Lancet. 2007;370:1422-1431 (Pubitemid 47576168)
    • (2007) Lancet , vol.370 , Issue.9596 , pp. 1422-1431
    • Wenzel, S.1    Wilbraham, D.2    Fuller, R.3    Getz, E.B.4    Longphre, M.5
  • 128
    • 78650405313 scopus 로고    scopus 로고
    • Tralokinumab, an anti-IL-13 mAb for the potential treatment of asthma and COPD
    • Walsh GM. Tralokinumab, an anti-IL-13 mAb for the potential treatment of asthma and COPD. Curr Opin Investig Drugs. 2010;11:1305-1312
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1305-1312
    • Walsh, G.M.1
  • 129
    • 77950271175 scopus 로고    scopus 로고
    • A review of treatment with mepolizumab, an anti-IL-5 mAb, in hypereosinophilic syndromes and asthma
    • Busse WW, Ring J, Huss-Marp J, et al. A review of treatment with mepolizumab, an anti-IL-5 mAb, in hypereosinophilic syndromes and asthma. J Allergy Clin Immunol. 2010;125:803-813
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 803-813
    • Busse, W.W.1    Ring, J.2    Huss-Marp, J.3
  • 130
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie MJ, ten Brinke A, Khan J, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 2000;356:2144-2148
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    Ten Brinke, A.2    Khan, J.3
  • 133
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med. 2009;360:973-984
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3
  • 134
    • 61849155730 scopus 로고    scopus 로고
    • Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    • Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med. 2009;360:985-993
    • (2009) N Engl J Med , vol.360 , pp. 985-993
    • Nair, P.1    Pizzichini, M.M.2    Kjarsgaard, M.3
  • 135
    • 81455155725 scopus 로고    scopus 로고
    • Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo-controlled study
    • Castro M, Mathur S, Hargreave F, et al. Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo-controlled study. Am J Respir Crit Care Med. 2011;184:1125-1132
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 1125-1132
    • Castro, M.1    Mathur, S.2    Hargreave, F.3
  • 136
    • 81455138227 scopus 로고    scopus 로고
    • Reslizumab and eosinophilic asthma one step closer to phenotype-directed therapy?
    • McCallister JW. Reslizumab and eosinophilic asthma: One step closer to phenotype-directed therapy? Am J Respir Crit Care Med. 2011;184:1096-1097
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 1096-1097
    • McCallister, J.W.1
  • 137
    • 79958219647 scopus 로고    scopus 로고
    • Biology of the interleukin-9 pathway and its therapeutic potential for the treatment of asthma
    • Oh CK, Raible D, Geba GP, et al. Biology of the interleukin-9 pathway and its therapeutic potential for the treatment of asthma. Inflamm Allergy Drug Targets. 2011; 10:180-186
    • (2011) Inflamm Allergy Drug Targets , vol.10 , pp. 180-186
    • Oh, C.K.1    Raible, D.2    Geba, G.P.3
  • 138
    • 65549123549 scopus 로고    scopus 로고
    • Two first-in-human, open-label, phase I dose-escalation safety trials of MEDI-528, a monoclonal antibody against interleukin-9, in healthy adult volunteers
    • White B, Leon F, White W, et al. Two first-in-human, open-label, phase I dose-escalation safety trials of MEDI-528, a monoclonal antibody against interleukin-9, in healthy adult volunteers. Clin Ther. 2009;31: 728-740
    • (2009) Clin Ther , vol.31 , pp. 728-740
    • White, B.1    Leon, F.2    White, W.3
  • 139
    • 79952049626 scopus 로고    scopus 로고
    • Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma
    • Parker JM, Oh CK, LaForce C, et al. Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma. BMC Pulm Med. 2011;11:14
    • (2011) BMC Pulm Med , vol.11 , pp. 14
    • Parker, J.M.1    Oh, C.K.2    LaForce, C.3
  • 140
    • 44949095421 scopus 로고    scopus 로고
    • New drugs targeting Th2 lymphocytes in asthma
    • Caramori G, Groneberg D, Ito K, et al. New drugs targeting Th2 lymphocytes in asthma. J Occup Med Toxicol. 2008;3(SUPPL1):S6
    • (2008) J Occup Med Toxicol , vol.3 , Issue.SUPPL. 1
    • Caramori, G.1    Groneberg, D.2    Ito, K.3
  • 141
    • 84655167630 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study CRTH2 antagonist OC000459 moderate persistent asthma
    • Barnes N, Pavord I, Chuchalin A, et al. A randomized, double-blind, placebo-controlled study CRTH2 antagonist OC000459 moderate persistent asthma. Clin Exp Allergy. 2012;42:38-48
