Conformational changes in the metallo-β-lactamase ImiS during the catalytic reaction: An EPR spectrokinetic study of Co(II)-spin label interactions

Journal of the American Chemical Society

Volumn 130, Issue 26, 2008, Pages 8215-8222

  Sharma, Narayan ^a   Hu, Zhenxin ^a   Crowder, Michael W ^a   Bennett, Brian ^b  

^a MIAMI UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; BINDING SITES; CATALYSIS; CONFORMATIONS; ELECTRON RESONANCE; HEALTH; IONS; MAGNETISM; METAL IONS; METALS; PARAMAGNETIC RESONANCE; PARAMAGNETISM; SPIN DYNAMICS;

ACTIVE SITES; ANTIBIOTIC-RESISTANCE; CATALYTIC REACTIONS; CONFORMATIONAL CHANGES; ELECTRON PARAMAGNETIC RESONANCE; LACTAMASE; LACTAMASES; ORGANIC PART; PATHOGENIC BACTERIA; SPIN LABELLING; SUBSTRATE BINDING; SUBSTRATE SPECIFICITY; TRANSIENT REACTIONS;

SUBSTRATES;

COBALT; IMIPENEM; METALLO BETA LACTAMASE;

ALPHA HELIX; ARTICLE; CATALYSIS; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; ELECTRON SPIN RESONANCE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME SUBSTRATE; MOLECULAR INTERACTION;

BACTERIAL PROTEINS; BETA-LACTAMASES; CATALYSIS; COBALT; ELECTRON SPIN RESONANCE SPECTROSCOPY; KINETICS; PROTEIN CONFORMATION; SPIN LABELS; SUBSTRATE SPECIFICITY;

EID: 46049100791     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0774562     Document Type: Article

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