mRNA expression and activity of ADAM17 in hippocampus after chronic cerebral hypoperfusion: Experiment with aged rats

National Medical Journal of China

Volumn 87, Issue 35, 2007, Pages 2515-2517

  Yan, Fu Ling ^a   Zhang, Jie ^b   Guan, Xue Neng ^b   Hong, Zhen ^b  

^a FUDAN UNIVERSITY   (China)

^b NONE

Author keywords

Brain ischemia; Cognition disorders; Disintegrins; Metalloendopeptidases

Indexed keywords

ADAM PROTEIN; ADAM17 PROTEIN; ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PERFUSION; CAROTID ARTERY OBSTRUCTION; COGNITIVE DEFECT; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FLUORESCENCE SPECTROSCOPY; GENE EXPRESSION; HIPPOCAMPUS; LEARNING; MAZE TEST; MEMORY DISORDER; NEUROPATHOLOGY; NONHUMAN; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; WISTAR RAT;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN ISCHEMIA; GENE EXPRESSION; HIPPOCAMPUS; MALE; RANDOM ALLOCATION; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECTROMETRY, FLUORESCENCE;

EID: 37149055912     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Allinson TM, Parkin ET, Turner AJ, et al. ADAMs family members as amyloid precursor protein α-secretase. J Neurosci Res, 2003, 74: 342-352.
2. Skovronsky DM, Fath S, Lee VM, et al. Neuronal localization of the TNF alpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques. J Neurobiol, 2001,49: 40-46.
3. Wakita H, Tomimoto H, Akiguchi I, et al. Ibudilast, a phosphodiesterase inhibitor, protects white matter damage under chronic cerebral hypoperfusion in the rat. Brain Res, 2003,992: 53-59.
4. de la Torre JC. How do heart disease and stroke become risk factors for Alzheimer's disease? Neurol Res, 2006,28:637-644.
5. Kalaria R. Similarities between Alzheimer's disease and vascular dementia. J Neurosci, 2002,203-204:29-34.
6. de la Torre JC. Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics. Lancet Neurol, 2004,3:184-190.
7. van Groen T, Puurunen K, Maki ahm, et al. Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats. Stroke, 2005,36:1551-1556.
8. de la Torre JC, Pappas BA, Prevot V, et al. Hippocampal nitric oxide upregulation precedes memory loss and A beta 1-40 accumulation after chronic brain hypoperfusion in rats. Neurol Res. 2003,25:635-641.
9. McCarty MF. Toward prevention of Alzheimer's disease-potential nutraceutical strategies or suppressing the production of amyloid beta peptides. Med Hypotheses, 2006,67:682-697.
10. Turner PR, O'Connor K, Tate WP, et al. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol, 2003,70:1-32.