Characterization of the metal ion binding properties of the hepatitis C virus RNA polymerase

Journal of Biological Chemistry

Volumn 278, Issue 6, 2003, Pages 3868-3875

  Bougie, Isabelle ^b   Charpentier, Sébastien ^b   Bisaillon, Martin ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSTS; CONFORMATIONS; DISSOCIATION; FLUORESCENCE; IONS; POLYMERIZATION; RNA; SPECTRUM ANALYSIS; TITRATION; VIRUSES;

METAL IONS;

PROTEINS;

LIGAND; MAGNESIUM; MANGANESE; METAL ION; NONSTRUCTURAL 5B PROTEIN; PHOSPHATE; RNA POLYMERASE; TRYPTOPHAN; UNCLASSIFIED DRUG; VIRUS PROTEIN; DIVALENT CATION; DNA DIRECTED RNA POLYMERASE; METAL; NS 5 PROTEIN, HEPATITIS C VIRUS; NS-5 PROTEIN, HEPATITIS C VIRUS;

ARTICLE; BINDING COMPETITION; BINDING KINETICS; CATALYSIS; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME SUBSTRATE; FLAME PHOTOMETRY; FLUORESCENCE; HEPATITIS C VIRUS; METAL BINDING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN RNA BINDING; PROTEIN STABILITY; REACTION ANALYSIS; TITRIMETRY; ULTRAVIOLET SPECTROSCOPY; ENZYMOLOGY; GEL MOBILITY SHIFT ASSAY; KINETICS; METABOLISM; PROTEIN BINDING; SPECTROFLUOROMETRY;

HEPATITIS C VIRUS; RNA VIRUSES;

CATIONS, DIVALENT; CIRCULAR DICHROISM; DNA-DIRECTED RNA POLYMERASES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HEPACIVIRUS; KINETICS; METALS; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0037423270     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209785200     Document Type: Article

References (44)

