Functional characterization of t cell populations in a mouse model of chronic obstructive pulmonary disease

Journal of Immunology

Volumn 190, Issue 3, 2013, Pages 1331-1340

  Eppert, Bryan L ^a   Wortham, Brian W ^a   Flury, Jennifer L ^a   Borchers, Michael T ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b Department of Otolaryngology Head and Neck Surgery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DONOR; FEMALE; LUNG ALVEOLUS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SMOKING; T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL;

ADOPTIVE TRANSFER; ANIMALS; ANTIGEN PRESENTATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FREUND'S ADJUVANT; GENE REARRANGEMENT, T-LYMPHOCYTE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOLOGIC DEFICIENCY SYNDROMES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; PULMONARY ALVEOLI; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH17 CELLS; TOBACCO SMOKE POLLUTION;

EID: 84872706645     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202442     Document Type: Article

References (47)

1. Jemal, A., E. Ward, Y. Hao, and M. Thun. 2005. Trends in the leading causes of death in the United States, 1970-2002. JAMA 294: 1255-1259. (Pubitemid 41352114)
2. Xu, J., K. D. Kochanek, S. L. Murphy, and B. Tejada-Vera. 2010. Deaths: Final data for 2007. In National Vital Statistics Reports, Vol. 58. Centers for Disease Control and Prevention, Hyattsville, MD, p. 1-136
3. Mathers, C., T. Boerma, and D. Ma Fat. 2008. The Global Burden of Disease: 2004 Update. World Health Organization, Geneva, Switzerland.
4. Buist, A. S., M. A. McBurnie, W. M. Vollmer, S. Gillespie, P. Burney, D. M. Mannino, A. M. B. Menezes, S. D. Sullivan, T. A. Lee, K. B. Weiss, et al; BOLD Collaborative Research Group. 2007. International variation in the prevalence of COPD (the BOLD Study): A population-based prevalence study. Lancet 370: 741-750. (Pubitemid 47321907)
5. Decramer, M., W. Janssens, and M. Miravitlles. 2012. Chronic obstructive pulmonary disease. Lancet 379: 1341-1351.
6. Cosio, M. G., M. Saetta, and A. Agusti. 2009. Immunologic aspects of chronic obstructive pulmonary disease. N. Engl. J. Med. 360: 2445-2454.
7. Hautamaki, R. D., D. K. Kobayashi, R. M. Senior, and S. D. Shapiro. 1997. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277: 2002-2004. (Pubitemid 27449144)
8. Russell, R. E. K., A. Thorley, S. V. Culpitt, S. Dodd, L. E. Donnelly, C. Demattos, M. Fitzgerald, and P. J. Barnes. 2002. Alveolar macrophagemediated elastolysis: Roles of matrix metalloproteinases, cysteine, and serine proteases. Am. J. Physiol. Lung Cell. Mol. Physiol. 283: L867-L873.
9. Woodruff, P. G., L. L. Koth, Y. H. Yang, M. W. Rodriguez, S. Favoreto, G. M. Dolganov, A. C. Paquet, and D. J. Erle. 2005. A distinctive alveolar macrophage activation state induced by cigarette smoking. Am. J. Respir. Crit. Care Med. 172: 1383-1392. (Pubitemid 43069811)
10. Borchers, M. T., S. C. Wesselkamper, V. Curull, A. Ramirez-Sarmiento, A. Sánchez-Font, J. Garcia-Aymerich, C. Coronell, J. Lloreta, A. G. Agusti, J. Gea, et al. 2009. Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease. J. Clin. Invest. 119: 636-649.
11. Wortham, B. W., B. L. Eppert, G. T. Motz, J. L. Flury, M. Orozco-Levi, K. Hoebe, R. J. Panos, M. Maxfield, S. W. Glasser, A. P. Senft, et al. 2012. NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease. J. Immunol. 188: 4468-4475.
12. Zhu, X., A. S. Gadgil, R. Givelber, M. P. George, M. W. Stoner, F. C. Sciurba, and S. R. Duncan. 2009. Peripheral T cell functions correlate with the severity of chronic obstructive pulmonary disease. J. Immunol. 182: 3270-3277.
13. Grumelli, S., D. B. Corry, L.-Z. Song, L. Song, L. Green, J. Huh, J. Hacken, R. Espada, R. Bag, D. E. Lewis, and F. Kheradmand. 2004. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med. 1: E8.