    • (2012) Clin Exp Allergy , vol.42 , pp. 38-48
    • Barnes, N.1    Pavord, I.2    Chuchalin, A.3
  • 142
    • 77957783557 scopus 로고    scopus 로고
    • The immunostimulant OM-85 BV prevents wheezing attacks in preschool children
    • Razi CH, Harmanci K, Abaci A, et al. The immunostimulant OM-85 BV prevents wheezing attacks in preschool children. J Allergy Clin Immunol. 2010;126: 763-769
    • (2010) J Allergy Clin Immunol , vol.126 , pp. 763-769
    • Razi, C.H.1    Harmanci, K.2    Abaci, A.3
  • 143
    • 84872931665 scopus 로고    scopus 로고
    • Deerfield IL Takeda Pharmaceuticals America Inc
    • Pioglitazone, [Package Insert]. Deerfield, IL: Takeda Pharmaceuticals America, Inc; 2007
    • (2007) Pioglitazone, [Package Insert
  • 144
    • 0036479812 scopus 로고    scopus 로고
    • Improvement of asthma after administration of pioglitazone
    • Hashimoto Y, Nakahara K. Improvement of asthma after administration of pioglitazone. Diabetes Care. 2002;25:401
    • (2002) Diabetes Care , vol.25 , pp. 401
    • Hashimoto, Y.1    Nakahara, K.2
  • 145
    • 67650617728 scopus 로고    scopus 로고
    • Bronchodilatory effect of the PPAR-[gamma] agonist rosiglitazone in smokers with asthma
    • Spears M, Donnelly I, Jolly L, et al. Bronchodilatory effect of the PPAR-[gamma] agonist rosiglitazone in smokers with asthma. Clin Pharmacol Ther. 2009;86: 49-53
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 49-53
    • Spears, M.1    Donnelly, I.2    Jolly, L.3
  • 146
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med. 2007;356:2457-2471 (Pubitemid 46919772)
    • (2007) New England Journal of Medicine , vol.356 , Issue.24 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 148
    • 23944456884 scopus 로고    scopus 로고
    • Nebulised furosemide in acute adult asthma
    • DOI 10.1136/emj.2005.028670
    • Yen Z-S, Chen S-C. Nebulised furosemide in acute adult asthma. Emerg Med J. 2005;22:654-655 (Pubitemid 41200638)
    • (2005) Emergency Medicine Journal , vol.22 , Issue.9 , pp. 654-655
    • Yen, Z.-S.1    Chen, S.-C.2
  • 149
    • 0033811380 scopus 로고    scopus 로고
    • Effect of inhaled low molecular weight heparin on methacholine-induced bronchoconstriction
    • Ceyhan BB, Celikel T. Effect of inhaled low molecular weight heparin on methacholine-induced bronchoconstriction. Int J Clin Pharmacol Ther. 2000;38:446-451
    • (2000) Int J Clin Pharmacol Ther , vol.38 , pp. 446-451
    • Ceyhan, B.B.1    Celikel, T.2
  • 152
    • 84872905295 scopus 로고    scopus 로고
    • Role of mycophenolate mofetil in steroid dependent asthma
    • Suppl
    • Patel K, MK, Dudney T, et al. Role of mycophenolate mofetil in steroid dependent asthma. Am J Respirat Crit Care Med. 2010;181(Suppl):A2755
    • (2010) Am J Respirat Crit Care Med , vol.181
    • Patel, K.M.K.1    Dudney, T.2
  • 153
    • 84872944205 scopus 로고    scopus 로고
    • Treatment with mycophenolat mofetil of steroid-dependent asthmaone case of severe asthma
    • Backer V, Hjardem E, Karlsmark T. Treatment with mycophenolat mofetil of steroid-dependent asthmaone case of severe asthma. J Allergy (Cairo). 2009;2009: 821013
    • (2009) J Allergy (Cairo , vol.2009 , pp. 821013
    • Backer, V.1    Hjardem, E.2    Karlsmark, T.3
  • 154
    • 0031720221 scopus 로고    scopus 로고
    • Management of steroid-dependent asthma with methotrexate: A meta-analysis of randomized clinical trials
    • DOI 10.1016/S0954-6111(98)90355-9
    • Aaron SD, Dales RE, Pham B. Management of steroiddependent asthma with methotrexate: A meta-Analysis of randomized clinical trials. Respir Med. 1998;92: 1059-1065 (Pubitemid 28416838)
    • (1998) Respiratory Medicine , vol.92 , Issue.8 , pp. 1059-1065
    • Aaron, S.D.1    Dales, R.E.2    Pham, B.3
  • 157
    • 0031906382 scopus 로고    scopus 로고
    • Prospective, double-blind, placebo-controlled, multicentre study on the effect of high-dose, intravenous immunoglobulin in children and adolescents with severe bronchial asthma
    • DOI 10.1046/j.1365-2222.1998.00214.x
    • Niggemann B, Leupold W, Schuster A, et al. Prospective, double-blind, placebo-controlled, multicentre study effect high-dose, intravenous immunoglobulin children adolescents severe bronchial asthma. Clin Exp Allergy. 1998;28:205-210 (Pubitemid 28137336)
    • (1998) Clinical and Experimental Allergy , vol.28 , Issue.2 , pp. 205-210