1. Sarbah, S., and Younossi, Z. (2000) J. Clin. Gastro. 30, 125-143
2. Choo, Q. L., Kuo, G., Weiner, A. J., Overby, L. R., Bradley, D. W., and Houghton, M. (1989) Science 244, 359-362
3. Saito, I., Miyamura, T., Ohbayashi, A., Harada, H., Katayama, T., Kikuchi, S., Watanabe, Y., Koi, S., Onji, M., Ohta, Y., Choo, Q. L., Houghton, M., and Kuo, G. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 6547-6549
4. Alter, H. J. (1995) Blood 85, 1681-1695
5. Houghton, M. (1996) Virology (Fields, B. N., Knipe, D. M., and Howley, P. M., eds) Lippincott-Raven Publishers, Philadelphia, PA
6. Bartenschlager, R. (1997) Antiviral. Chem. Chemother. 8, 281-301
7. Al, R. H., Xie, Y., Wang, Y., and Hagedorn, C. H. (1998) Virus Res. 53, 141-149
8. Behrens, S. E., Tomei, L., and De Francesco, R. (1996) EMBO J. 15, 12-22
9. De Francesco, R., Behrens, S. E., Tomei, L., Altamura, S., and Jiricny, J. (1996) Methods Enzymol. 275, 58-67
10. Lohmann, V., Korner, F., Herian, U., and Bartenschlager, R. (1997) J. Virol. 71, 8416-8428
11. Yuan, Z. H., Kumar, U., Thomas, H. C., Wen, Y. M., and Monjardino, J. (1997) Biochem. Biophys. Res. Commun. 232, 231-235
12. Oh, J. W., Sheu, G. T., and Lai, M. M. (2000) J. Biol. Chem. 275, 17710-17717
13. Miller, R. H., and Purcell, R. H. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 2057-2061
14. Ferrari, E., Wright-Minogue, J., Fang, J. W., Baroudy, B. M., Lau, J. Y., and Hong, Z. (1999) J. Virol. 73, 1649-1654
15. Lohmann, V., Roos, A., Korner, F., Koch, J. O., and Bartenschlager R. (2000) J. Viral Hepatitis 7, 167-174
16. Cheney, I. W., Naim, S., Lai, V. C. H., Dempsey, S., Bellows, D., Walker, M. P., Shim, J. H., Horscroft, N., Hong, Z., and Zhong, W. (2002) Virology 297, 298-306
17. Kao, C. C., Yang, X., Kline, A., Wang, Q. M., Barket, D., and Heinz, B. A. (2000) J. Virol. 74, 11121-11128
18. Oh, J. W., Ito, T., and Lai, M. M. C. (1999) J. Virol. 73, 7694-7702
19. Carroll, S. S., Sardana, V., Yang, Z., Jacobs, A. R., Mizenko, C., Hall, D., Hill, L., Zugay-Murphy, J., and Kuo, L. C. (2000) Biochemistry 39, 8243-8249
20. Sun, X. L., Johnson, R. B., Hockman, M. A., and Wang, Q. M. (2000) Biochem. Biophys. Res. Commun. 268, 798-803
21. Uchiyama, Y., Huang, Y., Kanamori, H., Uchida, M., Doi, T., Takamizawa, A., Hamakubo, T., and Kodama, T. (2002) Hepatol. Res. 23, 90-97
22. Tomei, L., Vitale R. L., Iccitti, I., Serafini, S., Altamura, S., Vitelli, A., and De Francesco, R. (2002) J. Gen. Virol. 81, 759-767
23. Zhong, W., Uss, A. S., Ferrari, E., Lau, J. Y. N., and Hong, Z. (2000) J. Virol. 74, 2017-2022
24. Yamashita, T., Kaneko, S., Shirota, Y., Qin, W., Nomura, T., Kobayashi, K., and Murakami, S. (1998) J. Biol. Chem. 273, 15479-15486
25. Luo, G., Hamatake, R. K., Mathis, D. M., Racela, J., Rigat, K. L., Lemm, J., and Colonno, R. J. (2000) J. Virol. 74, 851-863
26. Johnson, R. B., Sun, X. L., Hockman, M. A., Villarreal, E. C., Wakulchik, M., and Wang, Q. M. (2000) Arch. Biochem. Biophys. 377, 129-134
27. Zhong, W., Ferrari, E., Lesburg, C. A., Maag, D., Ghosh, S. K. B., Cameron, C. E., Lau, J. Y. N., and Hong, Z. (2000) J. Virol. 74, 9134-9143
28. Bressanelli, S., Tomei, L., Rey, F. A., and De Francesco, R. (2002) J. Virol. 76, 3482-3492
29. Painter, G. R., Wright, L. L., Hopkins, S., and Furman, P. A. (1991) J. Biol. Chem. 266, 19362-19368
30. Eftink, M. R., and Ghiron, C. A. (1976) Biochemistry 15, 672-680
31. van der Wolk, J. P. W., Klose, M., de Wit, J. G., den Blaauwen, T., Freudl, R., and Driessen, A. J. M. (1995) J. Biol. Chem. 270, 18975-18982
32. Zhu, C. X., Roche, C. J., and Tse-Dinh, Y. C. (1997) J. Biol. Chem. 272, 16206-16210
33. de Seny, D., Heinz, U., Wommer, S., Kiefer, M., Meyer-Klaucke, W., Galleni, M., Frère, J. M., Bauer, R., and Adolph, H. W. (2001) J. Biol. Chem. 276, 45065-45078
34. Lohman, T. M., and Overman, L. B. (1985) J. Biol. Chem. 260, 3594-3603
35. Kim, M., Kim, H., Cho, S. P., and Min, M. K. (2002) J. Virol. 76, 6944-6956
36. Bressanelli, S., Tomei, L., Roussel, A., Incitti, I., Vitale, R. L., Mathieu, M., De Francesco, R., and Rey, F. A. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 13034-13039
37. Lesburg, C. A., Cable, M. B., Ferrari, E., Hong, Z., Mannarino, A. F., and Weber, P. C. (1999) Nat. Struct. Biol. 6, 937-943
38. Ng, K. K. S., Cherney, M. M., Vazquez, A. L., Machin, A., Alonso, J. M. M., Parra, F., and James, M. N. G. (2002) J. Biol. Chem. 277, 1381-1387
39. Doublie, S., Sawaya, M. R., and Ellenberger, T. (1999) Structure 7, R31-R35
40. Huang, H., Chopra, R., Verdine, G. L., and Harrison, S. C. (1998) Science 282, 1669-1675
41. Brautigam, C. A., and Steitz, T. A. (1998) J. Mol. Biol. 277, 363-377
42. Beese, L. S., and Steitz, T. A. (1991) EMBO J. 10, 25-33
43. Ago, H., Adashi, T., Yoshida, A., Yamamoto, M., Habuka, N., Yatsunami, K., and Miyano, M. (1999) Structure 7, 1417-1426
44. Doublie, S., Tabor, S., Long, A. M., Richardson, C. C., and Ellenberger, T. (1998) Nature 391, 251-258