Modulation of hepatitis C virus RNA-dependent RNA polymerase activity by structure-based site-directed mutagenesis

Journal of Biological Chemistry

Volumn 277, Issue 41, 2002, Pages 38838-38846

  Labonté, Patrick ^a   Axelrod, Vladimir ^a   Agarwal, Atul ^a   Aulabaugh, Ann ^a   Amin, Anthony ^a   Mak, Paul ^a,b  

^a Department of Infectious Disease ^*  (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CENTRIFUGATION; COLUMN CHROMATOGRAPHY; CRYSTAL STRUCTURE; ENZYME KINETICS; ENZYMES; GENES; IMMUNOLOGY; MUTAGENESIS; RNA; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

IMMUNODEFICIENCY;

VIRUSES;

AMINO ACID; ARGININE; GENOMIC RNA; GLUTAMIC ACID; LYSINE; RNA DIRECTED RNA POLYMERASE;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL REACTION; COLUMN CHROMATOGRAPHY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME STRUCTURE; GENE REPLICATION; GENOME; HEPATITIS C VIRUS; KINETICS; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; ULTRACENTRIFUGATION;

BASE SEQUENCE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEOTIDES; PROTEIN STRUCTURE, TERTIARY; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; POLIOVIRUS; RNA VIRUSES;

EID: 0037064077     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M204657200     Document Type: Article

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