Cigarette smoke induction of osteopontin (SPP1) mediates T H17 inflammation in human and experimental emphysema

Science Translational Medicine

Volumn 4, Issue 117, 2012, Pages

  Shan, Ming ^a   Yuan, Xiaoyi ^a   Song, Li Zhen ^a   Roberts, Luz ^a   Zarinkamar, Nazanin ^a   Seryshev, Alexander ^a   Zhang, Yiqun ^a   Hilsenbeck, Susan ^a   Chang, Seon Hee ^b   Dong, Chen ^b   Corry, David B ^a,c   Kheradmand, Farrah ^a,c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; GAMMA INTERFERON; INTERLEUKIN 17; OSTEOPONTIN; T6 ANTIGEN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR IRF7; UNCLASSIFIED DRUG; CD1 ANTIGEN; CYTOKINE; SPP1 PROTEIN, HUMAN; SPP1 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CIGARETTE SMOKING; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMPHYSEMA; GAMMA DELTA T LYMPHOCYTE; GENE; HUMAN; IN VIVO STUDY; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY MECHANISM; SPP1 GENE; T LYMPHOCYTE SUBPOPULATION; TH17 CELL; ANIMAL; ANTIGEN PRESENTING CELL; BIOSYNTHESIS; C57BL MOUSE; CYTOLOGY; DISEASE MODEL; GENE EXPRESSION REGULATION; IMMUNOLOGY; LUNG; METABOLISM; SMOKING; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD1; CYTOKINES; DISEASE MODELS, ANIMAL; EMPHYSEMA; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-17; LUNG; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OSTEOPONTIN; SMOKING; TH17 CELLS;

EID: 84856068597     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003041     Document Type: Article

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