메뉴 건너뛰기




Volumn 1022, Issue 1-2, 2004, Pages 30-38

Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein

Author keywords

Cerebral ischemia; Hyperphosphorylation; Tau protein

Indexed keywords

TAU PROTEIN;

EID: 4444333265     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.05.106     Document Type: Article
Times cited : (125)

References (61)
  • 1
    • 0029976253 scopus 로고    scopus 로고
    • DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay
    • Anderson A.J., Su J.H., Cotman C.W. DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J. Neurosci. 16:1996;1710-1719
    • (1996) J. Neurosci. , vol.16 , pp. 1710-1719
    • Anderson, A.J.1    Su, J.H.2    Cotman, C.W.3
  • 2
    • 0036937699 scopus 로고    scopus 로고
    • Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
    • Augustinack J.C., Schneider A., Mandelkow E.M., Hyman B.T. Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol. (Berl.). 103:2002;26-35
    • (2002) Acta Neuropathol. (Berl.) , vol.103 , pp. 26-35
    • Augustinack, J.C.1    Schneider, A.2    Mandelkow, E.M.3    Hyman, B.T.4
  • 3
    • 0022483434 scopus 로고
    • Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination
    • Bederson J.B., Pitts L.H., Tsuji M., Nishimura M.C., Davis R.L., Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke. 17:1986;472-476
    • (1986) Stroke , vol.17 , pp. 472-476
    • Bederson, J.B.1    Pitts, L.H.2    Tsuji, M.3    Nishimura, M.C.4    Davis, R.L.5    Bartkowski, H.6
  • 4
    • 0033739282 scopus 로고    scopus 로고
    • Apoptosis and Alzheimer's disease
    • Behl C. Apoptosis and Alzheimer's disease. J. Neural Transm. 107:2000;1325-1344
    • (2000) J. Neural Transm. , vol.107 , pp. 1325-1344
    • Behl, C.1
  • 5
    • 0036254698 scopus 로고    scopus 로고
    • Oxidative nerve cell death in Alzheimer's disease and stroke: Antioxidants as neuroprotective compounds
    • Behl C., Moosmann B. Oxidative nerve cell death in Alzheimer's disease and stroke: antioxidants as neuroprotective compounds. Biol. Chem. 383:2002;521-536
    • (2002) Biol. Chem. , vol.383 , pp. 521-536
    • Behl, C.1    Moosmann, B.2
  • 6
    • 0027338266 scopus 로고
    • Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
    • Biernat J., Gustke N., Drewes G., Mandelkow E.M., Mandelkow E. Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding. Neuron. 11:1993;153-163
    • (1993) Neuron , vol.11 , pp. 153-163
    • Biernat, J.1    Gustke, N.2    Drewes, G.3    Mandelkow, E.M.4    Mandelkow, E.5
  • 7
    • 0031007546 scopus 로고    scopus 로고
    • Regulated phosphorylation and dephosphorylation of tau protein: Effects on microtubule interaction, intracellular trafficking and neurodegeneration
    • Billingsley M.L., Kincaid R.L. Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration. Biochem. J. 323(Pt 3):1997;577-591
    • (1997) Biochem. J. , vol.323 , Issue.PART 3 , pp. 577-591
    • Billingsley, M.L.1    Kincaid, R.L.2
  • 8
    • 0027308924 scopus 로고
    • Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
    • Bramblett G.T., Goedert M., Jakes R., Merrick S.E., Trojanowski J.Q., Lee V.M. Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron. 10:1993;1089-1099
    • (1993) Neuron , vol.10 , pp. 1089-1099
    • Bramblett, G.T.1    Goedert, M.2    Jakes, R.3    Merrick, S.E.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 9
    • 0016690181 scopus 로고
    • Artificial embolization of the middle cerebral artery in primates. Description of an experimental model with extracranial technique
    • Bremer A.M., Watanabe O., Bourke R.S. Artificial embolization of the middle cerebral artery in primates. Description of an experimental model with extracranial technique. Stroke. 6:1975;387-390
    • (1975) Stroke , vol.6 , pp. 387-390
    • Bremer, A.M.1    Watanabe, O.2    Bourke, R.S.3
  • 11
    • 0032409926 scopus 로고    scopus 로고
    • Alterations in tau phosphorylation in rat and human neocortical brain slices following hypoxia and glucose deprivation
    • Burkhart K.K., Beard D.C., Lehman R.A., Billingsley M.L. Alterations in tau phosphorylation in rat and human neocortical brain slices following hypoxia and glucose deprivation. Exp. Neurol. 154:1998;464-472
    • (1998) Exp. Neurol. , vol.154 , pp. 464-472
