Cytotoxic potential of lung CD8+ T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15

Journal of Immunology

Volumn 184, Issue 11, 2010, Pages 6504-6513

  Freeman, Christine M ^a,b   Han, MeiLan K ^b   Martinez, Fernando J ^b   Murray, Susan ^c   Liu, Lyrica X ^c   Chensue, Stephen W ^a,b   Polak, Timothy J ^c   Sonstein, Joanne ^c   Todt, Jill C ^c   Ames, Theresa M ^c   Arenberg, Douglas A ^c   Meldrum, Catherine A ^c   Getty, Christi ^c   McCloskey, Lisa ^c   Curtis, Jeffrey L ^a,b,c  

^a VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD57 ANTIGEN; CORTICOSTEROID; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 5; INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 8; NATURAL KILLER CELL LECTIN LIKE RECEPTOR; PERFORIN; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR GAMMA; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3; TUMOR NECROSIS FACTOR ALPHA; CD69 ANTIGEN; CYTOKINE; INTERLEUKIN 18; LECTIN; LEUKOCYTE ANTIGEN; MESSENGER RNA; T LYMPHOCYTE ANTIGEN;

ADULT; ARTICLE; CD8+ T LYMPHOCYTE; CEREBROSPINAL FLUID; CHRONIC DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CORRELATION ANALYSIS; CYTOKINE RELEASE; CYTOLYSIS; CYTOTOXICITY; DISEASE SEVERITY; DRUG BINDING; DRUG USE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INFECTION; INTROSPECTION; KILLER CELL; LUNG CANCER; LUNG PARENCHYMA; LUNG RESECTION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBPOPULATION; MALE; PATHOGENESIS; POPULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT INFECTION; SECRETION; SMOKING; TISSUE HOMOGENATE; AGED; BIOSYNTHESIS; CELL SEPARATION; FLOW CYTOMETRY; FORCED EXPIRATORY VOLUME; IMMUNOLOGY; LUNG FUNCTION TEST; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE SUBPOPULATION;

AGED; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD8-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; FORCED EXPIRATORY VOLUME; HUMANS; INTERLEUKIN-15; INTERLEUKIN-18; LECTINS, C-TYPE; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY FUNCTION TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTE SUBSETS;

EID: 77953402276     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000006     Document Type: Article

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