14. O'Shaughnessy, T. C., T. W. Ansari, N. C. Barnes, and P. K. Jeffery. 1997. Inflammation in bronchial biopsies of subjects with chronic bronchitis: Inverse relationship of CD8+ T lymphocytes with FEV1. Am. J. Respir. Crit. Care Med. 155: 852-857. (Pubitemid 27133393)
15. Saetta, M., S. Baraldo, L. Corbino, G. Turato, F. Braccioni, F. Rea, G. Cavallesco, G. Tropeano, C. E. Mapp, P. Maestrelli, et al. 1999. CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 160: 711-717. (Pubitemid 29380694)
16. Chrysofakis, G., N. Tzanakis, D. Kyriakoy, M. Tsoumakidou, I. Tsiligianni, M. Klimathianaki, and N. M. Siafakas. 2004. Perforin expression and cytotoxic activity of sputum CD8+ lymphocytes in patients with COPD. Chest 125: 71-76. (Pubitemid 38114566)
17. Freeman, C. M., M. K. Han, F. J. Martinez, S. Murray, L. X. Liu, S. W. Chensue, T. J. Polak, J. Sonstein, J. C. Todt, T. M. Ames, et al. 2010. Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15. J. Immunol. 184: 6504-6513.
18. Maeno, T., A. M. Houghton, P. A. Quintero, S. Grumelli, C. A. Owen, and S. D. Shapiro. 2007. CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J. Immunol. 178: 8090-8096. (Pubitemid 46898081)
19. van der Strate, B. W. A., D. S. Postma, C.-A. Brandsma, B. N. Melgert, M. A. Luinge, M. Geerlings, M. N. Hylkema, A. van den Berg, W. Timens, and H. A. M. Kerstjens. 2006. Cigarette smoke-induced emphysema: A role for the B cell? Am. J. Respir. Crit. Care Med. 173: 751-758.
20. Agustí, A., W. MacNee, K. Donaldson, and M. Cosio. 2003. Hypothesis: Does COPD have an autoimmune component? Thorax 58: 832-834. (Pubitemid 37239227)
21. Sullivan, A. K., P. L. Simonian, M. T. Falta, J. D. Mitchell, G. P. Cosgrove, K. K. Brown, B. L. Kotzin, N. F. Voelkel, and A. P. Fontenot. 2005. Oligoclonal CD4+ T cells in the lungs of patients with severe emphysema. Am. J. Respir. Crit. Care Med. 172: 590-596. (Pubitemid 41232970)
22. Lee, S.-H., S. Goswami, A. Grudo, L.-Z. Song, V. Bandi, S. Goodnight-White, L. Green, J. Hacken-Bitar, J. Huh, F. Bakaeen, et al. 2007. Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat. Med. 13: 567-569. (Pubitemid 46828488)
23. Feghali-Bostwick, C. A., A. S. Gadgil, L. E. Otterbein, J. M. Pilewski, M. W. Stoner, E. Csizmadia, Y. Zhang, F. C. Sciurba, and S. R. Duncan. 2008. Autoantibodies in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 177: 156-163.
24. Karayama, M., N. Inui, T. Suda, Y. Nakamura, H. Nakamura, and K. Chida. 2010. Anti-endothelial cell antibodies in patients with COPD. Chest 138: 1303-1308.
25. Núnez, B., J. Sauleda, J. M. Antó, M. R. Julia, M. Orozco, E. Monsó, A. Noguera, F. P. Gómez, J. Garcia-Aymerich, and A. Agustí; PAC-COPD Investigators. 2011. Anti-tissue antibodies are related to lung function in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 183: 1025-1031.
26. Kirkham, P. A., G. Caramori, P. Casolari, A. A. Papi, M. Edwards, B. Shamji, K. Triantaphyllopoulos, F. Hussain, M. Pinart, Y. Khan, et al. 2011. Oxidative stressinduced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 184: 796-802.
27. Motz, G. T., B. L. Eppert, G. Sun, S. C.Wesselkamper, M. J. Linke, R. Deka, and M. T. Borchers. 2008. Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette smoke-induced emphysema. J. Immunol. 181: 8036-8043.
28. Motz, G. T., B. L. Eppert, S. C. Wesselkamper, J. L. Flury, and M. T. Borchers. 2010. Chronic cigarette smoke exposure generates pathogenic T cells capable of driving COPD-like disease in Rag2-/-mice. Am. J. Respir. Crit. Care Med. 181: 1223-1233.
29. Rose, N. R., and C. Bona. 1993. Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol. Today 14: 426-430. (Pubitemid 23271739)