    • Burkhart, K.K.1    Beard, D.C.2    Lehman, R.A.3    Billingsley, M.L.4
  • 12
    • 0017649032 scopus 로고
    • Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin
    • Cleveland D.W., Hwo S.Y., Kirschner M.W. Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J. Mol. Biol. 116:1977;207-225
    • (1977) J. Mol. Biol. , vol.116 , pp. 207-225
    • Cleveland, D.W.1    Hwo, S.Y.2    Kirschner, M.W.3
  • 13
    • 0029968149 scopus 로고    scopus 로고
    • The underlying molecular mechanism of apolipoprotein e polymorphism: Relationships to lipid disorders, cardiovascular disease, and Alzheimer's disease
    • Contois J.H., Anamani D.E., Tsongalis G.J. The underlying molecular mechanism of apolipoprotein E polymorphism: relationships to lipid disorders, cardiovascular disease, and Alzheimer's disease. Clin. Lab. Med. 16:1996;105-123
    • (1996) Clin. Lab. Med. , vol.16 , pp. 105-123
    • Contois, J.H.1    Anamani, D.E.2    Tsongalis, G.J.3
  • 14
    • 0029912056 scopus 로고    scopus 로고
    • Mechanisms of neuronal death in Alzheimer's disease
    • Cotman C.W., Su J.H. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol. 6:1996;493-506
    • (1996) Brain Pathol. , vol.6 , pp. 493-506
    • Cotman, C.W.1    Su, J.H.2
  • 15
    • 0345405447 scopus 로고    scopus 로고
    • Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
    • Cruz J.C., Tseng H.C., Goldman J.A., Shih H., Tsai L.H. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron. 40:2003;471-483
    • (2003) Neuron , vol.40 , pp. 471-483
    • Cruz, J.C.1    Tseng, H.C.2    Goldman, J.A.3    Shih, H.4    Tsai, L.H.5
  • 16
    • 0027359805 scopus 로고
    • Alz-50 and ubiquitin immunoreactivity is induced by permanent focal cerebral ischaemia in the cat
    • Dewar D., Graham D.I., Teasdale G.M., McCulloch J. Alz-50 and ubiquitin immunoreactivity is induced by permanent focal cerebral ischaemia in the cat. Acta Neuropathol. (Berl.). 86:1993;623-629
    • (1993) Acta Neuropathol. (Berl.) , vol.86 , pp. 623-629
    • Dewar, D.1    Graham, D.I.2    Teasdale, G.M.3    McCulloch, J.4
  • 17
    • 0027058857 scopus 로고
    • Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau
    • Drechsel D.N., Hyman A.A., Cobb M.H., Kirschner M.W. Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol. Biol. Cell. 3:1992;1141-1154
    • (1992) Mol. Biol. Cell , vol.3 , pp. 1141-1154
    • Drechsel, D.N.1    Hyman, A.A.2    Cobb, M.H.3    Kirschner, M.W.4
  • 18
    • 0141960033 scopus 로고    scopus 로고
    • Beta-amyloid induces paired helical filament-like tau filaments in tissue culture
    • Ferrari A., Hoerndli F., Baechi T., Nitsch R.M., Gotz J. Beta-amyloid induces paired helical filament-like tau filaments in tissue culture. J. Biol. Chem. 278:2003;40162-40168
    • (2003) J. Biol. Chem. , vol.278 , pp. 40162-40168
    • Ferrari, A.1    Hoerndli, F.2    Baechi, T.3    Nitsch, R.M.4    Gotz, J.5
  • 20
    • 0002792366 scopus 로고
    • Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: Identification as the microtubule-associated protein tau
    • Goedert M., Wischik C.M., Crowther R.A., Walker J.E., Klug A. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc. Natl. Acad. Sci. U. S. A. 85:1988;4051-4055
    • (1988) Proc. Natl. Acad. Sci. U. S. A. , vol.85 , pp. 4051-4055
    • Goedert, M.1    Wischik, C.M.2    Crowther, R.A.3    Walker, J.E.4    Klug, A.5
  • 22
    • 0035808361 scopus 로고    scopus 로고
    • Tau filament formation in transgenic mice expressing P301L tau
    • Gotz J., Chen F., Barmettler R., Nitsch R.M. Tau filament formation in transgenic mice expressing P301L tau. J. Biol. Chem. 276:2001;529-534
    • (2001) J. Biol. Chem. , vol.276 , pp. 529-534
    • Gotz, J.1    Chen, F.2    Barmettler, R.3    Nitsch, R.M.4
  • 23
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
    • Gotz J., Chen F., van Dorpe J., Nitsch R.M. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science. 293:2001;1491-1495
    • (2001) Science , vol.293 , pp. 1491-1495
    • Gotz, J.1    Chen, F.2    Van Dorpe, J.3    Nitsch, R.M.4
  • 24
    • 0034725178 scopus 로고    scopus 로고
    • Neurons containing Alz-50-immunoreactive granules around the cerebral infarction: Evidence for the lysosomal degradation of altered tau in human brain?
