Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation?

Journal of Neurology, Supplement

Volumn 250, Issue 3, 2003, Pages 44-46

  Freed, Curt R ^a   Leehey, Maureen A ^a   Zawada, Michael ^a   Bjugstad, Kimberly ^a   Thompson, Laetitia ^a   Breeze, Robert E ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Double blind; Embryonic stem cells; Fluorodopa; Neurosurgery; Positron emission tomography (PET); Putamen

Indexed keywords

DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; NEUROTROPHIC FACTOR;

CLINICAL TRIAL; CONFERENCE PAPER; DISEASE COURSE; DRUG EFFICACY; DRUG RESPONSE; DYSKINESIA; EMBRYONIC DOPAMINE CELL TRANSPLANTATION; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; NEUROSURGERY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; TREATMENT OUTCOME;

BRAIN; BRAIN TISSUE TRANSPLANTATION; DISEASE PROGRESSION; DOPAMINE; DOUBLE-BLIND METHOD; EMBRYO; FETAL TISSUE TRANSPLANTATION; HUMANS; LEVODOPA; MIDDLE AGED; NEURONS; PARKINSON DISEASE; STEM CELL TRANSPLANTATION; TOMOGRAPHY, EMISSION-COMPUTED; TRANSPLANTS; TREATMENT OUTCOME;

EID: 0142093660     PISSN: 09391517     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (8)

1. Freed CR, Breeze RE, Rosenberg NL, et al. (1990) Transplantation of human fetal dopamine cells for Parkinson's disease: Results at 1 year. Arch Neurol 47:505-512
2. Lindvall O, Brundin P, Widner H, et al. (1990) Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 247:574-577
3. Freed CR, Breeze RE, Rosenberg NL, Schneck SA, Kriek E, Qi J-X, Lone T, Zhang Y-B, Snyder JA, Wells TH, Ramig LO, Thompson L, Mazziotta JC, Huang SC, Grafton ST, Brooks D, Sawle G, Schroter G, Ansari AA (1992) Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's Disease. N Engl J Med 327:1549-1555
4. Cohen J (1994) New fight over fetal tissue grafts. Science 263:600-601
5. Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel W, Kao R, Dillon S, Winfield H, Culver S, Trojanowski JQ, Eidelberg D, Fahn S (2001) Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 344:710-719
6. th International Congress of Parkinson's Disease and Movement Disorders, Abstract P692, 12 November
7. Olanow-CW, Goetz CG, Kordower KH, Stoessl AJ, Sossi V, Brin MF, Shannon KM, Nauert GM, Perl DP, Godbold J, Freeman TB (2003) A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol 54:403-414
8. Freed CR (2002) Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease? Proc Natl Acad Sci USA 99:1755-1757