    • Niggemann, B.1    Leupold, W.2    Schuster, A.3    Schuster, R.4    Berg, A.V.5    Grubl, A.6    Hardt, H.V.D.7    Eibl, M.M.8    Wahn, U.9
  • 159
    • 0026593983 scopus 로고
    • Auranofin in the treatment of steroid dependent asthma: A double blind study
    • Nierop G, Gijzel WP, Bel EH, et al. Auranofin in the treatment of steroid dependent asthma: A double blind study. Thorax. 1992;47:349-354
    • (1992) Thorax , vol.47 , pp. 349-354
    • Nierop, G.1    Gijzel, W.P.2    Bel, E.H.3
  • 161
    • 0025837165 scopus 로고
    • TNF alpha mRNA expression allergic inflammation
    • Ying S, Robinson DS, Varney V, et al. TNF alpha mRNA expression allergic inflammation. Clin Exp Allergy. 1991; 21:745-750
    • (1991) Clin Exp Allergy , vol.21 , pp. 745-750
    • Ying, S.1    Robinson, D.S.2    Varney, V.3
  • 162
    • 0028432821 scopus 로고
    • Interleukin-4, -5, and -6 and tumor necrosis factor-Alpha in normal and asthmatic airways: Evidence for the human mast cell as a source of these cytokines
    • Bradding P, Roberts JA, Britten KM, et al. Interleukin-4, -5, and -6 and tumor necrosis factor-Alpha in normal and asthmatic airways: Evidence for the human mast cell as a source of these cytokines. Am J Respirat Cell Mol Biol. 1994;10:471-480
    • (1994) Am J Respirat Cell Mol Biol , vol.10 , pp. 471-480
    • Bradding, P.1    Roberts, J.A.2    Britten, K.M.3
  • 163
    • 0028983633 scopus 로고
    • Tumor necrosis factor-Alpha increases airway responsiveness and sputum neutrophilia in normal human subjects
    • Thomas PS, Yates DH, Barnes PJ. Tumor necrosis factor-Alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. Am J Respir Crit Care Med. 1995;152:76-80
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 76-80
    • Thomas, P.S.1    Yates, D.H.2    Barnes, P.J.3
  • 164
    • 0025789703 scopus 로고
    • Tumour necrosis factor stimulates human skin mast cells to release histamine and tryptase
    • van Overveld FJ, Jorens PG, Rampart M, et al. Tumour necrosis factor stimulates human skin mast cells to release histamine and tryptase. Clin Exp Allergy. 1991; 21:711-714
    • (1991) Clin Exp Allergy , vol.21 , pp. 711-714
    • Van Overveld, F.J.1    Jorens, P.G.2    Rampart, M.3
  • 165
    • 6344223281 scopus 로고    scopus 로고
    • Thousand Oaks, CA: Immunex Corporation
    • Enbrel, [Package Insert]. Thousand Oaks, CA: Immunex Corporation; 2003
    • (2003) Enbrel [Package Insert
  • 169
    • 0003547850 scopus 로고    scopus 로고
    • Malvern PA Centocor Inc
    • Remicade, [Package Insert]. Malvern, PA: Centocor, Inc; 2000
    • (2000) Remicade, [Package Insert
  • 170
    • 79954571723 scopus 로고    scopus 로고
    • Retraction of four articles and abstracts
    • On Behalf of the American Thoracic Society
    • On Behalf of the American Thoracic Society. Retraction of four articles and abstracts. Am J Respir Crit Care Med. 2011;183:418
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 418
  • 171
    • 62549084077 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled Study of tumor necrosis Factor-{alpha} Blockade in severe persistent asthma
    • Wenzel SE, Barnes PJ, Bleecker ER, et al. A randomized, double-blind, placebo-controlled Study of tumor necrosis Factor-{alpha} Blockade in severe persistent asthma. Am J Respir Crit Care Med. 2009;179:549-558
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 549-558
    • Wenzel, S.E.1    Barnes, P.J.2    Bleecker, E.R.3
  • 172
    • 75749095929 scopus 로고    scopus 로고
    • TNF-Alpha inhibitors in asthma and COPD: We must not throw the baby out with the bath water
    • Matera MG, Calzetta L, Cazzola M. TNF-Alpha inhibitors in asthma and COPD: We must not throw the baby out with the bath water. Pulmonary Pharmacol Ther. 2010;23:121-128
    • (2010) Pulmonary Pharmacol Ther , vol.23 , pp. 121-128
    • Matera, M.G.1    Calzetta, L.2    Cazzola, M.3
  • 173
    • 33747079023 scopus 로고    scopus 로고
    • Potential therapeutic role for statins in respiratory disease
    • DOI 10.1136/thx.2005.057976
    • Hothersall E, McSharry C, Thomson NC. Potential therapeutic role for statins in respiratory disease. Thorax. 2006;61:729-734 (Pubitemid 44211783)
    • (2006) Thorax , vol.61 , Issue.8 , pp. 729-734
    • Hothersall, E.1    McSharry, C.2    Thomson, N.C.3
  • 175
    • 70349878485 scopus 로고    scopus 로고
    • Simvastatin inhibits airway hyperreactivity: Implications for the mevalonate pathway and beyond
