Prospective, double-blind, placebo-controlled, multicentre study on the effect of high-dose, intravenous immunoglobulin in children and adolescents with severe bronchial asthma

Clinical and Experimental Allergy

Volumn 28, Issue 2, 1998, Pages 205-210

  Niggemann, B ^a,i   Leupold, W ^b   Schuster, A ^c   Schuster, R ^d   Berg, A V ^e   Grubl A ^f   Hardt, H V D ^g   Eibl, M M ^h   Wahn, U ^a  

^a University Hospital   (Germany)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^d Children's Hospital   (Germany)

^e Div Paediatrics   (Germany)

^f LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^g Depts Pediat Hematol and Oncology   (Germany)

^h UNIVERSITY OF VIENNA   (Austria)

ⁱ CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Asthma; Children; Immunoglobulin; IVIG

Indexed keywords

IMMUNOGLOBULIN; PLACEBO; SERUM ALBUMIN;

ADOLESCENT; ADULT; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INCIDENCE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCHOOL CHILD; TREATMENT PLANNING; UPPER RESPIRATORY TRACT INFECTION;

ADOLESCENT; ADULT; ASTHMA; CHILD; DOUBLE-BLIND METHOD; FEMALE; GERMANY; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULINS, INTRAVENOUS; MALE; PROSPECTIVE STUDIES; RESPIRATORY TRACT INFECTIONS;

EID: 0031906382     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.1998.00214.x     Document Type: Article

References (33)

