Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q

Psychiatric Genetics

Volumn 13, Issue 2, 2003, Pages 77-84

  Curtis, David ^a,d   Kalsi, Gursharan ^b   Brynjolfsson, Jon ^c   McInnis, Melvin ^c   O'Neill, Jane ^b   Smyth, Ciaran ^b   Moloney, Eamonn ^b   Murphy, Patrice ^b   McQuillin, Andrew ^b   Petursson, Hannes ^c   Gurling, Hugh ^b  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c General Hospital   (Iceland)

^d ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

Bipolar disorder; Genome scan; Linkage

Indexed keywords

ARTICLE; BIPOLAR DISORDER; CHROMOSOME 12Q; CHROMOSOME 1P; CHROMOSOME 1Q; CONTROLLED STUDY; DISEASE TRANSMISSION; GENE LOCUS; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MICROSATELLITE MARKER; MODEL; PEDIGREE; PEDIGREE ANALYSIS; PRIORITY JOURNAL;

EID: 12444256025     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ypg.0000056684.89558.d2     Document Type: Article

References (30)

1. Barden N, Morissette J (1999). Chromosome 13 workshop report. Am J Med Genet 88:260-262.
2. Chalifa-Caspi V, Prilusky J, Lancet D (2000). The Unified Database [http://bioinformatics.weizmann.ac.illudb]. Rehovot: Weizmann Institute of Science.
3. Cottingham RW, Idury RM, Schaffer AA (1993). Faster sequential genetic linkage computations. Am J Hum Genet 53:252-263.
4. Craddock N, Jones I (1999). Genetics of bipolar disorder. J Med Genet 36:565-594.
5. Craddock N, Owen M, Burge S, Kurian B, Thomas P, McGuffin P (1994). Familial cosegregation of major affective disorder and Darier's disease (keratosis follicularis). Br J Psychiatry 164:355-358.
6. Cruts M, van Duijn CM, Backhovens H, Van den Broeck M, Wehnert A, Serneels S, et al. (1998). Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. Hum Mol Genet 7:43-51.
7. Curtis D, Sham PC (1995). Model-free linkage analysis using likelihoods. Am J Hum Genet 57:703-716.
8. Curtis D (1996). Genetic dissection of complex traits [Letter]. Nat Genet 12:356-358.
9. Curtis D (1999). Chromosome 21 workshop. Am J Med Genet 88:272-275.
10. Curtis D, Zhao JH, Sham PC (1999). Comparison of GENEHUNTER and MFLINK for analysis of COGA linkage data. Genet Epidemiol 17(Suppl 1):S115-S120.
11. Detera-Wadleigh SD (1999). Chromosomes 12 and 16 workshop. Am J Med Genet 88:255-259.
12. Detera-Wadleigh SD, Badner JA, Berrettini WH, Yoshikawa T, Goldin LR, Turner G, et al. (1999). A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 96:5604-5609.
13. Ewald H, Degn B, Mors O, Kruse TA (1998). Significant linkage between bipolar affective disorder and chromosome 12q24. Psychiatr Genet 8:131-140.
14. Friddle C, Koskela R, Ranade K, Hebert J, Cargill M, Clark CD, et al. (2000). Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. Am J Hum Genet 66:205-215.
15. Greenberg DA, Abreu P, Hodge SE (1998). The power to detect linkage in complex disease by means of simple LOD- score analyses. Am J Hum Genet 63:870-879.
16. Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, et al. (1994). The 1993-94 Genethon human genetic linkage map [see comments]. Nat Genet 7:246-339.
17. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996). Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363.
18. Lander E, Kruglyak L (1995). Genetic dissection of complex traits. Nat Genet 11:241-247.
19. McInnes LA, Escamilla MA, Service SK, Reus VI, Leon P, Silva S, et al. (1996). A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees. Proc Natl Acad Sci USA 93:13060-13065.
20. McMahon FJ, Hopkins PJ, Xu J, McInnis MG, Shaw S, Cardon L, et al. (1997). Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series. Am J Hum Genet 61:1397-1404.
21. Nothen MM, Cichon S, Rohleder H, Hemmer S, Franzek E, Fritze J, et al. (1999). Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families. Mol Psychiatry 4:76-84.
22. O'Connell JR, Weeks DE (1995). The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recording and fuzzy inheritance. Nat Genet 11:402-408.
23. Risch N, Giuffra L (1992). Model misspecification and multipoint linkage analysis. Hum Hered 42:77-92.
24. Schaffer AA (1996). Faster linkage analysis computations for pedigrees with loops or unused alleles. Hum Hered 46:226-235.
25. Smyth C, Kalsi G, Curtis D, Brynjolfsson J, O'Neill J, Rifkin L, et al. (1997). Two-locus admixture linkage analysis of bipolar and unipolar affective disorder supports the presence of susceptibility loci on chromosomes 11p15 and 21q22. Genomics 39:271-278.
26. Spitzer R, Endicott J (1977). The Schedule for Affective Disorders and Schizophrenia, Lifetime Version, 3rd edition. New York: New York State Psychiatric Institute.
27. Spitzer R, Endicott J, Robins E (1978). Research Diagnostic Criteria for a Selected Group of Functional Disorders. New York: New York State Psychiatric Institute.
28. Stine OC, Xu J, Koskela R, McMahon FJ, Gschwend M, Friddle C, et al. (1995). Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J Hum Genet 57:1384-1394.
29. Thompson ME, Jensen RA, Obermiller PS, Page DL, Holt JT (1995). Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat Genet 9:444-450.
30. Turecki G, Smith M, Mari JJ (1995). Type I bipolar disorder associated with a fragile site on chromosome 1. Am J Med Genet 60:179-182.