    • Zeki AA, Franzi L, Last J, et al. Simvastatin inhibits airway hyperreactivity: Implications for the mevalonate pathway and beyond. Am J Respir Crit Care Med. 2009; 180:731-740
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 731-740
    • Zeki, A.A.1    Franzi, L.2    Last, J.3
  • 176
    • 61649128772 scopus 로고    scopus 로고
    • Northumberland United Kingdom Merck Sharp Dohme Ltd
    • Zocor, [Package Insert]. Northumberland, United Kingdom: Merck Sharp & Dohme, Ltd; 2008
    • (2008) Zocor, [Package Insert
  • 177
    • 57149101949 scopus 로고    scopus 로고
    • Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma
    • Hothersall EJ, Chaudhuri R, McSharry C, et al. Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma. Thorax. 2008;63:1070-1075
    • (2008) Thorax , vol.63 , pp. 1070-1075
    • Hothersall, E.J.1    Chaudhuri, R.2    McSharry, C.3
  • 178
    • 84872973960 scopus 로고    scopus 로고
    • Dubin Ireland Pfizer Ireland Pharmaceuticals Inc
    • Lipitor, [Package insert]. Dubin, Ireland: Pfizer Ireland Pharmaceuticals, Inc; 2006
    • (2006) Lipitor, [Package insert
  • 179
    • 84863645652 scopus 로고    scopus 로고
    • Do statins improve outcomes in patients with asthma on inhaled corticosteroid therapy? A retrospective cohort analysis
    • Lokhandwala T, West-Strum D, Banahan BF, et al. Do statins improve outcomes in patients with asthma on inhaled corticosteroid therapy? A retrospective cohort analysis. BMJ Open. 2012;2
    • (2012) BMJ Open , pp. 2
    • Lokhandwala, T.1    West-Strum, D.2    Banahan, B.F.3
  • 180
    • 79953746639 scopus 로고    scopus 로고
    • Statin use in patients with asthma - A nationwide population-based study
    • Huang C-C, Chan W-L, Chen Y-C, et al. Statin use in patients with asthma - A nationwide population-based study. Eur J Clin Invest. 2011;41:507-512
    • (2011) Eur J Clin Invest , vol.41 , pp. 507-512
    • Huang, C.-C.1    Chan, W.-L.2    Chen, Y.-C.3
  • 181
    • 70249144985 scopus 로고    scopus 로고
    • Statin exposure reduces the risk of asthma-related hospitalizations and emergency room visits in asthmatic patients on inhaled corticosteroids
    • Stanek E, Aubert R, Xia F, et al. Statin exposure reduces the risk of asthma-related hospitalizations and emergency room visits in asthmatic patients on inhaled corticosteroids. J Allergy Clin Immunol. 2009;123:S65
    • (2009) J Allergy Clin Immunol , vol.123
    • Stanek, E.1    Aubert, R.2    Xia, F.3
  • 182
    • 80052028124 scopus 로고    scopus 로고
    • Treatment of allergic asthma: Modulation of Th2 cells and their responses
    • Bosnjak B, Stelzmueller B, Erb KJ, et al. Treatment of allergic asthma: Modulation of Th2 cells and their responses. Respir Res. 2011;12:114
    • (2011) Respir Res , vol.12 , pp. 114
    • Bosnjak, B.1    Stelzmueller, B.2    Erb, K.J.3
  • 183
    • 72449175250 scopus 로고    scopus 로고
    • Bronchial hyperreactivity in non-Atopic children with asthma and reflux: Effect of anti-reflux treatment
    • Khoshoo V, Mohnot S, Haydel R Jr, et al. Bronchial hyperreactivity in non-Atopic children with asthma and reflux: Effect of anti-reflux treatment. Pediatr Pulmonol. 2009;44:1070-1074
    • (2009) Pediatr Pulmonol , vol.44 , pp. 1070-1074
    • Khoshoo, V.1    Mohnot, S.2    Haydel Jr., R.3
  • 184
    • 33847723887 scopus 로고    scopus 로고
    • Effect of antireflux treatment on asthma exacerbations in nonatopic children
    • DOI 10.1097/MPG.0b013e31802fe89c, PII 0000517620070300000007
    • Khoshoo V, Haydel R Jr. Effect of antireflux treatment on asthma exacerbations in nonatopic children. J Pediatr Gastroenterol Nutr. 2007;44:331-335 (Pubitemid 46673380)
    • (2007) Journal of Pediatric Gastroenterology and Nutrition , vol.44 , Issue.3 , pp. 331-335
    • Khoshoo, V.1    Haydel Jr., R.2
  • 185
    • 70350441332 scopus 로고    scopus 로고
    • Effects of asymptomatic proximal and distal gastroesophageal reflux on asthma severity
    • DiMango E, Holbrook JT, Simpson E, et al. Effects of asymptomatic proximal and distal gastroesophageal reflux on asthma severity. Am J Respir Crit Care Med. 2009;180:809-816
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 809-816
    • DiMango, E.1    Holbrook, J.T.2    Simpson, E.3
  • 187
    • 84856179016 scopus 로고    scopus 로고
    • Lansoprazole for children with poorly controlled asthma
    • Centers W.C.F.T.A.L.A.A.C.R.