30. Lyerla, T. A., M. E. Rusiniak, M. Borchers, G. Jahreis, J. Tan, P. Ohtake, E. K. Novak, and R. T. Swank. 2003. Aberrant lung structure, composition, and function in a murine model of Hermansky-Pudlak syndrome. Am. J. Physiol. Lung Cell. Mol. Physiol. 285: L643-L653. (Pubitemid 37022866)
31. Olson, W. C., M. E. Smolkin, E. M. Farris, R. J. Fink, A. R. Czarkowski, J. H. Fink, K. A. Chianese-Bullock, and C. L. Slingluff, Jr. 2011. Shipping blood to a central laboratory in multicenter clinical trials: Effect of ambient temperature on specimen temperature, and effects of temperature on mononuclear cell yield, viability and immunologic function. J. Transl. Med. 9: 26-38.
32. Harrison, O. J., J. Foley, B. J. Bolognese, E. Long, III, P. L. Podolin, and P. T. Walsh. 2008. Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement. Immunol. Lett. 121: 13-21.
33. Shan, M., H.-F. Cheng, L.-Z. Song, L. Roberts, L. Green, J. Hacken-Bitar, J. Huh, F. Bakaeen, H. O. Coxson, C. Storness-Bliss, et al 2009. Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. Sci. Transl. Med. 1: 4ra10.
34. Shan, M., X. Yuan, L.-Z. Song, L. Roberts, N. Zarinkamar, A. Seryshev, Y. Zhang, S. Hilsenbeck, S.-H. Chang, C. Dong, et al 2012. Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. Sci. Transl. Med. 4: 117ra119.
35. Demoor, T., K. R. Bracke, G. F. Joos, and G. G. Brusselle. 2010. Increased T-regulatory cells in lungs and draining lymph nodes in a murine model of COPD. Eur. Respir. J. 35: 688-689.
36. Barceló, B., J. Pons, J. M. Ferrer, J. Sauleda, A. Fuster, and A. G. Agustí. 2008. Phenotypic characterisation of T-lymphocytes in COPD: Abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking. Eur. Respir. J. 31: 555-562.
37. DiLorenzo, T. P., R. T. Graser, T. Ono, G. J. Christianson, H. D. Chapman, D. C. Roopenian, S. G. Nathenson, and D. V. Serreze. 1998. Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement. Proc. Natl. Acad. Sci. USA 95: 12538-12543.
38. Sun, D., J. N. Whitaker, Z. Huang, D. Liu, C. Coleclough, H. Wekerle, and C. S. Raine. 2001. Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J. Immunol. 166: 7579-7587. (Pubitemid 32525639)
39. D'hulst, A. I., T. Maes, K. R. Bracke, I. K. Demedts, K. G. Tournoy, G. F. Joos, and G. G. Brusselle. 2005. Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required? Respir. Res. 6: 147-159.
40. Chen, K., D. A. Pociask, J. P. McAleer, Y. R. Chan, J. F. Alcorn, J. L. Kreindler, M. R. Keyser, S. D. Shapiro, A. M. Houghton, J. K. Kolls, and M. Zheng. 2011. IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS ONE 6: E20333.
41. Belz, G. T., D. Wodarz, G. Diaz, M. A. Nowak, and P. C. Doherty. 2002. Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-celldeficient mice. J. Virol. 76: 12388-12393. (Pubitemid 35304341)
42. Sun, J. C., and M. J. Bevan. 2003. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300: 339-342. (Pubitemid 36433727)
43. Sun, J. C., M. A. Williams, and M. J. Bevan. 2004. CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nat. Immunol. 5: 927-933. (Pubitemid 39276237)
44. Matloubian, M., R. J. Concepcion, and R. Ahmed. 1994. CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J. Virol. 68: 8056-8063. (Pubitemid 24362694)
45. Cederbom, L., H. Hall, and F. Ivars. 2000. CD4+CD25+ regulatory T cells downregulate co-stimulatory molecules on antigen-presenting cells. Eur. J. Immunol. 30: 1538-1543. (Pubitemid 30342794)
46. Misra, N., J. Bayry, S. Lacroix-Desmazes, M. D. Kazatchkine, and S. V. Kaveri. 2004. Cutting edge: Human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells. J. Immunol. 172: 4676-4680. (Pubitemid 38456386)
47. Qureshi, O. S., Y. Zheng, K. Nakamura, K. Attridge, C. Manzotti, E. M. Schmidt, J. Baker, L. E. Jeffery, S. Kaur, Z. Briggs, et al. 2011. Transendocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4. Science 332: 600-603.