13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and γ-glutamyl cycle activity in a clonal pancreatic beta-cell line

Diabetologia

Volumn 46, Issue 11, 2003, Pages 1512-1521

  Brennan, L ^a   Corless, M ^a   Hewage, C ^a   Malthouse, J P G ^a   McClenaghan, N H ^b   Flatt, P R ^b   Newsholme, P ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

glutamyl cycle; Glutathione; L glutamate; L glutamine; NMR; Pancreatic beta cells

Indexed keywords

2 OXOGLUTARIC ACID; AMINO ACID; AMINOOXYACETIC ACID; AMINOTRANSFERASE INHIBITOR; CARBON; CARBON 13; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; GLUTAMATE CYSTEINE LIGASE; GLUTAMIC ACID; GLUTAMINASE; GLUTAMINE; GLUTATHIONE; GLYCINE; INSULIN; PYRUVIC ACID; ASPARTIC ACID; GAMMA GLUTAMYLCYCLOTRANSFERASE;

AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYST; CELL CLONE; CELL CULTURE; CELL METABOLISM; CELL STRAIN; CHEMICAL REACTION; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME MECHANISM; EXTRACTION; GLUCOSE METABOLISM; GLUTATHIONE METABOLISM; INSULIN RELEASE; METABOLITE; NONHUMAN; OXIDATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; STIMULUS SECRETION COUPLING; ANIMAL; BIOLOGICAL MODEL; DRUG EFFECT; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PANCREAS ISLET;

ANIMALS; ASPARTIC ACID; CARBON ISOTOPES; CLONE CELLS; GAMMA-GLUTAMYLCYCLOTRANSFERASE; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; ISLETS OF LANGERHANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, BIOLOGICAL;

EID: 0345548707     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1184-7     Document Type: Article

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