    • Centers, W.C.f.t.A.L.A.A.C.R. Lansoprazole for children with poorly controlled asthma. JAMA. 2012;307: 373-380
    • (2012) JAMA , vol.307 , pp. 373-380
  • 188
    • 64349113168 scopus 로고    scopus 로고
    • Efficacy of esomeprazole for treatment of poorly controlled asthma
    • American Lung Association Asthma Clinical Research Centre
    • American Lung Association Asthma Clinical Research Centre. Efficacy of esomeprazole for treatment of poorly controlled asthma. N Engl J Med. 2009;360: 1487-1499
    • (2009) N Engl J Med , vol.360 , pp. 1487-1499
  • 192
    • 84872959176 scopus 로고    scopus 로고
    • Combivent, [Package Insert
    • Combivent, [Package Insert]. Ridgefield, CT; 2008
    • (2008) Ridgefield CT
  • 194
    • 70449652591 scopus 로고    scopus 로고
    • Effect of beta2-Adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): A genotype-stratified, randomised, placebo-controlled, crossover trial
    • Wechsler ME, Kunselman SJ, Chinchilli VM, et al. Effect of beta2-Adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): A genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet. 2009;374:1754-1764
    • (2009) Lancet , vol.374 , pp. 1754-1764
    • Wechsler, M.E.1    Kunselman, S.J.2    Chinchilli, V.M.3
  • 195
    • 79961046696 scopus 로고    scopus 로고
    • Diagnosis and management of stable chronic obstructive pulmonary disease: A clinical practice guideline update from the american college of physicians, american college of chest physicians, american thoracic society, and european respiratory society
    • Qaseem A, Wilt TJ, Weinberger SE, et al. Diagnosis and management of stable chronic obstructive pulmonary disease: A clinical practice guideline update from the American College of physicians, American College of chest physicians, American Thoracic Society, and European respiratory Society. Ann Intern Med. 2011;155:179-191
    • (2011) Ann Intern Med , vol.155 , pp. 179-191
    • Qaseem, A.1    Wilt, T.J.2    Weinberger, S.E.3
  • 196
    • 84859912502 scopus 로고    scopus 로고
    • Spiriva, [Package Insert Ridgefield CT, Inc. and Pfizer, Inc
    • Spiriva, [Package Insert]. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc. and Pfizer, Inc; 2011
    • (2011) Boehringer Ingelheim Pharmaceuticals
  • 197
    • 77957768543 scopus 로고    scopus 로고
    • Tiotropium bromide step-up therapy for adults with uncontrolled asthma
    • Peters SP, Kunselman SJ, Icitovic N, et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 2010;363:1715-1726
    • (2010) N Engl J Med , vol.363 , pp. 1715-1726
    • Peters, S.P.1    Kunselman, S.J.2    Icitovic, N.3
  • 198
    • 79961016525 scopus 로고    scopus 로고
    • Tiotropium improves lung function in patients with severe uncontrolled asthma: A randomized controlled trial
    • Kerstjens HA, Disse B, Schroder-Babo W, et al. Tiotropium improves lung function in patients with severe uncontrolled asthma: A randomized controlled trial. J Allergy Clin Immunol. 2011;128:308-314
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 308-314
    • Kerstjens, H.A.1    Disse, B.2    Schroder-Babo, W.3
  • 200
    • 58349115630 scopus 로고    scopus 로고
    • Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study
    • Denning DW, O'Driscoll BR, Powell G, et al. Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study. Am J Respir Crit Care Med. 2009;179:11-18
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 11-18
    • Denning, D.W.1    O'Driscoll, B.R.2    Powell, G.3
