Biapenem Inactivation by B2 Metallo β-Lactamases: Energy Landscape of the Hydrolysis Reaction

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Ackerman, Sharon H ^a   Gatti, Domenico L ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIAPENEM; CARBAPENEMASE; CARBOXYL GROUP; METALLO BETA LACTAMASE; NUCLEOPHILE; PROTEIN CPHA; UNCLASSIFIED DRUG; ZINC ION;

AEROMONAS HYDROPHILA; ARTICLE; CHEMICAL MODEL; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG INACTIVATION; ENERGY LANDSCAPE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; IONIZATION; MOLECULAR MECHANICS; NONHUMAN; POTENTIAL ENERGY SURFACE; PRODUCT STATE; PROTON TRANSPORT; QUANTUM MECHANICS; REACTANT STATE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY;

EID: 84872859833     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055136     Document Type: Article

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