    • Ikeda K., Akiyama H., Arai T., Kondo H., Haga C., Tsuchiya K., Yamada S., Murayama S., Hori A. Neurons containing Alz-50-immunoreactive granules around the cerebral infarction: evidence for the lysosomal degradation of altered tau in human brain? Neurosci. Lett. 284:2000;187-189
    • (2000) Neurosci. Lett. , vol.284 , pp. 187-189
    • Ikeda, K.1    Akiyama, H.2    Arai, T.3    Kondo, H.4    Haga, C.5    Tsuchiya, K.6    Yamada, S.7    Murayama, S.8    Hori, A.9
  • 25
    • 0029982615 scopus 로고    scopus 로고
    • Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos
    • James N.D., Davis D.R., Sindon J., Hanger D.P., Brion J.P., Miller C.C., Rosenberg M.P., Anderton B.H., Propst F. Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos. Neurobiol. Aging. 17:1996;235-241
    • (1996) Neurobiol. Aging , vol.17 , pp. 235-241
    • James, N.D.1    Davis, D.R.2    Sindon, J.3    Hanger, D.P.4    Brion, J.P.5    Miller, C.C.6    Rosenberg, M.P.7    Anderton, B.H.8    Propst, F.9
  • 26
    • 0030936599 scopus 로고    scopus 로고
    • Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau
    • Jicha G.A., Bowser R., Kazam I.G., Davies P. Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau. J. Neurosci. Res. 48:1997;128-132
    • (1997) J. Neurosci. Res. , vol.48 , pp. 128-132
    • Jicha, G.A.1    Bowser, R.2    Kazam, I.G.3    Davies, P.4
  • 27
    • 0024438227 scopus 로고
    • Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA
    • Kanai Y., Takemura R., Oshima T., Mori H., Ihara Y., Yanagisawa M., Masaki T., Hirokawa N. Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA. J. Cell Biol. 109:1989;1173-1184
    • (1989) J. Cell Biol. , vol.109 , pp. 1173-1184
    • Kanai, Y.1    Takemura, R.2    Oshima, T.3    Mori, H.4    Ihara, Y.5    Yanagisawa, M.6    Masaki, T.7    Hirokawa, N.8
  • 28
    • 0026711059 scopus 로고
    • Fetal-type phosphorylation of the tau in paired helical filaments
    • Kanemaru K., Takio K., Miura R., Titani K., Ihara Y. Fetal-type phosphorylation of the tau in paired helical filaments. J. Neurochem. 58:1992;1667-1675
    • (1992) J. Neurochem. , vol.58 , pp. 1667-1675
    • Kanemaru, K.1    Takio, K.2    Miura, R.3    Titani, K.4    Ihara, Y.5
  • 30
  • 31
  • 32
    • 0038705066 scopus 로고    scopus 로고
    • Cdk5: One of the links between senile plaques and neurofibrillary tangles?
