Glucose promotion of GABA metabolism contributes to the stimulation of insulin secretion in β-cells

Biochemical Journal

Volumn 431, Issue 3, 2010, Pages 381-389

  Pizarro Delgado, Javier ^a   Braun, Matthias ^b   Hernández Fisac, Inés ^a   Martín Del Río, Rafael ^c   Tamarit Rodriguez, Jorge ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Glucose; Glutamic acid decarboxylase (GAD); Insulin; Pancreatic islet; aminobutyric acid (GABA); aminobutyric acid transaminase (GABA T)

Indexed keywords

AMINO ACIDS; CITRIC ACID; ENZYME ACTIVITY; GENE EXPRESSION; GLUCOSE; INSULIN; METABOLISM;

2-OXOGLUTARATE; ACTION POTENTIALS; AMINOBUTYRIC ACIDS; ATP CONTENT; BI-PHASIC; DOSE-DEPENDENT; GLUCOSE METABOLISM; GLUTAMIC ACID DECARBOXYLASE; HIGH GLUCOSE CONCENTRATIONS; INSULIN SECRETION; KETO ACIDS; L-GLUTAMINE; PANCREATIC ISLET; SUCCINIC ACIDS;

PHYSIOLOGY;

4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; GABACULINE; GLUCOSE; GLUTAMINE; OXOGLUTARATE DEHYDROGENASE; POTASSIUM CHANNEL; SUCCINIC SEMIALDEHYDE; INSULIN;

ACTION POTENTIAL; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE POTENTIAL; CITRIC ACID CYCLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEPOLARIZATION; ENZYME ACTIVITY; GENE EXPRESSION; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN SECRETION; RAT; TRANSAMINATION; ANIMAL; MEMBRANE POTENTIAL; METABOLISM; PATCH CLAMP TECHNIQUE; SECRETION (PROCESS); WISTAR RAT;

RATTUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; GAMMA-AMINOBUTYRIC ACID; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; MALE; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR;

EID: 78049268157     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100714     Document Type: Article

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