PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation

Journal of Biological Chemistry

Volumn 287, Issue 52, 2012, Pages 43516-43526

  Valentin Hansen, Louise ^a,b   Holst, Birgitte ^a,b   Frimurer, Thomas M ^b,c   Schwartz, Thue W ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Capital Region   (Denmark)

^c University of Copenhagen   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTORS; AROMATIC RESIDUES; CELL SURFACE EXPRESSION; COMPUTATIONAL ANALYSIS; CONFORMATIONAL CHANGE; CONSERVED RESIDUES; G PROTEIN COUPLED RECEPTORS; GHRELIN RECEPTOR; HYDROPHOBIC POCKETS; HYDROPHOBIC RESIDUES; MICROSWITCHES; MUTATIONAL ANALYSIS; RECEPTOR ACTIVATION; RECEPTOR SIGNALING; TRANSMEMBRANE SEGMENTS; TRANSMEMBRANES; X-RAY STRUCTURE;

AROMATIC COMPOUNDS; CELL MEMBRANES; CONFORMATIONS;

HYDROPHOBICITY;

ALANINE; BETA 2 ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 119; GHRELIN RECEPTOR; LEUCINE; NEUROKININ 1 RECEPTOR; PHENYLALANINE; SEVEN TRANSMEMBRANE RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HYDROPHOBICITY; MATHEMATICAL ANALYSIS; MICROSWITCH; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MUTATION, MISSENSE; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROKININ-1;

EID: 84871579031     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.395137     Document Type: Article

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