Asp-120 locates Zn2 for optimal metallo-β-lactamase activity

Journal of Biological Chemistry

Volumn 282, Issue 25, 2007, Pages 18276-18285

  Llarrull, Leticia I ^a   Fabiane, Stella M ^b   Kowalski, Jason M ^c   Bennett, Brian ^c   Sutton, Brian J ^c   Vila, Alejandro J ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CRYSTALLOGRAPHY; LIGANDS; NITROGEN; ZINC COMPOUNDS;

LACTAMASE ACTIVITY; METAL LIGANDS; METAL LIGATING CAPABILITIES; PROTON DONORS;

ENZYMES;

ASPARTIC ACID DERIVATIVE; BACTERIAL ENZYME; METALLO BETA LACTAMASE; PENICILLINASE; ZINC;

AMINO ACID SUBSTITUTION; ARTICLE; BACILLUS CEREUS; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME SPECIFICITY; ENZYME STABILITY; METAL BINDING; MUTANT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTON TRANSPORT; SITE DIRECTED MUTAGENESIS; SPECTROSCOPY; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

ASPARTIC ACID; BACILLUS CEREUS; BETA-LACTAMASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESCHERICHIA COLI; KINETICS; LIGANDS; METALS; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; SPECTROPHOTOMETRY; ZINC;

BACILLUS CEREUS;

EID: 34547094371     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M700742200     Document Type: Article

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