  • 201
    • 0003557928 scopus 로고    scopus 로고
    • Titusville NJ Janssen Pharmaceutica Products L.P
    • Sporanox, [Package insert]. Titusville, NJ: Janssen Pharmaceutica Products, L.P; 2001
    • (2001) Sporanox, [Package insert
  • 203
  • 204
    • 0036185807 scopus 로고    scopus 로고
    • Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: A randomised trial
    • DOI 10.1136/thorax.57.3.212
    • Wolter J, Seeney S, Bell S, et al. Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: A randomised trial. Thorax. 2002;57: 212-216 (Pubitemid 34214405)
    • (2002) Thorax , vol.57 , Issue.3 , pp. 212-216
    • Wolter, J.1    Seeney, S.2    Bell, S.3    Bowler, S.4    Masel, P.5    McCormack, J.6
  • 205
    • 33749984264 scopus 로고    scopus 로고
    • Long term effects of azithromycin in patients with cystic fibrosis: A double blind, placebo controlled trial
    • DOI 10.1136/thx.2005.057950
    • Clement A, Tamalet A, Leroux E, et al. Long term effects of azithromycin in patients with cystic fibrosis: A double blind, placebo controlled trial. Thorax. 2006; 61:895-902 (Pubitemid 44570311)
    • (2006) Thorax , vol.61 , Issue.10 , pp. 895-902
    • Clement, A.1    Tamalet, A.2    Leroux, E.3    Ravilly, S.4    Fauroux, B.5    Jais, J.-P.6
  • 206
    • 80052157895 scopus 로고    scopus 로고
    • Azithromycin for prevention of exacerbations of COPD
    • Albert RK, Connett J, Bailey WC, et al. Azithromycin for prevention of exacerbations of COPD. N Engl J Med. 2011;365:689-698
    • (2011) N Engl J Med , vol.365 , pp. 689-698
    • Albert, R.K.1    Connett, J.2    Bailey, W.C.3
  • 207
    • 4243126943 scopus 로고    scopus 로고
    • Low-dose, long-Term macrolide therapy in asthma: An overview
    • Hatipoglu U, Rubinstein I. Low-dose, long-Term macrolide therapy in asthma: An overview. Clin Mol Allergy. 2004;2:4
    • (2004) Clin Mol Allergy , vol.2 , pp. 4
    • Hatipoglu, U.1    Rubinstein, I.2
  • 208
    • 84872943369 scopus 로고    scopus 로고
    • North Chicago IL: Abbott Laboratories
    • Biaxin, [Package Insert]. North Chicago, IL: Abbott Laboratories; 2011
    • (2011) Biaxin, [Package Insert
  • 209
    • 38348998987 scopus 로고    scopus 로고
    • Clarithromycin targets neutrophilic airway inflammation in refractory asthma
    • Simpson JL, Powell H, Boyle MJ, et al. Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med. 2008;177:148-155
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 148-155
    • Simpson, J.L.1    Powell, H.2    Boyle, M.J.3
  • 212
    • 0019182871 scopus 로고
    • The effect of troleandomycin on methylprednisolone elimination
    • DOI 10.1016/0091-6749(80)90004-4
    • Szefler SJ, Rose JQ, Ellis EF, et al. The effect of troleandomycin on methylprednisolone elimination. J Allergy Clin Immunol. 1980;66:447-451 (Pubitemid 11207451)
    • (1980) Journal of Allergy and Clinical Immunology , vol.66 , Issue.6 , pp. 447-451
    • Szefler, S.J.1    Rose, J.Q.2    Ellis, E.F.3
  • 213
    • 0035229122 scopus 로고    scopus 로고
    • Troleandomycin as an oral corticosteroid steroid sparing agent in stable asthma
    • Evans DJ, Cullinan P, Geddes DM. Troleandomycin as an oral corticosteroid steroid sparing agent in stable asthma. Cochrane Database Syst Rev. 2001;CD002987
    • (2001) Cochrane Database Syst Rev
    • Evans, D.J.1    Cullinan, P.2    Geddes, D.M.3
  • 214
    • 29744465421 scopus 로고    scopus 로고
    • Chlamydophila pneumoniae and Mycoplasma pneumoniae: A role in asthma pathogenesis?
