Affinity labeling of hepatitis C virus replicase with a nucleotide analogue: Identification of binding site

Biochemistry

Volumn 52, Issue 2, 2013, Pages 432-444

  Manvar, Dinesh ^a   Singh, Kamlendra ^a   Pandey, Virendra N ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP-BINDING SITE; CONCENTRATION-DEPENDENT; DOUBLE-STRANDED RNA; HEPATITIS C VIRUS; HPLC ANALYSIS; LC/MS/MS; NUCLEOTIDE ANALOGUES; PHOTO-CROSS-LINK; TRYPTIC PEPTIDES;

AMINO ACIDS; ENZYMES; NUCLEOTIDES; RNA; STOICHIOMETRY; VIRUSES;

PEPTIDES;

5' (4 FLUOROSULFONYLBENZOYL)ADENOSINE; ADENOSINE TRIPHOSPHATE; ALANINE; DOUBLE STRANDED RNA; NONSTRUCTURAL PROTEIN 5B; NUCLEOTIDE; RNA DIRECTED RNA POLYMERASE; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; ENZYME ACTIVITY; HEPATITIS C VIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; STOICHIOMETRY;

ADENOSINE; ADENOSINE TRIPHOSPHATE; AFFINITY LABELS; AMINO ACID SEQUENCE; BINDING SITES; HEPACIVIRUS; HEPATITIS C; HUMANS; MOLECULAR DOCKING SIMULATION; MUTAGENESIS; NUCLEOTIDES; POINT MUTATION; PROTEIN BINDING; RNA REPLICASE; SEQUENCE ALIGNMENT; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

HEPATITIS C VIRUS;

EID: 84872575070     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301098g     Document Type: Article

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