1. Åberg N, Hesselmar B, Åberg B, Eriksson B. Increase of asthma, allergic rhinitis and eczema in Swedish schoolchildren between 1979 and 1991. Clin Exp Allergy 1995; 25:815-19.
2. Rona RJ, Chinn S, Burney PGJ. Trends in the prevalence of asthma in Scottish and English primary school children 1982-1992. Thorax 1995; 50:992-3.
3. Guss S, Portnoy J. Methotrexate treatment of severe asthma in children. Pediatrics 1992; 89:635-9.
4. Stempel DA, Lammert J, Mullarkey MF. Use of methotrexate in the treatment of steroid-dependent adolescent asthmatics. Ann Allergy 1991; 67:346-8.
5. Alexander AG, Barnes NC, Kay AB. Trial of cyclosporin in cortico-steroid-dependent chronic severe asthma. Lancet 1992; 339:324-8.
6. Lock SH, Kay AB, Barnes NC. Double-blind, placebo-controlled study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma. Am J Respir Crit Care Med 1996; 153:509-14.
7. Boguniewicz M, Schneider LC, Milgrom H et al. Treatment of steroid-dependent asthma with recombinant interferon-gamma. Clin Exp Allergy 1993; 23: 785-90.
8. Flotte TR, Loughlin GM. Benefits and complications of troleando-mycin (TAO) in young children with steroid-dependent asthma. Ped Pulmonol 1991; 10:178-82.
9. Kamada AK, Hill MR, Iklé DN, Brenner AM, Szefler SJ. Efficacy and safety of low-dose troleandomycin therapy in children with severe, steroid-requiring asthma. J Allergy Clin Immunol 1993; 91:873-82.
10. Adalioglu G, Türktas I, Saraclar Y, Tuncer A. A clinical study of colchicine in childhood asthma. J Asthma 1994; 31:361-6.
11. Berlow BA, Liebhaber MI, Dyer Z, Spiegel TM. The effect in dapsone in steroid-dependent asthma. J Allergy Clin Immunol 1991; 87:710-15.
12. Mazer BD, Giclas PC, Gelfand EW. Immunomodulatory effects of intravenous immunoglobulin in severe steroid-dependent asthma. Clin Immunol Immunopathol 1989; 53: S156-63.
13. Mazer BD, Gelfand EW. An open-label study of high-dose intravenous immunoglobulin in severe childhood asthma. J Allergy Clin Immunol 1991; 87:976-83.
14. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987; 136:225-44.
15. Matthys H, Knoch M, Eltsehka R. A new aerosol device for bronchial provocation tests. Respiration 1993; 60:343-50.
16. Axen R, Dreven H, Kober A, Yman L. A new laboratory diagnostic system applied to allergy testing. N Engl J Med 1988; 9:503.
17. Ballow M, White W, Desbonnet C. Modulation of in vitro synthesis of immunoglobulin and the induction of suppressor activity by therapy with intravenous immune globulin. J Allergy Clin Immunol 1989; 84:595-602.
18. Buckley RH. The use of intravenous immune globulin in immuno-deficiency diseases. N Engl J Med 1991; 325:110-17.
19. Bernatowska-Matuszkiewicz E, Pac M, Skopcynska H, Pum M, Eibl MM. Clinical efficacy of intravenous immunoglobulin in patients with severe inflammatory chest disease and IgG3 subclass deficiency. Clin Exp Immunol 1991; 85:193-7.
20. Leung DYM, Burns JC, Newburger JW, Geha RS. Reversal of lymphocyte activation in vivo in the Kawasaki syndrome by intravenous gammaglobulin. J Clin Invest 1987; 79:468-72.
21. Leung DYM. Immunomodulation by intravenous immune globulin in Kawasaki disease. J Allergy Clin Immunol 1989; 84:588-94.
22. Yanagawa H, Yashiro M, Nakamura Y, Sakata K, Kawasaki T. Iv gamma globulin treatment of Kawasaki disease in Japan: results of a nationwide survey. Acta Pædiatr 1995; 84:765-8.
23. Blanchette VS, Luke B, Andrew M, Sommerville-Nielsen S, Barbard D, De Veber B, Gent M. A prospective, randomized trial of high-dose intravenous immune globulin G therapy, oral prednisone therapy, and no therapy in childhood acute immune thrombocytopenic purpura. J Pediatr 1993; 123:989-95.
24. Dalakas MC, Illa I, Dambrosia JM, Soueidan SA, Stein DP, Otero C, Dinsmore ST, McCrosky S. A controlled trial of high-dose intravenous immune globulin infusions as treatment for dermatomyositis. N Engl J Med 1993; 329:1993-2000.
25. Mobini N, Sarela A, Ahmed AR. Intravenous immunoglobulins in the therapy of autoimmune and systemic inflammatory disorders. Ann Allergy 1995; 74:119-28.
26. Sansome A, Dubowitz V. Intravenous immunoglobulin in juvenile dermatomyositis - four year review on nine cases. Arch Dis Child 1995; 72:25-8.
27. Gelfand EW, Landwehr LP, Esterl B, Mazer B. Intravenous immune globulin: an alternative therapy in steroid-dependent allergic disease. Clin Exp Immunol 1996; 104 (Suppl. 1):61-6.
28. Kimata H. High dose gammaglobulin treatment for atopic dermatitis. Arch Dis Child 1994; 70:335-6.
29. Abernathy RS, Stretn EL, Good RA. Chronic asthma in childhood: double-blind controlled study of treatment with gamma-globulin. Pediatrics 1958; June:980-93.
30. Lahdensuo A, Haahtela T, Herrala J, Kava T, Kiviranta K, Kuusisto P, Perämäki E, Poussa T, Saarelainen S, Svahn T. Randomised comparison of guided self management and traditional treatment of asthma over one year. Brit Med J 1996; 312:748-52.
31. Fireman P, Friday G. Asthma - A role for IVIG therapy? Clin Rev Allergy 1992; 10:135-42.
32. Levinson AI. Intravenous immunoglobulin: A new therapeutic approach in steroid-dependent asthma? J Allergy Clin Immunol 1991; 88:552-4.
33. Jacobsson T, Croner S, Kjellrnan NIM, Pettersson A, Vassella C, Björkstén B. Slight steroid-sparing effect of intravenous immuno-globulin in children and adolescents with moderately severe bronchial asthma. Allergy 1994; 49:413-20.