    • DOI 10.1164/rccm.200412-1743PP
    • Johnston SL, Martin RJ. Chlamydophila pneumoniae and Mycoplasma pneumoniae: A role in asthma pathogenesis? Am J Respir Crit Care Med. 2005;172:1078-1089 (Pubitemid 43066642)
    • (2005) American Journal of Respiratory and Critical Care Medicine , vol.172 , Issue.9 , pp. 1078-1089
    • Johnston, S.L.1    Martin, R.J.2
  • 215
    • 0036279989 scopus 로고    scopus 로고
    • Mycoplasma pneumoniae and Chlamydia pneumoniae in asthma: Effect of clarithromycin
    • DOI 10.1378/chest.121.6.1782
    • Kraft M, Cassell GH, Pak J, et al. Mycoplasma pneumoniae and Chlamydia pneumoniae in asthma: Effect of clarithromycin. Chest. 2002;121:1782-1788 (Pubitemid 34634396)
    • (2002) Chest , vol.121 , Issue.6 , pp. 1782-1788
    • Kraft, M.1    Cassell, G.H.2    Pak, J.3    Martin, R.J.4
  • 217
    • 77957795745 scopus 로고    scopus 로고
    • A trial of clarithromycin for the treatment of suboptimally controlled asthma
    • Sutherland ER, King TS, Icitovic N, et al. A trial of clarithromycin for the treatment of suboptimally controlled asthma. J Allergy Clin immunol. 2010;126: 747-753
    • (2010) J Allergy Clin immunol , vol.126 , pp. 747-753
    • Sutherland, E.R.1    King, T.S.2    Icitovic, N.3
  • 218
    • 33645791946 scopus 로고    scopus 로고
    • The effect of telithromycin in acute exacerbations of asthma
    • Johnston SL, Blasi F, Black PN, et al. The effect of telithromycin in acute exacerbations of asthma. N Engl J Med. 2006;354:1589-1600
    • (2006) N Engl J Med , vol.354 , pp. 1589-1600
    • Johnston, S.L.1    Blasi, F.2    Black, P.N.3
  • 219
    • 84864622679 scopus 로고    scopus 로고
    • St. Louis MO: Forest Pharmaceuticals Inc
    • Daliresp, [Package Insert]. St. Louis, MO: Forest Pharmaceuticals Inc; 2011
    • (2011) Daliresp, [Package Insert
  • 221
    • 33644811309 scopus 로고    scopus 로고
    • Phosphodiesterase inhibitors in airways disease
    • DOI 10.1016/j.ejphar.2005.12.059, PII S0014299905013919, The Pharmacology of the Respiratory Tract
    • Fan Chung K. Phosphodiesterase inhibitors in airways disease. Eur J Pharmacol. 2006;533:110-117 (Pubitemid 43348344)
    • (2006) European Journal of Pharmacology , vol.533 , Issue.1-3 , pp. 110-117
    • Fan Chung, K.1
  • 222
    • 11844267183 scopus 로고    scopus 로고
    • Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease
    • DOI 10.1016/S0140-6736(05)17708-3, PII S0140673605177083
    • Lipworth BJ. Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease. Lancet. 2005;365:167-175 (Pubitemid 40091808)
    • (2005) Lancet , vol.365 , Issue.9454 , pp. 167-175
    • Lipworth, B.J.1
  • 225
    • 0032747518 scopus 로고    scopus 로고
    • Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B
    • Manning CD, Burman M, Christensen SB, et al. Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B. Br J Pharmacol. 1999;128:1393-1398
    • (1999) Br J Pharmacol , vol.128 , pp. 1393-1398
    • Manning, C.D.1    Burman, M.2    Christensen, S.B.3
  • 226
    • 0021910016 scopus 로고
    • Bronchodilator actions of xanthine derivatives administered by inhalation in asthma
    • Cushley MJ, Holgate ST. Bronchodilator actions of xanthine derivatives administered by inhalation in asthma. Thorax. 1985;40:176-179 (Pubitemid 15108300)
    • (1985) Thorax , vol.40 , Issue.3 , pp. 176-179
    • Cushley, M.J.1    Holgate, S.T.2
  • 227
    • 79960963904 scopus 로고    scopus 로고
    • New therapeutic options in the management of COPD - focus on roflumilast
    • Antoniu SA. New therapeutic options in the management of COPD - focus on roflumilast. Int J Chron Obstruct Pulmon Dis. 2011;6:147-155
    • (2011) Int J Chron Obstruct Pulmon Dis , vol.6 , pp. 147-155
    • Antoniu, S.A.1
  • 228
    • 0030051755 scopus 로고    scopus 로고
    • Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs
    • Ortiz JL, Valles JM, Marti-Cabrera M, et al. Effects of selective phosphodiesterase inhibitors on platelet-Activating factor and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs. Naunyn Schmiedebergs Arch Pharmacol. 1996;353:200-206 (Pubitemid 26042731)
    • (1996) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.353 , Issue.2 , pp. 200-206
    • Ortiz, J.L.1    Valles, J.M.2    Marti-Cabrera, M.3    Cortijo, J.4    Morcillo, E.J.5
  • 229
    • 1642493925 scopus 로고    scopus 로고
    • Effect of Phosphodiesterase-5 Inhibitor, Sildenafil (Viagra), in Animal Models of Airways Disease
    • DOI 10.1164/rccm.200211-1372OC
    • Toward TJ, Smith N, Broadley KJ. Effect of phosphodiesterase-5 inhibitor, sildenafil (Viagra), in animal models of airways disease. Am J Respir Crit Care Med. 2004; 169:227-234 (Pubitemid 38114539)
    • (2004) American Journal of Respiratory and Critical Care Medicine , vol.169 , Issue.2 , pp. 227-234
    • Toward, T.J.1    Smith, N.2    Broadley, K.J.3
  • 230
    • 0034881183 scopus 로고    scopus 로고
    • Does sildenafil also improve breathing?