    • Lee M.S., Tsai L.H. Cdk5: one of the links between senile plaques and neurofibrillary tangles? J. Alzheimer's Dis. 5:2003;127-137
    • (2003) J. Alzheimer's Dis. , vol.5 , pp. 127-137
    • Lee, M.S.1    Tsai, L.H.2
  • 33
    • 0025904444 scopus 로고
    • A68: A major subunit of paired helical filaments and derivatized forms of normal Tau
    • Lee V.M., Balin B.J., Otvos L. Jr., Trojanowski J.Q. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. Science. 251:1991;675-678
    • (1991) Science , vol.251 , pp. 675-678
    • Lee, V.M.1    Balin, B.J.2    Otvos Jr., L.3    Trojanowski, J.Q.4
  • 35
    • 0030884358 scopus 로고    scopus 로고
    • Apoptosis and protein expression after focal cerebral ischemia in rat
    • Li Y., Chopp M., Powers C., Jiang N. Apoptosis and protein expression after focal cerebral ischemia in rat. Brain Res. 765:1997;301-312
    • (1997) Brain Res. , vol.765 , pp. 301-312
    • Li, Y.1    Chopp, M.2    Powers, C.3    Jiang, N.4
  • 36
    • 0026757951 scopus 로고
    • Dementia associated with lacunar infarction
    • Loeb C., Gandolfo C., Croce R., Conti M. Dementia associated with lacunar infarction. Stroke. 23:1992;1225-1229
    • (1992) Stroke , vol.23 , pp. 1225-1229
    • Loeb, C.1    Gandolfo, C.2    Croce, R.3    Conti, M.4
  • 37
    • 0033600242 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein
    • Lu P.J., Wulf G., Zhou X.Z., Davies P., Lu K.P. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature. 399:1999;784-788
    • (1999) Nature , vol.399 , pp. 784-788
    • Lu, P.J.1    Wulf, G.2    Zhou, X.Z.3    Davies, P.4    Lu, K.P.5
  • 38
    • 0034829801 scopus 로고    scopus 로고
    • The molecular bases of Alzheimer's disease and other neurodegenerative disorders
    • Maccioni R.B., Munoz J.P., Barbeito L. The molecular bases of Alzheimer's disease and other neurodegenerative disorders. Arch. Med. Res. 32:2001;367-381
    • (2001) Arch. Med. Res. , vol.32 , pp. 367-381
    • MacCioni, R.B.1    Munoz, J.P.2    Barbeito, L.3
  • 40
    • 0022827447 scopus 로고
    • Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2
    • Neve R.L., Harris P., Kosik K.S., Kurnit D.M., Donlon T.A. Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. Brain Res. 387:1986;271-280
    • (1986) Brain Res. , vol.387 , pp. 271-280
    • Neve, R.L.1    Harris, P.2    Kosik, K.S.3    Kurnit, D.M.4    Donlon, T.A.5
  • 41
    • 0025810513 scopus 로고
    • Altered phosphorylation of tau protein in heat-shocked rats and patients with Alzheimer disease
    • Papasozomenos S.C., Su Y. Altered phosphorylation of tau protein in heat-shocked rats and patients with Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 88:1991;4543-4547
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 4543-4547
    • Papasozomenos, S.C.1    Su, Y.2
  • 42
    • 0031046204 scopus 로고    scopus 로고
    • Why are stroke patients prone to develop dementia?
    • Pasquier F., Leys D. Why are stroke patients prone to develop dementia? J. Neurol. 244:1997;135-142
    • (1997) J. Neurol. , vol.244 , pp. 135-142
    • Pasquier, F.1    Leys, D.2
  • 43
    • 0034672554 scopus 로고    scopus 로고
    • Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal
    • Perez M., Cuadros R., Smith M.A., Perry G., Avila J. Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal. FEBS Lett. 486:2000;270-274
    • (2000) FEBS Lett. , vol.486 , pp. 270-274
    • Perez, M.1    Cuadros, R.2    Smith, M.A.3    Perry, G.4    Avila, J.5
  • 46
    • 0034826217 scopus 로고    scopus 로고
    • The microtubule-associated protein tau in neurodegenerative diseases. Tauopathies
    • Sanchez M.P., Alvarez-Tallada V., Avila J. The microtubule-associated protein tau in neurodegenerative diseases. Tauopathies. Rev. Neurol. 33:2001;169-177
    • (2001) Rev. Neurol. , vol.33 , pp. 169-177
    • Sanchez, M.P.1    Alvarez-Tallada, V.2    Avila, J.3
  • 47
    • 0033596946 scopus 로고    scopus 로고
    • Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments
    • Schneider A., Biernat J., von Bergen M., Mandelkow E., Mandelkow E.M. Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. Biochemistry. 38:1999;3549-3558
    • (1999) Biochemistry , vol.38 , pp. 3549-3558
    • Schneider, A.1    Biernat, J.2    Von Bergen, M.3    Mandelkow, E.4    Mandelkow, E.M.5
  • 48
    • 0032411608 scopus 로고    scopus 로고
    • Dephosphorylation of tau during transient forebrain ischemia in the rat
    • Shackelford D.A., Yeh R.Y. Dephosphorylation of tau during transient forebrain ischemia in the rat. Mol. Chem. Neuropathol. 34:1998;103-120
    • (1998) Mol. Chem. Neuropathol. , vol.34 , pp. 103-120
    • Shackelford, D.A.1    Yeh, R.Y.2
  • 49
    • 0033957494 scopus 로고    scopus 로고
    • Hypoperfusion induces overexpression of beta-amyloid precursor protein mRNA in a focal ischemic rodent model
    • Shi J., Yang S.H., Stubley L., Day A.L., Simpkins J.W. Hypoperfusion induces overexpression of beta-amyloid precursor protein mRNA in a focal ischemic rodent model. Brain Res. 853:2000;1-4
    • (2000) Brain Res. , vol.853 , pp. 1-4
    • Shi, J.1    Yang, S.H.2    Stubley, L.3    Day, A.L.4    Simpkins, J.W.5
  • 53
    • 0025376092 scopus 로고
    • Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease
    • Spillantini M.G., Goedert M., Jakes R., Klug A. Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 87:1990;3947-3951
    • (1990) Proc. Natl. Acad. Sci. U. S. A. , vol.87 , pp. 3947-3951
    • Spillantini, M.G.1    Goedert, M.2    Jakes, R.3    Klug, A.4
  • 54
    • 0028577208 scopus 로고
    • Immunohistochemical evidence for apoptosis in Alzheimer's disease
    • Su J.H., Anderson A.J., Cummings B.J., Cotman C.W. Immunohistochemical evidence for apoptosis in Alzheimer's disease. NeuroReport. 5:1994;2529-2533
    • (1994) NeuroReport , vol.5 , pp. 2529-2533
    • Su, J.H.1    Anderson, A.J.2    Cummings, B.J.3    Cotman, C.W.4
  • 57
    • 0028305902 scopus 로고
    • Paired helical filament tau in Alzheimer's disease. the kinase connection
    • Trojanowski J.Q., Lee V.M. Paired helical filament tau in Alzheimer's disease. The kinase connection. Am. J. Pathol. 144:1994;449-453
    • (1994) Am. J. Pathol. , vol.144 , pp. 449-453
    • Trojanowski, J.Q.1    Lee, V.M.2
  • 59
    • 0036674986 scopus 로고    scopus 로고
    • Estrogens and neuroprotection
    • Wise P.M. Estrogens and neuroprotection. Trends Endocrinol. Metab. 13:2002;229-230
    • (2002) Trends Endocrinol. Metab. , vol.13 , pp. 229-230
    • Wise, P.M.1
  • 60
    • 0035089767 scopus 로고    scopus 로고
    • Minireview: Neuroprotective effects of estrogen-new insights into mechanisms of action
    • Wise P.M., Dubal D.B., Wilson M.E., Rau S.W., Bottner M. Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action. Endocrinology. 142:2001;969-973
    • (2001) Endocrinology , vol.142 , pp. 969-973
    • Wise, P.M.1    Dubal, D.B.2    Wilson, M.E.3    Rau, S.W.4    Bottner, M.5
  • 61
    • 0029792928 scopus 로고    scopus 로고
    • New clues to Alzheimer's disease: Unraveling the roles of amyloid and tau
    • Yankner B.A. New clues to Alzheimer's disease: unraveling the roles of amyloid and tau. Nat. Med. 2:1996;850-852
    • (1996) Nat. Med. , vol.2 , pp. 850-852
    • Yankner, B.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.