    • DOI 10.1378/chest.120.1.305
    • Charan NB. Does sildenafil also improve breathing? Chest. 2001;120:305-306 (Pubitemid 32744895)
    • (2001) Chest , vol.120 , Issue.1 , pp. 305-306
    • Charan, N.B.1
  • 231
    • 36348992469 scopus 로고    scopus 로고
    • Effects of L-arginine and phosphodiesterase-5 inhibitor, sildenafil, on inflammation and airway responsiveness of sensitized BP2 mice
    • DOI 10.1111/j.1472-8206.2007.00523.x
    • Al Qadi-Nassar B, Bichon-Laurent F, Portet K, et al. Effects of L-Arginine and phosphodiesterase-5 inhibitor, sildenafil, on inflammation and airway responsiveness of sensitized BP2 mice. Fundam Clin Pharmacol. 2007;21:611-620 (Pubitemid 350151247)
    • (2007) Fundamental and Clinical Pharmacology , vol.21 , Issue.6 , pp. 611-620
    • Al Qadi-Nassar, B.1    Bichon-Laurent, F.2    Portet, K.3    Tramini, P.4    Arnoux, B.5    Michel, A.6
  • 232
    • 84872924813 scopus 로고    scopus 로고
    • Lack of involvement of type 7 phosphodiesterase in an experimental model of asthma
    • Chevalier E, Lagente V, Dupont M, et al. Lack of involvement of type 7 phosphodiesterase in an experimental model of asthma. Eur Respir J. 2011
    • (2011) Eur Respir J.
    • Chevalier, E.1    Lagente, V.2    Dupont, M.3
  • 234
    • 0032511375 scopus 로고    scopus 로고
    • Association of inhaled corticosteroid use with cataract extraction in elderly patients
    • DOI 10.1001/jama.280.6.539
    • Garbe E, Suissa S, LeLorier J. Association of inhaled corticosteroid use with cataract extraction in elderly patients. JAMA. 1998;280:539-543 (Pubitemid 28377673)
    • (1998) Journal of the American Medical Association , vol.280 , Issue.6 , pp. 539-543
    • Garbe, E.1    Suissa, S.2    Lelorier, J.3
  • 235
    • 0030859363 scopus 로고    scopus 로고
    • Use of inhaled corticosteroids and the risk of cataracts
    • DOI 10.1056/NEJM199707033370102
    • Cumming RG, Mitchell P, Leeder SR. Use of inhaled corticosteroids and the risk of cataracts. N Engl J Med. 1997;337:8-14 (Pubitemid 27290841)
    • (1997) New England Journal of Medicine , vol.337 , Issue.1 , pp. 8-14
    • Cumming, R.G.1    Mitchell, P.2    Leeder, S.R.3
  • 238
    • 70349254245 scopus 로고    scopus 로고
    • Combination formoterol and budesonide as maintenance and reliever therapy versus inhaled steroid maintenance for chronic asthma in adults and children
    • Cates CJ, Lasserson TJ. Combination formoterol and budesonide as maintenance and reliever therapy versus inhaled steroid maintenance for chronic asthma in adults and children. Cochrane Database Syst Rev. 2009;CD007313
    • (2009) Cochrane Database Syst Rev
    • Cates, C.J.1    Lasserson, T.J.2
  • 239
    • 77954071818 scopus 로고    scopus 로고
    • Pharmacogenomic approaches to asthma treatment
    • Cho SH. Pharmacogenomic approaches to asthma treatment. Allergy Asthma Immunol Res. 2010;2:177-182
    • (2010) Allergy Asthma Immunol Res , vol.2 , pp. 177-182
    • Cho, S.H.1
  • 240
    • 84857410928 scopus 로고    scopus 로고
    • Severe asthma: Lessons learned from the national heart, lung, and blood institute severe asthma research program
    • Jarjour NN, Erzurum SC, Bleecker ER, et al. Severe asthma: Lessons learned from the national heart, lung, and blood institute severe asthma research program. Am J Respirat Crit Care Med. 2012;185:356-362
    • (2012) Am J Respirat Crit Care Med , vol.185 , pp. 356-362
    • Jarjour, N.N.1    Erzurum, S.C.2    Bleecker, E.R.3
  • 241
    • 84860373149 scopus 로고    scopus 로고
    • Trials and tribulations in identifying new biologic treatments for asthma
    • Holgate ST. Trials and tribulations in identifying new biologic treatments for asthma. Trends Immunol. 2012;33:238-246
    • (2012) Trends Immunol , vol.33 , pp. 238-246
    • Holgate, S.T.1
  • 242
    • 33645979680 scopus 로고    scopus 로고
    • Brief questionnaires for patient-reported outcomes in asthma: Validation and usefulness in a primary care setting
    • Ehrs PO, Nokela M, Stallberg B, et al. Brief questionnaires for patient-reported outcomes in asthma: Validation and usefulness in a primary care setting. Chest. 2006;129:925-932
    • (2006) Chest , vol.129 , pp. 925-932
    • Ehrs, P.O.1    Nokela, M.2    Stallberg, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.